TYRA — Détenteurs institutionnels (13F)
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $389 624 083 | 12 198 625 | 17,79% | Actions |
| FMR LLC | $284 921 184 | 8 920 513 | 13,01% | Actions |
| JANUS HENDERSON GROUP PLC | $148 867 244 | 3 890 589 | 6,80% | Actions |
| Alta Partners Management Company, L.P. | $122 120 195 | 3 823 425 | 5,58% | Actions |
| Nextech Invest Ltd. | $113 501 505 | 3 553 585 | 5,18% | Actions |
| TCG Crossover Management, LLC | $103 772 421 | 3 248 980 | 4,74% | Actions |
| BlackRock, Inc. | $96 841 186 | 3 031 972 | 4,42% | Actions |
| STATE STREET CORP | $68 363 354 | 2 140 368 | 3,12% | Actions |
| Commodore Capital LP | $59 887 500 | 1 875 000 | 2,73% | Actions |
| Paradigm Biocapital Advisors LP | $58 405 708 | 1 828 607 | 2,67% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $48 179 797 | 1 508 447 | 2,20% | Actions |
| BVF INC/IL | $47 149 700 | 1 476 196 | 2,15% | Actions |
| VANGUARD GROUP INC | $41 348 518 | 1 572 785 | 1,89% | Actions |
| 5AM Venture Management, LLC | $32 875 778 | 1 029 298 | 1,50% | Actions |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $32 482 980 | 1 017 000 | 1,48% | Actions |
| Hood River Capital Management LLC | $32 475 794 | 1 016 775 | 1,48% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $31 010 333 | 970 734 | 1,42% | Actions |
| Caligan Partners LP | $25 775 133 | 806 986 | 1,18% | Actions |
| Canaan Partners XI LLC | $23 955 000 | 750 000 | 1,09% | Actions |
| Siren, L.L.C. | $23 156 500 | 725 000 | 1,06% | Actions |
| Sio Capital Management, LLC | $22 208 361 | 695 315 | 1,01% | Actions |
| STEMPOINT CAPITAL LP | $20 210 163 | 632 754 | 0,92% | Actions |
| MARSHALL WACE, LLP | $18 625 268 | 583 133 | 0,85% | Actions |
| GOLDMAN SACHS GROUP INC | $14 803 455 | 463 477 | 0,68% | Actions |
| JENNISON ASSOCIATES LLC | $14 403 791 | 450 964 | 0,66% | Actions |
| TWO SIGMA INVESTMENTS, LP | $14 366 868 | 449 808 | 0,66% | Actions |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $12 872 427 | 403 019 | 0,59% | Actions |
| Defilade Capital Management, L.P. | $12 037 228 | 376 870 | 0,55% | Actions |
| BANK OF AMERICA CORP /DE/ | $11 170 440 | 349 732 | 0,51% | Actions |
| Walleye Capital LLC | $11 111 862 | 347 898 | 0,51% | Actions |
| Woodline Partners LP | $10 222 078 | 320 040 | 0,47% | Actions |
| NORTHERN TRUST CORP | $9 904 084 | 310 084 | 0,45% | Actions |
| MORGAN STANLEY | $9 592 284 | 300 322 | 0,44% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $9 086 930 | 284 500 | 0,41% | Option d'achat |
| CITADEL ADVISORS LLC | $8 889 126 | 278 307 | 0,41% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $8 550 306 | 267 699 | 0,39% | Actions |
| Qube Research & Technologies Ltd | $8 525 872 | 266 934 | 0,39% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $7 672 850 | 240 227 | 0,35% | Actions |
| ALGERT GLOBAL LLC | $7 637 493 | 239 120 | 0,35% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $7 180 272 | 224 805 | 0,33% | Actions |
| DIMENSIONAL FUND ADVISORS LP | $6 933 472 | 217 078 | 0,32% | Actions |
| Affinity Asset Advisors, LLC | $6 388 383 | 200 012 | 0,29% | Actions |
