| MONTANOVA CAPITAL, LLC |
$156869547 |
4515531 |
9.43% |
股份
|
| INFINITUM ASSET MANAGEMENT, LLC |
$154189460 |
4438384 |
9.27% |
股份
|
| HHLR ADVISORS, LTD. |
$136497525 |
3929117 |
8.21% |
股份
|
| BlackRock, Inc. |
$112918757 |
3250396 |
6.79% |
股份
|
| ORBIMED ADVISORS LLC |
$105169375 |
3027328 |
6.32% |
股份
|
| FMR LLC |
$96541033 |
2778959 |
5.81% |
股份
|
| Octagon Capital Advisors LP |
$68474416 |
1971054 |
4.12% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$61659088 |
1774873 |
3.71% |
股份
|
| Sofinnova Investments, Inc. |
$58945164 |
1696752 |
3.54% |
股份
|
| STATE STREET CORP |
$58814334 |
1692986 |
3.54% |
股份
|
| Vivo Capital, LLC |
$58436050 |
1682097 |
3.51% |
股份
|
| NOVO HOLDINGS A/S |
$52110000 |
1500000 |
3.13% |
股份
|
| General Catalyst Group Management, LLC |
$51928866 |
1494786 |
3.12% |
股份
|
| VANGUARD GROUP INC |
$37609632 |
1869266 |
2.26% |
股份
|
| Logos Global Management LP |
$34740000 |
1000000 |
2.09% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$33795640 |
972626 |
2.03% |
股份
|
| D. E. Shaw & Co., Inc. |
$30293662 |
872011 |
1.82% |
股份
|
| GOLDMAN SACHS GROUP INC |
$29658337 |
853723 |
1.78% |
股份
|
| HSG Holding Ltd |
$23043320 |
663308 |
1.39% |
股份
|
| Point72 Asset Management, L.P. |
$19690493 |
566796 |
1.18% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$17658342 |
508300 |
1.06% |
买入期权
|
| MILLENNIUM MANAGEMENT LLC |
$15239187 |
438664 |
0.92% |
股份
|
| UBS Group AG |
$15236756 |
438594 |
0.92% |
股份
|
| Balyasny Asset Management L.P. |
$13737829 |
395447 |
0.83% |
股份
|
| AMERIPRISE FINANCIAL INC |
$13256401 |
381589 |
0.80% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$11649017 |
335320 |
0.70% |
股份
|
| NORTHERN TRUST CORP |
$11559840 |
332753 |
0.70% |
股份
|
| Foresite Capital Management VI LLC |
$10468586 |
301341 |
0.63% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$10221342 |
294224 |
0.61% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$9007735 |
259290 |
0.54% |
股份
|
| Seven Fleet Capital Management LP |
$8567092 |
246606 |
0.52% |
股份
|
| ACUTA CAPITAL PARTNERS, LLC |
$7597430 |
218694 |
0.46% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$7347651 |
211509 |
0.44% |
股份
|
| MORGAN STANLEY |
$6597474 |
189910 |
0.40% |
股份
|
| Squadron Capital Management LLC |
$6357420 |
183000 |
0.38% |
买入期权
|
| BANK OF AMERICA CORP /DE/ |
$6074845 |
174866 |
0.37% |
股份
|
| CITADEL ADVISORS LLC |
$5445217 |
156742 |
0.33% |
股份
|
| NOMURA HOLDINGS INC |
$5371395 |
154617 |
0.32% |
股份
|
| Woodline Partners LP |
$5128979 |
147639 |
0.31% |
股份
|
| JANE STREET GROUP, LLC |
$4811490 |
138500 |
0.29% |
买入期权
|
| Affinity Asset Advisors, LLC |
$4342500 |
125000 |
0.26% |
股份
|
| E Fund Management Co., Ltd. |
$3798055 |
109328 |
0.23% |
股份
|
| Nuveen, LLC |
$3746745 |
107851 |
0.23% |
股份
|
| Bank of New York Mellon Corp |
$3610563 |
103931 |
0.22% |
股份
|
| KVP Capital Advisors, LP |
$3543480 |
102000 |
0.21% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$3503702 |
100855 |
0.21% |
股份
|
| Burkehill Global Management, LP |
$3474000 |
100000 |
0.21% |
股份
|
| CITADEL ADVISORS LLC |
$2834784 |
81600 |
0.17% |
买入期权
|
| SECTORAL ASSET MANAGEMENT INC |
$2745954 |
79043 |
0.17% |
股份
|
| Trexquant Investment LP |
$2496416 |
71860 |
0.15% |
股份
|
| BARCLAYS PLC |
$2465497 |
70970 |
0.15% |
股份
|
| JPMORGAN CHASE & CO |
$2257834 |
65692 |
0.14% |
股份
|
| XTX Topco Ltd |
$2165414 |
62332 |
0.13% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$2008111 |
57804 |
0.12% |
股份
|
| Soleus Capital Management, L.P. |
$1737000 |
