TYRA Tyra Biosciences, Inc. - Common Stock
$26,53
Prix · Aoû 19, 2026
Données fondamentales au Aoû 4, 2026
Fourchette 52 semaines
$10–$41
54% of range
Note des analystes
BUY
22 analysts
Objectif de cours
$51
+92% upside
P/E (TTM)
-13.2
ROE
-42.7%
Marge nette
—
TYRA Aperçu de l'action Prix, capitalisation boursière, P/E, EPS, ROE, dette/capitaux propres, fourchette sur 52 semaines
Prix
$26.53
Capitalisation Boursière
$1.42B
P/E (TTM)
-13.2
BPA (TTM)
$-2.01
Revenus (TTM)
—
Rendement div.
—
ROE
-42.7%
Dette/Capitaux propres
—
Fourchette 52 semaines
$10 – $41
TYRA Graphique du cours de l'action OHLCV quotidien avec indicateurs techniques — panoramique, zoom et personnalisez votre vue
Configure
Performance sur 10 ans Tendances du chiffre d'affaires, du bénéfice net, des marges et du BPA
Revenus et bénéfice net
—
BPA
$-2.01
2021-12-31
→
2025-12-31
Flux de trésorerie libre
$-95M
2021-12-31
→
2025-12-31
Marges
—
Valorisation Ratios P/E, P/S, P/B, EV/EBITDA — l'action est-elle chère ou bon marché ?
Métrique
Tendance sur 5 ans
TYRA
Médiane des pairs
P/E (TTM)
-13.2
—
P/B
5.5
2.7
Price / FCF (Cours / FCF)
-15.0
—
Rentabilité Marges brutes, d'exploitation et nettes ; ROE, ROA, ROIC
Métrique
Tendance sur 5 ans
TYRA
Médiane des pairs
ROA
-37.1%
-43.1%
ROE
-42.7%
-49.0%
Santé financière Dette, liquidité, solvabilité — solidité du bilan
Métrique
Tendance sur 5 ans
TYRA
Médiane des pairs
Current Ratio (Ratio de liquidité)
14.7
9.0
Quick Ratio (Ratio de liquidité réduite)
4.3
—
Croissance Croissance du chiffre d'affaires, du BPA et du bénéfice net : Année/Année, TCAC 3 ans, TCAC 5 ans
Métrique
Tendance sur 5 ans
TYRA
Médiane des pairs
Efficacité du capital Rotation des actifs, rotation des stocks, rotation des créances
Métrique
Tendance sur 5 ans
TYRA
Médiane des pairs
TYRA Consensus des analystes Opinions des analystes haussières et baissières, objectif de cours à 12 mois, potentiel de hausse
ACHAT
22 analystes
- Achat fort 9 40,9%
- Achat 11 50,0%
- Conserver 2 9,1%
- Vente 0 0,0%
- Vente forte 0 0,0%
Objectif de cours à 12 mois
11 analystes · 2026-08-16
Médiane
$53.00
Moyenne
$50.82
← En dessous de tous les objectifs
$26.53
Bas
$39.00
Haut
$59.00
Objectif médian
$53.00
+99,8%
Objectif moyen
$50.82
+91,5%
Historique des bénéfices BPA réel vs estimation, surprise %, taux de succès, prochaine date de publication des résultats
Surprise Moyenne
0.00%
| Période | EPS Actual | BPA est. | Surprise |
|---|---|---|---|
| 30 juin 2026 | $-0.69 | $-0.66 | -0.03% |
| 31 mars 2026 | $-0.64 | $-0.60 | -0.04% |
| 31 décembre 2025 | $-0.57 | $-0.54 | -0.03% |
| 30 septembre 2025 | $-0.50 | $-0.51 | 0.01% |
| 30 juin 2025 | $-0.47 | $-0.54 | 0.07% |
| 31 mars 2025 | $-0.47 | $-0.50 | 0.03% |
Comparaison des pairs (sous-secteur GICS) Indicateurs clés par rapport aux pairs du secteur
| Ticker | Capitalisation Boursière | P/E | Revenus Année/Année | Marge Nette | ROE | Marge Brute |
|---|---|---|---|---|---|---|
| TYRA | $1.41B | -13.1 | — | — | -42.7% | — |
| RXRX | $2.16B | -2.8 | 26.9% | -863.4% | -62.9% | — |
| FBRX | $353M | -5.8 | 106.6% | -2555.2% | -86.9% | — |
| ZYME | $1.97B | -24.4 | 38.9% | -76.6% | -26.9% | — |
| BCAX | $953M | -6.7 | — | — | -33.0% | — |
| XNCR | $1.10B | -12.3 | 13.7% | -73.2% | -14.0% | — |
| JBIO | $761M | -4.8 | — | — | -47.7% | — |
| TRAX | — | — | — | — | — | — |
| VIR | $841M | -1.9 | -7.6% | -638.9% | -51.1% | — |
| ABSI | $529M | -4.2 | -38.2% | -4113.7% | -63.5% | — |
| AVBP | $854M | -4.7 | — | — | -59.7% | — |
Fondamentaux complets Tous les indicateurs par an — compte de résultat, bilan, flux de trésorerie
Compte de résultat 12
| Métrique | Tendance | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| R&D Expense | $103M | $80M | $63M | $43M | $21M | $7M | |
| SG&A Expense | $30M | $24M | $17M | $16M | $6M | $2M | |
| Operating Expenses | $133M | $104M | $80M | $59M | $26M | $9M | |
| Operating Income | $-133M | $-104M | $-80M | $-59M | $-26M | $-9M | |
