| BlackRock, Inc. |
$50830842 |
6575788 |
12.51% |
股份
|
| Balyasny Asset Management L.P. |
$28029853 |
3626113 |
6.90% |
股份
|
| Woodline Partners LP |
$23195040 |
3000652 |
5.71% |
股份
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$22631106 |
2927698 |
5.57% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$19837283 |
2566272 |
4.88% |
股份
|
| BVF INC/IL |
$19325000 |
2500000 |
4.75% |
股份
|
| Caligan Partners LP |
$19325000 |
2500000 |
4.75% |
股份
|
| Affinity Asset Advisors, LLC |
$19308489 |
2497864 |
4.75% |
股份
|
| FEDERATED HERMES, INC. |
$16130307 |
2086715 |
3.97% |
股份
|
| GREAT POINT PARTNERS LLC |
$15691382 |
2029933 |
3.86% |
股份
|
| STATE STREET CORP |
$15422061 |
1995092 |
3.79% |
股份
|
| Saturn V Capital Management LP |
$11439766 |
1479918 |
2.81% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$11165095 |
1444019 |
2.75% |
股份
|
| Blue Owl Capital Holdings LP |
$9744005 |
1260544 |
2.40% |
股份
|
| VANGUARD GROUP INC |
$7456536 |
1259550 |
1.83% |
股份
|
| BAKER BROS. ADVISORS LP |
$7366659 |
952996 |
1.81% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$7243203 |
937025 |
1.78% |
股份
|
| Aberdeen Group plc |
$6552721 |
847700 |
1.61% |
股份
|
| GOLDMAN SACHS GROUP INC |
$5867734 |
759086 |
1.44% |
股份
|
| HHLR ADVISORS, LTD. |
$5602704 |
724800 |
1.38% |
股份
|
| AMERIPRISE FINANCIAL INC |
$4492807 |
581217 |
1.11% |
股份
|
| Vestal Point Capital, LP |
$4139044 |
535452 |
1.02% |
股份
|
| NORTHERN TRUST CORP |
$3620617 |
468385 |
0.89% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$3587454 |
464095 |
0.88% |
股份
|
| ADAR1 Capital Management, LLC |
$3381875 |
437500 |
0.83% |
股份
|
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
$3207950 |
415000 |
0.79% |
股份
|
| Seven Fleet Capital Management LP |
$3119403 |
403545 |
0.77% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$3118916 |
403482 |
0.77% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$3098478 |
400838 |
0.76% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$3076547 |
397972 |
0.76% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$2681746 |
346927 |
0.66% |
股份
|
| Atom Investors LP |
$2674719 |
346018 |
0.66% |
股份
|
| UBS Group AG |
$2627659 |
339930 |
0.65% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$2566538 |
332023 |
0.63% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2236289 |
289300 |
0.55% |
买入期权
|
| Rock Springs Capital Management LP |
$1932500 |
250000 |
0.48% |
股份
|
| Palo Alto Investors LP |
$1932500 |
250000 |
0.48% |
股份
|
| BARCLAYS PLC |
$1761907 |
227931 |
0.43% |
股份
|
| Pale Fire Capital SE |
$1715094 |
221875 |
0.42% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$1712512 |
221541 |
0.42% |
股份
|
| Bank of New York Mellon Corp |
$1551011 |
200648 |
0.38% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1440872 |
186400 |
0.35% |
卖出期权
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1359491 |
175872 |
0.33% |
股份
|
| Sofinnova Investments, Inc. |
$1288336 |
166667 |
0.32% |
股份
|
| Driehaus Capital Management LLC |
$1288336 |
166667 |
0.32% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$1110677 |
143684 |
0.27% |
股份
|
| Nuveen, LLC |
$1087124 |
140637 |
0.27% |
股份
|
| CITADEL ADVISORS LLC |
$1035047 |
133900 |
0.25% |
卖出期权
|
| Propel Bio Management, LLC |
$973037 |
125878 |
0.24% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$927878 |
120036 |
0.23% |
股份
|
| CITADEL ADVISORS LLC |
$808814 |
104633 |
0.20% |
股份
|
| MORGAN STANLEY |
$790214 |
102227 |
0.19% |
股份
|
| RB Capital Management, LLC |
$749810 |
97000 |
0.18% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$633102 |
81902 |
0.16% |
股份
|
| AWM Investment Company, Inc. |
$618400 |
