| VANGUARD GROUP INC |
$40258533 |
3559552 |
12.28% |
股份
|
| BlackRock, Inc. |
$32296788 |
8824259 |
9.85% |
股份
|
| EcoR1 Capital, LLC |
$23972510 |
6549866 |
7.31% |
股份
|
| TANG CAPITAL MANAGEMENT LLC |
$23868368 |
6521412 |
7.28% |
股份
|
| Nantahala Capital Management, LLC |
$20038646 |
5475040 |
6.11% |
股份
|
| MONTANOVA CAPITAL, LLC |
$13472171 |
3680921 |
4.11% |
股份
|
| D. E. Shaw & Co., Inc. |
$11142449 |
3044385 |
3.40% |
股份
|
| CITADEL ADVISORS LLC |
$9898488 |
2704505 |
3.02% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$9871811 |
2697216 |
3.01% |
股份
|
| JANE STREET GROUP, LLC |
$8116043 |
2217498 |
2.47% |
股份
|
| STATE STREET CORP |
$7455512 |
2037025 |
2.27% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$7320000 |
2000000 |
2.23% |
股份
|
| GSK plc |
$6535713 |
1785714 |
1.99% |
股份
|
| Qube Research & Technologies Ltd |
$6399389 |
1748467 |
1.95% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$6030948 |
1647800 |
1.84% |
股份
|
| ADAR1 Capital Management, LLC |
$5728006 |
1565029 |
1.75% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$5438039 |
1485803 |
1.66% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$5242680 |
1432133 |
1.60% |
股份
|
| MARSHALL WACE, LLP |
$4971828 |
1358423 |
1.52% |
股份
|
| UBS Group AG |
$4589307 |
1253909 |
1.40% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$4322262 |
1180946 |
1.32% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$4037935 |
1103261 |
1.23% |
股份
|
| GOLDMAN SACHS GROUP INC |
$4005595 |
1094425 |
1.22% |
股份
|
| Ikarian Capital, LLC |
$3839929 |
1049161 |
1.17% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$3817486 |
1043029 |
1.16% |
股份
|
| Jump Financial, LLC |
$3678300 |
1005000 |
1.12% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$3515976 |
960547 |
1.07% |
股份
|
| Assenagon Asset Management S.A. |
$3056847 |
835204 |
0.93% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$2974724 |
812766 |
0.91% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$2862647 |
782144 |
0.87% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$2727860 |
745317 |
0.83% |
股份
|
| Balyasny Asset Management L.P. |
$2534082 |
692372 |
0.77% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$2495505 |
681832 |
0.76% |
股份
|
| Point72 Asset Management, L.P. |
$2384223 |
651427 |
0.73% |
股份
|
| NORTHERN TRUST CORP |
$1785600 |
487869 |
0.54% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1585585 |
433220 |
0.48% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$1265072 |
345648 |
0.39% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$1112596 |
303988 |
0.34% |
股份
|
| Peapod Lane Capital LLC |
$1046021 |
285798 |
0.32% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$1043408 |
285084 |
0.32% |
股份
|
| Engineers Gate Manager LP |
$885720 |
242000 |
0.27% |
股份
|
| EntryPoint Capital, LLC |
$794948 |
217199 |
0.24% |
股份
|
| XTX Topco Ltd |
$765844 |
209247 |
0.23% |
股份
|
| CITADEL ADVISORS LLC |
$743712 |
203200 |
0.23% |
卖出期权
|
| Quadrature Capital Ltd |
$692176 |
189119 |
0.21% |
股份
|
| MORGAN STANLEY |
$674143 |
184192 |
0.21% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$641964 |
175400 |
0.20% |
卖出期权
|
| ALLIANCEBERNSTEIN L.P. |
$639448 |
83370 |
0.19% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$570477 |
155868 |
0.17% |
股份
|
| Nuveen, LLC |
$566828 |
154871 |
0.17% |
股份
|
| Bank of New York Mellon Corp |
$565519 |
154513 |
0.17% |
股份
|
| Simplify Asset Management Inc. |
$562886 |
153794 |
0.17% |
股份
|
| Fiduciary Trust Co |
$499791 |
136555 |