| Other Non-op | $13M | $18M | $11M | $4M | $-6.0K | $-39.0K | |
| Income Tax | $0 | $0 | $0 | $2.0K | $1.0K | $1.0K | |
| Net Income | $-120M | $-86M | $-69M | $-55M | $-26M | $-9M | |
| EPS (Basic) | $-2.01 | $-1.51 | $-1.62 | $-1.32 | $-1.91 | · | |
| EPS (Diluted) | $-2.01 | $-1.51 | $-1.62 | $-1.32 | $-1.91 | · | |
| Shares (Basic) | 59,602,328 | 57,217,746 | 42,704,876 | 41,883,904 | 13,780,546 | · | |
| Shares (Diluted) | 59,602,328 | 57,217,746 | 42,704,876 | 41,883,904 | 13,780,546 | · | |
| EBITDA | $-132M | $-104M | $-80M | $-59M | $-26M | · |
Bilan 19
| Métrique | Tendance | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $77M | $92M | $58M | $251M | $302M | $15M | |
| Prepaid Expense | $9M | $6M | $8M | $6M | $2M | $57.0K | |
| Current Assets | $265M | $347M | $212M | $257M | $304M | $15M | |
| PP&E (Net) | $1M | $2M | $2M | $1M | $1M | $297.0K | |
| PP&E (Gross) | · | $3M | $2M | $2M | $1M | $340.0K | |
| Accum. Depreciation | · | $1M | $807.0K | $461.0K | $169.0K | $43.0K | |
| Other Non-current Assets | $9M | $7M | $5M | $4M | $312.0K | $21.0K | |
| Total Assets | $283M | $364M | $226M | $266M | $307M | $16M | |
| Accounts Payable | $1M | $590.0K | $5M | $1M | $599.0K | $664.0K | |
| Current Liabilities | $18M | $15M | $15M | $6M | $4M | $2M | |
| Capital Leases | $5M | $6M | $6M | $2M | $981.0K | $0 | |
| Other Non-current Liabilities | $0 | $3.0K | $46.0K | $169.0K | $367.0K | $140.0K | |
| Total Liabilities | $23M | $20M | $22M | $8M | $5M | $2M | |
| Common Stock | $5.0K | $5.0K | $4.0K | $4.0K | $4.0K | $0 | |
| Retained Earnings | $-371M | $-251M | $-165M | $-96M | $-40M | $-14M | |
| AOCI | $393.0K | $770.0K | $381.0K | $0 | · | · | |
| Stockholders' Equity | $259M | $343M | $204M | $258M | $302M | $-14M | |
| Liabilities + Equity | $283M | $364M | $226M | $266M | $307M | $16M | |
| Shares Outstanding | 53,706,357 | 50,749,945 | 43,024,634 | 42,353,550 | 41,441,135 | 1,829,377 |
Flux de trésorerie 9
| Métrique | Tendance | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| D&A | $546.0K | $519.0K | $357.0K | $296.0K | $140.0K | $47.0K | |
| Stock-based Comp | $28M | $23M | $14M | $11M | $3M | $439.0K | |
| Other Non-cash | $-4M | $-7M | $5M | $-6M | $-478.0K | · | |
| Operating Cash Flow | $-95M | $-70M | $-50M | $-50M | $-24M | $-8M | |
| CapEx | $141.0K | $664.0K | $770.0K | $559.0K | $661.0K | $312.0K | |
| Investing Cash Flow | $72M | $-98M | $-145M | $-559.0K | $-645.0K | $-312.0K | |
| Financing Cash Flow | $8M | $202M | $2M | $632.0K | $311M | $23M | |
| Net Change in Cash | $-15M | $34M | $-193M | $-50M | $287M | $15M | |
| Free Cash Flow | $-95M | $-70M | $-51M | $-51M | $-24M | · |
Rentabilité 2
| Métrique | Tendance | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| ROA | -37.1% | -29.3% | -28.1% | -19.3% | -16.3% | · | |
| ROE | -42.7% | -24.5% | -32.4% | -21.1% | -8.6% | · |
Liquidité et Solvabilité 2
| Métrique | Tendance | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| Current Ratio | 14.7 | 23.8 | 13.8 | 45.1 | 84.1 | · | |
| Quick Ratio | 4.3 | 6.3 | 3.8 | 44.1 | 83.6 | · |
Valorisation (TTM) 8
| Métrique | Tendance | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| Net Income TTM | $-120M | $-86M | $-69M | $-55M | $-26M | · | |
| Market Cap | $1.41B | $705M | $596M | $322M | $583M | · | |
| P/E | -13.1 | -9.2 | -8.5 | -5.8 | -7.4 | · | |
| P/B | 5.4 | 2.1 | 2.9 | 1.2 | 1.9 | · | |
| P / Tangible Book | 5.4 | 2.1 | 2.9 | 1.2 | 1.9 | · | |
| P / Cash Flow | -14.8 | -10.1 | -11.9 | -6.4 | -24.6 | · | |
| P / FCF | -14.8 | -10.0 | -11.7 | -6.3 | -23.9 | · | |
| Earnings Yield | -7.6% | -10.9% | -11.7% | -17.4% | -13.6% | · |
Compte de résultat 11
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R&D Expense | $39M | $33M | $28M | $25M | $24M | $25M | $22M | $23M | $18M | $17M | $21M | $19M | $12M | $10M | $10M | $11M | |
| SG&A Expense | $10M | $9M | $8M | $7M | $7M | $7M | $8M | $6M | $6M | $5M | $5M | $5M | $4M | $4M | $10M | $173.0K | |
