| Cormorant Asset Management, LP |
$21995828 |
2344971 |
14.25% |
股份
|
| ORBIMED ADVISORS LLC |
$16295752 |
1737287 |
10.56% |
股份
|
| BlackRock, Inc. |
$12486047 |
1331135 |
8.09% |
股份
|
| Aberdeen Group plc |
$12398015 |
1321750 |
8.03% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$7137617 |
760940 |
4.62% |
股份
|
| VANGUARD GROUP INC |
$6995573 |
859407 |
4.53% |
股份
|
| Jones Hill Capital LP |
$6130505 |
653572 |
3.97% |
股份
|
| Prosight Management, LP |
$6097000 |
650000 |
3.95% |
股份
|
| DIADEMA PARTNERS LP |
$5945044 |
633800 |
3.85% |
买入期权
|
| Caption Management, LLC |
$5368174 |
572300 |
3.48% |
买入期权
|
| Stonepine Capital Management, LLC |
$3986500 |
425000 |
2.58% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$3972122 |
423374 |
2.57% |
股份
|
| ADAR1 Capital Management, LLC |
$3956362 |
421787 |
2.56% |
股份
|
| DIADEMA PARTNERS LP |
$2825856 |
301264 |
1.83% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2750244 |
293203 |
1.78% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2511964 |
267800 |
1.63% |
买入期权
|
| STATE STREET CORP |
$2388823 |
254672 |
1.55% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$1783533 |
190214 |
1.16% |
股份
|
| Exome Asset Management LLC |
$1734493 |
184914 |
1.12% |
股份
|
| COMERICA BANK |
$1628008 |
200001 |
1.05% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$1422383 |
151640 |
0.92% |
股份
|
| JANE STREET GROUP, LLC |
$1305068 |
139133 |
0.85% |
股份
|
| NORTHERN TRUST CORP |
$1171618 |
124906 |
0.76% |
股份
|
| CITADEL ADVISORS LLC |
$1071196 |
114200 |
0.69% |
买入期权
|
| VANGUARD FIDUCIARY TRUST CO |
$1054284 |
112397 |
0.68% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$1044013 |
111302 |
0.68% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$1039510 |
110822 |
0.67% |
股份
|
| DAFNA Capital Management LLC |
$1010911 |
107773 |
0.65% |
股份
|
| CITADEL ADVISORS LLC |
$864405 |
92154 |
0.56% |
股份
|
| Advisory Services Network, LLC |
$843740 |
89951 |
0.55% |
股份
|
| MARSHALL WACE, LLP |
$744125 |
79331 |
0.48% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$732766 |
78120 |
0.47% |
股份
|
| Persistent Asset Partners Ltd |
$721500 |
76919 |
0.47% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$712683 |
75979 |
0.46% |
股份
|
| XTX Topco Ltd |
$634595 |
67654 |
0.41% |
股份
|
| Verdad Advisers, LP |
$596596 |
63603 |
0.39% |
股份
|
| GOLDMAN SACHS GROUP INC |
$589655 |
62863 |
0.38% |
股份
|
| ADAR1 Capital Management, LLC |
$562800 |
60000 |
0.36% |
买入期权
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$520168 |
55455 |
0.34% |
股份
|
| DOLIVER ADVISORS, LP |
$518149 |
75975 |
0.34% |
股份
|
| HSBC HOLDINGS PLC |
$504747 |
55224 |
0.33% |
股份
|
| UBS Group AG |
$457716 |
48797 |
0.30% |
股份
|
| Bank of New York Mellon Corp |
$424746 |
45282 |
0.28% |
股份
|
| Rangeley Capital, LLC |
$412720 |
44000 |
0.27% |
股份
|
| CANTOR FITZGERALD, L. P. |
$376117 |
40098 |
0.24% |
股份
|
| Driehaus Capital Management LLC |
$365604 |
38977 |
0.24% |
股份
|
| LMR Partners LLP |
$332990 |
35500 |
0.22% |
股份
|
| Engineers Gate Manager LP |
$279524 |
29800 |
0.18% |
股份
|
| Caption Management, LLC |
$261252 |
27852 |
0.17% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$250446 |
26700 |
0.16% |
卖出期权
|
| Velan Capital Investment Management LP |
$243880 |
26000 |
0.16% |
股份
|
| Jump Financial, LLC |
$242004 |
25800 |
0.16% |
股份
|
| Persistent Asset Partners Ltd |
$235063 |
1615 |
0.15% |
买入期权
|
| Pale Fire Capital SE |
$227943 |
24301 |
0.15% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$212419 |
22646 |
0.14% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$211116 |
22507 |
0.14% |
股份
|
| Brevan Howard Capital Management LP |
$210834 |
22477 |
0.14% |
股份
|
| Nuveen, LLC |
$209249 |
22308 |
0.14% |
股份
|
| Seven Fleet Capital Management LP |
$201032 |
21432 |
0.13% |
股份