0.15% |
股份
|
| Squarepoint Ops LLC |
$463202 |
126558 |
0.14% |
股份
|
| Verdad Advisers, LP |
$458320 |
125224 |
0.14% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$435679 |
119038 |
0.13% |
股份
|
| HSBC HOLDINGS PLC |
$426477 |
109353 |
0.13% |
股份
|
| Rangeley Capital, LLC |
$420497 |
114890 |
0.13% |
股份
|
| Invesco Ltd. |
$414748 |
113319 |
0.13% |
股份
|
| Russell Investments Group, Ltd. |
$381366 |
104199 |
0.12% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$374784 |
102400 |
0.11% |
股份
|
| ALGERT GLOBAL LLC |
$370978 |
101360 |
0.11% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$349607 |
95521 |
0.11% |
股份
|
| TWO SIGMA ADVISERS, LP |
$344955 |
30500 |
0.11% |
股份
|
| FMR LLC |
$337917 |
92327 |
0.10% |
股份
|
| Headlands Technologies LLC |
$328386 |
89723 |
0.10% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$313223 |
85580 |
0.10% |
股份
|
| BARCLAYS PLC |
$305145 |
83373 |
0.09% |
股份
|
| Matisse Capital |
$304108 |
39649 |
0.09% |
股份
|
| AXQ CAPITAL, LP |
$298228 |
81483 |
0.09% |
股份
|
| Allostery Investments LP |
$277629 |
40353 |
0.08% |
股份
|
| RHUMBLINE ADVISERS |
$268793 |
73443 |
0.08% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$263520 |
72000 |
0.08% |
买入期权
|
| RBF Capital, LLC |
$256200 |
70000 |
0.08% |
股份
|
| PRELUDE CAPITAL MANAGEMENT, LLC |
$248357 |
67857 |
0.08% |
股份
|
| ALPS ADVISORS INC |
$247533 |
67632 |
0.08% |
股份
|
| CITIGROUP INC |
$229753 |
62774 |
0.07% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$206592 |
56446 |
0.06% |
股份
|
| DEUTSCHE BANK AG\ |
$191714 |
52381 |
0.06% |
股份
|
| WELLS FARGO & COMPANY/MN |
$181887 |
49696 |
0.06% |
股份
|
| STRS OHIO |
$169092 |
46200 |
0.05% |
股份
|
| JANE STREET GROUP, LLC |
$161772 |
44200 |
0.05% |
买入期权
|
| JPMORGAN CHASE & CO |
$154314 |
41371 |
0.05% |
股份
|
| COMMONWEALTH EQUITY SERVICES, LLC |
$146400 |
40000 |
0.04% |
股份
|
| Marquette Asset Management, LLC |
$141101 |
38552 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$124729 |
34079 |
0.04% |
股份
|
| FRANKLIN RESOURCES INC |
$124671 |
34063 |
0.04% |
股份
|
| CITADEL ADVISORS LLC |
$124440 |
34000 |
0.04% |
买入期权
|
| PROFUND ADVISORS LLC |
$119001 |
32514 |
0.04% |
股份
|
| SEI INVESTMENTS CO |
$112292 |
30681 |
0.03% |
股份
|
| COUNTRY TRUST BANK |
$109950 |
30041 |
0.03% |
股份
|
| LMR Partners LLP |
$109800 |
30000 |
0.03% |
股份
|
| AlphaQuest LLC |
$109232 |
9658 |
0.03% |
股份
|
| Aigen Investment Management, LP |
$108014 |
29512 |
0.03% |
股份
|
| Scientech Research LLC |
$104617 |
28584 |
0.03% |
股份
|
| Mariner, LLC |
$102861 |
28104 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$100010 |
27325 |
0.03% |
股份
|
| CWM, LLC |
$92761 |
12094 |
0.03% |
股份
|
| Graham Capital Management, L.P. |
$91745 |
25067 |
0.03% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$91690 |
25052 |
0.03% |
股份
|
| Rafferty Asset Management, LLC |
$89809 |
24538 |
0.03% |
股份
|
| JANE STREET GROUP, LLC |
$87840 |
24000 |
0.03% |
卖出期权
|
| Creative Planning |
$78225 |
21373 |
0.02% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$78214 |
21370 |
0.02% |
股份
|
| Castleview Partners, LLC |
$69906 |
19100 |
0.02% |
股份
|
| Vanguard Global Advisers, LLC |
$69020 |
18858 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$67937 |
18562 |
0.02% |
股份
|
| Seven Fleet Capital Management LP |
$66206 |
18089 |
0.02% |
股份
|
| Westshore Wealth, LLC |
$62220 |
17000 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$61192 |
16719 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$59226 |
16182 |
0.02% |
股份
|
| Schonfeld Strategic Advisors LLC |