| Operating Expenses | $49M | $42M | $37M | $33M | $31M | $32M | $30M | $29M | $24M | $22M | $26M | $24M | $16M | $14M | $15M | $14M | |
| Operating Income | $-49M | $-42M | $-37M | $-33M | $-31M | $-32M | $-30M | $-29M | $-24M | $-22M | $-26M | $-24M | $-16M | $-14M | $-15M | $-14M | |
| Other Non-op | $3M | $3M | $3M | $3M | $3M | $4M | $4M | $5M | $5M | $4M | $3M | $3M | $3M | $2M | $3M | $5.0K | |
| Net Income | $-46M | $-39M | $-34M | $-30M | $-28M | $-28M | $-26M | $-24M | $-19M | $-18M | $-23M | $-21M | $-13M | $-12M | $-13M | $-13M | |
| EPS (Basic) | $-0.69 | $-0.64 | $-0.57 | $-0.50 | $-0.47 | $-0.47 | $-0.43 | $-0.41 | $-0.32 | $-0.35 | $-0.54 | $-0.49 | $-0.31 | $-0.28 | $-0.30 | $-0.30 | |
| EPS (Diluted) | $-0.69 | $-0.64 | $-0.57 | $-0.50 | $-0.47 | $-0.47 | $-0.43 | $-0.41 | $-0.32 | $-0.35 | $-0.54 | $-0.49 | $-0.31 | $-0.28 | $-0.30 | $-0.30 | |
| Shares (Basic) | 65,991,171 | 61,746,050 | -118,955,750 | 59,670,757 | 59,550,771 | 59,336,550 | -112,554,397 | 58,874,497 | 58,668,712 | 52,228,934 | -85,147,300 | 42,868,340 | 42,589,213 | 42,394,623 | -83,442,210 | 41,997,195 | |
| Shares (Diluted) | 65,991,171 | 61,746,050 | -118,955,750 | 59,670,757 | 59,550,771 | 59,336,550 | -112,554,397 | 58,874,497 | 58,668,712 | 52,228,934 | -85,147,300 | 42,868,340 | 42,589,213 | 42,394,623 | -83,442,210 | 41,997,195 | |
| EBITDA | $-49M | $-42M | · | $-33M | $-31M | $-32M | · | $-29M | $-24M | $-22M | · | $-24M | $-16M | $-14M | · | $-14M |
Bilan 19
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $74M | $85M | $77M | $62M | $98M | $101M | $92M | $104M | $99M | $254M | $58M | $216M | $232M | $242M | $251M | $263M | |
| Prepaid Expense | $13M | $11M | $9M | $6M | $6M | $6M | $6M | $5M | $5M | $8M | $8M | $9M | $8M | $5M | $6M | $4M | |
| Current Assets | $367M | $395M | $265M | $281M | $302M | $325M | $347M | $366M | $379M | $391M | $212M | $225M | $241M | $247M | $257M | $267M | |
| PP&E (Net) | $1M | $1M | $1M | $1M | $1M | $2M | $2M | $2M | $2M | $2M | $2M | $1M | $1M | $1M | $1M | $1M | |
| PP&E (Gross) | · | · | · | · | · | $3M | · | $3M | $3M | $3M | $2M | $2M | $2M | $2M | $2M | $2M | |
| Accum. Depreciation | · | · | · | · | · | $1M | · | $1M | $1M | $926.0K | $807.0K | $706.0K | $629.0K | $544.0K | $461.0K | $379.0K | |
| Other Non-current Assets | $9M | $10M | $9M | $13M | $11M | $10M | $7M | $6M | $5M | $5M | $5M | $5M | $866.0K | $4M | $4M | $4M | |
| Total Assets | $383M | $412M | $283M | $302M | $321M | $343M | $364M | $381M | $392M | $405M | $226M | $238M | $250M | $255M | $266M | $276M | |
| Accounts Payable | $2M | $4M | $1M | $2M | $2M | $2M | $590.0K | $1M | $2M | $3M | $5M | $2M | $1M | $1M | $1M | $3M | |
| Current Liabilities | $25M | $19M | $18M | $16M | $14M | $14M | $15M | $12M | $10M | $9M | $15M | $10M | $5M | $4M | $6M | $5M | |
| Capital Leases | $5M | $5M | $5M | $5M | $6M | $6M | $6M | $6M | $6M | $6M | $6M | $6M | $6M | $2M | $2M | $3M | |
| Other Non-current Liabilities | · | · | $0 | $0 | $0 | $0 | $3.0K | $11.0K | $20.0K | $29.0K | $46.0K | $77.0K | $108.0K | $139.0K | $169.0K | $226.0K | |
| Total Liabilities | $30M | $24M | $23M | $21M | $19M | $20M | $20M | $18M | $16M | $15M | $22M | $16M | $11M | $6M | $8M | $8M | |
| Common Stock | $6.0K | $6.0K | $5.0K | $5.0K | $5.0K | $5.0K | $5.0K | $5.0K | $5.0K | $5.0K | $4.0K | $4.0K | $4.0K | $4.0K | $4.0K | $4.0K | |
| Retained Earnings | $-456M | $-411M | $-371M | $-337M | $-308M | $-279M | $-251M | $-226M | $-202M | $-183M | $-165M | $-142M | $-121M | $-108M | $-96M | $-83M | |
| AOCI | $-580.0K | $107.0K | $393.0K | $442.0K | $436.0K | $688.0K | $770.0K | $2M | $-184.0K | $-6.0K | $381.0K | · | · | · | $0 | · | |
| Stockholders' Equity | $354M | $388M | $259M | $281M | $302M | $324M | $343M | $362M | $376M | $390M | $204M | $222M | $239M | $249M | $258M | $268M | |
