ANNX — Détenteurs institutionnels (13F)
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| FMR LLC | $111 450 614 | 19 518 496 | 10,53% | Actions |
| BlackRock, Inc. | $77 311 938 | 13 539 744 | 7,31% | Actions |
| Redmile Group, LLC | $67 776 998 | 11 869 877 | 6,41% | Actions |
| STATE STREET CORP | $56 096 873 | 9 824 321 | 5,30% | Actions |
| BVF INC/IL | $49 666 568 | 8 698 173 | 4,69% | Actions |
| Woodline Partners LP | $39 542 133 | 6 925 067 | 3,74% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $39 233 496 | 6 871 015 | 3,71% | Actions |
| VANGUARD GROUP INC | $38 922 003 | 7 753 387 | 3,68% | Actions |
| MAK CAPITAL ONE LLC | $33 473 048 | 5 862 180 | 3,16% | Actions |
| GOLDMAN SACHS GROUP INC | $33 264 057 | 5 825 579 | 3,14% | Actions |
| Siren, L.L.C. | $25 458 869 | 4 458 646 | 2,41% | Actions |
| Bain Capital Life Sciences Investors, LLC | $25 339 444 | 4 437 731 | 2,39% | Actions |
| Bellevue Group AG | $23 411 091 | 4 100 016 | 2,21% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $23 056 071 | 4 037 193 | 2,18% | Actions |
| MPM BIOIMPACT LLC | $20 238 261 | 3 544 354 | 1,91% | Actions |
| AMERIPRISE FINANCIAL INC | $20 039 948 | 3 509 623 | 1,89% | Actions |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $19 985 000 | 3 500 000 | 1,89% | Actions |
| GREAT POINT PARTNERS LLC | $19 985 000 | 3 500 000 | 1,89% | Actions |
| MORGAN STANLEY | $17 954 827 | 3 144 453 | 1,70% | Actions |
| Palo Alto Investors LP | $16 833 594 | 2 948 090 | 1,59% | Actions |
| Balyasny Asset Management L.P. | $16 164 873 | 2 830 976 | 1,53% | Actions |
| Nuveen, LLC | $15 788 607 | 2 765 080 | 1,49% | Actions |
| Qube Research & Technologies Ltd | $15 702 277 | 2 749 961 | 1,48% | Actions |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $12 829 228 | 2 246 800 | 1,21% | Actions |
| Opaleye Management Inc. | $9 789 515 | 1 714 451 | 0,93% | Actions |
| Logos Global Management LP | $8 565 000 | 1 500 000 | 0,81% | Actions |
| DIMENSIONAL FUND ADVISORS LP | $8 550 585 | 1 497 756 | 0,81% | Actions |
| Point72 Asset Management, L.P. | $7 895 211 | 1 382 699 | 0,75% | Actions |
| NORTHERN TRUST CORP | $7 720 182 | 1 352 046 | 0,73% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $7 182 032 | 1 257 799 | 0,68% | Actions |
| Tetragon Partners GP Ltd | $7 094 418 | 1 242 455 | 0,67% | Actions |
| Candriam S.C.A. | $6 817 695 | 1 195 142 | 0,64% | Actions |
| MILLENNIUM MANAGEMENT LLC | $6 765 956 | 1 184 931 | 0,64% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $6 312 120 | 1 105 450 | 0,60% | Actions |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $5 923 360 | 1 037 366 | 0,56% | Actions |
| JPMORGAN CHASE & CO | $5 593 995 | 1 004 308 | 0,53% | Actions |
| WELLS FARGO & COMPANY/MN | $5 584 694 | 978 055 | 0,53% | Actions |
| PANAGORA ASSET MANAGEMENT INC | $5 526 857 | 967 926 | 0,52% | Actions |
| KENNEDY CAPITAL MANAGEMENT LLC | $5 129 830 | 898 394 | 0,48% | Actions |
| Ishara Investments LP | $4 682 200 | 820 000 | 0,44% | Actions |
| Ensign Peak Advisors, Inc | $4 570 946 | 800 516 | 0,43% | Actions |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $4 213 609 | 737 935 | 0,40% | Actions |
| Y-Intercept (Hong Kong) Ltd | $4 194 480 | 734 585 | 0,40% | Actions |
