| FMR LLC |
$227027106 |
6565272 |
10.21% |
股份
|
| GENERAL ATLANTIC, L.P. |
$226525177 |
6550757 |
10.18% |
股份
|
| Foresite Capital Management IV, LLC |
$165243331 |
4778581 |
7.43% |
股份
|
| venBio Partners LLC |
$160569809 |
4643430 |
7.22% |
股份
|
| VIKING GLOBAL INVESTORS LP |
$126331460 |
3653310 |
5.68% |
股份
|
| EQT Fund Management S.a r.l. |
$118422979 |
3424609 |
5.32% |
股份
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$116743532 |
3376042 |
5.25% |
股份
|
| Bain Capital Life Sciences Investors, LLC |
$92519101 |
2675509 |
4.16% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$82747658 |
2392934 |
3.72% |
股份
|
| Polar Capital Holdings Plc |
$80446532 |
2326389 |
3.62% |
股份
|
| Point72 Asset Management, L.P. |
$56752696 |
1641200 |
2.55% |
股份
|
| Commodore Capital LP |
$49276500 |
1425000 |
2.22% |
股份
|
| NOVO HOLDINGS A/S |
$48412000 |
1400000 |
2.18% |
股份
|
| Saturn V Capital Management LP |
$45442339 |
1314122 |
2.04% |
股份
|
| TCG Crossover Management, LLC |
$34864559 |
1008229 |
1.57% |
股份
|
| Sofinnova Investments, Inc. |
$30475319 |
881299 |
1.37% |
股份
|
| 5AM Venture Management, LLC |
$27581008 |
797600 |
1.24% |
股份
|
| Seven Fleet Capital Management LP |
$26782245 |
774501 |
1.20% |
股份
|
| BlackRock, Inc. |
$26676879 |
771454 |
1.20% |
股份
|
| Cormorant Asset Management, LP |
$25935000 |
750000 |
1.17% |
股份
|
| Soleus Capital Management, L.P. |
$25274764 |
730907 |
1.14% |
股份
|
| Jones Hill Capital LP |
$23441056 |
677879 |
1.05% |
股份
|
| Patient Square Capital LP |
$23210407 |
671209 |
1.04% |
股份
|
| Foresite Capital Management V, LLC |
$22966030 |
664142 |
1.03% |
股份
|
| Kynam Capital Management, LP |
$22884871 |
661795 |
1.03% |
股份
|
| Rock Springs Capital Management LP |
$22419355 |
648333 |
1.01% |
股份
|
| Elmind Capital, LP |
$18180435 |
525750 |
0.82% |
股份
|
| Balyasny Asset Management L.P. |
$18130363 |
524302 |
0.81% |
股份
|
| DV EQUITIES, LLC |
$16685680 |
482524 |
0.75% |
股份
|
| D. E. Shaw & Co., Inc. |
$16301081 |
471402 |
0.73% |
股份
|
| Octagon Capital Advisors LP |
$15793412 |
456721 |
0.71% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$14779596 |
427403 |
0.66% |
股份
|
| Alyeska Investment Group, L.P. |
$14068147 |
406829 |
0.63% |
股份
|
| Eversept Partners, LP |
$13361124 |
386383 |
0.60% |
股份
|
| Ikarian Capital, LLC |
$10680241 |
308856 |
0.48% |
股份
|
| Tetragon Partners GP Ltd |
$10222782 |
295627 |
0.46% |
股份
|
| UBS Group AG |
$8810638 |
254790 |
0.40% |
股份
|
| CITADEL ADVISORS LLC |
$8360925 |
241785 |
0.38% |
股份
|
| EcoR1 Capital, LLC |
$8126300 |
235000 |
0.37% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$7491411 |
216640 |
0.34% |
股份
|
| ORBIMED ADVISORS LLC |
$7102732 |
205400 |
0.32% |
股份
|
| Walleye Capital LLC |
$6930489 |
200419 |
0.31% |
股份
|
| Kalehua Capital Management LLC |
$6873536 |
198772 |
0.31% |
股份
|
| JANE STREET GROUP, LLC |
$6226579 |
180063 |
0.28% |
股份
|
| STATE STREET CORP |
$5831260 |
168631 |
0.26% |
股份
|
| Cinctive Capital Management LP |
$5571288 |
161113 |
0.25% |
股份
|
| HighVista Strategies LLC |
$5549882 |
160494 |
0.25% |
股份
|
| GOLDMAN SACHS GROUP INC |
$5186240 |
149978 |
0.23% |
股份
|
| Qube Research & Technologies Ltd |
$4836013 |
139850 |
0.22% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$4800050 |
138810 |
0.22% |
股份
|
| Trexquant Investment LP |
$4713427 |
136305 |
0.21% |
股份
|
| XTX Topco Ltd |
$3795501 |
109760 |
0.17% |
股份
|
| NEXTBio Capital Management LP |
$3736542 |
108055 |
0.17% |
股份
|
| ADAR1 Capital Management, LLC |
$3649158 |
105528 |
0.16% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$3554582 |
102793 |
0.16% |
股份
|
| MORGAN STANLEY |
$3365879 |
97336 |
0.15% |
股份
|
| LAZARD ASSET MANAGEMENT LLC |
$3212102 |
92889 |
0.14% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$3108722 |
89912 |
0.14% |
股份
|
| NORTHERN TRUST CORP |
$2862602 |
82782 |
0.13% |
股份
|
| STEMPOINT CAPITAL LP |
$2797764 |
80907 |
0.13% |
股份
|
| TWO SIGMA ADVISERS, LP |
$2486400 |
89600 |
0.11% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$2193500 |
77646 |
0.10% |
股份
|
| DEUTSCHE BANK AG\ |
$1848958 |
53469 |
0.08% |
股份
|
| Amundi |
$1727064 |
49944 |
0.08% |
股份
|
| Squarepoint Ops LLC |
$1543271 |
44629 |
0.07% |
股份
|
| MOORE CAPITAL MANAGEMENT, LP |
$1521555 |
44001 |
0.07% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$1380918 |
39934 |
0.06% |
股份
|