| Liabilities + Equity | $383M | $412M | $283M | $302M | $321M | $343M | $364M | $381M | $392M | $405M | $226M | $238M | $250M | $255M | $266M | $276M | |
| Shares Outstanding | 59,662,877 | 59,469,687 | 53,706,357 | 53,318,198 | 53,233,494 | 53,089,957 | 50,749,945 | 52,871,825 | 52,736,458 | 52,474,533 | 43,024,634 | 42,928,884 | 42,817,233 | 42,535,374 | 42,353,550 | 42,136,971 |
Flux de trésorerie 11
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $138.0K | $138.0K | $132.0K | $131.0K | $140.0K | $143.0K | $144.0K | $127.0K | $126.0K | $122.0K | $102.0K | $86.0K | $89.0K | $83.0K | $82.0K | $82.0K | |
| Stock-based Comp | $10M | $8M | $8M | $8M | $6M | $6M | $7M | $8M | $4M | $4M | $4M | $4M | $3M | $2M | $3M | $1M | |
| Other Non-cash | · | $-1M | · | · | · | $-4M | · | · | · | $-8M | · | · | · | $-483.0K | · | · | |
| Operating Cash Flow | $-31M | $-33M | $-24M | $-22M | $-24M | $-25M | $-20M | $-18M | $-10M | $-22M | $-14M | $-17M | $-10M | $-10M | $-12M | $-12M | |
| CapEx | $66.0K | $88.0K | $57.0K | $39.0K | $31.0K | $14.0K | $6.0K | $52.0K | $470.0K | $136.0K | $603.0K | $83.0K | $43.0K | $41.0K | $21.0K | $48.0K | |
| Investing Cash Flow | $18M | $-120M | $34M | $-15M | $21M | $32M | $7M | $22M | $-145M | $18M | $-144M | $-83.0K | $-43.0K | $-41.0K | $-21.0K | $-48.0K | |
| Stock Issued | $0 | $148M | · | · | $0 | $0 | · | · | · | · | · | · | · | · | · | · | |
| Net Stock Activity | · | $148M | · | · | · | · | · | · | · | · | · | · | · | · | · | · | |
| Financing Cash Flow | $2M | $160M | $5M | $647.0K | $583.0K | $2M | $706.0K | $743.0K | $373.0K | $200M | $324.0K | $467.0K | $370.0K | $376.0K | $3.0K | $364.0K | |
| Net Change in Cash | $-11M | $8M | $15M | $-37M | $-2M | $9M | $-12M | $4M | $-155M | $196M | $-158M | $-17M | $-9M | $-10M | $-12M | $-12M | |
| Free Cash Flow | · | $-33M | · | · | · | $-25M | · | · | · | $-22M | · | · | · | $-10M | · | · |
Rentabilité 2
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROA | -12.9% | -10.4% | · | -8.8% | -7.9% | -7.5% | · | -7.8% | -5.8% | -5.5% | · | -8.2% | -4.9% | -4.3% | · | -4.2% | |
| ROE | -13.9% | -11.1% | · | -9.3% | -8.3% | -7.9% | · | -8.2% | -6.1% | -5.7% | · | -8.6% | -5.1% | -4.4% | · | -4.3% |
Liquidité et Solvabilité 2
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 14.9 | 20.5 | · | 17.7 | 21.9 | 22.8 | · | 29.5 | 36.5 | 44.8 | · | 22.1 | 44.5 | 67.0 | · | 48.7 | |
| Quick Ratio | 3.0 | 4.4 | · | 3.9 | 7.2 | 7.1 | · | 8.4 | 9.6 | 29.2 | · | 21.3 | 43.0 | 65.6 | · | 48.0 |
Valorisation (TTM) 8
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Income TTM | $-143M | $-125M | · | $-110M | $-99M | $-89M | · | $-82M | $-71M | $-64M | · | $-59M | $-53M | $-54M | · | $-49M | |
| Market Cap | $1.91B | $2.28B | · | $746M | $509M | $494M | · | $1.24B | $843M | $861M | · | $591M | $729M | $684M | · | $370M | |
| P/E | -13.9 | -18.4 | · | -7.6 | -5.7 | -6.0 | · | -15.0 | -10.9 | -11.5 | · | -10.0 | -13.6 | -12.4 | · | -5.1 | |
| P/B | 5.4 | 5.9 | · | 2.7 | 1.7 | 1.5 | · | 3.4 | 2.2 | 2.2 | · | 2.7 | 3.1 | 2.7 | · | 1.4 | |
| P / Tangible Book | 5.4 | 5.9 | · | 2.7 | 1.7 | 1.5 | · | 3.4 | 2.2 | 2.2 | · | 2.7 | 3.1 | 2.7 | · | 1.4 | |
| P / Cash Flow | · | -69.9 | · | · | · | -19.4 | · | · | · | -39.1 | · | · | · | -69.4 | · | · | |
| P / FCF | · | -69.7 | · | · | · | -19.4 | · | · | · | -38.8 | · | · | · | -69.1 | · | · | |
| Earnings Yield | -7.2% | -5.4% | · | -13.2% | -17.4% | -16.7% | · | -6.7% | -9.2% | -8.7% | · | -10.0% | -7.3% | -8.1% | · | -19.8% |
États financiers Compte de résultat, bilan, flux de trésorerie — annuel, sur les 5 dernières années
Compte de résultat
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Résultat net | $-120M | $-86M | $-69M | $-55M | $-26M |
| BPA dilué | $-2.01 | $-1.51 | $-1.62 | $-1.32 | $-1.91 |
Bilan
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Ratio de liquidité | 14.7 | 23.8 | 13.8 | 45.1 | 84.1 |
| Ratio de liquidité réduite | 4.3 | 6.3 | 3.8 | 44.1 | 83.6 |
