| Opaleye Management Inc. |
$103532000 |
2860000 |
14.05% |
股份
|
| EcoR1 Capital, LLC |
$78624156 |
2171938 |
10.67% |
股份
|
| BlackRock, Inc. |
$68629156 |
1895833 |
9.31% |
股份
|
| Nantahala Capital Management, LLC |
$42569426 |
1175951 |
5.78% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$35351834 |
976570 |
4.80% |
股份
|
| MORGAN STANLEY |
$27800585 |
767972 |
3.77% |
股份
|
| STATE STREET CORP |
$25404653 |
701786 |
3.45% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$23618970 |
652303 |
3.21% |
股份
|
| VANGUARD GROUP INC |
$22805976 |
1348668 |
3.10% |
股份
|
| OBERWEIS ASSET MANAGEMENT INC/ |
$18157920 |
501600 |
2.46% |
股份
|
| National Philanthropic Trust |
$17814454 |
492112 |
2.42% |
股份
|
| Westside Investment Management, Inc. |
$15608010 |
431160 |
2.12% |
股份
|
| Pillsbury Lake Capital LLC |
$14015083 |
387157 |
1.90% |
股份
|
| Nuveen, LLC |
$13600593 |
375707 |
1.85% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$11673269 |
322466 |
1.58% |
股份
|
| Woodline Partners LP |
$11253820 |
310879 |
1.53% |
股份
|
| NORTHERN TRUST CORP |
$9261733 |
255849 |
1.26% |
股份
|
| MARSHALL WACE, LLP |
$9020387 |
249182 |
1.22% |
股份
|
| Panoramic Capital, LLC |
$7536550 |
208192 |
1.02% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$7044194 |
194591 |
0.96% |
股份
|
| JPMORGAN CHASE & CO |
$7038753 |
191635 |
0.96% |
股份
|
| D. E. Shaw & Co., Inc. |
$6821962 |
188452 |
0.93% |
股份
|
| JANE STREET GROUP, LLC |
$6722232 |
185697 |
0.91% |
股份
|
| Lumbard & Kellner, LLC |
$6367906 |
175909 |
0.86% |
股份
|
| CANNELL CAPITAL LLC |
$6181041 |
170747 |
0.84% |
股份
|
| NORGES BANK |
$6135900 |
169500 |
0.83% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$6101112 |
168539 |
0.83% |
股份
|
| Informed Momentum Co LLC |
$5721229 |
158045 |
0.78% |
股份
|
| Prospect Capital Advisors, LLC |
$5690640 |
157200 |
0.77% |
股份
|
| Aristides Capital LLC |
$5263842 |
145410 |
0.71% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$5149704 |
142257 |
0.70% |
股份
|
| PRELUDE CAPITAL MANAGEMENT, LLC |
$4980106 |
137572 |
0.68% |
股份
|
| GOLDMAN SACHS GROUP INC |
$4799505 |
132583 |
0.65% |
股份
|
| Bank of New York Mellon Corp |
$4280614 |
118249 |
0.58% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$4209734 |
116291 |
0.57% |
股份
|
| WELLS FARGO & COMPANY/MN |
$4150510 |
114655 |
0.56% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$3232660 |
89300 |
0.44% |
买入期权
|
| Bridge City Capital, LLC |
$3190378 |
88132 |
0.43% |
股份
|
| Walleye Capital LLC |
$3122214 |
86249 |
0.42% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$2788558 |
77032 |
0.38% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$2754928 |
76103 |
0.37% |
股份
|
| Diametric Capital, LP |
$2646256 |
73101 |
0.36% |
股份
|
| Numerai GP LLC |
$2538127 |
70114 |
0.34% |
股份
|
| UBS Group AG |
$2368349 |
65424 |
0.32% |
股份
|
| Squarepoint Ops LLC |
$2156144 |
59562 |
0.29% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$2082079 |
57516 |
0.28% |
股份
|
| BARCLAYS PLC |
$2033751 |
56181 |
0.28% |
股份
|
| HighTower Advisors, LLC |
$1915233 |
52907 |
0.26% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$1893260 |
52300 |
0.26% |
股份
|
| CITADEL ADVISORS LLC |
$1772678 |
48969 |
0.24% |
股份
|
| POLEN CAPITAL MANAGEMENT LLC |
$1642720 |
45379 |
0.22% |
股份
|
| Point72 Asset Management, L.P. |
$1626032 |
44918 |
0.22% |
股份
|
| Aquatic Capital Management LLC |
$1585343 |
43794 |
0.22% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1571080 |
43400 |
0.21% |
卖出期权
|
| DIMENSIONAL FUND ADVISORS LP |
$1537921 |
42484 |
0.21% |
股份
|
| HSBC HOLDINGS PLC |
$1530789 |
40974 |
0.21% |
股份
|
