ZYME — Détenteurs institutionnels (13F)
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| EcoR1 Capital, LLC | $600 445 942 | 22 970 388 | 32,29% | Actions |
| Rubric Capital Management LP | $182 980 000 | 7 000 000 | 9,84% | Actions |
| BlackRock, Inc. | $111 121 925 | 4 251 030 | 5,98% | Actions |
| PERCEPTIVE ADVISORS LLC | $109 342 391 | 4 182 953 | 5,88% | Actions |
| BVF INC/IL | $95 388 572 | 3 649 142 | 5,13% | Actions |
| VANGUARD GROUP INC | $61 315 382 | 2 328 727 | 3,30% | Actions |
| MORGAN STANLEY | $58 325 141 | 2 231 260 | 3,14% | Actions |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $46 558 373 | 1 781 116 | 2,50% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $40 752 208 | 1 558 998 | 2,19% | Actions |
| Assenagon Asset Management S.A. | $32 727 986 | 1 252 027 | 1,76% | Actions |
| Nextech Invest Ltd. | $29 118 548 | 1 113 946 | 1,57% | Actions |
| STATE STREET CORP | $28 445 966 | 1 088 216 | 1,53% | Actions |
| DIMENSIONAL FUND ADVISORS LP | $25 995 770 | 994 955 | 1,40% | Actions |
| CITADEL ADVISORS LLC | $23 895 516 | 914 136 | 1,29% | Actions |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $23 259 000 | 889 802 | 1,25% | Actions |
| FMR LLC | $18 365 133 | 702 568 | 0,99% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $18 099 012 | 692 410 | 0,97% | Actions |
| Prosight Management, LP | $17 629 705 | 674 434 | 0,95% | Actions |
| Qube Research & Technologies Ltd | $15 516 443 | 593 590 | 0,83% | Actions |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $13 332 236 | 510 032 | 0,72% | Actions |
| Redmile Group, LLC | $12 851 836 | 491 654 | 0,69% | Actions |
| Capricorn Fund Managers Ltd | $12 717 868 | 486 529 | 0,68% | Actions |
| GOLDMAN SACHS GROUP INC | $12 307 288 | 470 822 | 0,66% | Actions |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $10 939 512 | 418 497 | 0,59% | Actions |
| DEUTSCHE BANK AG\ | $10 382 547 | 397 190 | 0,56% | Actions |
| Hillsdale Investment Management Inc. | $10 009 581 | 382 922 | 0,54% | Actions |
| FIRST TRUST ADVISORS LP | $8 897 088 | 340 363 | 0,48% | Actions |
| Granahan Investment Management, LLC | $8 787 144 | 336 157 | 0,47% | Actions |
| NORTHERN TRUST CORP | $8 392 849 | 321 073 | 0,45% | Actions |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $7 997 401 | 319 385 | 0,43% | Actions |
| Pictet Asset Management Holding SA | $7 446 189 | 308 187 | 0,40% | Actions |
| PICTON MAHONEY ASSET MANAGEMENT | $7 092 908 | 271 343 | 0,38% | Actions |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | $5 849 243 | 223 766 | 0,31% | Actions |
| BANK OF AMERICA CORP /DE/ | $5 726 515 | 219 071 | 0,31% | Actions |
| WELLS FARGO & COMPANY/MN | $5 677 573 | 217 199 | 0,31% | Actions |
| SummitTX Capital, L.P. | $5 510 364 | 210 802 | 0,30% | Actions |
| Man Group plc | $5 509 763 | 210 779 | 0,30% | Actions |
| FEDERATED HERMES, INC. | $4 914 190 | 187 995 | 0,26% | Actions |
| RAYMOND JAMES FINANCIAL INC | $4 350 114 | 166 416 | 0,23% | Actions |