50000 |
0.10% |
股份
|
| Quadrature Capital Ltd |
$1706603 |
49125 |
0.10% |
股份
|
| Swiss National Bank |
$1695312 |
48800 |
0.10% |
股份
|
| ALPS ADVISORS INC |
$1635351 |
47074 |
0.10% |
股份
|
| RHUMBLINE ADVISERS |
$1606853 |
46254 |
0.10% |
股份
|
| Moody Aldrich Partners LLC |
$1530089 |
44044 |
0.09% |
股份
|
| CITIGROUP INC |
$1433546 |
41265 |
0.09% |
股份
|
| DEUTSCHE BANK AG\ |
$1361114 |
39180 |
0.08% |
股份
|
| WELLS FARGO & COMPANY/MN |
$1273915 |
36670 |
0.08% |
股份
|
| Quantinno Capital Management LP |
$1273256 |
36651 |
0.08% |
股份
|
| Invesco Ltd. |
$1145239 |
32966 |
0.07% |
股份
|
| Jump Financial, LLC |
$1029833 |
29644 |
0.06% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$1004929 |
43560 |
0.06% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$992939 |
28582 |
0.06% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$982551 |
28283 |
0.06% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$976194 |
28100 |
0.06% |
卖出期权
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$930963 |
26798 |
0.06% |
股份
|
| Ellsworth Advisors, LLC |
$889683 |
27001 |
0.05% |
股份
|
| Rafferty Asset Management, LLC |
$846961 |
24380 |
0.05% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$808990 |
23287 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$776786 |
22360 |
0.05% |
股份
|
| Engineers Gate Manager LP |
$773278 |
22259 |
0.05% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$747500 |
21517 |
0.04% |
股份
|
| TWO SIGMA ADVISERS, LP |
$746452 |
37100 |
0.04% |
股份
|
| Corient Private Wealth LP |
$709739 |
20430 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$703966 |
20294 |
0.04% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$678611 |
19534 |
0.04% |
股份
|
| OPTIMIZE FINANCIAL INC. |
$654884 |
18851 |
0.04% |
股份
|
| TEMA ETFS LLC |
$643981 |
32007 |
0.04% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$610694 |
17579 |
0.04% |
股份
|
| Squarepoint Ops LLC |
$609479 |
17544 |
0.04% |
股份
|
| Caption Management, LLC |
$554694 |
15967 |
0.03% |
股份
|
| Persistent Asset Partners Ltd |
$546599 |
15734 |
0.03% |
股份
|
| Legal & General Group Plc |
$537810 |
15481 |
0.03% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$517383 |
14893 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$513561 |
14783 |
0.03% |
股份
|
| PROFUND ADVISORS LLC |
$439218 |
12643 |
0.03% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$413337 |
11898 |
0.02% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$411426 |
11843 |
0.02% |
股份
|
| Vanguard Global Advisers, LLC |
$406597 |
11704 |
0.02% |
股份
|
| Jain Global LLC |
$399058 |
11487 |
0.02% |
股份
|
| DeepCurrents Investment Group LLC |
$390026 |
11227 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$388532 |
11184 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$388046 |
11170 |
0.02% |
股份
|
| Virtus Investment Advisers, LLC |
$372204 |
10714 |
0.02% |
股份
|
| Aquatic Capital Management LLC |
$368175 |
10598 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$360011 |
10363 |
0.02% |
股份
|
| Creative Planning |
$347851 |
10013 |
0.02% |
股份
|
| GLENMEDE TRUST CO NA |
$346357 |
9970 |
0.02% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$343335 |
9883 |
0.02% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$335936 |
9670 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$332358 |
9567 |
0.02% |
股份
|
| Skopos Labs, Inc. |
$325864 |
14125 |
0.02% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$325688 |
9375 |
0.02% |
股份
|
| Russell Investments Group, Ltd. |
$318149 |
9158 |