| ANCHOR CAPITAL ADVISORS LLC |
$1470408 |
40619 |
0.20% |
股份
|
| CITADEL ADVISORS LLC |
$1317680 |
36400 |
0.18% |
卖出期权
|
| SEI INVESTMENTS CO |
$1256068 |
34698 |
0.17% |
股份
|
| Jefferies Financial Group Inc. |
$1231777 |
34027 |
0.17% |
股份
|
| RHUMBLINE ADVISERS |
$1220040 |
33703 |
0.17% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$1214220 |
33542 |
0.16% |
股份
|
| Invesco Ltd. |
$1208501 |
33384 |
0.16% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$1186600 |
32779 |
0.16% |
股份
|
| BLAIR WILLIAM & CO/IL |
$1173568 |
32419 |
0.16% |
股份
|
| Riggs Asset Managment Co. Inc. |
$1160065 |
32046 |
0.16% |
股份
|
| Sigma Planning Corp |
$1086000 |
30000 |
0.15% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$1054325 |
29125 |
0.14% |
股份
|
| JUNCTURE WEALTH STRATEGIES, LLC |
$1044334 |
28849 |
0.14% |
股份
|
| DEUTSCHE BANK AG\ |
$960096 |
26522 |
0.13% |
股份
|
| STRS OHIO |
$854320 |
23600 |
0.12% |
股份
|
| Guilbault Capital LLC |
$849252 |
23460 |
0.12% |
股份
|
| JANE STREET GROUP, LLC |
$785540 |
21700 |
0.11% |
买入期权
|
| PRUDENTIAL FINANCIAL INC |
$765015 |
21133 |
0.10% |
股份
|
| CITIGROUP INC |
$758463 |
20952 |
0.10% |
股份
|
| ESSEX INVESTMENT MANAGEMENT CO LLC |
$728742 |
20131 |
0.10% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$707493 |
19544 |
0.10% |
股份
|
| FIRST TRUST ADVISORS LP |
$705067 |
19477 |
0.10% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$697210 |
28250 |
0.09% |
股份
|
| NAVELLIER & ASSOCIATES INC |
$651962 |
18010 |
0.09% |
股份
|
| BANK OF NOVA SCOTIA |
$622640 |
17200 |
0.08% |
股份
|
| CHICAGO TRUST Co NA |
$604540 |
16700 |
0.08% |
股份
|
| Man Group plc |
$584702 |
16152 |
0.08% |
股份
|
| Gotham Asset Management, LLC |
$578548 |
15982 |
0.08% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$567435 |
15675 |
0.08% |
股份
|
| MetLife Investment Management, LLC |
$567363 |
15673 |
0.08% |
股份
|
| PDT Partners, LLC |
$539054 |
14891 |
0.07% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$525081 |
14505 |
0.07% |
股份
|
| Vanguard Global Advisers, LLC |
$512773 |
14165 |
0.07% |
股份
|
| LPL Financial LLC |
$507415 |
14017 |
0.07% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$476030 |
13150 |
0.06% |
股份
|
| JANE STREET GROUP, LLC |
$452500 |
12500 |
0.06% |
卖出期权
|
| RAYMOND JAMES FINANCIAL INC |
$450473 |
12444 |
0.06% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$445115 |
12296 |
0.06% |
股份
|
| Quantum Private Wealth, LLC |
$416300 |
11500 |
0.06% |
股份
|
| Menard Financial Group LLC |
$385240 |
10642 |
0.05% |
股份
|
| &PARTNERS |
$362000 |
10000 |
0.05% |
股份
|
| MACKENZIE FINANCIAL CORP |
$347158 |
9590 |
0.05% |
股份
|
| ENVESTNET ASSET MANAGEMENT INC |
$346868 |
9582 |
0.05% |
股份
|
| BRC Group Holdings, Inc. |
$339665 |
9383 |
0.05% |
股份
|
| Sheets Smith Investment Management |
$322517 |
14842 |
0.04% |
股份
|
| Granite Investment Partners, LLC |
$306940 |
8479 |
0.04% |
股份
|
| Russell Investments Group, Ltd. |
$295645 |
8167 |
0.04% |
股份
|
| Brevan Howard Capital Management LP |
$287971 |
7955 |
0.04% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$285980 |
7900 |
0.04% |
股份
|
| Mutual Advisors, LLC |
$273708 |
7561 |
0.04% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$268713 |
7423 |
0.04% |
股份
|
| Voleon Capital Management LP |
$261617 |
7227 |
0.04% |
股份
|
| Jain Global LLC |
$261400 |
7221 |
0.04% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$260966 |
7209 |
0.04% |
股份
|
| Legal & General Group Plc |
$258143 |
7131 |
0.04% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$253255 |
6996 |
0.03% |
股份
|
| TWO SIGMA ADVISERS, LP |
$248577 |
14700 |
0.03% |
股份
|