| STATE OF WISCONSIN INVESTMENT BOARD | $4 066 835 | 155 579 | 0,22% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $3 984 154 | 152 416 | 0,21% | Actions |
| KENNEDY CAPITAL MANAGEMENT LLC | $3 800 390 | 145 386 | 0,20% | Actions |
| D. E. Shaw & Co., Inc. | $3 785 255 | 144 807 | 0,20% | Actions |
| DIADEMA PARTNERS LP | $3 715 330 | 142 132 | 0,20% | Actions |
| CITIGROUP INC | $3 435 868 | 131 441 | 0,18% | Actions |
| Bank of New York Mellon Corp | $3 427 107 | 131 106 | 0,18% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $3 408 656 | 130 400 | 0,18% | Option d'achat |
| XTX Topco Ltd | $3 290 425 | 125 877 | 0,18% | Actions |
| Nuveen, LLC | $3 120 829 | 119 389 | 0,17% | Actions |
| PANAGORA ASSET MANAGEMENT INC | $3 100 282 | 118 603 | 0,17% | Actions |
| UBS Group AG | $3 008 583 | 115 095 | 0,16% | Actions |
| Invesco Ltd. | $2 933 222 | 112 212 | 0,16% | Actions |
| AQR CAPITAL MANAGEMENT LLC | $2 908 911 | 111 282 | 0,16% | Actions |
| WELLINGTON MANAGEMENT GROUP LLP | $2 875 766 | 110 014 | 0,15% | Actions |
| PLATINUM INVESTMENT MANAGEMENT LTD | $2 749 510 | 105 184 | 0,15% | Actions |
| AXA Investment Managers S.A. | $2 705 745 | 158 416 | 0,15% | Actions |
| Manatuck Hill Partners, LLC | $2 614 000 | 100 000 | 0,14% | Actions |
| JPMORGAN CHASE & CO | $2 564 192 | 106 398 | 0,14% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $2 451 932 | 93 800 | 0,13% | Option de vente |
| KORNITZER CAPITAL MANAGEMENT INC /KS | $2 321 232 | 88 800 | 0,12% | Actions |
| MACKENZIE FINANCIAL CORP | $2 293 654 | 87 745 | 0,12% | Actions |
| PRINCIPAL FINANCIAL GROUP INC | $2 221 639 | 84 990 | 0,12% | Actions |
| Y-Intercept (Hong Kong) Ltd | $2 181 514 | 83 455 | 0,12% | Actions |
| LMR Partners LLP | $2 156 550 | 82 500 | 0,12% | Actions |
| AMERIPRISE FINANCIAL INC | $2 150 380 | 82 264 | 0,12% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $2 094 337 | 80 120 | 0,11% | Actions |
| STIFEL FINANCIAL CORP | $2 018 373 | 77 214 | 0,11% | Actions |
| FRANKLIN RESOURCES INC | $2 000 443 | 76 528 | 0,11% | Actions |
| TEMA ETFS LLC | $2 000 422 | 75 975 | 0,11% | Actions |
| RHUMBLINE ADVISERS | $1 962 211 | 75 066 | 0,11% | Actions |
| Swiss National Bank | $1 939 588 | 74 200 | 0,10% | Actions |
| MARTINGALE ASSET MANAGEMENT L P | $1 915 592 | 73 282 | 0,10% | Actions |
| TWO SIGMA INVESTMENTS, LP | $1 878 786 | 71 874 | 0,10% | Actions |
| Dana Investment Advisors, Inc. | $1 873 192 | 71 660 | 0,10% | Actions |
| CREDIT AGRICOLE S A | $1 855 940 | 71 000 | 0,10% | Actions |
| Fisher Asset Management, LLC | $1 850 057 | 70 775 | 0,10% | Actions |
| SEGALL BRYANT & HAMILL, LLC | $1 747 093 | 66 836 | 0,09% | Actions |
| Verdad Advisers, LP | $1 743 224 | 66 688 | 0,09% | Actions |
| Susquehanna Portfolio Strategies, LLC | $1 705 583 | 65 248 | 0,09% | Actions |
| Campbell & CO Investment Adviser LLC | $1 591 246 | 60 874 | 0,09% | Actions |
| ROYAL BANK OF CANADA | $1 471 000 | 56 278 | 0,08% | Actions |
| ALLIANCEBERNSTEIN L.P. | $1 399 636 | 55 896 | 0,08% | Actions |
