| Sanofi |
$164791427 |
12197737 |
15.52% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$145727749 |
10786658 |
13.72% |
股份
|
| Rubric Capital Management LP |
$122941000 |
9100000 |
11.58% |
股份
|
| JOHNSON & JOHNSON |
$89720775 |
6641064 |
8.45% |
股份
|
| BlackRock, Inc. |
$64269475 |
4757178 |
6.05% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$59444000 |
4400000 |
5.60% |
股份
|
| Opaleye Management Inc. |
$47960500 |
3550000 |
4.52% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$40148370 |
2971752 |
3.78% |
股份
|
| 683 Capital Management, LLC |
$31073000 |
2300000 |
2.93% |
股份
|
| Woodline Partners LP |
$20266824 |
1500135 |
1.91% |
股份
|
| STATE STREET CORP |
$18822429 |
1393222 |
1.77% |
股份
|
| MORGAN STANLEY |
$17734617 |
1312703 |
1.67% |
股份
|
| Knoll Capital Management, LLC |
$16887500 |
1250000 |
1.59% |
股份
|
| KENNEDY CAPITAL MANAGEMENT LLC |
$14934238 |
1105421 |
1.41% |
股份
|
| Long Focus Capital Management, LLC |
$14594853 |
1080300 |
1.37% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$13714082 |
1015106 |
1.29% |
股份
|
| D. E. Shaw & Co., Inc. |
$11522706 |
852902 |
1.08% |
股份
|
| HEIGHTS CAPITAL MANAGEMENT, INC |
$11483500 |
850000 |
1.08% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$11471097 |
849082 |
1.08% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$9775336 |
723563 |
0.92% |
股份
|
| CITADEL ADVISORS LLC |
$8788106 |
650489 |
0.83% |
股份
|
| Erste Asset Management GmbH |
$8667648 |
691200 |
0.82% |
股份
|
| Nuveen, LLC |
$8639091 |
639459 |
0.81% |
股份
|
| J. Goldman & Co LP |
$8132642 |
601972 |
0.77% |
股份
|
| PFM Health Sciences, LP |
$6150914 |
455286 |
0.58% |
股份
|
| NORTHERN TRUST CORP |
$5537141 |
409855 |
0.52% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$4730851 |
350174 |
0.45% |
股份
|
| GOLDMAN SACHS GROUP INC |
$4423390 |
327416 |
0.42% |
股份
|
| VANGUARD GROUP INC |
$3933287 |
494753 |
0.37% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$3914117 |
289720 |
0.37% |
股份
|
| Point72 Asset Management, L.P. |
$2734329 |
202393 |
0.26% |
股份
|
| Ghisallo Capital Management LLC |
$2702000 |
200000 |
0.25% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$2655837 |
196583 |
0.25% |
股份
|
| Privium Fund Management B.V. |
$2649473 |
196112 |
0.25% |
股份
|
| JPMORGAN CHASE & CO |
$2573360 |
205212 |
0.24% |
股份
|
| UBS Group AG |
$2493594 |
184574 |
0.23% |
股份
|
| Squarepoint Ops LLC |
$2194186 |
162412 |
0.21% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$2000358 |
148065 |
0.19% |
股份
|
| Russell Investments Group, Ltd. |
$1990413 |
147329 |
0.19% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$1930890 |
142923 |
0.18% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1924283 |
142434 |
0.18% |
股份
|
| Bank of New York Mellon Corp |
$1869129 |
138352 |
0.18% |
股份
|
| BLAIR WILLIAM & CO/IL |
$1695208 |
125478 |
0.16% |
股份
|
| Voleon Capital Management LP |
$1591343 |
117790 |
0.15% |
股份
|
| Swiss National Bank |
$1505014 |
111400 |
0.14% |
股份
|
| BARCLAYS PLC |
$1336882 |
98955 |
0.13% |
股份
|
| Invesco Ltd. |
$1277235 |
94540 |
0.12% |
股份
|
| ALPS ADVISORS INC |
$1258943 |
93186 |
0.12% |
股份
|
| Prosight Management, LP |
$1215900 |
90000 |
0.11% |
股份
|
| Aquatic Capital Management LLC |
$1176235 |
87064 |
0.11% |
股份
|
| RHUMBLINE ADVISERS |
$1173305 |
86848 |
0.11% |
股份
|
| J. Goldman & Co LP |
$1118628 |
82800 |
0.11% |
买入期权
|
| TOCQUEVILLE ASSET MANAGEMENT L.P. |
$1049727 |
77700 |
0.10% |
股份
|
| DAVENPORT & Co LLC |
$977719 |
72370 |
0.09% |
股份
|
