| WELLINGTON MANAGEMENT GROUP LLP |
$181671753 |
5721945 |
11.22% |
股份
|
| RTW INVESTMENTS, LP |
$154616087 |
4869798 |
9.55% |
股份
|
| FMR LLC |
$136755061 |
4307246 |
8.45% |
股份
|
| PRIMECAP MANAGEMENT CO/CA/ |
$115514154 |
3638241 |
7.13% |
股份
|
| Bellevue Group AG |
$88526779 |
2788245 |
5.47% |
股份
|
| TANG CAPITAL MANAGEMENT LLC |
$84117434 |
2649368 |
5.19% |
股份
|
| Vestal Point Capital, LP |
$57150000 |
1800000 |
3.53% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$52355210 |
1648983 |
3.23% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$50705925 |
1597037 |
3.13% |
股份
|
| ARMISTICE CAPITAL, LLC |
$45339000 |
1428000 |
2.80% |
股份
|
| Caligan Partners LP |
$43856815 |
1381317 |
2.71% |
股份
|
| Kynam Capital Management, LP |
$43656250 |
1375000 |
2.70% |
股份
|
| BVF INC/IL |
$41099200 |
1294463 |
2.54% |
股份
|
| Trails Edge Capital Partners, LP |
$33757680 |
1063234 |
2.08% |
股份
|
| BlackRock, Inc. |
$31895988 |
1004598 |
1.97% |
股份
|
| Point72 Asset Management, L.P. |
$31441390 |
990280 |
1.94% |
股份
|
| Logos Global Management LP |
$19050000 |
600000 |
1.18% |
股份
|
| MARSHALL WACE, LLP |
$18762377 |
590941 |
1.16% |
股份
|
| Hudson Bay Capital Management LP |
$18732500 |
590000 |
1.16% |
股份
|
| CITADEL ADVISORS LLC |
$17994662 |
566761 |
1.11% |
股份
|
| JANUS HENDERSON GROUP PLC |
$17918673 |
594712 |
1.11% |
股份
|
| BRAIDWELL LP |
$16552132 |
521327 |
1.02% |
股份
|
| Jones Hill Capital LP |
$16283178 |
512856 |
1.01% |
股份
|
| PRINCIPAL FINANCIAL GROUP INC |
$15423801 |
485789 |
0.95% |
股份
|
| Frazier Life Sciences Management, L.P. |
$15391829 |
484782 |
0.95% |
股份
|
| Fulcrum Asset Management LLP |
$14298161 |
470025 |
0.88% |
股份
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$12929203 |
407219 |
0.80% |
股份
|
| D. E. Shaw & Co., Inc. |
$12862433 |
405116 |
0.79% |
股份
|
| Candriam S.C.A. |
$11832815 |
373046 |
0.73% |
股份
|
| TWO SIGMA ADVISERS, LP |
$11187033 |
322300 |
0.69% |
股份
|
| CANTOR FITZGERALD, L. P. |
$10798175 |
340100 |
0.67% |
股份
|
| Woodline Partners LP |
$10057194 |
316762 |
0.62% |
股份
|
| Deep Track Capital, LP |
$9881172 |
311218 |
0.61% |
股份
|
| Legal & General Group Plc |
$9511559 |
299670 |
0.59% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$9383586 |
295546 |
0.58% |
股份
|
| MOORE CAPITAL MANAGEMENT, LP |
$8720550 |
274663 |
0.54% |
股份
|
| DIADEMA PARTNERS LP |
$8091900 |
254863 |
0.50% |
股份
|
| JANE STREET GROUP, LLC |
$7408799 |
233348 |
0.46% |
股份
|
| Qube Research & Technologies Ltd |
$7084187 |
223124 |
0.44% |
股份
|
| MORGAN STANLEY |
$5964259 |
187850 |
0.37% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$5889625 |
185500 |
0.36% |
卖出期权
|
| Caption Management, LLC |
$5495925 |
173100 |
0.34% |
卖出期权
|
| Caption Management, LLC |
$5476970 |
172503 |
0.34% |
股份
|
| Catalio Capital Management, LP |
$4700429 |
148045 |
0.29% |
股份
|
| GOLDMAN SACHS GROUP INC |
$4360101 |
137326 |
0.27% |
股份
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$4259739 |
134165 |
0.26% |
股份
|
| Jump Financial, LLC |
$4189381 |
131949 |
0.26% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$4021201 |
126652 |
0.25% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$3687572 |
