| AyurMaya Capital Management Company, LP |
$426031355 |
15139707 |
13.18% |
股份
|
| BlackRock, Inc. |
$231258771 |
8218151 |
7.16% |
股份
|
| FMR LLC |
$190484444 |
6769170 |
5.89% |
股份
|
| Deep Track Capital, LP |
$178648422 |
6348558 |
5.53% |
股份
|
| SAMSARA BIOCAPITAL, LLC |
$178554463 |
6345219 |
5.53% |
股份
|
| Foresite Capital Management V, LLC |
$165941439 |
5896995 |
5.14% |
股份
|
| venBio Partners LLC |
$127429401 |
4528408 |
3.94% |
股份
|
| Foresite Capital Management VI LLC |
$119529434 |
4247670 |
3.70% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$118629882 |
4215703 |
3.67% |
股份
|
| Nextech Invest Ltd. |
$99643684 |
3540998 |
3.08% |
股份
|
| Cormorant Asset Management, LP |
$92456671 |
3285596 |
2.86% |
股份
|
| Saturn V Capital Management LP |
$82040566 |
2915443 |
2.54% |
股份
|
| Octagon Capital Advisors LP |
$79655898 |
2830700 |
2.47% |
股份
|
| STATE STREET CORP |
$61549665 |
2187266 |
1.90% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$61033791 |
2168517 |
1.89% |
股份
|
| MPM BIOIMPACT LLC |
$56815223 |
2019020 |
1.76% |
股份
|
| BAKER BROS. ADVISORS LP |
$56631750 |
2012500 |
1.75% |
股份
|
| SR One Capital Management, LP |
$55151473 |
1959896 |
1.71% |
股份
|
| JANUS HENDERSON GROUP PLC |
$46790086 |
2124408 |
1.45% |
股份
|
| VANGUARD GROUP INC |
$40048110 |
4103290 |
1.24% |
股份
|
| Invesco Ltd. |
$33022796 |
1173518 |
1.02% |
股份
|
| NOVO HOLDINGS A/S |
$30954000 |
1100000 |
0.96% |
股份
|
| PRINCIPAL FINANCIAL GROUP INC |
$30055208 |
1068060 |
0.93% |
股份
|
| D. E. Shaw & Co., Inc. |
$27246105 |
968234 |
0.84% |
股份
|
| UBS Group AG |
$26783540 |
951796 |
0.83% |
股份
|
| JPMORGAN CHASE & CO |
$26407356 |
969617 |
0.82% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$25922878 |
921211 |
0.80% |
股份
|
| Ikarian Capital, LLC |
$24497220 |
870548 |
0.76% |
股份
|
| GREAT POINT PARTNERS LLC |
$24089557 |
856061 |
0.75% |
股份
|
| GOLDMAN SACHS GROUP INC |
$23409581 |
831897 |
0.72% |
股份
|
| NORTHERN TRUST CORP |
$20369111 |
723849 |
0.63% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$19701771 |
700134 |
0.61% |
股份
|
| Integral Health Asset Management, LLC |
$19698000 |
700000 |
0.61% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$18576396 |
660142 |
0.57% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$17221961 |
612010 |
0.53% |
股份
|
| Opaleye Management Inc. |
$15477000 |
550000 |
0.48% |
股份
|
| ORBIMED ADVISORS LLC |
$15425307 |
548163 |
0.48% |
股份
|
| ROYCE & ASSOCIATES LP |
$14782026 |
525303 |
0.46% |
股份
|
| Woodline Partners LP |
$13677503 |
486052 |
0.42% |
股份
|
| Spruce Street Capital LP |
$11047032 |
392574 |
0.34% |
股份
|
| Trium Capital LLP |
$10982142 |
390268 |
0.34% |
股份
|
| CITIGROUP INC |
$10845156 |
385400 |
0.34% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$10583989 |
376119 |
0.33% |
股份
|
| MARSHALL WACE, LLP |
$10355915 |
368014 |
0.32% |
股份
|
| Ikarian Capital, LLC |
$10026282 |
356300 |
0.31% |
买入期权
|
| MORGAN STANLEY |
$9037528 |
321163 |
0.28% |
股份
|
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
$9029029 |
320861 |
0.28% |
股份
|
| Weiss Asset Management LP |
$8761980 |
311371 |
0.27% |
股份
|
| Artia Global Partners LP |
$7838284 |
278546 |
0.24% |
股份
|
| BARCLAYS PLC |
$7702368 |
273716 |
0.24% |
股份
|
| Yu Fan |
$7110190 |
252672 |
0.22% |
股份
|
| Nuveen, LLC |
$6862558 |
243872 |
0.21% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$6825019 |
242538 |
0.21% |
股份
|
| Omega Fund Management, LLC |
$6788916 |
241255 |
0.21% |
股份
|
| SCHRODER INVESTMENT MANAGEMENT GROUP |
