| VANGUARD GROUP INC |
$38670499 |
3894310 |
8.42% |
股份
|
| MONTANOVA CAPITAL, LLC |
$29718451 |
6384200 |
6.47% |
股份
|
| JANUS HENDERSON GROUP PLC |
$28510358 |
4976429 |
6.21% |
股份
|
| Affinity Asset Advisors, LLC |
$27034429 |
5807611 |
5.88% |
股份
|
| BlackRock, Inc. |
$26717165 |
5739455 |
5.82% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$23275000 |
5000000 |
5.07% |
股份
|
| Frazier Life Sciences Management, L.P. |
$22459095 |
4824725 |
4.89% |
股份
|
| STATE STREET CORP |
$20271394 |
4354757 |
4.41% |
股份
|
| Vestal Point Capital, LP |
$20109600 |
4320000 |
4.38% |
股份
|
| Paradigm Biocapital Advisors LP |
$19436403 |
4175382 |
4.23% |
股份
|
| ORBIMED ADVISORS LLC |
$18377242 |
3947850 |
4.00% |
股份
|
| CITADEL ADVISORS LLC |
$18147843 |
3898570 |
3.95% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$14551032 |
3125893 |
3.17% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$13190510 |
2833622 |
2.87% |
股份
|
| Woodline Partners LP |
$11639976 |
2500532 |
2.53% |
股份
|
| Balyasny Asset Management L.P. |
$11231314 |
2412742 |
2.44% |
股份
|
| GOLDMAN SACHS GROUP INC |
$10006444 |
2149612 |
2.18% |
股份
|
| 683 Capital Management, LLC |
$8728124 |
1875000 |
1.90% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$8138547 |
1747959 |
1.77% |
股份
|
| ADAR1 Capital Management, LLC |
$7289497 |
1565950 |
1.59% |
股份
|
| Avoro Capital Advisors LLC |
$6932175 |
1489189 |
1.51% |
股份
|
| Qube Research & Technologies Ltd |
$6406313 |
1376222 |
1.39% |
股份
|
| Nantahala Capital Management, LLC |
$6051500 |
1300000 |
1.32% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$5992745 |
1287185 |
1.30% |
股份
|
| Spruce Street Capital LP |
$4322600 |
928593 |
0.94% |
股份
|
| Blackstone Inc. |
$4217109 |
904959 |
0.92% |
股份
|
| NORTHERN TRUST CORP |
$4037705 |
867391 |
0.88% |
股份
|
| Aberdeen Group plc |
$3142553 |
675092 |
0.68% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$2857360 |
613826 |
0.62% |
股份
|
| Ikarian Capital, LLC |
$2388066 |
513011 |
0.52% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$2282490 |
490331 |
0.50% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$2004890 |
430696 |
0.44% |
股份
|
| MORGAN STANLEY |
$1839200 |
395102 |
0.40% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$1807993 |
388398 |
0.39% |
股份
|
| DAFNA Capital Management LLC |
$1755210 |
377059 |
0.38% |
股份
|
| UBS Group AG |
$1648074 |
354044 |
0.36% |
股份
|
| Trexquant Investment LP |
$1465818 |
314891 |
0.32% |
股份
|
| Squarepoint Ops LLC |
$1372173 |
294774 |
0.30% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$1194757 |
256661 |
0.26% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$1165449 |
250365 |
0.25% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$942093 |
202383 |
0.21% |
股份
|
| Nuveen, LLC |
$932941 |
200417 |
0.20% |
股份
|
| Bank of New York Mellon Corp |
$855975 |
183883 |
0.19% |
股份
|
| TWO SIGMA ADVISERS, LP |
$807309 |
81300 |
0.18% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$803495 |
172609 |
0.17% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$749744 |
161062 |
0.16% |
股份
|
| Privium Fund Management B.V. |
$722300 |
155000 |
0.16% |
股份
|
| XTX Topco Ltd |
$677563 |
145556 |
0.15% |
股份
|
| FMR LLC |
$657035 |
141146 |
0.14% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$634835 |
136377 |
0.14% |
股份
|
| Burkehill Global Management, LP |
$581875 |
125000 |
0.13% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$546441 |
117388 |
0.12% |
股份
|
| Palumbo Wealth Management LLC |
$534129 |
114743 |
0.12% |
股份
|
| Fisher Asset Management, LLC |
$532168 |
114322 |
0.12% |
股份
|
| EntryPoint Capital, LLC |
$482481 |
103648 |
0.11% |
股份
|
| JPMORGAN CHASE & CO |
$463155 |
96290 |
0.10% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$446916 |
77860 |
0.10% |
股份
|
| CITIGROUP INC |
$436374 |
93743 |
0.09% |
股份
|
| DEUTSCHE BANK AG\ |
$383485 |
82293 |
0.08% |
股份
|
| RHUMBLINE ADVISERS |
$371505 |
79809 |
0.08% |
股份
|
| Invesco Ltd. |
$354800 |
76219 |
0.08% |
股份
|
| Virtus Investment Advisers, LLC |
$348538 |
74874 |
0.08% |
股份
|
| Walleye Capital LLC |
$343856 |
73868 |
0.07% |
股份
|
| Creative Planning |
$338070 |
72625 |
0.07% |
股份
|
| Rafferty Asset Management, LLC |
$314375 |
67535 |
0.07% |
股份
|
| WELLS FARGO & COMPANY/MN |
$276344 |
59365 |
0.06% |
股份
|
| JANE STREET GROUP, LLC |
$241129 |
51800 |
0.05% |
卖出期权
|
| Mitsubishi UFJ Asset Management Co., Ltd. |
$232694 |
49988 |
0.05% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$224948 |
48324 |
0.05% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$224259 |
48176 |
0.05% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$189673 |
40485 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$184096 |
39548 |
0.04% |
股份
|
| PROFUND ADVISORS LLC |