| CITADEL ADVISORS LLC | $1 364 508 | 52 200 | 0,07% | Option d'achat |
| Virtus Investment Advisers, LLC | $1 328 566 | 50 825 | 0,07% | Actions |
| ENVESTNET ASSET MANAGEMENT INC | $1 272 365 | 48 675 | 0,07% | Actions |
| Russell Investments Group, Ltd. | $1 251 241 | 47 867 | 0,07% | Actions |
| Quantinno Capital Management LP | $1 245 362 | 47 642 | 0,07% | Actions |
| Legal & General Group Plc | $1 128 017 | 43 160 | 0,06% | Actions |
| VICTORY CAPITAL MANAGEMENT INC | $1 111 577 | 42 524 | 0,06% | Actions |
| MARSHALL WACE, LLP | $1 070 380 | 40 948 | 0,06% | Actions |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | $1 033 419 | 39 534 | 0,06% | Actions |
| Aquilo Capital Management, LLC | $1 006 181 | 84 482 | 0,05% | Actions |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $986 628 | 37 744 | 0,05% | Actions |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $965 141 | 36 922 | 0,05% | Actions |
| TUDOR INVESTMENT CORP ET AL | $953 352 | 36 471 | 0,05% | Actions |
| HighTower Advisors, LLC | $943 654 | 36 100 | 0,05% | Actions |
| Persistent Asset Partners Ltd | $939 341 | 35 935 | 0,05% | Actions |
| HighVista Strategies LLC | $889 100 | 34 013 | 0,05% | Actions |
| COMMONWEALTH EQUITY SERVICES, LLC | $837 838 | 32 052 | 0,05% | Actions |
| TWO SIGMA ADVISERS, LP | $827 157 | 31 415 | 0,04% | Actions |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $807 360 | 30 886 | 0,04% | Actions |
| Creative Planning | $777 168 | 29 731 | 0,04% | Actions |
| SBI Okasan Asset Management Co.Ltd. | $771 200 | 32 000 | 0,04% | Actions |
| MetLife Investment Management, LLC | $728 888 | 27 884 | 0,04% | Actions |
| JOURNEY STRATEGIC WEALTH LLC | $727 412 | 29 050 | 0,04% | Actions |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $723 294 | 27 670 | 0,04% | Actions |
| STRS OHIO | $692 710 | 26 500 | 0,04% | Actions |
| VANGUARD ASSET MANAGEMENT, Ltd | $686 933 | 26 279 | 0,04% | Actions |
| Brevan Howard Capital Management LP | $678 490 | 25 956 | 0,04% | Actions |
| Jump Financial, LLC | $669 393 | 25 608 | 0,04% | Actions |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $657 735 | 25 162 | 0,04% | Actions |
| RITHOLTZ WEALTH MANAGEMENT | $633 712 | 24 243 | 0,03% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $607 206 | 23 229 | 0,03% | Actions |
| Duncan Williams Asset Management, LLC | $577 563 | 22 095 | 0,03% | Actions |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $564 049 | 21 578 | 0,03% | Actions |
| BARCLAYS PLC | $538 562 | 20 603 | 0,03% | Actions |
| VIRGINIA RETIREMENT SYSTEMS ET Al | $508 031 | 19 435 | 0,03% | Actions |
| SIMPLEX TRADING, LLC | $507 926 | 19 431 | 0,03% | Actions |
| BetterWealth, LLC | $486 779 | 18 622 | 0,03% | Actions |
| BANK OF MONTREAL /CAN/ | $481 394 | 18 416 | 0,03% | Actions |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $477 499 | 18 267 | 0,03% | Actions |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | $475 356 | 18 185 | 0,03% | Actions |