| FRANKLIN RESOURCES INC | $6 143 340 | 192 340 | 0,28% | Actions |
| HighVista Strategies LLC | $5 901 681 | 184 774 | 0,27% | Actions |
| RAYMOND JAMES FINANCIAL INC | $5 777 339 | 180 881 | 0,26% | Actions |
| JPMORGAN CHASE & CO | $5 743 677 | 178 263 | 0,26% | Actions |
| MILLENNIUM MANAGEMENT LLC | $5 674 844 | 177 672 | 0,26% | Actions |
| BOOTHBAY FUND MANAGEMENT, LLC | $5 543 474 | 173 559 | 0,25% | Actions |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $5 174 280 | 162 000 | 0,24% | Actions |
| Jump Financial, LLC | $5 014 580 | 157 000 | 0,23% | Actions |
| VICTORY CAPITAL MANAGEMENT INC | $4 873 565 | 152 585 | 0,22% | Actions |
| Ensign Peak Advisors, Inc | $4 680 392 | 146 537 | 0,21% | Actions |
| Trexquant Investment LP | $4 239 716 | 132 740 | 0,19% | Actions |
| UBS Group AG | $4 150 443 | 129 945 | 0,19% | Actions |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $3 942 035 | 123 420 | 0,18% | Actions |
| BARCLAYS PLC | $3 631 578 | 113 700 | 0,17% | Option d'achat |
| Bank of New York Mellon Corp | $3 312 823 | 103 720 | 0,15% | Actions |
| Russell Investments Group, Ltd. | $3 280 346 | 102 703 | 0,15% | Actions |
| ORBIMED ADVISORS LLC | $3 257 880 | 102 000 | 0,15% | Actions |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $2 849 208 | 89 205 | 0,13% | Actions |
| OPPENHEIMER & CO INC | $2 676 029 | 83 783 | 0,12% | Actions |
| XTX Topco Ltd | $2 597 361 | 81 320 | 0,12% | Actions |
| Nuveen, LLC | $2 517 798 | 78 829 | 0,11% | Actions |
| Kalehua Capital Management LLC | $2 378 412 | 74 465 | 0,11% | Actions |
| SEI INVESTMENTS CO | $2 127 428 | 66 607 | 0,10% | Actions |
| Squarepoint Ops LLC | $2 037 932 | 63 805 | 0,09% | Actions |
| CITIGROUP INC | $1 989 192 | 62 279 | 0,09% | Actions |
| Fisher Asset Management, LLC | $1 923 745 | 60 230 | 0,09% | Actions |
| ALPS ADVISORS INC | $1 921 478 | 60 159 | 0,09% | Actions |
| WELLINGTON MANAGEMENT GROUP LLP | $1 903 655 | 59 601 | 0,09% | Actions |
| ALLIANCEBERNSTEIN L.P. | $1 854 486 | 48 420 | 0,08% | Actions |
| AXA Investment Managers S.A. | $1 801 758 | 128 789 | 0,08% | Actions |
| RHUMBLINE ADVISERS | $1 662 114 | 52 039 | 0,08% | Actions |
| TD Asset Management Inc | $1 597 000 | 50 000 | 0,07% | Actions |
| Arkadios Wealth Advisors | $1 575 792 | 49 336 | 0,07% | Actions |
| TWO SIGMA ADVISERS, LP | $1 548 481 | 58 900 | 0,07% | Actions |
| STATE OF WISCONSIN INVESTMENT BOARD | $1 491 502 | 46 697 | 0,07% | Actions |
| JANE STREET GROUP, LLC | $1 437 300 | 45 000 | 0,07% | Option de vente |
| Susquehanna Portfolio Strategies, LLC | $1 433 403 | 44 878 | 0,07% | Actions |
| Swiss National Bank | $1 427 718 | 44 700 | 0,07% | Actions |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $1 415 804 | 44 327 | 0,06% | Actions |
| ExodusPoint Capital Management, LP | $1 310 370 | 41 026 | 0,06% | Actions |
| Rafferty Asset Management, LLC | $1 236 142 | 38 702 | 0,06% | Actions |
| DEUTSCHE BANK AG\ | $1 179 704 | 36 935 | 0,05% | Actions |
| Verdad Advisers, LP | $1 149 936 | 36 003 | 0,05% | Actions |
| WELLS FARGO & COMPANY/MN | $1 071 938 | 33 561 | 0,05% | Actions |