| Russell Investments Group, Ltd. | $4 027 213 | 705 291 | 0,38% | Actions |
| AQR CAPITAL MANAGEMENT LLC | $3 950 245 | 691 812 | 0,37% | Actions |
| Parkman Healthcare Partners LLC | $3 660 276 | 641 029 | 0,35% | Actions |
| UBS Group AG | $3 557 866 | 623 094 | 0,34% | Actions |
| DEUTSCHE BANK AG\ | $3 520 153 | 616 489 | 0,33% | Actions |
| BANK OF AMERICA CORP /DE/ | $3 507 002 | 614 186 | 0,33% | Actions |
| CITADEL ADVISORS LLC | $3 406 483 | 596 582 | 0,32% | Actions |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $3 334 143 | 583 913 | 0,32% | Actions |
| SIRIOS CAPITAL MANAGEMENT L P | $3 250 566 | 569 276 | 0,31% | Actions |
| Schonfeld Strategic Advisors LLC | $3 046 666 | 533 567 | 0,29% | Actions |
| TWO SIGMA INVESTMENTS, LP | $2 928 065 | 512 796 | 0,28% | Actions |
| Bank of New York Mellon Corp | $2 863 235 | 501 442 | 0,27% | Actions |
| Board of Trustees of The Leland Stanford Junior University | $2 755 360 | 482 550 | 0,26% | Actions |
| RENAISSANCE TECHNOLOGIES LLC | $2 620 890 | 459 000 | 0,25% | Actions |
| Ikarian Capital, LLC | $2 456 693 | 430 244 | 0,23% | Actions |
| MOORE CAPITAL MANAGEMENT, LP | $2 428 646 | 425 332 | 0,23% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $2 352 520 | 412 000 | 0,22% | Option d'achat |
| Trexquant Investment LP | $2 339 199 | 409 667 | 0,22% | Actions |
| WELLINGTON MANAGEMENT GROUP LLP | $2 322 799 | 406 795 | 0,22% | Actions |
| Susquehanna Portfolio Strategies, LLC | $2 256 763 | 395 230 | 0,21% | Actions |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | $2 253 166 | 394 600 | 0,21% | Actions |
| DIADEMA PARTNERS LP | $2 016 772 | 353 200 | 0,19% | Option d'achat |
| Invesco Ltd. | $1 888 463 | 330 729 | 0,18% | Actions |
| Engineers Gate Manager LP | $1 821 815 | 319 057 | 0,17% | Actions |
| DAFNA Capital Management LLC | $1 700 507 | 297 812 | 0,16% | Actions |
| Jump Financial, LLC | $1 700 438 | 297 800 | 0,16% | Actions |
| STATE OF WISCONSIN INVESTMENT BOARD | $1 635 201 | 286 375 | 0,15% | Actions |
| D. E. Shaw & Co., Inc. | $1 514 772 | 265 284 | 0,14% | Actions |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $1 427 643 | 250 025 | 0,13% | Actions |
| Swiss National Bank | $1 396 666 | 244 600 | 0,13% | Actions |
| CITIGROUP INC | $1 347 502 | 235 990 | 0,13% | Actions |
| CITADEL ADVISORS LLC | $1 340 137 | 234 700 | 0,13% | Option d'achat |
| Cinctive Capital Management LP | $1 231 921 | 215 748 | 0,12% | Actions |
| MARSHALL WACE, LLP | $1 202 566 | 210 607 | 0,11% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1 086 042 | 190 200 | 0,10% | Option de vente |
| RHUMBLINE ADVISERS | $1 082 480 | 189 578 | 0,10% | Actions |
| SEI INVESTMENTS CO | $1 049 635 | 183 817 | 0,10% | Actions |
| Squarepoint Ops LLC | $989 457 | 173 285 | 0,09% | Actions |
| Rafferty Asset Management, LLC | $989 423 | 173 279 | 0,09% | Actions |
| Point72 Europe (London) LLP | $923 726 | 302 861 | 0,09% | Actions |
| OSAIC HOLDINGS, INC. | $842 933 | 147 624 | 0,08% | Actions |
| ALLIANCEBERNSTEIN L.P. | $815 710 | 147 240 | 0,08% | Actions |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $766 619 | 134 259 | 0,07% | Actions |
| VICTORY CAPITAL MANAGEMENT INC | $727 100 | 127 338 | 0,07% | Actions |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $723 784 | 130 647 | 0,07% | Actions |