$6427865 |
236841 |
0.20% |
股份
|
| Bank of New York Mellon Corp |
$6377030 |
226618 |
0.20% |
股份
|
| TOWERVIEW LLC |
$6255353 |
222294 |
0.19% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$5847183 |
207789 |
0.18% |
股份
|
| Exome Asset Management LLC |
$5752323 |
204418 |
0.18% |
股份
|
| DIADEMA PARTNERS LP |
$5628000 |
200000 |
0.17% |
买入期权
|
| HighVista Strategies LLC |
$5627100 |
199968 |
0.17% |
股份
|
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD |
$5583008 |
1399250 |
0.17% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$5059628 |
179802 |
0.16% |
股份
|
| WELLS FARGO & COMPANY/MN |
$4922024 |
174912 |
0.15% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$4862001 |
172779 |
0.15% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$4575086 |
162583 |
0.14% |
股份
|
| Russell Investments Group, Ltd. |
$4330918 |
153906 |
0.13% |
股份
|
| Ensign Peak Advisors, Inc |
$4135736 |
146970 |
0.13% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$4120736 |
146437 |
0.13% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$3895082 |
138418 |
0.12% |
股份
|
| MOORE CAPITAL MANAGEMENT, LP |
$3849636 |
136803 |
0.12% |
股份
|
| Swiss National Bank |
$3824226 |
135900 |
0.12% |
股份
|
| STEMPOINT CAPITAL LP |
$3819611 |
135736 |
0.12% |
股份
|
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
$3795000 |
134850 |
0.12% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$3723794 |
132331 |
0.12% |
股份
|
| Quantinno Capital Management LP |
$3688929 |
131092 |
0.11% |
股份
|
| Elmind Capital, LP |
$3658200 |
130000 |
0.11% |
股份
|
| STIFEL FINANCIAL CORP |
$3097510 |
110075 |
0.10% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$2943444 |
104600 |
0.09% |
买入期权
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$2820050 |
100215 |
0.09% |
股份
|
| Caption Management, LLC |
$2814000 |
100000 |
0.09% |
买入期权
|
| Ghisallo Capital Management LLC |
$2814000 |
100000 |
0.09% |
股份
|
| TD Asset Management Inc |
$2729636 |
97002 |
0.08% |
股份
|
| RHUMBLINE ADVISERS |
$2723010 |
96767 |
0.08% |
股份
|
| FIRST TRUST ADVISORS LP |
$2646454 |
94046 |
0.08% |
股份
|
| Harvest Investment Services, LLC |
$2610407 |
92765 |
0.08% |
股份
|
| Caption Management, LLC |
$2532600 |
90000 |
0.08% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2490390 |
88500 |
0.08% |
买入期权
|
| DEUTSCHE BANK AG\ |
$2366939 |
84113 |
0.07% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$2299800 |
104394 |
0.07% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$2217939 |
78818 |
0.07% |
股份
|
| Ally Bridge Group (NY) LLC |
$2151556 |
76459 |
0.07% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2040150 |
72500 |
0.06% |
卖出期权
|
| Mariner, LLC |
$2018263 |
71726 |
0.06% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$1808090 |
82074 |
0.06% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1652296 |
58717 |
0.05% |
股份
|
| ALGERT GLOBAL LLC |
$1625648 |
57770 |
0.05% |
股份
|
| CITADEL ADVISORS LLC |
$1581468 |
56200 |
0.05% |
买入期权
|
| Legal & General Group Plc |
$1545730 |
54930 |
0.05% |
股份
|
| ACT CAPITAL MANAGEMENT, LLC |
$1452024 |
51600 |
0.04% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$1424306 |
50615 |
0.04% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$1418622 |
50413 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$1400134 |
49756 |
0.04% |
股份
|
| Squarepoint Ops LLC |
$1339183 |
47590 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$1303220 |
46312 |
0.04% |
股份
|
| CITADEL ADVISORS LLC |
$1224090 |
43500 |