| Sofinnova Investments, Inc. | $1 030 608 | 32 267 | 0,05% | Actions |
| Engineers Gate Manager LP | $1 020 739 | 31 958 | 0,05% | Actions |
| AQR CAPITAL MANAGEMENT LLC | $953 505 | 29 853 | 0,04% | Actions |
| PDT Partners, LLC | $820 347 | 25 684 | 0,04% | Actions |
| MILLENNIUM MANAGEMENT LLC | $798 500 | 25 000 | 0,04% | Option d'achat |
| Invesco Ltd. | $795 083 | 24 893 | 0,04% | Actions |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $783 935 | 24 544 | 0,04% | Actions |
| STRS OHIO | $705 874 | 22 100 | 0,03% | Actions |
| Creative Planning | $696 387 | 21 803 | 0,03% | Actions |
| MetLife Investment Management, LLC | $693 833 | 21 723 | 0,03% | Actions |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $683 131 | 21 364 | 0,03% | Actions |
| LMR Partners LLP | $675 563 | 21 151 | 0,03% | Actions |
| Auour Investments LLC | $671 379 | 21 020 | 0,03% | Actions |
| VOYA INVESTMENT MANAGEMENT LLC | $647 807 | 20 282 | 0,03% | Actions |
| BARCLAYS PLC | $647 585 | 20 275 | 0,03% | Actions |
| D. E. Shaw & Co., Inc. | $644 837 | 20 189 | 0,03% | Actions |
| Vanguard Global Advisers, LLC | $643 719 | 20 154 | 0,03% | Actions |
| Elmind Capital, LP | $638 800 | 20 000 | 0,03% | Actions |
| PROFUND ADVISORS LLC | $625 641 | 19 588 | 0,03% | Actions |
| Legal & General Group Plc | $575 463 | 18 017 | 0,03% | Actions |
| Cubist Systematic Strategies, LLC | $549 946 | 39 310 | 0,03% | Actions |
| AMERIPRISE FINANCIAL INC | $540 425 | 16 920 | 0,02% | Actions |
| WINTON GROUP Ltd | $536 592 | 16 800 | 0,02% | Actions |
| VANGUARD ASSET MANAGEMENT, Ltd | $494 399 | 15 479 | 0,02% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $479 100 | 15 000 | 0,02% | Option de vente |
| FOX RUN MANAGEMENT, L.L.C. | $461 533 | 14 450 | 0,02% | Actions |
| NEW YORK STATE COMMON RETIREMENT FUND | $412 761 | 12 923 | 0,02% | Actions |
| Virtus Investment Advisers, LLC | $387 209 | 12 123 | 0,02% | Actions |
| Police & Firemen's Retirement System of New Jersey | $346 549 | 10 850 | 0,02% | Actions |
| BAKER BROS. ADVISORS LP | $338 788 | 10 607 | 0,02% | Actions |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | $334 060 | 10 459 | 0,02% | Actions |
| Cinctive Capital Management LP | $325 277 | 10 184 | 0,01% | Actions |
| CAPSTONE INVESTMENT ADVISORS, LLC | $321 029 | 10 051 | 0,01% | Actions |
| China Universal Asset Management Co., Ltd. | $302 312 | 9 465 | 0,01% | Actions |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $299 966 | 7 832 | 0,01% | Actions |
| Jain Global LLC | $274 844 | 8 605 | 0,01% | Actions |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $272 225 | 8 523 | 0,01% | Actions |
| Savant Capital, LLC | $251 375 | 7 141 | 0,01% | Actions |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | $237 059 | 7 422 | 0,01% | Actions |
| INTECH INVESTMENT MANAGEMENT LLC | $236 963 | 7 419 | 0,01% | Actions |
| Vanguard Investments Australia, Ltd. | $234 727 | 7 349 | 0,01% | Actions |
| State of New Jersey Common Pension Fund D | $230 383 | 7 213 | 0,01% | Actions |
| CANADA PENSION PLAN INVESTMENT BOARD | $229 968 | 7 200 | 0,01% | Actions |