| BOOTHBAY FUND MANAGEMENT, LLC | $685 937 | 120 129 | 0,06% | Actions |
| IEQ CAPITAL, LLC | $685 257 | 120 010 | 0,06% | Actions |
| J. Goldman & Co LP | $662 623 | 116 046 | 0,06% | Actions |
| XTX Topco Ltd | $640 359 | 112 147 | 0,06% | Actions |
| Vanguard Global Advisers, LLC | $582 803 | 102 067 | 0,06% | Actions |
| Quarry LP | $571 000 | 100 000 | 0,05% | Actions |
| SCS Capital Management LLC | $565 290 | 99 000 | 0,05% | Actions |
| Legal & General Group Plc | $560 254 | 98 118 | 0,05% | Actions |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $520 567 | 91 661 | 0,05% | Actions |
| MetLife Investment Management, LLC | $519 639 | 91 005 | 0,05% | Actions |
| JANE STREET GROUP, LLC | $516 755 | 90 500 | 0,05% | Option d'achat |
| J. Safra Sarasin Holding AG | $516 681 | 90 487 | 0,05% | Actions |
| CITADEL ADVISORS LLC | $507 619 | 88 900 | 0,05% | Option de vente |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $505 438 | 88 518 | 0,05% | Actions |
| CAPTRUST FINANCIAL ADVISORS | $501 960 | 87 909 | 0,05% | Actions |
| PROFUND ADVISORS LLC | $499 676 | 87 509 | 0,05% | Actions |
| VANGUARD ASSET MANAGEMENT, Ltd | $453 865 | 79 486 | 0,04% | Actions |
| DNB Asset Management AS | $417 669 | 73 147 | 0,04% | Actions |
| Virtus Investment Advisers, LLC | $396 662 | 69 468 | 0,04% | Actions |
| Jain Global LLC | $369 545 | 64 719 | 0,03% | Actions |
| China Universal Asset Management Co., Ltd. | $354 454 | 62 076 | 0,03% | Actions |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $354 437 | 62 073 | 0,03% | Actions |
| DIVERSIFIED TRUST CO | $352 860 | 61 797 | 0,03% | Actions |
| DLD Asset Management, LP | $343 200 | 60 000 | 0,03% | Option d'achat |
| JANUS HENDERSON GROUP PLC | $327 710 | 59 100 | 0,03% | Actions |
| VIRGINIA RETIREMENT SYSTEMS ET Al | $310 053 | 54 300 | 0,03% | Actions |
| WINTON GROUP Ltd | $272 938 | 47 800 | 0,03% | Actions |
| JUPITER ASSET MANAGEMENT LTD | $263 083 | 46 074 | 0,02% | Actions |
| Creative Planning | $262 374 | 45 950 | 0,02% | Actions |
| Police & Firemen's Retirement System of New Jersey | $261 592 | 45 813 | 0,02% | Actions |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $255 272 | 44 706 | 0,02% | Actions |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $254 009 | 44 485 | 0,02% | Actions |
| Allegheny Financial Group | $244 959 | 42 900 | 0,02% | Actions |
| BARCLAYS PLC | $238 193 | 41 715 | 0,02% | Actions |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $237 062 | 41 517 | 0,02% | Actions |
| State of New Jersey Common Pension Fund D | $225 025 | 39 409 | 0,02% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $224 940 | 39 394 | 0,02% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $224 146 | 39 255 | 0,02% | Actions |
| FIFTH THIRD BANCORP | $220 634 | 38 640 | 0,02% | Actions |
| CANADA PENSION PLAN INVESTMENT BOARD | $220 406 | 38 600 | 0,02% | Actions |
| CWM, LLC | $219 672 | 39 652 | 0,02% | Actions |
| NEW YORK STATE COMMON RETIREMENT FUND | $208 803 | 36 568 | 0,02% | Actions |
| Persistent Asset Partners Ltd | $206 640 | 897 | 0,02% | Option d'achat |
| Vanguard Investments Australia, Ltd. | $200 044 | 35 034 | 0,02% | Actions |
| ARIZONA STATE RETIREMENT SYSTEM | $192 027 | 33 630 | 0,02% | Actions |