0.04% |
卖出期权
|
| FRED ALGER MANAGEMENT, LLC |
$1211624 |
43057 |
0.04% |
股份
|
| Creative Planning |
$1176759 |
41818 |
0.04% |
股份
|
| JANE STREET GROUP, LLC |
$1136856 |
40400 |
0.04% |
卖出期权
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$1023536 |
36373 |
0.03% |
股份
|
| Corient Private Wealth LP |
$988953 |
35144 |
0.03% |
股份
|
| Trexquant Investment LP |
$960615 |
34137 |
0.03% |
股份
|
| FRANKLIN RESOURCES INC |
$918321 |
32634 |
0.03% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$882949 |
31377 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$781363 |
27767 |
0.02% |
股份
|
| J. Goldman & Co LP |
$727306 |
25846 |
0.02% |
股份
|
| Jain Global LLC |
$710704 |
25256 |
0.02% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$710141 |
25236 |
0.02% |
股份
|
| JANE STREET GROUP, LLC |
$680988 |
24200 |
0.02% |
买入期权
|
| BNP PARIBAS FINANCIAL MARKETS |
$677555 |
24078 |
0.02% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$675163 |
23993 |
0.02% |
股份
|
| Inscription Capital, LLC |
$664076 |
23599 |
0.02% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$656647 |
23335 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$655521 |
23295 |
0.02% |
股份
|
| XTX Topco Ltd |
$642549 |
22834 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$616238 |
21899 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$586803 |
20853 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$552782 |
19644 |
0.02% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$525880 |
18688 |
0.02% |
股份
|
| Vanguard Investments Australia, Ltd. |
$457894 |
16272 |
0.01% |
股份
|
| Persistent Asset Partners Ltd |
$443667 |
508 |
0.01% |
买入期权
|
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. |
$433243 |
15396 |
0.01% |
股份
|
| OCCUDO QUANTITATIVE STRATEGIES LP |
$430458 |
15297 |
0.01% |
股份
|
| VIRGINIA RETIREMENT SYSTEMS ET Al |
$422100 |
15000 |
0.01% |
股份
|
| Brevan Howard Capital Management LP |
$416782 |
14811 |
0.01% |
股份
|
| ProShare Advisors LLC |
$405020 |
14393 |
0.01% |
股份
|
| PROFUND ADVISORS LLC |
$401023 |
14251 |
0.01% |
股份
|
| OpenArc Corporate Advisory, LLC |
$400714 |
14240 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$399588 |
14200 |
0.01% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$382817 |
13604 |
0.01% |
股份
|
| Virtus Investment Advisers, LLC |
$381269 |
13549 |
0.01% |
股份
|
| TWO SIGMA ADVISERS, LP |
$371602 |
38074 |
0.01% |
股份
|
| Point72 Asset Management, L.P. |
$343308 |
12200 |
0.01% |
买入期权
|
| Point72 Asset Management, L.P. |
$343308 |
12200 |
0.01% |
卖出期权
|
| Verdad Advisers, LP |
$342942 |
12187 |
0.01% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$322119 |
11447 |
0.01% |
股份
|
| SmartHarvest Portfolios, LLC |
$303096 |
10771 |
0.01% |
股份
|
| Allianz Asset Management GmbH |
$301098 |
10700 |
0.01% |
股份
|
| Vanguard Personalized Indexing Management, LLC |
$300169 |
10667 |
0.01% |
股份
|
| Voleon Capital Management LP |
$299550 |
10645 |
0.01% |
股份
|
| Pictet Asset Management Holding SA |
$295217 |
10491 |
0.01% |
股份
|
| Rafferty Asset Management, LLC |
$278670 |
9903 |
0.01% |
股份
|
| CAPSTONE INVESTMENT ADVISORS, LLC |
$236967 |
8421 |
0.01% |
股份
|
| SEI INVESTMENTS CO |
$234621 |
8337 |
0.01% |
股份
|
| Vident Advisory, LLC |
$233449 |
8296 |
0.01% |
股份
|
| CWM, LLC |
$228870 |
10389 |
0.01% |
股份
|
| TEACHER RETIREMENT SYSTEM OF TEXAS |
$222081 |
7892 |
0.01% |
股份
|
| Arax Advisory Partners |
$221884 |
7885 |
0.01% |
股份
|
| XPONANCE LLC |
$218113 |
7751 |
0.01% |
股份
|
| HAP Trading, LLC |