Flux de trésorerie
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Flux de trésorerie libre | $-95M | $-70M | $-51M | $-51M | $-24M |
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Détenteurs institutionnels (13F) 182 déclarants · $1.9B total · Au 30 juin 2026
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
Activité institutionnelle — Q2 2026 vs trimestre précédent
| Nouvelles positions | Positions clôturées | Augmenté | Diminué | Variation nette des actions |
|---|---|---|---|---|
| 41 (-9 vs T. préc.) | 22 (+9 vs T. préc.) | 60 (+8 vs T. préc.) | 49 (+12 vs T. préc.) | +7.7M |
Comparé à Q1 2026. Les dépôts de formulaire 13F de la SEC sont dus dans les 45 jours suivant la fin du trimestre, plus une courte période tampon pour les déposants tardifs — les trimestres encore dans cette fenêtre sont ignorés au profit de la paire la plus récente entièrement déclarée.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $389 624 083 | 12 198 625 | 20,33% | Actions |
| FMR LLC | $259 465 452 | 8 123 527 | 13,54% | Actions |
| Alta Partners Management Company, L.P. | $122 120 195 | 3 823 425 | 6,37% | Actions |
| Nextech Invest Ltd. | $113 501 505 | 3 553 585 | 5,92% | Actions |
| TCG Crossover Management, LLC | $103 772 421 | 3 248 980 | 5,42% | Actions |
| STATE STREET CORP | $68 363 354 | 2 140 368 | 3,57% | Actions |
| Commodore Capital LP | $59 887 500 | 1 875 000 | 3,13% | Actions |
| Paradigm Biocapital Advisors LP | $58 405 708 | 1 828 607 | 3,05% | Actions |
| Nextech Invest Ltd. | $56 376 468 | 4 055 861 | 2,94% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $48 179 797 | 1 508 447 | 2,51% | Actions |
| BVF INC/IL | $47 149 700 | 1 476 196 | 2,46% | Actions |
| VANGUARD GROUP INC | $36 938 081 | 1 405 024 | 1,93% | Actions |
| 5AM Venture Management, LLC | $32 875 778 | 1 029 298 | 1,72% | Actions |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $32 482 980 | 1 017 000 | 1,70% | Actions |
| Hood River Capital Management LLC | $32 475 794 | 1 016 775 | 1,69% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $27 157 539 | 850 108 | 1,42% | Actions |
| Caligan Partners LP | $25 775 133 | 806 986 | 1,34% | Actions |
| Canaan Partners XI LLC | $23 955 000 | 750 000 | 1,25% | Actions |
| Siren, L.L.C. | $23 156 500 | 725 000 | 1,21% | Actions |
| Sio Capital Management, LLC | $22 208 361 | 695 315 | 1,16% | Actions |
| STEMPOINT CAPITAL LP | $20 210 163 | 632 754 | 1,05% | Actions |
| MARSHALL WACE, LLP | $18 625 268 | 583 133 | 0,97% | Actions |
| JENNISON ASSOCIATES LLC | $14 403 791 | 450 964 | 0,75% | Actions |
| TWO SIGMA INVESTMENTS, LP | $14 366 868 | 449 808 | 0,75% | Actions |
| GOLDMAN SACHS GROUP INC | $13 394 997 | 419 380 | 0,70% | Actions |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $12 872 427 | 403 019 | 0,67% | Actions |
| Defilade Capital Management, L.P. | $12 037 228 | 376 870 | 0,63% | Actions |
| Walleye Capital LLC | $11 111 862 | 347 898 | 0,58% | Actions |
| Woodline Partners LP | $10 222 078 | 320 040 | 0,53% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $9 086 930 | 284 500 | 0,47% | Option d'achat |
| BANK OF AMERICA CORP /DE/ | $8 955 529 | 280 386 | 0,47% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $8 550 306 | 267 699 | 0,45% | Actions |
| Qube Research & Technologies Ltd | $8 525 872 | 266 934 | 0,44% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $7 672 850 | 240 227 | 0,40% | Actions |
| ALGERT GLOBAL LLC | $7 637 493 | 239 120 | 0,40% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $7 180 272 | 224 805 | 0,37% | Actions |
| DIMENSIONAL FUND ADVISORS LP | $6 691 686 | 209 508 | 0,35% | Actions |
| Affinity Asset Advisors, LLC | $6 388 383 | 200 012 | 0,33% | Actions |
| FRANKLIN RESOURCES INC | $6 143 340 | 192 340 | 0,32% | Actions |
| HighVista Strategies LLC | $5 901 681 | 184 774 | 0,31% | Actions |
| MILLENNIUM MANAGEMENT LLC | $5 674 844 | 177 672 | 0,30% | Actions |