$58844 |
16078 |
0.02% |
股份
|
| Jain Global LLC |
$55852 |
15260 |
0.02% |
股份
|
| Vanguard Personalized Indexing Management, LLC |
$55826 |
15253 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$47946 |
13100 |
0.01% |
股份
|
| Brevan Howard Capital Management LP |
$47939 |
13098 |
0.01% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$45183 |
12345 |
0.01% |
股份
|
| China Universal Asset Management Co., Ltd. |
$38814 |
10605 |
0.01% |
股份
|
| GUGGENHEIM CAPITAL LLC |
$38734 |
10583 |
0.01% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$35889 |
10254 |
0.01% |
股份
|
| FEDERATED HERMES, INC. |
$30792 |
8413 |
0.01% |
股份
|
| Caitong International Asset Management Co., Ltd |
$29013 |
7927 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$27428 |
7494 |
0.01% |
股份
|
| ASSETMARK, INC |
$26795 |
7321 |
0.01% |
股份
|
| Legal & General Group Plc |
$19219 |
5251 |
0.01% |
股份
|
| LMR Partners LLP |
$18300 |
5000 |
0.01% |
买入期权
|
| Ameritas Investment Partners, Inc. |
$17927 |
4898 |
0.01% |
股份
|
| GROUP ONE TRADING LLC |
$13015 |
3556 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$11569 |
3161 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$11000 |
2827 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$10907 |
2980 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$9165 |
2462 |
0.00% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$8755 |
2392 |
0.00% |
股份
|
| Allworth Financial LP |
$7551 |
2063 |
0.00% |
股份
|
| Arax Advisory Partners |
$6763 |
1848 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$5929 |
773 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$5164 |
1411 |
0.00% |
股份
|
| IFP Advisors, Inc |
$5007 |
1368 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$4377 |
1196 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$3794 |
1038797 |
0.00% |
股份
|
| COMERICA BANK |
$3246 |
287 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$2990 |
817 |
0.00% |
股份
|
| Essential Partners LLC |
$2979 |
814 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$1936 |
529 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$1844 |
504 |
0.00% |
股份
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$1728 |
472 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$1675 |
459 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$1255 |
343 |
0.00% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$1080 |
295 |
0.00% |
股份
|
| BESSEMER GROUP INC |
$1051 |
286988 |
0.00% |
股份
|
| Optiver Holding B.V. |
$739 |
202 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$614 |
168 |
0.00% |
股份
|
| Rialto Wealth Management, LLC |
$582 |
159 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$527 |
143911 |
0.00% |
股份
|
| Altshuler Shaham Ltd |
$366 |
100 |
0.00% |
股份
|
| ZIONS BANCORPORATION, NATIONAL ASSOCIATION /UT/ |
$355 |
97 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$345 |
94235 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$282 |
77 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$275 |
75 |
0.00% |
股份
|
| True Wealth Design, LLC |
$260 |
71 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$198 |
54 |
0.00% |
股份
|
| State of Alaska, Department of Revenue |
$113 |
31000 |
0.00% |
股份
|
| Virtu Financial LLC |
$61 |
16596 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$40 |
10966 |
0.00% |
股份
|
| PrairieView Partners, LLC |
$34 |
5000 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$26 |
7 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$15 |
4 |
0.00% |
股份
|