| Engineers Gate Manager LP |
$933433 |
69092 |
0.09% |
股份
|
| Fort Sheridan Advisors LLC |
$897611 |
66441 |
0.08% |
股份
|
| Quantinno Capital Management LP |
$893470 |
66134 |
0.08% |
股份
|
| Trexquant Investment LP |
$883459 |
65393 |
0.08% |
股份
|
| AMERIPRISE FINANCIAL INC |
$869612 |
64368 |
0.08% |
股份
|
| FRANKLIN RESOURCES INC |
$825069 |
61071 |
0.08% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$818031 |
60550 |
0.08% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$817220 |
60490 |
0.08% |
股份
|
| DEUTSCHE BANK AG\ |
$804832 |
59573 |
0.08% |
股份
|
| AlphaCentric Advisors LLC |
$735876 |
54469 |
0.07% |
股份
|
| WELLS FARGO & COMPANY/MN |
$728311 |
53909 |
0.07% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$677689 |
50162 |
0.06% |
股份
|
| BROWN ADVISORY INC |
$675500 |
50000 |
0.06% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$664692 |
49200 |
0.06% |
股份
|
| AMH Equity Ltd |
$658400 |
80000 |
0.06% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$654884 |
48474 |
0.06% |
股份
|
| MARTINGALE ASSET MANAGEMENT L P |
$646508 |
47854 |
0.06% |
股份
|
| SEI INVESTMENTS CO |
$643076 |
47600 |
0.06% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$544980 |
40339 |
0.05% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$543007 |
40193 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$476606 |
35278 |
0.04% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$473615 |
54690 |
0.04% |
股份
|
| EntryPoint Capital, LLC |
$466230 |
34510 |
0.04% |
股份
|
| Virtus Investment Advisers, LLC |
$460948 |
34119 |
0.04% |
股份
|
| Legal & General Group Plc |
$442530 |
32780 |
0.04% |
股份
|
| CITIGROUP INC |
$442223 |
32733 |
0.04% |
股份
|
| LETKO, BROSSEAU & ASSOCIATES INC |
$432320 |
32000 |
0.04% |
股份
|
| AXQ CAPITAL, LP |
$421363 |
31189 |
0.04% |
股份
|
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
$414757 |
30700 |
0.04% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$388669 |
28769 |
0.04% |
股份
|
| HSBC HOLDINGS PLC |
$379142 |
28898 |
0.04% |
股份
|
| XTX Topco Ltd |
$378375 |
28007 |
0.04% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$378212 |
27995 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$374011 |
27684 |
0.04% |
股份
|
| Beacon Pointe Advisors, LLC |
$361569 |
26763 |
0.03% |
股份
|
| CreativeOne Wealth, LLC |
$356988 |
26424 |
0.03% |
股份
|
| Mitsubishi UFJ Asset Management Co., Ltd. |
$331373 |
24528 |
0.03% |
股份
|
| SkyView Investment Advisors, LLC |
$324000 |
24000 |
0.03% |
股份
|
| DIVERSIFIED TRUST CO |
$323186 |
23922 |
0.03% |
股份
|
| IEQ CAPITAL, LLC |
$301678 |
22330 |
0.03% |
股份
|
| STRS OHIO |
$299922 |
22200 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$284561 |
21063 |
0.03% |
股份
|
| Creative Planning |
$276401 |
20459 |
0.03% |
股份
|
| CIBC Bancorp USA Inc. |
$247490 |
18319 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$242599 |
17957 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$239559 |
17732 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$230075 |
17030 |
0.02% |
股份
|
| Vanguard Investments Australia, Ltd. |
$209891 |
15536 |
0.02% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$207027 |
15324 |
0.02% |
股份
|
| Entropy Technologies, LP |
$204487 |
15136 |
0.02% |
股份
|
| Perigon Wealth Management, LLC |
$203042 |
15029 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$199124 |
14739 |
0.02% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$195909 |
14501 |
0.02% |
股份
|
| nVerses Capital, LLC |
$189977 |
14062 |
0.02% |
股份
|