0.02% |
股份
|
| Brevan Howard Capital Management LP |
$306511 |
8823 |
0.02% |
股份
|
| KLP KAPITALFORVALTNING AS |
$284868 |
8200 |
0.02% |
股份
|
| VARCOV Co. |
$283166 |
8151 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$273091 |
7861 |
0.02% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$262006 |
11357 |
0.02% |
股份
|
| ENVESTNET ASSET MANAGEMENT INC |
$259577 |
7472 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$257493 |
7412 |
0.02% |
股份
|
| MARTINGALE ASSET MANAGEMENT L P |
$246759 |
7103 |
0.01% |
股份
|
| PSP Research LLC |
$244604 |
7041 |
0.01% |
股份
|
| JANE STREET GROUP, LLC |
$239706 |
6900 |
0.01% |
卖出期权
|
| ARIZONA STATE RETIREMENT SYSTEM |
$233036 |
6708 |
0.01% |
股份
|
| Morgan Creek Capital Management, LLC |
$229284 |
6600 |
0.01% |
股份
|
| ProShare Advisors LLC |
$225498 |
6491 |
0.01% |
股份
|
| SIMPLEX TRADING, LLC |
$223308 |
6428 |
0.01% |
股份
|
| AXQ CAPITAL, LP |
$222058 |
6392 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$215909 |
6215 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$211115 |
6077 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$119540 |
3441 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$72363 |
2083 |
0.00% |
股份
|
| Quantbot Technologies LP |
$59266 |
1706 |
0.00% |
股份
|
| AlphaQuest LLC |
$56336 |
2800 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$54160 |
1559 |
0.00% |
股份
|
| US BANCORP \DE\ |
$52457 |
1510 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$46000 |
1331 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$30467 |
877 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$24387 |
702 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$21731 |
631 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$21122 |
608 |
0.00% |
股份
|
| Arax Advisory Partners |
$19941 |
574 |
0.00% |
股份
|
| GAMMA Investing LLC |
$15112 |
435 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$14695 |
423 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$13618 |
392 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$12784 |
368 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$12784 |
368 |
0.00% |
股份
|
| Larson Financial Group LLC |
$9623 |
277 |
0.00% |
股份
|
| CWM, LLC |
$9043 |
392 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$7434 |
214 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$4620 |
133 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$4211 |
121224 |
0.00% |
股份
|
| Optiver Holding B.V. |
$3752 |
108 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$3474 |
100 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$2182 |
118 |
0.00% |
股份
|
| Allworth Financial LP |
$1842 |
53 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$1097 |
31551 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$938 |
27 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$903 |
26 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$862 |
24805 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$834 |
24 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$799 |
23 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$764 |
22 |
0.00% |
股份
|
| Torren Management, LLC |
$761 |
33 |
0.00% |
股份
|
| Essential Partners LLC |
$347 |
10 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$313 |
9 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$278 |
8 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$139 |
4 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$14 |
407 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
13 |
0.00% |
股份
|