$159746 |
34317 |
0.03% |
股份
|
| Russell Investments Group, Ltd. |
$154885 |
33273 |
0.03% |
股份
|
| Dynamic Technology Lab Private Ltd |
$152000 |
32651 |
0.03% |
股份
|
| Verdad Advisers, LP |
$142401 |
30591 |
0.03% |
股份
|
| ExodusPoint Capital Management, LP |
$129781 |
27880 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$118865 |
25535 |
0.03% |
股份
|
| AlphaQuest LLC |
$116439 |
11726 |
0.03% |
股份
|
| Quantinno Capital Management LP |
$113084 |
24293 |
0.02% |
股份
|
| Vanguard Global Advisers, LLC |
$108857 |
23385 |
0.02% |
股份
|
| CWM, LLC |
$105140 |
18317 |
0.02% |
股份
|
| PRELUDE CAPITAL MANAGEMENT, LLC |
$104738 |
22500 |
0.02% |
股份
|
| Soltis Investment Advisors LLC |
$93174 |
20016 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$92574 |
19887 |
0.02% |
股份
|
| D. E. Shaw & Co., Inc. |
$92476 |
19866 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$92192 |
19805 |
0.02% |
股份
|
| Vanguard Personalized Indexing Management, LLC |
$90614 |
19466 |
0.02% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$87770 |
18855 |
0.02% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$86118 |
18500 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$82938 |
17817 |
0.02% |
股份
|
| CAXTON CORP |
$78959 |
16962 |
0.02% |
股份
|
| Jain Global LLC |
$77203 |
16585 |
0.02% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$76424 |
16400 |
0.02% |
买入期权
|
| BARCLAYS PLC |
$75677 |
16257 |
0.02% |
股份
|
| Spark Investment Management LLC |
$69825 |
15000 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$66241 |
14230 |
0.01% |
股份
|
| Cerity Partners LLC |
$64756 |
13911 |
0.01% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$61431 |
12745 |
0.01% |
股份
|
| China Universal Asset Management Co., Ltd. |
$58174 |
12497 |
0.01% |
股份
|
| ProShare Advisors LLC |
$55175 |
11853 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$53928 |
11585 |
0.01% |
股份
|
| COMMONWEALTH EQUITY SERVICES, LLC |
$51780 |
11123 |
0.01% |
股份
|
| Tyche Wealth Partners LLC |
$46550 |
10000 |
0.01% |
股份
|
| Legal & General Group Plc |
$32036 |
6882 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$31000 |
6646 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$24378 |
5237 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$23838 |
5121 |
0.01% |
股份
|
| Cubist Systematic Strategies, LLC |
$16642 |
2506 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$16348 |
3512 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$16275 |
3500 |
0.00% |
股份
|
| Arax Advisory Partners |
$15869 |
3409 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$12871 |
2765 |
0.00% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$12764 |
2742 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$7192 |
1545 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$6652 |
1429 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$5162 |
1109 |
0.00% |
股份
|
| Chung Wu Investment Group, LLC |
$4655 |
1000 |
0.00% |
股份
|
| HARBOUR INVESTMENTS, INC. |
$4655 |
1000 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$4315 |
927 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$2765 |
594 |
0.00% |
股份
|
| US BANCORP \DE\ |
$2751 |
591 |
0.00% |
股份
|
| Optiver Holding B.V. |
$2532 |
544 |
0.00% |
股份
|
| Truvestments Capital LLC |
$1862 |
400 |
0.00% |
股份
|
| Essential Partners LLC |
$1648 |
354 |
0.00% |
股份
|
| GAMMA Investing LLC |
$1150 |
247 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$1090 |
234 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$1061 |
228 |
0.00% |
股份
|
| Torren Management, LLC |
$1022 |
178 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$945 |
203 |
0.00% |
股份
|
| Key Financial Inc |
$931 |
200 |
0.00% |
股份
|
| True Wealth Design, LLC |
$918 |
197 |
0.00% |
股份
|
| Allworth Financial LP |
$913 |
196 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$815 |
175 |
0.00% |
股份
|
| IFP Advisors, Inc |
$801 |
172 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$740 |
159 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$740 |
159 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$698 |
150 |
0.00% |
股份
|
| Rialto Wealth Management, LLC |
$624 |
134 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$466 |
100 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$321 |
56 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$271 |
58194 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$92 |
16 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$49 |
10555 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$47 |
10 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$28 |
6 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$19 |
4 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$5 |
1128 |
0.00% |
股份
|