| ProShare Advisors LLC | $216 074 | 6 765 | 0,01% | Actions |
| KLP KAPITALFORVALTNING AS | $162 894 | 5 100 | 0,01% | Actions |
| Ameritas Investment Partners, Inc. | $106 648 | 3 339 | 0,00% | Actions |
| Tower Research Capital LLC (TRC) | $93 584 | 2 930 | 0,00% | Actions |
| PRICE T ROWE ASSOCIATES INC /MD/ | $88 876 | 2 782 567 | 0,00% | Actions |
| Mirae Asset Global Investments Co., Ltd. | $84 960 | 2 660 | 0,00% | Actions |
| State of Wyoming | $76 305 | 2 389 | 0,00% | Actions |
| Hilton Head Capital Partners, LLC | $64 647 | 2 024 | 0,00% | Actions |
| Chung Wu Investment Group, LLC | $63 880 | 2 000 | 0,00% | Actions |
| Caitong International Asset Management Co., Ltd | $61 261 | 1 918 | 0,00% | Actions |
| CWM, LLC | $59 978 | 1 566 | 0,00% | Actions |
| AlphaQuest LLC | $56 234 | 2 139 | 0,00% | Actions |
| Steward Partners Investment Advisory, LLC | $39 190 | 1 227 | 0,00% | Actions |
| OSAIC HOLDINGS, INC. | $38 007 | 1 190 | 0,00% | Actions |
| GF FUND MANAGEMENT CO. LTD. | $36 124 | 1 131 | 0,00% | Actions |
| ROYAL BANK OF CANADA | $36 000 | 1 126 | 0,00% | Actions |
| NISA INVESTMENT ADVISORS, LLC | $24 626 | 771 | 0,00% | Actions |
| Versant Capital Management, Inc | $17 912 | 819 | 0,00% | Actions |
| GAMMA Investing LLC | $16 130 | 505 | 0,00% | Actions |
| Rockefeller Capital Management L.P. | $13 447 | 421 | 0,00% | Actions |
| FEDERATED HERMES, INC. | $11 786 | 369 | 0,00% | Actions |
| PNC Financial Services Group, Inc. | $6 645 | 208 | 0,00% | Actions |
| Larson Financial Group LLC | $4 791 | 150 | 0,00% | Actions |
| True Wealth Design, LLC | $4 536 | 142 | 0,00% | Actions |
| Sterling Capital Management LLC | $4 120 | 129 | 0,00% | Actions |
| Smartleaf Asset Management LLC | $4 078 | 127 | 0,00% | Actions |
| LORD, ABBETT & CO. LLC | $3 891 | 121 833 | 0,00% | Actions |
| Allworth Financial LP | $3 194 | 100 | 0,00% | Actions |
| Atlantic Union Bankshares Corp | $3 194 | 100 | 0,00% | Actions |
| Optiver Holding B.V. | $3 130 | 98 | 0,00% | Actions |
| Arax Advisory Partners | $2 779 | 87 | 0,00% | Actions |
| Farther Finance Advisors, LLC | $1 919 | 60 | 0,00% | Actions |
| ROTHSCHILD INVESTMENT LLC | $1 757 | 55 | 0,00% | Actions |
| EverSource Wealth Advisors, LLC | $1 406 | 44 | 0,00% | Actions |
| SIGNATUREFD, LLC | $1 373 | 43 | 0,00% | Actions |
| SG Americas Securities, LLC | $940 | 29 444 | 0,00% | Actions |
| Clearstead Advisors, LLC | $921 | 29 | 0,00% | Actions |
| Fortitude Family Office, LLC | $543 | 17 | 0,00% | Actions |
| NATIONAL BANK OF CANADA /FI/ | $480 | 15 | 0,00% | Actions |
| Quarry LP | $383 | 12 | 0,00% | Actions |
| Global Retirement Partners, LLC | $224 | 7 | 0,00% | Actions |
| ACADIAN ASSET MANAGEMENT LLC | $92 | 2 906 | 0,00% | Actions |
| SBI Securities Co., Ltd. | $64 | 2 | 0,00% | Actions |
| Keating Financial Advisory Services, Inc. | $32 | 1 | 0,00% | Actions |
| TFC Financial Management, Inc. | $32 | 1 | 0,00% | Actions |
| Silver Grove Financial Group, Inc. | $32 | 1 | 0,00% | Actions |
| Pacer Advisors, Inc. | $21 | 646 | 0,00% | Actions |
| Covestor Ltd | $1 | 16 | 0,00% | Actions |