| Atom Investors LP |
$1365288 |
39482 |
0.06% |
股份
|
| Swiss National Bank |
$1360965 |
39357 |
0.06% |
股份
|
| TD Asset Management Inc |
$1329878 |
38458 |
0.06% |
股份
|
| JANE STREET GROUP, LLC |
$1310582 |
37900 |
0.06% |
卖出期权
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1186094 |
34300 |
0.05% |
卖出期权
|
| VOYA INVESTMENT MANAGEMENT LLC |
$1166556 |
33735 |
0.05% |
股份
|
| SummitTX Capital, L.P. |
$1153381 |
33354 |
0.05% |
股份
|
| Engineers Gate Manager LP |
$1143180 |
33059 |
0.05% |
股份
|
| Aquatic Capital Management LLC |
$1045111 |
30223 |
0.05% |
股份
|
| Birchview Capital, LP |
$1032109 |
29847 |
0.05% |
股份
|
| DIADEMA PARTNERS LP |
$1013920 |
29321 |
0.05% |
股份
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$1013644 |
29313 |
0.05% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$817679 |
23646 |
0.04% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$799490 |
23120 |
0.04% |
股份
|
| Palumbo Wealth Management LLC |
$726319 |
21004 |
0.03% |
股份
|
| BARCLAYS PLC |
$715875 |
20702 |
0.03% |
股份
|
| Legal & General Group Plc |
$712763 |
20612 |
0.03% |
股份
|
| JPMORGAN CHASE & CO |
$693055 |
19967 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$629425 |
18202 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$594776 |
17200 |
0.03% |
买入期权
|
| VANGUARD GROUP INC |
$535853 |
19310 |
0.02% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$520775 |
15060 |
0.02% |
股份
|
| PSP Research LLC |
$518700 |
15000 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$508983 |
14719 |
0.02% |
股份
|
| ExodusPoint Capital Management, LP |
$496880 |
14369 |
0.02% |
股份
|
| OpenArc Corporate Advisory, LLC |
$470115 |
13595 |
0.02% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$454623 |
13147 |
0.02% |
股份
|
| Nuveen, LLC |
$437575 |
12654 |
0.02% |
股份
|
| OCCUDO QUANTITATIVE STRATEGIES LP |
$393002 |
11365 |
0.02% |
股份
|
| Virtus Investment Advisers, LLC |
$368312 |
10651 |
0.02% |
股份
|
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
$311220 |
9000 |
0.01% |
股份
|
| CITADEL ADVISORS LLC |
$297388 |
8600 |
0.01% |
卖出期权
|
| TEACHER RETIREMENT SYSTEM OF TEXAS |
$291025 |
8416 |
0.01% |
股份
|
| Cubist Systematic Strategies, LLC |
$290392 |
11639 |
0.01% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$284905 |
8239 |
0.01% |
股份
|
| Persistent Asset Partners Ltd |
$273320 |
7904 |
0.01% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$253685 |
8980 |
0.01% |
股份
|
| ALGERT GLOBAL LLC |
$237910 |
6880 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$210558 |
6089 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$200564 |
5800 |
0.01% |
股份
|
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
$196034 |
5669 |
0.01% |
股份
|
| BARCLAYS PLC |
$172900 |
5000 |
0.01% |
买入期权
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$157719 |
4561 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$108063 |
3125 |
0.00% |
股份
|
| CoreCap Advisors, LLC |
$93366 |
2700 |
0.00% |
股份
|
| CITIGROUP INC |
$79672 |
2304 |
0.00% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$59754 |
1728 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$46960 |
1358 |
0.00% |
股份
|
| Quantbot Technologies LP |
$41081 |
1188 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$23376 |
676 |
0.00% |
股份
|
| SIMPLEX TRADING, LLC |
$21577 |
624 |
0.00% |
股份
|
| 1620 INVESTMENT ADVISORS, INC. |
$17982 |
520 |
0.00% |
股份
|
| WELLS FARGO & COMPANY/MN |
$15561 |
450 |
0.00% |
股份
|
| State of Wyoming |
$12829 |
371 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$12389 |
358270 |
0.00% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$11377 |
329 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$7000 |
214 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$5706 |
165 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$4011 |
116 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$2122 |
61389 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$1902 |
55 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$558 |
16148 |
0.00% |
股份
|
| Bare Financial Services, Inc |
$484 |
14 |
0.00% |
股份
|
| Quarry LP |
$242 |
7 |
0.00% |
股份
|
| Larson Financial Group LLC |
$207 |
6 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$35 |
1 |
0.00% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$25 |
1 |
0.00% |
股份
|
| Centerpoint Advisors, LLC |
$3 |
100 |
0.00% |
股份
|