116144 |
0.23% |
股份
|
| XTX Topco Ltd |
$3687286 |
116135 |
0.23% |
股份
|
| AXA Investment Managers S.A. |
$3457599 |
95172 |
0.21% |
股份
|
| TD Asset Management Inc |
$3287967 |
103558 |
0.20% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$3251200 |
102400 |
0.20% |
股份
|
| STATE STREET CORP |
$3118771 |
98229 |
0.19% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$2887631 |
90949 |
0.18% |
股份
|
| Elmind Capital, LP |
$2576290 |
81143 |
0.16% |
股份
|
| Cubist Systematic Strategies, LLC |
$2491221 |
68572 |
0.15% |
股份
|
| Quadrature Capital Ltd |
$2347214 |
73928 |
0.14% |
股份
|
| Trexquant Investment LP |
$2312861 |
72846 |
0.14% |
股份
|
| JANE STREET GROUP, LLC |
$2225675 |
70100 |
0.14% |
卖出期权
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$2150682 |
67738 |
0.13% |
股份
|
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
$2144967 |
67558 |
0.13% |
股份
|
| CITADEL ADVISORS LLC |
$2136775 |
67300 |
0.13% |
卖出期权
|
| Persistent Asset Partners Ltd |
$2070545 |
65214 |
0.13% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2070100 |
65200 |
0.13% |
买入期权
|
| Engineers Gate Manager LP |
$1915382 |
60327 |
0.12% |
股份
|
| Caption Management, LLC |
$1905000 |
60000 |
0.12% |
买入期权
|
| J. Goldman & Co LP |
$1696403 |
53430 |
0.10% |
股份
|
| ALPS ADVISORS INC |
$1632585 |
51420 |
0.10% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$1561433 |
49179 |
0.10% |
股份
|
| Eagle Health Investments LP |
$1470025 |
46300 |
0.09% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$1459674 |
45974 |
0.09% |
股份
|
| HighVista Strategies LLC |
$1371125 |
43185 |
0.08% |
股份
|
| Virtus Investment Advisers, LLC |
$1274921 |
40155 |
0.08% |
股份
|
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS |
$1255141 |
39532 |
0.08% |
股份
|
| SEI INVESTMENTS CO |
$1245021 |
39213 |
0.08% |
股份
|
| Bridgewater Associates, LP |
$1165447 |
36707 |
0.07% |
股份
|
| Crossmark Global Holdings, Inc. |
$1156208 |
36416 |
0.07% |
股份
|
| State of New Jersey Common Pension Fund D |
$1088231 |
34275 |
0.07% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1084898 |
34170 |
0.07% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$1078929 |
33982 |
0.07% |
股份
|
| Brevan Howard Capital Management LP |
$1071567 |
34450 |
0.07% |
股份
|
| CITIGROUP INC |
$952500 |
30000 |
0.06% |
买入期权
|
| CITIGROUP INC |
$952500 |
30000 |
0.06% |
卖出期权
|
| BARCLAYS PLC |
$937165 |
29517 |
0.06% |
股份
|
| EntryPoint Capital, LLC |
$724376 |
22815 |
0.04% |
股份
|
| Cinctive Capital Management LP |
$695452 |
21904 |
0.04% |
股份
|
| CITIGROUP INC |
$683070 |
21514 |
0.04% |
股份
|
| Orion Portfolio Solutions, LLC |
$680452 |
22934 |
0.04% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$603218 |
18999 |
0.04% |
股份
|
| CITADEL ADVISORS LLC |
$568325 |
17900 |
0.04% |
买入期权
|
| Aquatic Capital Management LLC |
$558260 |
17583 |
0.03% |
股份
|
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
$540988 |
17039 |
0.03% |
股份
|
| PSP Research LLC |
$480727 |
15141 |
0.03% |
股份
|
| UBS Group AG |
$415957 |
13101 |
0.03% |
股份
|
| Entropy Technologies, LP |
$403860 |
12720 |
0.02% |
股份
|
| Federation des caisses Desjardins du Quebec |
$403287 |
12710 |
0.02% |
股份
|