$213125 |
402500 |
0.01% |
卖出期权
|
| Abel Hall, LLC |
$209277 |
7437 |
0.01% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$201794 |
7128 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$201708 |
7168 |
0.01% |
股份
|
| Fulcrum Asset Management LLP |
$193128 |
7116 |
0.01% |
股份
|
| State of Wyoming |
$188876 |
6712 |
0.01% |
股份
|
| Farther Finance Advisors, LLC |
$174890 |
6215 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$155333 |
5520 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$153279 |
5447 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$146325 |
5199838 |
0.00% |
股份
|
| SIMPLEX TRADING, LLC |
$140306 |
4986 |
0.00% |
股份
|
| ASSETMARK, INC |
$118441 |
4209 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$75331 |
2677 |
0.00% |
股份
|
| STRS OHIO |
$73164 |
2600 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$72630 |
2581 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$72000 |
2559 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$57940 |
2059 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$36188 |
1286 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$32839 |
1167 |
0.00% |
股份
|
| GAMMA Investing LLC |
$27971 |
994 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$27852 |
1055 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$27774 |
987 |
0.00% |
股份
|
| Kemnay Advisory Services Inc. |
$25664 |
912 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$15280 |
543 |
0.00% |
股份
|
| Allworth Financial LP |
$13142 |
467 |
0.00% |
股份
|
| Essential Partners LLC |
$12382 |
440 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$11566 |
411 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$11031 |
392 |
0.00% |
股份
|
| Aster Capital Management (DIFC) Ltd |
$9258 |
329 |
0.00% |
股份
|
| COMERICA BANK |
$9096 |
932 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$8188 |
291 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$7851 |
279 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$7795 |
277 |
0.00% |
股份
|
| US BANCORP \DE\ |
$7401 |
263 |
0.00% |
股份
|
| True Wealth Design, LLC |
$6529 |
232 |
0.00% |
股份
|
| BFSG, LLC |
$5403 |
192 |
0.00% |
股份
|
| Larson Financial Group LLC |
$4334 |
154 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$4013 |
543 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$3994 |
142 |
0.00% |
股份
|
| Transamerica Financial Advisors, LLC |
$2729 |
97 |
0.00% |
股份
|
| Quarry LP |
$2701 |
96 |
0.00% |
股份
|
| Optiver Holding B.V. |
$2645 |
94 |
0.00% |
股份
|
| Decker Retirement Planning Inc. |
$2561 |
91 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$2167 |
77 |
0.00% |
股份
|
| IFP Advisors, Inc |
$1548 |
55 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$957 |
34 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$900 |
32 |
0.00% |
股份
|
| CoreCap Advisors, LLC |
$732 |
26 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$703 |
25 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$643 |
22867 |
0.00% |
股份
|
| HARBOUR INVESTMENTS, INC. |
$634 |
23 |
0.00% |
股份
|
| Stone House Investment Management, LLC |
$619 |
22 |
0.00% |
股份
|
| SALEM INVESTMENT COUNSELORS INC |
$563 |
20 |
0.00% |
股份
|
| HAP Trading, LLC |
$272 |
340000 |
0.00% |
卖出期权
|
| HAP Trading, LLC |
$260 |
266900 |
0.00% |
买入期权
|
| Sunbelt Securities, Inc. |
$154 |
7 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$103 |
3696 |
0.00% |
股份
|
| KBC Group NV |
$54 |
1929 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
28 |
0.00% |
股份
|