| Blueshift Asset Management, LLC | $190 360 | 33 338 | 0,02% | Actions |
| PRELUDE CAPITAL MANAGEMENT, LLC | $180 676 | 31 642 | 0,02% | Actions |
| VOYA INVESTMENT MANAGEMENT LLC | $176 268 | 30 870 | 0,02% | Actions |
| Lido Advisors, LLC | $176 114 | 30 843 | 0,02% | Actions |
| EntryPoint Capital, LLC | $175 794 | 30 787 | 0,02% | Actions |
| INTECH INVESTMENT MANAGEMENT LLC | $170 895 | 29 929 | 0,02% | Actions |
| Bridgefront Capital, LLC | $162 895 | 28 528 | 0,02% | Actions |
| COMERICA BANK | $162 432 | 32 357 | 0,02% | Actions |
| Quadrature Capital Ltd | $159 098 | 27 863 | 0,02% | Actions |
| DIADEMA PARTNERS LP | $157 116 | 27 516 | 0,01% | Actions |
| KLP KAPITALFORVALTNING AS | $150 173 | 26 300 | 0,01% | Actions |
| ProShare Advisors LLC | $146 810 | 25 711 | 0,01% | Actions |
| Verdad Advisers, LP | $144 463 | 25 300 | 0,01% | Actions |
| Brevan Howard Capital Management LP | $144 389 | 25 287 | 0,01% | Actions |
| AlphaCentric Advisors LLC | $142 019 | 24 872 | 0,01% | Actions |
| PRUDENTIAL FINANCIAL INC | $141 894 | 24 850 | 0,01% | Actions |
| E Fund Management Co., Ltd. | $139 512 | 24 433 | 0,01% | Actions |
| Crown Wealth Group, LLC | $135 687 | 23 763 | 0,01% | Actions |
| SBI Securities Co., Ltd. | $132 615 | 23 225 | 0,01% | Actions |
| RAYMOND JAMES FINANCIAL INC | $130 582 | 22 869 | 0,01% | Actions |
| STRS OHIO | $121 052 | 21 200 | 0,01% | Actions |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | $119 967 | 21 010 | 0,01% | Actions |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | $118 843 | 20 813 | 0,01% | Actions |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | $117 467 | 20 253 | 0,01% | Actions |
| Corient Private Wealth LP | $112 510 | 19 704 | 0,01% | Actions |
| State of Wyoming | $111 225 | 19 479 | 0,01% | Actions |
| MERCER GLOBAL ADVISORS INC /ADV | $97 510 | 17 077 | 0,01% | Actions |
| Coastal Bridge Advisors, LLC | $97 070 | 17 000 | 0,01% | Actions |
| Pictet Asset Management Holding SA | $95 363 | 16 701 | 0,01% | Actions |
| Mariner, LLC | $94 053 | 16 469 | 0,01% | Actions |
| LPL Financial LLC | $90 269 | 15 809 | 0,01% | Actions |
| Balefire, LLC | $85 713 | 15 011 | 0,01% | Actions |
| DLD Asset Management, LP | $85 650 | 15 000 | 0,01% | Actions |
| XPONANCE LLC | $84 879 | 14 865 | 0,01% | Actions |
| Forefront Analytics, LLC | $81 310 | 14 240 | 0,01% | Actions |
| TEACHER RETIREMENT SYSTEM OF TEXAS | $81 270 | 14 233 | 0,01% | Actions |
| Ameritas Investment Partners, Inc. | $80 494 | 14 097 | 0,01% | Actions |
| Private Advisor Group, LLC | $80 054 | 14 020 | 0,01% | Actions |
| Cerity Partners LLC | $79 182 | 13 867 | 0,01% | Actions |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $73 088 | 12 800 | 0,01% | Actions |
| Tower Research Capital LLC (TRC) | $73 008 | 12 786 | 0,01% | Actions |
| Vanguard Personalized Indexing Management, LLC | $71 306 | 12 488 | 0,01% | Actions |
| Quantinno Capital Management LP | $70 022 | 12 263 | 0,01% | Actions |
| Cubist Systematic Strategies, LLC | $69 451 | 22 771 | 0,01% | Actions |
| PRINCIPAL FINANCIAL GROUP INC | $67 812 | 11 876 | 0,01% | Actions |
| Merit Financial Group, LLC | $63 398 | 11 103 | 0,01% | Actions |
| FOX RUN MANAGEMENT, L.L.C. | $62 353 | 10 920 | 0,01% | Actions |
| NISA INVESTMENT ADVISORS, LLC | $61 548 | 10 779 | 0,01% | Actions |