| CITADEL ADVISORS LLC | $5 581 036 | 174 735 | 0,29% | Actions |
| BOOTHBAY FUND MANAGEMENT, LLC | $5 543 474 | 173 559 | 0,29% | Actions |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $5 174 280 | 162 000 | 0,27% | Actions |
| Jump Financial, LLC | $5 014 580 | 157 000 | 0,26% | Actions |
| VICTORY CAPITAL MANAGEMENT INC | $4 873 565 | 152 585 | 0,25% | Actions |
| Ensign Peak Advisors, Inc | $4 680 392 | 146 537 | 0,24% | Actions |
| Trexquant Investment LP | $4 239 716 | 132 740 | 0,22% | Actions |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $3 931 495 | 123 090 | 0,21% | Actions |
| BARCLAYS PLC | $3 631 578 | 113 700 | 0,19% | Option d'achat |
| ORBIMED ADVISORS LLC | $3 257 880 | 102 000 | 0,17% | Actions |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $2 849 208 | 89 205 | 0,15% | Actions |
| JANUS HENDERSON GROUP PLC | $2 711 816 | 70 814 | 0,14% | Actions |
| OPPENHEIMER & CO INC | $2 676 029 | 83 783 | 0,14% | Actions |
| XTX Topco Ltd | $2 597 361 | 81 320 | 0,14% | Actions |
| Kalehua Capital Management LLC | $2 378 412 | 74 465 | 0,12% | Actions |
| RAYMOND JAMES FINANCIAL INC | $2 177 094 | 68 162 | 0,11% | Actions |
| SEI INVESTMENTS CO | $2 127 428 | 66 607 | 0,11% | Actions |
| Squarepoint Ops LLC | $2 037 932 | 63 805 | 0,11% | Actions |
| Fisher Asset Management, LLC | $1 923 745 | 60 230 | 0,10% | Actions |
| ALPS ADVISORS INC | $1 921 478 | 60 159 | 0,10% | Actions |
| CITIGROUP INC | $1 921 383 | 60 156 | 0,10% | Actions |
| ALLIANCEBERNSTEIN L.P. | $1 854 486 | 48 420 | 0,10% | Actions |
| AXA Investment Managers S.A. | $1 801 758 | 128 789 | 0,09% | Actions |
| RHUMBLINE ADVISERS | $1 662 114 | 52 039 | 0,09% | Actions |
| TD Asset Management Inc | $1 597 000 | 50 000 | 0,08% | Actions |
| Arkadios Wealth Advisors | $1 575 792 | 49 336 | 0,08% | Actions |
| TWO SIGMA ADVISERS, LP | $1 548 481 | 58 900 | 0,08% | Actions |
| STATE OF WISCONSIN INVESTMENT BOARD | $1 491 502 | 46 697 | 0,08% | Actions |
| JANE STREET GROUP, LLC | $1 437 300 | 45 000 | 0,08% | Option de vente |
| Susquehanna Portfolio Strategies, LLC | $1 433 403 | 44 878 | 0,07% | Actions |
| Swiss National Bank | $1 427 718 | 44 700 | 0,07% | Actions |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $1 415 804 | 44 327 | 0,07% | Actions |
| ExodusPoint Capital Management, LP | $1 310 370 | 41 026 | 0,07% | Actions |
| Rafferty Asset Management, LLC | $1 236 142 | 38 702 | 0,06% | Actions |
| Bank of New York Mellon Corp | $1 224 612 | 38 341 | 0,06% | Actions |
| Verdad Advisers, LP | $1 149 936 | 36 003 | 0,06% | Actions |
| WELLS FARGO & COMPANY/MN | $1 071 938 | 33 561 | 0,06% | Actions |
| Sofinnova Investments, Inc. | $1 030 608 | 32 267 | 0,05% | Actions |
| Engineers Gate Manager LP | $1 020 739 | 31 958 | 0,05% | Actions |
| BlackRock, Inc. | $841 236 | 26 338 | 0,04% | Actions |
| PDT Partners, LLC | $820 347 | 25 684 | 0,04% | Actions |
| MILLENNIUM MANAGEMENT LLC | $798 500 | 25 000 | 0,04% | Option d'achat |
| STRS OHIO | $705 874 | 22 100 | 0,04% | Actions |
| MetLife Investment Management, LLC | $693 833 | 21 723 | 0,04% | Actions |
| LMR Partners LLP | $675 563 | 21 151 | 0,04% | Actions |
| Auour Investments LLC | $671 379 | 21 020 | 0,04% | Actions |
| Vanguard Global Advisers, LLC | $643 719 | 20 154 | 0,03% | Actions |
| Elmind Capital, LP | $638 800 | 20 000 | 0,03% | Actions |
| PROFUND ADVISORS LLC | $625 641 | 19 588 | 0,03% | Actions |
| WELLINGTON MANAGEMENT GROUP LLP | $594 467 | 18 612 | 0,03% | Actions |
| Cubist Systematic Strategies, LLC | $549 946 | 39 310 | 0,03% | Actions |
| AMERIPRISE FINANCIAL INC | $540 425 | 16 920 | 0,03% | Actions |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $538 764 | 16 868 | 0,03% | Actions |
| WINTON GROUP Ltd | $536 592 | 16 800 | 0,03% | Actions |
| VANGUARD ASSET MANAGEMENT, Ltd | $494 399 | 15 479 | 0,03% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $479 100 | 15 000 | 0,03% | Option de vente |