| Quantinno Capital Management LP |
$241128 |
6661 |
0.03% |
股份
|
| PROFUND ADVISORS LLC |
$236531 |
6534 |
0.03% |
股份
|
| ANCHYRA PARTNERS LLC |
$220132 |
6081 |
0.03% |
股份
|
| XTX Topco Ltd |
$215933 |
5965 |
0.03% |
股份
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$203625 |
5625 |
0.03% |
股份
|
| BankChampaign, National Association |
$202358 |
5590 |
0.03% |
股份
|
| Quantbot Technologies LP |
$164710 |
4550 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$157832 |
4360 |
0.02% |
股份
|
| Kemnay Advisory Services Inc. |
$134519 |
3716 |
0.02% |
股份
|
| State of Wyoming |
$106790 |
2950 |
0.01% |
股份
|
| Persistent Asset Partners Ltd |
$90247 |
2493 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$87713 |
2423 |
0.01% |
股份
|
| FMR LLC |
$76912 |
2125 |
0.01% |
股份
|
| AlphaQuest LLC |
$70160 |
4149 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$44345 |
1225 |
0.01% |
股份
|
| TOTH FINANCIAL ADVISORY CORP |
$43440 |
1200 |
0.01% |
股份
|
| Truvestments Capital LLC |
$42825 |
1183 |
0.01% |
股份
|
| Caitong International Asset Management Co., Ltd |
$30480 |
842 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$29000 |
811 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$25883 |
715 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$25774 |
712 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$20598 |
569 |
0.00% |
股份
|
| FEDERATED HERMES, INC. |
$17159 |
474 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$15856 |
438 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$13032 |
360 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$11331 |
313 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$10969 |
303 |
0.00% |
股份
|
| THOMPSON SIEGEL & WALMSLEY LLC |
$10760 |
297232 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$9082 |
368 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$8961 |
251 |
0.00% |
股份
|
| Pinnacle Wealth Planning Services, Inc. |
$7674 |
212 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$5611 |
155 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$4518 |
123 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$3759 |
73 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$3403 |
94 |
0.00% |
股份
|
| CWM, LLC |
$2641 |
107 |
0.00% |
股份
|
| Institute for Wealth Management, LLC. |
$2634 |
73 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$1882 |
52 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$1520 |
42 |
0.00% |
股份
|
| Aster Capital Management (DIFC) Ltd |
$1267 |
35 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$1231 |
34 |
0.00% |
股份
|
| Investors Portfolio Services LLC |
$1231 |
34 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$1195 |
33 |
0.00% |
股份
|
| Quarry LP |
$941 |
26 |
0.00% |
股份
|
| Allworth Financial LP |
$833 |
23 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$794 |
21932 |
0.00% |
股份
|
| GAMMA Investing LLC |
$760 |
21 |
0.00% |
股份
|
| US BANCORP \DE\ |
$688 |
19 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$541 |
15013 |
0.00% |
股份
|
| Larson Financial Group LLC |
$398 |
11 |
0.00% |
股份
|
| Arax Advisory Partners |
$362 |
10 |
0.00% |
股份
|
| Virtu Financial LLC |
$329 |
9102 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$326 |
9 |
0.00% |
股份
|
| State of Alaska, Department of Revenue |
$250 |
6943 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$144 |
4 |
0.00% |
股份
|
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM |
$84 |
2334 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$36 |
1 |
0.00% |
股份
|
| Essential Partners LLC |
$36 |
1 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
16 |
0.00% |
股份
|