| JANUS HENDERSON GROUP PLC |
$42857157 |
33094330 |
16.66% |
股份
|
| VANGUARD GROUP INC |
$26438823 |
10703977 |
10.28% |
股份
|
| BVF INC/IL |
$24571146 |
28165000 |
9.55% |
股份
|
| MAVERICK CAPITAL LTD |
$16550225 |
18970913 |
6.44% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$16131231 |
18490636 |
6.27% |
股份
|
| BlackRock, Inc. |
$14076073 |
16134885 |
5.47% |
股份
|
| Mithril II GP LP |
$12365738 |
11241580 |
4.81% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$9152954 |
10496507 |
3.56% |
股份
|
| M28 Capital Management LP |
$8068173 |
9248250 |
3.14% |
股份
|
| Saturn V Capital Management LP |
$7321432 |
8392288 |
2.85% |
股份
|
| Soleus Capital Management, L.P. |
$6725093 |
7708727 |
2.61% |
股份
|
| Point72 Asset Management, L.P. |
$6579694 |
7542061 |
2.56% |
股份
|
| MORGAN STANLEY |
$4999678 |
5730948 |
1.94% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$4728560 |
5418774 |
1.84% |
股份
|
| Siren, L.L.C. |
$4362000 |
5000000 |
1.70% |
股份
|
| Driehaus Capital Management LLC |
$4193228 |
4806543 |
1.63% |
股份
|
| ADAR1 Capital Management, LLC |
$3321599 |
3807427 |
1.29% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$3194275 |
3661480 |
1.24% |
股份
|
| CITADEL ADVISORS LLC |
$3124013 |
3580941 |
1.21% |
股份
|
| STATE STREET CORP |
$3016260 |
3457428 |
1.17% |
股份
|
| Qube Research & Technologies Ltd |
$2896576 |
3320238 |
1.13% |
股份
|
| Ikarian Capital, LLC |
$2317592 |
2656570 |
0.90% |
股份
|
| Redmile Group, LLC |
$2266285 |
2597759 |
0.88% |
股份
|
| TWO SIGMA ADVISERS, LP |
$2264002 |
916600 |
0.88% |
股份
|
| 683 Capital Management, LLC |
$2165770 |
2482543 |
0.84% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$2035723 |
2333474 |
0.79% |
股份
|
| Eversept Partners, LP |
$1951572 |
2237015 |
0.76% |
股份
|
| Ensign Peak Advisors, Inc |
$1501641 |
1721276 |
0.58% |
股份
|
| NORTHERN TRUST CORP |
$1404872 |
1610353 |
0.55% |
股份
|
| Boxer Capital Management, LLC |
$1308600 |
1500000 |
0.51% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$1272258 |
1459012 |
0.49% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$1236262 |
1417732 |
0.48% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$1051765 |
1205599 |
0.41% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$868329 |
995334 |
0.34% |
股份
|
| GOLDMAN SACHS GROUP INC |
$853689 |
978552 |
0.33% |
股份
|
| DEUTSCHE BANK AG\ |
$687952 |
790749 |
0.27% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$675792 |
774635 |
0.26% |
股份
|
| UBS Group AG |
$481570 |
552260 |
0.19% |
股份
|
| Bank of New York Mellon Corp |
$451833 |
517920 |
0.18% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$409781 |
469717 |
0.16% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$397412 |
455539 |
0.15% |
股份
|
| Invesco Ltd. |
$396532 |
454530 |
0.15% |
股份
|
| CANTOR FITZGERALD, L. P. |
$392680 |
450115 |
0.15% |
股份
|
| EMERALD MUTUAL FUND ADVISERS TRUST |
$374126 |
428847 |
0.15% |
股份
|
| Virtus Investment Advisers, LLC |
$370712 |
424933 |
0.14% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$311234 |
356920 |
0.12% |
股份
|
| Birchview Capital, LP |
$298601 |
342275 |
0.12% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$281097 |
323100 |
0.11% |
卖出期权
|
| Nuveen, LLC |
$244563 |
280333 |
0.10% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$241599 |
277700 |
0.09% |
买入期权
|
| Squarepoint Ops LLC |
$201939 |
231475 |
0.08% |
股份
|
| MML INVESTORS SERVICES, LLC |
$178350 |
204436 |
0.07% |
股份
|
| WELLS FARGO & COMPANY/MN |
$154001 |
176526 |
0.06% |
股份
|
| Verdad Advisers, LP |
$150381 |
172376 |
0.06% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$150020 |
115400 |
0.06% |
股份
|
| FMR LLC |
$144477 |
165609 |
0.06% |
股份
|
| COMMONWEALTH EQUITY SERVICES, LLC |
$141320 |
161989 |
0.05% |
股份
|
| CITADEL ADVISORS LLC |
$138363 |
158600 |
0.05% |
买入期权
|
| RHUMBLINE ADVISERS |
$137416 |
157594 |
0.05% |
股份
|
| Jain Global LLC |
$135441 |
155251 |
0.05% |
股份
|
| JANE STREET GROUP, LLC |
$116989 |
134100 |
0.05% |
买入期权
|
| MetLife Investment Management, LLC |
$116727 |
133800 |
0.05% |
股份
|
| Miller Financial Services LLC |
$116029 |
133000 |
0.05% |
股份
|
| JPMORGAN CHASE & CO |
$103109 |
109261 |
0.04% |
股份
|
| CITIGROUP INC |
$98298 |
112675 |
0.04% |
股份
|
| SIMON QUICK ADVISORS, LLC |
$92959 |
106555 |
0.04% |
股份
|
| Knott David M Jr |
$87240 |
100000 |
0.03% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$86542 |
99200 |
0.03% |
股份
|