| Invesco Ltd. | $463 897 | 14 524 | 0,02% | Actions |
| FOX RUN MANAGEMENT, L.L.C. | $461 533 | 14 450 | 0,02% | Actions |
| NEW YORK STATE COMMON RETIREMENT FUND | $412 761 | 12 923 | 0,02% | Actions |
Initiés de la société 24 initiés · 12 dirigeants · 12 administrateurs
| Dirigeant | Rôle | Dernière activité | Actions détenues | Achats 12m | Ventes 12m | Net 12m |
|---|---|---|---|---|---|---|
| Todd Harris | President and CEO | 5 mai 2026 A | 1 437 631 | 0 | 0 | $0 |
| Alan Fuhrman | Chief Financial Officer | 5 mai 2026 A | 36 164 | 0 | 0 | $0 |
| Esther Van Den Boom | Chief Financial Officer | 15 septembre 2022 A | 121 897 | 0 | 0 | $0 |
| Bhavesh Ashar | Chief Operating Officer | 5 mai 2026 A | 15 013 | 0 | 0 | $0 |
| Yuliya Rueb | Vice President, Finance (PAO) | 5 mai 2026 A | 43 354 | 0 | 0 | $0 |
| Douglas J Warner | Chief Medical Officer | 5 mai 2026 A | 25 000 | 0 | 0 | $0 |
| Daniel Bensen | Chief Discovery Officer | 12 février 2026 S | 146 981 | 0 | 11 | $-4 811 405 |
| Hiroomi Tada | Chief Medical Officer | 15 mars 2024 A | 86 435 | 0 | 0 | $0 |
| Patel Piyush R. | Chief Development Officer | 21 février 2023 G | 73 794 | 0 | 0 | $0 |
| Robert L. Hudkins | Chief Technology Officer | 15 septembre 2022 A | 273 576 | 0 | 0 | $0 |
| Ronald V. Swanson | Chief Scientific Officer | 6 septembre 2022 A | 273 254 | 0 | 0 | $0 |
| Ali D. Fawaz | General Counsel and Secretary | 16 mai 2022 A | — | 0 | 0 | $0 |
| Habib J Dable | Administrateur | 16 avril 2026 A | — | 0 | 0 | $0 |
| Gilla Kaplan | Administrateur | 26 mars 2026 M | 28 231 | 0 | 1 | $-528 486 |
| Robert J More | Administrateur | 19 décembre 2025 S | 3 823 425 | 0 | 2 | $-5 249 138 |
| Stephen Michael Rothenberg | Administrateur | 29 mai 2025 A | — | 0 | 0 | $0 |
| Rehan Verjee | Administrateur | 29 mai 2025 A | — | 0 | 0 | $0 |
| Susan Moran | Administrateur | 29 mai 2025 A | — | 0 | 0 | $0 |
| Nina S Kjellson | Administrateur | 5 février 2025 S | 443 885 | 0 | 0 | $0 |
| Adele M. Gulfo | Administrateur | 29 janvier 2025 A | — | 0 | 0 | $0 |
| Siddarth Subramony | Administrateur | 29 mai 2024 A | — | 0 | 0 | $0 |
| Jake Simson | Administrateur | 29 mai 2024 A | — | 0 | 0 | $0 |
| Isan Chen | Administrateur | 31 mai 2023 A | 192 783 | 0 | 0 | $0 |
| Boxer Capital Management, LLC | — | 18 octobre 2024 A | 4 448 359 | 0 | 0 | $0 |
Initiés issus des déclarations SEC Form 3/4/5 ; net = uniquement P/S de marché
Activistes et détenteurs de 5%+ 5 participations
Investisseurs ayant déposé un Schedule 13D auprès de la SEC — détention effective supérieure à 5% avec l'intention d'influencer l'émetteur (participations activistes, campagnes pour le conseil d'administration, fusions-acquisitions). Chaque ligne montre le dernier état connu de la position du déposant.
| Déclarant | Déposé | Participation | Statut | Objectif | Dépôt |
|---|---|---|---|---|---|
| RA Capital Management, L.P., Peter Kolchinsky, Rajeev Shah, RA Capital Healthcare Fund, L.P. ×7 dépôts | 6 mars 2026 | 21,20% | Amendement | — | SEC |
| MVA Investors, LLC, Aaron I. Davis, Boxer Capital Management, LLC ×3 dépôts | 6 décembre 2024 | — | Dépôt initial | — | SEC |
| Boxer Asset Management Inc, Joe Lewis | 15 octobre 2024 | — | Dépôt initial | — | SEC |
| Boxer Capital, LLC, MVA Investors, LLC, Aaron I. Davis, Boxer Capital Management, LLC, Siddarth Subramony ×4 dépôts | 15 octobre 2024 | — | Dépôt initial | — | SEC |
| Alta Partners NextGen Fund II, L.P., Alta Partners NextGen Fund II Management, LLC, Peter Hudson, Daniel Janney, Robert More | 27 septembre 2021 | — | Dépôt initial | Investissement passif | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
Détention d'ETF Détenu par 42 ETFs
Le poids reflète uniquement les participations directes en actions (N-PORT) ; les fonds à effet de levier ou basés sur des dérivés peuvent détenir une exposition supplémentaire aux swaps non indiquée.