| JANUS HENDERSON GROUP PLC | $455 819 | 18 200 | 0,02% | Actions |
| JANE STREET GROUP, LLC | $455 803 | 17 437 | 0,02% | Actions |
| NEW YORK STATE COMMON RETIREMENT FUND | $454 078 | 17 371 | 0,02% | Actions |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $452 483 | 17 310 | 0,02% | Actions |
| Squarepoint Ops LLC | $423 468 | 16 200 | 0,02% | Actions |
| HSBC HOLDINGS PLC | $421 205 | 15 588 | 0,02% | Actions |
| Vinva Investment Management Ltd | $419 717 | 11 983 | 0,02% | Actions |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $400 988 | 15 340 | 0,02% | Actions |
| AGF MANAGEMENT LTD | $392 100 | 15 000 | 0,02% | Actions |
| Police & Firemen's Retirement System of New Jersey | $358 170 | 13 702 | 0,02% | Actions |
| INTECH INVESTMENT MANAGEMENT LLC | $311 981 | 11 935 | 0,02% | Actions |
| State of New Jersey Common Pension Fund D | $311 667 | 11 923 | 0,02% | Actions |
| China Universal Asset Management Co., Ltd. | $303 799 | 11 622 | 0,02% | Actions |
| JAMES INVESTMENT RESEARCH, INC. | $285 580 | 10 925 | 0,02% | Actions |
| Ewing Morris & Co. Investment Partners Ltd. | $283 619 | 10 850 | 0,02% | Actions |
| ARIZONA STATE RETIREMENT SYSTEM | $265 975 | 10 175 | 0,01% | Actions |
| Jain Global LLC | $261 661 | 10 010 | 0,01% | Actions |
| PSP Research LLC | $261 400 | 10 000 | 0,01% | Actions |
| Mitsubishi UFJ Trust & Banking Corp | $250 134 | 9 569 | 0,01% | Actions |
| VOYA INVESTMENT MANAGEMENT LLC | $243 991 | 9 334 | 0,01% | Actions |
| Vanguard Investments Australia, Ltd. | $230 110 | 8 803 | 0,01% | Actions |
| Allspring Global Investments Holdings, LLC | $225 359 | 8 762 | 0,01% | Actions |
| ProShare Advisors LLC | $223 681 | 8 557 | 0,01% | Actions |
| AlphaQuest LLC | $218 881 | 8 313 | 0,01% | Actions |
| INCEPTIONR LLC | $217 302 | 8 313 | 0,01% | Actions |
| Magnetar Financial LLC | $216 753 | 8 292 | 0,01% | Actions |
| KLP KAPITALFORVALTNING AS | $209 120 | 8 000 | 0,01% | Actions |
| PRUDENTIAL FINANCIAL INC | $207 552 | 7 940 | 0,01% | Actions |
| CWM, LLC | $174 153 | 6 955 | 0,01% | Actions |
| Vanguard Global Advisers, LLC | $142 698 | 5 459 | 0,01% | Actions |
| Northwest & Ethical Investments L.P. | $111 583 | 4 630 | 0,01% | Actions |
| Ameritas Investment Partners, Inc. | $108 847 | 4 164 | 0,01% | Actions |
| Mirae Asset Global Investments Co., Ltd. | $85 373 | 3 266 | 0,00% | Actions |
| Arax Advisory Partners | $78 368 | 2 998 | 0,00% | Actions |
| State of Wyoming | $72 983 | 2 792 | 0,00% | Actions |
| Tower Research Capital LLC (TRC) | $62 030 | 2 373 | 0,00% | Actions |
| GF FUND MANAGEMENT CO. LTD. | $41 432 | 1 585 | 0,00% | Actions |
| TD Waterhouse Canada Inc. | $37 014 | 1 439 | 0,00% | Actions |
| Caitong International Asset Management Co., Ltd | $34 217 | 1 309 | 0,00% | Actions |
| Eurizon Capital SGR S.p.A. | $31 865 | 1 321 | 0,00% | Actions |
| GAMMA Investing LLC | $29 120 | 1 114 | 0,00% | Actions |
| Optiver Holding B.V. | $27 159 | 1 039 | 0,00% | Actions |
| Steward Partners Investment Advisory, LLC | $25 382 | 971 | 0,00% | Actions |