| Voleon Capital Management LP |
$84809 |
97214 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$84554 |
96921 |
0.03% |
股份
|
| UNITED CAPITAL FINANCIAL ADVISORS, LLC |
$84193 |
96507 |
0.03% |
股份
|
| EMERALD ADVISERS, LLC |
$78462 |
89938 |
0.03% |
股份
|
| BARCLAYS PLC |
$71502 |
81960 |
0.03% |
股份
|
| a16z Perennial Management, L.P. |
$69678 |
79869 |
0.03% |
股份
|
| XTX Topco Ltd |
$63276 |
72531 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$63238 |
72487 |
0.02% |
股份
|
| Vanguard Global Advisers, LLC |
$60398 |
69264 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$54158 |
62079 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$53042 |
60800 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$51657 |
59213 |
0.02% |
股份
|
| Rangeley Capital, LLC |
$51472 |
59000 |
0.02% |
股份
|
| Cubist Systematic Strategies, LLC |
$46217 |
42015 |
0.02% |
股份
|
| Scientech Research LLC |
$46144 |
52893 |
0.02% |
股份
|
| JANE STREET GROUP, LLC |
$37164 |
42600 |
0.01% |
卖出期权
|
| BNP PARIBAS FINANCIAL MARKETS |
$36709 |
42078 |
0.01% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$35425 |
40606 |
0.01% |
股份
|
| ProShare Advisors LLC |
$32471 |
37220 |
0.01% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$31200 |
28364 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$28658 |
32850 |
0.01% |
股份
|
| Abel Hall, LLC |
$26846 |
30772 |
0.01% |
股份
|
| Massar Capital Management, LP |
$24665 |
28273 |
0.01% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$23605 |
27058 |
0.01% |
股份
|
| CITADEL ADVISORS LLC |
$23555 |
27000 |
0.01% |
卖出期权
|
| Tower Research Capital LLC (TRC) |
$20416 |
23402 |
0.01% |
股份
|
| OXFORD FINANCIAL GROUP, LTD. LLC |
$20147 |
23094 |
0.01% |
股份
|
| ArchPoint Investors |
$20065 |
23000 |
0.01% |
股份
|
| Cetera Investment Advisers |
$20065 |
23000 |
0.01% |
股份
|
| Vanguard Personalized Indexing Management, LLC |
$18898 |
21662 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$18000 |
20830 |
0.01% |
股份
|
| US BANCORP \DE\ |
$17884 |
20500 |
0.01% |
股份
|
| Legal & General Group Plc |
$17827 |
20435 |
0.01% |
股份
|
| XPONANCE LLC |
$17478 |
20034 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$16665 |
19102 |
0.01% |
股份
|
| Wealthspire Advisors, LLC |
$15350 |
17595 |
0.01% |
股份
|
| Quantinno Capital Management LP |
$14747 |
16904 |
0.01% |
股份
|
| DGS Capital Management, LLC |
$14690 |
11300 |
0.01% |
股份
|
| Russell Investments Group, Ltd. |
$14675 |
16822 |
0.01% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$14220 |
16300 |
0.01% |
股份
|
| CIBC Asset Management Inc |
$13243 |
15180 |
0.01% |
股份
|
| State of Wyoming |
$13212 |
15144 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$11495 |
13176 |
0.00% |
股份
|
| CIBC Bancorp USA Inc. |
$10138 |
11621 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$9750 |
7500 |
0.00% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$9110 |
10443 |
0.00% |
股份
|
| NAPLES GLOBAL ADVISORS, LLC |
$8724 |
10000 |
0.00% |
股份
|
| COURIER CAPITAL LLC |
$8724 |
10000 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$8538 |
9583 |
0.00% |
股份
|
| Chicago Partners Investment Group LLC |
$7726 |
12683 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$5172 |
5929 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$3701 |
4242 |
0.00% |
股份
|
| NATIXIS |
$2617 |
3000 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$2529 |
2899 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$918 |
1052 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$913 |
1046 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$776 |
889 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$578 |
662065 |
0.00% |
股份
|
| CWM, LLC |
$549 |
422 |
0.00% |
股份
|
| Optiver Holding B.V. |
$489 |
560 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$436 |
500 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$433 |
496 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$371 |
426 |
0.00% |
股份
|
| Quarry LP |
$288 |
330 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$151 |
172695 |
0.00% |
股份
|
| Allworth Financial LP |
$144 |
165 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$25 |
28765 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$15 |
19 |
0.00% |
股份
|
| Arax Advisory Partners |
$2 |
2 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$1 |
1 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$1 |
1 |
0.00% |
股份
|