| Fonds | Poids | Unités | Au | Source |
|---|---|---|---|---|
| SBIO · ALPS ETF Trust | 1,15% | 55 509 NS | 31 mai 2026 | N-PORT |
| BBC · ETFis Series Trust I | 1,14% | 12 196 NS | 30 avril 2026 | N-PORT |
| CANC · Tema ETF Trust | 0,30% | 15 780 NS | 31 mai 2026 | N-PORT |
| ESSC · Strategy Shares | 0,25% | 1 876 NS | 30 avril 2026 | N-PORT |
| LABU · Direxion Shares ETF Trust | 0,25% | 37 514 NS | 30 avril 2026 | N-PORT |
| VFMO · VANGUARD WELLINGTON FUND | 0,13% | 81 594 SH | 8 août 2026 | Quotidien |
| IBBQ · Invesco Exchange-Traded Fund Trust … | 0,11% | 3 239 SH | 8 août 2026 | Quotidien |
| IBB · iShares Trust | 0,09% | 325 051 SH | 8 août 2026 | Quotidien |
| BIB · ProShares Trust | 0,09% | 1 974 NS | 31 mai 2026 | N-PORT |
| FFSM · FIDELITY COVINGTON TRUST | 0,09% | 33 120 NS | 30 avril 2026 | N-PORT |
| VTWG · VANGUARD SCOTTSDALE FUNDS | 0,07% | 39 429 SH | 8 août 2026 | Quotidien |
| IWO · iShares Trust | 0,06% | 331 311 SH | 8 août 2026 | Quotidien |
| VTWO · VANGUARD SCOTTSDALE FUNDS | 0,04% | 211 804 SH | 8 août 2026 | Quotidien |
| SMMV · iShares Trust | 0,04% | 4 107 SH | 8 août 2026 | Quotidien |
| IWM · iShares Trust | 0,03% | 933 036 SH | 8 août 2026 | Quotidien |
| RSSL · Global X Funds | 0,03% | 11 184 NS | 30 avril 2026 | N-PORT |
| GSSC · Goldman Sachs ETF Trust | 0,02% | 7 291 NS | 31 mai 2026 | N-PORT |
| ITWO · ProShares Trust | 0,02% | 1 219 NS | 31 mai 2026 | N-PORT |
| SCHA · SCHWAB STRATEGIC TRUST | 0,02% | 114 471 NS | 31 mai 2026 | N-PORT |
| OMFS · Invesco Exchange-Traded Self-Indexe… | 0,02% | 1 805 SH | 8 août 2026 | Quotidien |
| UWM · ProShares Trust | 0,01% | 954 NS | 31 mai 2026 | N-PORT |
| VXF · VANGUARD INDEX FUNDS | 0,01% | 340 900 SH | 8 août 2026 | Quotidien |
| VHT · VANGUARD WORLD FUND | 0,01% | 67 148 SH | 8 août 2026 | Quotidien |
| URTY · ProShares Trust | 0,01% | 967 NS | 31 mai 2026 | N-PORT |
| FHLC · FIDELITY COVINGTON TRUST | 0,01% | 6 122 NS | 30 avril 2026 | N-PORT |
| ISCV · iShares Trust | 0,01% | 1 827 SH | 8 août 2026 | Quotidien |
| ONEQ · Fidelity Commonwealth Trust | 0,01% | 18 052 NS | 31 mai 2026 | N-PORT |
| ISCB · iShares Trust | 0,01% | 583 SH | 8 août 2026 | Quotidien |
| MSSM · MORGAN STANLEY PATHWAY FUNDS | 0,00% | 1 002 NS | 31 mai 2026 | N-PORT |
| ISCG · iShares Trust | 0,00% | 1 509 SH | 8 août 2026 | Quotidien |
| WSML · iShares Trust | 0,00% | 955 SH | 8 août 2026 | Quotidien |
| HDG · ProShares Trust | 0,00% | 24 NS | 31 mai 2026 | N-PORT |
| DFAS · Dimensional ETF Trust | 0,00% | 12 741 NS | 30 avril 2026 | N-PORT |
| ITOT · iShares Trust | 0,00% | 46 810 SH | 8 août 2026 | Quotidien |
| SCHB · SCHWAB STRATEGIC TRUST | 0,00% | 13 115 NS | 31 mai 2026 | N-PORT |
| IWV · iShares Trust | 0,00% | 6 606 SH | 8 août 2026 | Quotidien |
| DCOR · Dimensional ETF Trust | 0,00% | 548 NS | 30 avril 2026 | N-PORT |
| DFUS · Dimensional ETF Trust | 0,00% | 1 440 NS | 30 avril 2026 | N-PORT |
| DFAU · Dimensional ETF Trust | 0,00% | 682 NS | 30 avril 2026 | N-PORT |
| AVSU · AMERICAN CENTURY ETF TRUST | 0,00% | 10 NS | 31 mai 2026 | N-PORT |
| VTI · VANGUARD INDEX FUNDS | 0,00% | 1 135 472 SH | 8 août 2026 | Quotidien |
| VTHR · VANGUARD SCOTTSDALE FUNDS | 0,00% | 3 044 SH | 8 août 2026 | Quotidien |