| LANARK FINANCIAL, INC. | $25 146 | 962 | 0,00% | Actions |
| PNC Financial Services Group, Inc. | $23 474 | 898 | 0,00% | Actions |
| OSAIC HOLDINGS, INC. | $23 055 | 882 | 0,00% | Actions |
| JONES FINANCIAL COMPANIES LLLP | $20 214 | 837 | 0,00% | Actions |
| Freestone Grove Partners LP | $16 939 | 648 | 0,00% | Actions |
| NATIONAL BANK OF CANADA /FI/ | $15 182 | 581 | 0,00% | Actions |
| Federation des caisses Desjardins du Quebec | $14 894 | 570 | 0,00% | Actions |
| NISA INVESTMENT ADVISORS, LLC | $12 573 | 481 | 0,00% | Actions |
| UMB Bank, n.a. | $12 129 | 464 | 0,00% | Actions |
| HUNTINGTON NATIONAL BANK | $12 024 | 460 | 0,00% | Actions |
| Parallel Advisors, LLC | $8 600 | 329 | 0,00% | Actions |
| US BANCORP \DE\ | $8 234 | 315 | 0,00% | Actions |
| SBI Securities Co., Ltd. | $8 156 | 312 | 0,00% | Actions |
| COMERICA BANK | $5 556 | 211 | 0,00% | Actions |
| Quarry LP | $5 489 | 210 | 0,00% | Actions |
| EverSource Wealth Advisors, LLC | $4 888 | 187 | 0,00% | Actions |
| Lindbrook Capital, LLC | $4 419 | 371 | 0,00% | Actions |
| Sterling Capital Management LLC | $4 313 | 165 | 0,00% | Actions |
| Fortitude Family Office, LLC | $3 032 | 116 | 0,00% | Actions |
| Allworth Financial LP | $2 824 | 108 | 0,00% | Actions |
| IFP Advisors, Inc | $2 509 | 96 | 0,00% | Actions |
| Versant Capital Management, Inc | $2 490 | 94 | 0,00% | Actions |
| ROTHSCHILD INVESTMENT LLC | $2 091 | 80 | 0,00% | Actions |
| HighMark Wealth Management LLC | $2 091 | 80 | 0,00% | Actions |
| SJS Investment Consulting Inc. | $2 013 | 77 | 0,00% | Actions |
| Kilter Group LLC | $1 726 | 66 | 0,00% | Actions |
| Bare Financial Services, Inc | $1 673 | 64 | 0,00% | Actions |
| Rockefeller Capital Management L.P. | $1 595 | 61 | 0,00% | Actions |
| True Wealth Design, LLC | $1 517 | 58 | 0,00% | Actions |
| Physician Wealth Advisors, Inc. | $1 334 | 51 | 0,00% | Actions |
| North Growth Management Ltd. | $1 201 | 46 000 | 0,00% | Actions |
| PRICE T ROWE ASSOCIATES INC /MD/ | $1 007 | 38 486 | 0,00% | Actions |
| Farther Finance Advisors, LLC | $784 | 30 | 0,00% | Actions |
| Sunbelt Securities, Inc. | $676 | 27 | 0,00% | Actions |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | $643 | 25 | 0,00% | Actions |
| Jackson Creek Investment Advisors LLC | $409 | 18 648 | 0,00% | Actions |
| Essential Partners LLC | $314 | 12 | 0,00% | Actions |
| Janney Montgomery Scott LLC | $310 | 11 865 | 0,00% | Actions |
| Smartleaf Asset Management LLC | $289 | 12 | 0,00% | Actions |
| SG Americas Securities, LLC | $165 | 6 321 | 0,00% | Actions |
| Clearstead Advisors, LLC | $157 | 6 | 0,00% | Actions |
| Larson Financial Group LLC | $157 | 6 | 0,00% | Actions |
| Silver Grove Financial Group, Inc. | $105 | 4 | 0,00% | Actions |
| DekaBank Deutsche Girozentrale | $94 | 3 843 | 0,00% | Actions |
| Hughes Financial Services, LLC | $78 | 3 | 0,00% | Actions |
| SHELL ASSET MANAGEMENT CO | $72 | 4 212 | 0,00% | Actions |
| Covestor Ltd | $1 | 40 | 0,00% | Actions |