| Squarepoint Ops LLC |
$372936 |
11746 |
0.02% |
股份
|
| WELLS FARGO & COMPANY/MN |
$349949 |
11022 |
0.02% |
股份
|
| Banque Transatlantique SA |
$322399 |
10150 |
0.02% |
股份
|
| Headlands Technologies LLC |
$289814 |
9128 |
0.02% |
股份
|
| Scientech Research LLC |
$281114 |
8854 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$231045 |
7277 |
0.01% |
股份
|
| denkapparat Operations GmbH |
$209233 |
6590 |
0.01% |
股份
|
| State of Tennessee, Department of Treasury |
$203169 |
6399 |
0.01% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$149716 |
4121 |
0.01% |
股份
|
| RHUMBLINE ADVISERS |
$112420 |
3541 |
0.01% |
股份
|
| JPMORGAN CHASE & CO |
$103885 |
3415 |
0.01% |
股份
|
| ASSETMARK, INC |
$102013 |
3213 |
0.01% |
股份
|
| WOLVERINE ASSET MANAGEMENT LLC |
$89598 |
2822 |
0.01% |
股份
|
| IFP Advisors, Inc |
$87281 |
2749 |
0.01% |
股份
|
| GROUP ONE TRADING LLC |
$64103 |
2019 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$63151 |
1989 |
0.00% |
股份
|
| GAMMA Investing LLC |
$60960 |
1920 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$38391 |
1209894 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$37370 |
1177 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$29496 |
929 |
0.00% |
股份
|
| Arax Advisory Partners |
$27369 |
862 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$27304 |
860 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$26387 |
831068 |
0.00% |
股份
|
| State of Wyoming |
$23050 |
726 |
0.00% |
股份
|
| CALDWELL SUTTER CAPITAL, INC. |
$19844 |
625 |
0.00% |
股份
|
| FTB Advisors, Inc. |
$16975 |
541 |
0.00% |
股份
|
| CIBC Private Wealth Group LLC |
$12716 |
350 |
0.00% |
股份
|
| Lowe fs, LLC |
$11989 |
330 |
0.00% |
股份
|
| J.Safra Asset Management Corp |
$5969 |
188 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$5578 |
185 |
0.00% |
股份
|
| Bell Investment Advisors, Inc |
$4255 |
134 |
0.00% |
股份
|
| Quantbot Technologies LP |
$3905 |
123 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$3270 |
103 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$3175 |
100 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$3048 |
96 |
0.00% |
股份
|
| Leonteq Securities AG |
$2000 |
63 |
0.00% |
股份
|
| Quarry LP |
$1969 |
62 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$1905 |
61 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$1802 |
56787 |
0.00% |
股份
|
| WEBSTER BANK, N. A. |
$1619 |
51 |
0.00% |
股份
|
| Larson Financial Group LLC |
$1365 |
43 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$1000 |
30 |
0.00% |
股份
|
| Russell Investments Group, Ltd. |
$953 |
30 |
0.00% |
股份
|
| CoreCap Advisors, LLC |
$857 |
27 |
0.00% |
股份
|
| Cornerstone Financial Management LLC |
$572 |
18 |
0.00% |
股份
|
| Virtu Financial LLC |
$539 |
16968 |
0.00% |
股份
|
| CWM, LLC |
$482 |
16 |
0.00% |
股份
|
| TrinityBridge Ltd |
$321 |
10100 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$254 |
8 |
0.00% |
股份
|
| Godfrey Financial Associates, Inc. |
$191 |
6 |
0.00% |
股份
|
| JTC Employer Solutions Trustee Ltd |
$84 |
2658 |
0.00% |
股份
|
| Elequin Capital, LP |
$32 |
1 |
0.00% |
股份
|
| Motiv8 Investments LLC |
$2 |
63 |
0.00% |
股份
|
| BESSEMER GROUP INC |
$2 |
50 |
0.00% |
股份
|