| ROYAL BANK OF CANADA |
$173000 |
12820 |
0.02% |
股份
|
| Schonfeld Strategic Advisors LLC |
$170684 |
12634 |
0.02% |
股份
|
| KLP KAPITALFORVALTNING AS |
$170226 |
12600 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$168834 |
12497 |
0.02% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$165322 |
12237 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$164890 |
12205 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$163120 |
12074 |
0.02% |
股份
|
| ALGERT GLOBAL LLC |
$158067 |
11700 |
0.01% |
股份
|
| ProShare Advisors LLC |
$147341 |
10906 |
0.01% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$144287 |
10680 |
0.01% |
股份
|
| Hudson Bay Capital Management LP |
$137667 |
10190 |
0.01% |
股份
|
| CIBC Private Wealth Group LLC |
$123450 |
15000 |
0.01% |
股份
|
| DIADEMA PARTNERS LP |
$113052 |
8368 |
0.01% |
股份
|
| Rockefeller Capital Management L.P. |
$91962 |
6807 |
0.01% |
股份
|
| FMR LLC |
$80367 |
5949 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$73711 |
5456 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$72170 |
5342 |
0.01% |
股份
|
| CWM, LLC |
$67271 |
7768 |
0.01% |
股份
|
| Arax Advisory Partners |
$57647 |
4267 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$55958 |
4142 |
0.01% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$39355 |
2913 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$31803 |
2354 |
0.00% |
股份
|
| Persistent Asset Partners Ltd |
$28817 |
2133 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$25894 |
2354 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$23021 |
1704 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$12678 |
1464 |
0.00% |
股份
|
| Atlantic Union Bankshares Corp |
$10808 |
800 |
0.00% |
股份
|
| GAMMA Investing LLC |
$6971 |
516 |
0.00% |
股份
|
| DIADEMA PARTNERS LP |
$6755 |
500 |
0.00% |
买入期权
|
| Sterling Capital Management LLC |
$5661 |
419 |
0.00% |
股份
|
| Sandy Spring Bank |
$5424 |
800 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$4330 |
324 |
0.00% |
股份
|
| Essential Partners LLC |
$4202 |
311 |
0.00% |
股份
|
| Allworth Financial LP |
$4148 |
307 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$3242 |
240 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$2229 |
165 |
0.00% |
股份
|
| IFP Advisors, Inc |
$2013 |
149 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$1878 |
139 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$1811 |
134 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$1054 |
78 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$1054 |
78 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$1040 |
77 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$1014 |
75 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$920 |
68 |
0.00% |
股份
|
| Persistent Asset Partners Ltd |
$690 |
2 |
0.00% |
买入期权
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$668 |
49380 |
0.00% |
股份
|
| Quarry LP |
$608 |
45 |
0.00% |
股份
|
| Torren Management, LLC |
$606 |
70 |
0.00% |
股份
|
| True Wealth Design, LLC |
$338 |
25 |
0.00% |
股份
|
| Ameritas Advisory Services, LLC |
$230 |
17 |
0.00% |
股份
|
| US BANCORP \DE\ |
$230 |
17 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$162 |
12 |
0.00% |
股份
|
| Larson Financial Group LLC |
$135 |
10 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$122 |
9 |
0.00% |
股份
|
| State of Alaska, Department of Revenue |
$54 |
4030 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$41 |
3 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
36 |
0.00% |
股份
|