|
| RHUMBLINE ADVISERS |
$191938 |
20463 |
0.12% |
股份
|
| MORGAN STANLEY |
$188473 |
20093 |
0.12% |
股份
|
| SECTORAL ASSET MANAGEMENT INC |
$187600 |
20000 |
0.12% |
股份
|
| AlphaQuest LLC |
$186455 |
22906 |
0.12% |
股份
|
| JANE STREET GROUP, LLC |
$181972 |
19400 |
0.12% |
买入期权
|
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
$176832 |
18852 |
0.11% |
股份
|
| CITADEL ADVISORS LLC |
$172592 |
18400 |
0.11% |
卖出期权
|
| PANAGORA ASSET MANAGEMENT INC |
$150896 |
16087 |
0.10% |
股份
|
| DEUTSCHE BANK AG\ |
$150746 |
16071 |
0.10% |
股份
|
| WELLS FARGO & COMPANY/MN |
$129777 |
13836 |
0.08% |
股份
|
| SHERBROOKE PARK ADVISERS LLC |
$125437 |
15410 |
0.08% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$124322 |
13254 |
0.08% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$116312 |
12400 |
0.08% |
股份
|
| Quadrature Capital Ltd |
$114427 |
12199 |
0.07% |
股份
|
| JANE STREET GROUP, LLC |
$110684 |
11800 |
0.07% |
卖出期权
|
| Mariner, LLC |
$109146 |
11636 |
0.07% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$107288 |
11438 |
0.07% |
股份
|
| CITIGROUP INC |
$106172 |
11319 |
0.07% |
股份
|
| FMR LLC |
$81146 |
8651 |
0.05% |
股份
|
| BARCLAYS PLC |
$75058 |
8002 |
0.05% |
股份
|
| JPMORGAN CHASE & CO |
$61549 |
6854 |
0.04% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$59928 |
6600 |
0.04% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$51402 |
5480 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$44039 |
4695 |
0.03% |
股份
|
| ROYAL BANK OF CANADA |
$35000 |
3663 |
0.02% |
股份
|
| Global Retirement Partners, LLC |
$16884 |
1800 |
0.01% |
股份
|
| Russell Investments Group, Ltd. |
$16508 |
1760 |
0.01% |
股份
|
| Legal & General Group Plc |
$14970 |
1596 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$14014 |
1494 |
0.01% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$11493 |
1224 |
0.01% |
股份
|
| Pinnacle Wealth Planning Services, Inc. |
$8902 |
949 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$8761 |
934 |
0.01% |
股份
|
| Atlantic Private Wealth, LLC |
$4690 |
500 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$4099 |
601 |
0.00% |
股份
|
| FEDERATED HERMES, INC. |
$3330 |
355 |
0.00% |
股份
|
| GAMMA Investing LLC |
$3152 |
336 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$3114 |
332 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$2692 |
287 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$2456 |
262 |
0.00% |
股份
|
| ORG Partners LLC |
$814 |
100 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$685 |
73 |
0.00% |
股份
|
| Golden State Wealth Management, LLC |
$685 |
73 |
0.00% |
股份
|
| CWM, LLC |
$648 |
69 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$621 |
71 |
0.00% |
股份
|
| Spire Wealth Management |
$619 |
66 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$516 |
55 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$385 |
41 |
0.00% |
股份
|
| HighMark Wealth Management LLC |
$384 |
41 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$349 |
37389 |
0.00% |
股份
|
| LANARK FINANCIAL, INC. |
$309 |
33 |
0.00% |
股份
|
| CHILTON CAPITAL MANAGEMENT LLC |
$273 |
29 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$247 |
26271 |
0.00% |
股份
|
| CoreCap Advisors, LLC |
$235 |
25 |
0.00% |
股份
|
| NFSG Corp |
$150 |
16 |
0.00% |
股份
|
| Fortis Group Advisors, LLC |
$131 |
14 |
0.00% |
股份
|
| VISION FINANCIAL MARKETS LLC |
$127 |
14 |
0.00% |
股份
|
| HARBOUR INVESTMENTS, INC. |
$122 |
13 |
0.00% |
股份
|
| NewEdge Advisors, LLC |
$75 |
8 |
0.00% |
股份
|
| Cassaday & Co Wealth Management LLC |
$57 |
6 |
0.00% |
股份
|
| EASTERN BANK |
$56 |
6 |
0.00% |
股份
|
| Arax Advisory Partners |
$28 |
3 |
0.00% |
股份
|
| BFSG, LLC |
$10 |
1 |
0.00% |
股份
|
| JTC Employer Solutions Trustee Ltd |
$10 |
1106 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$9 |
1 |
0.00% |
股份
|