| GROUP ONE TRADING LLC | $57 597 | 10 087 | 0,01% | Actions |
| Harbor Advisors LLC | $57 100 | 10 000 | 0,01% | Actions |
| Shay Capital LLC | $57 100 | 10 000 | 0,01% | Actions |
| JANE STREET GROUP, LLC | $57 100 | 10 000 | 0,01% | Option de vente |
| Fulcrum Asset Management LLP | $56 090 | 10 070 | 0,01% | Actions |
| Arax Advisory Partners | $43 876 | 7 684 | 0,00% | Actions |
| Mirae Asset Global Investments Co., Ltd. | $41 843 | 7 328 | 0,00% | Actions |
| Persistent Asset Partners Ltd | $38 971 | 6 825 | 0,00% | Actions |
| Geneos Wealth Management Inc. | $34 260 | 6 000 | 0,00% | Actions |
| ROYAL BANK OF CANADA | $31 000 | 5 395 | 0,00% | Actions |
| JONES FINANCIAL COMPANIES LLLP | $19 536 | 3 565 | 0,00% | Actions |
| GF FUND MANAGEMENT CO. LTD. | $17 501 | 3 065 | 0,00% | Actions |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $11 557 | 2 024 | 0,00% | Actions |
| BARCLAYS PLC | $11 420 | 2 000 | 0,00% | Option d'achat |
| Larson Financial Group LLC | $11 420 | 2 000 | 0,00% | Actions |
| Quantbot Technologies LP | $8 919 | 1 562 | 0,00% | Actions |
| PNC Financial Services Group, Inc. | $7 114 | 1 246 | 0,00% | Actions |
| Trask Adam Roland | $5 540 | 1 000 | 0,00% | Actions |
| Allworth Financial LP | $4 774 | 836 | 0,00% | Actions |
| Rockefeller Capital Management L.P. | $4 488 | 786 | 0,00% | Actions |
| Farther Finance Advisors, LLC | $4 185 | 738 | 0,00% | Actions |
| Essential Partners LLC | $3 849 | 674 | 0,00% | Actions |
| ACADIAN ASSET MANAGEMENT LLC | $3 588 | 629 127 | 0,00% | Actions |
| GAMMA Investing LLC | $3 255 | 570 | 0,00% | Actions |
| IFP Advisors, Inc | $3 249 | 569 | 0,00% | Actions |
| EverSource Wealth Advisors, LLC | $3 191 | 559 | 0,00% | Actions |
| Sterling Capital Management LLC | $3 112 | 545 | 0,00% | Actions |
| Caitong International Asset Management Co., Ltd | $2 838 | 497 | 0,00% | Actions |
| Fortitude Family Office, LLC | $2 758 | 483 | 0,00% | Actions |
| Optiver Holding B.V. | $2 318 | 406 | 0,00% | Actions |
| HighMark Wealth Management LLC | $1 713 | 300 | 0,00% | Actions |
| True Wealth Design, LLC | $1 616 | 283 | 0,00% | Actions |
| Physician Wealth Advisors, Inc. | $1 536 | 269 | 0,00% | Actions |
| ROTHSCHILD INVESTMENT LLC | $1 422 | 249 | 0,00% | Actions |
| Global Retirement Partners, LLC | $1 034 | 181 | 0,00% | Actions |
| PRICE T ROWE ASSOCIATES INC /MD/ | $738 | 129 243 | 0,00% | Actions |
| Sunbelt Securities, Inc. | $609 | 110 | 0,00% | Actions |
| GSA CAPITAL PARTNERS LLP | $596 | 104 378 | 0,00% | Actions |
| NATIONAL BANK OF CANADA /FI/ | $383 | 67 | 0,00% | Actions |
| SG Americas Securities, LLC | $245 | 42 823 | 0,00% | Actions |
| CANADA LIFE ASSURANCE Co | $124 | 21 646 | 0,00% | Actions |
| Cygnus Capital Advisors, LLC | $123 | 21 549 | 0,00% | Actions |
| SJS Investment Consulting Inc. | $115 | 20 | 0,00% | Actions |
| Stone House Investment Management, LLC | $91 | 16 | 0,00% | Actions |
| Clearstead Advisors, LLC | $86 | 15 | 0,00% | Actions |
| MOUNT VERNON ASSOCIATES INC /MD/ | $60 | 10 500 | 0,00% | Actions |
| Cambridge Investment Research Advisors, Inc. | $58 | 10 110 | 0,00% | Actions |
| Pacer Advisors, Inc. | $17 | 2 894 | 0,00% | Actions |
| Silver Grove Financial Group, Inc. | $6 | 1 | 0,00% | Actions |