80000 |
0.15% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$588214 |
76095 |
0.14% |
股份
|
| RHUMBLINE ADVISERS |
$574632 |
74339 |
0.14% |
股份
|
| DUMAC, INC. |
$550314 |
71192 |
0.14% |
股份
|
| Kestra Advisory Services, LLC |
$513380 |
66414 |
0.13% |
股份
|
| WELLS FARGO & COMPANY/MN |
$494689 |
63996 |
0.12% |
股份
|
| DEUTSCHE BANK AG\ |
$449901 |
58202 |
0.11% |
股份
|
| JANE STREET GROUP, LLC |
$411236 |
53200 |
0.10% |
卖出期权
|
| CITIGROUP INC |
$408445 |
52839 |
0.10% |
股份
|
| CITADEL ADVISORS LLC |
$397322 |
51400 |
0.10% |
买入期权
|
| Hudson Bay Capital Management LP |
$384823 |
49783 |
0.09% |
股份
|
| Quadrature Capital Ltd |
$367979 |
47604 |
0.09% |
股份
|
| Dynamic Technology Lab Private Ltd |
$331000 |
42770 |
0.08% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$315384 |
40800 |
0.08% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$310746 |
40200 |
0.08% |
股份
|
| Mariner, LLC |
$299924 |
38800 |
0.07% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$284603 |
36818 |
0.07% |
股份
|
| MetLife Investment Management, LLC |
$275822 |
35682 |
0.07% |
股份
|
| Invesco Ltd. |
$268471 |
34731 |
0.07% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$232994 |
30117 |
0.06% |
股份
|
| JPMORGAN CHASE & CO |
$225364 |
28930 |
0.06% |
股份
|
| Rafferty Asset Management, LLC |
$211230 |
27326 |
0.05% |
股份
|
| LPL Financial LLC |
$206778 |
26750 |
0.05% |
股份
|
| Cubist Systematic Strategies, LLC |
$189761 |
27662 |
0.05% |
股份
|
| SummitTX Capital, L.P. |
$175564 |
22712 |
0.04% |
股份
|
| D. E. Shaw & Co., Inc. |
$171428 |
22177 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$168189 |
21758 |
0.04% |
股份
|
| Composition Wealth, LLC |
$165236 |
21376 |
0.04% |
股份
|
| Cresset Asset Management, LLC |
$155211 |
20079 |
0.04% |
股份
|
| Steward Partners Investment Advisory, LLC |
$148277 |
19182 |
0.04% |
股份
|
| Abacus Planning Group, Inc. |
$139635 |
18064 |
0.03% |
股份
|
| RPG Investment Advisory, LLC |
$134116 |
17350 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$133969 |
17331 |
0.03% |
股份
|
| Baird Financial Group, Inc. |
$121183 |
15677 |
0.03% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$118331 |
15308 |
0.03% |
股份
|
| 1492 Capital Management LLC |
$115950 |
15000 |
0.03% |
股份
|
| SEI INVESTMENTS CO |
$114999 |
14877 |
0.03% |
股份
|
| JANE STREET GROUP, LLC |
$112858 |
14600 |
0.03% |
买入期权
|
| PROFUND ADVISORS LLC |
$112108 |
14503 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$108993 |
14100 |
0.03% |
股份
|
| Man Group plc |
$107107 |
13856 |
0.03% |
股份
|
| Cetera Investment Advisers |
$100490 |
13000 |
0.02% |
股份
|
| Jasper Ridge Partners, L.P. |
$99446 |
12865 |
0.02% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$95095 |
18200 |
0.02% |
股份
|
| NATIONS FINANCIAL GROUP INC, /IA/ /ADV |
$92760 |
12000 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$92258 |
11935 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$89908 |
11631 |
0.02% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$84644 |
10950 |
0.02% |
股份
|
| Persistent Asset Partners Ltd |
$80152 |
10369 |
0.02% |
股份
|
| PFG Investments, LLC |
$77300 |
10000 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$75275 |
9738 |
0.02% |
股份
|
| SHERBROOKE PARK ADVISERS LLC |
$59999 |
10135 |
0.01% |
股份
|
| State of Wyoming |
$52456 |
6786 |
0.01% |
股份
|
| Legal & General Group Plc |
$44053 |
5699 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$41224 |
5333 |
0.01% |
股份
|
| AlphaQuest LLC |
$36550 |
6174 |
0.01% |
股份
|
| Russell Investments Group, Ltd. |
$36323 |
4699 |
0.01% |
股份
|
| Global Retirement Partners, LLC |
$23192 |
3000 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$22000 |
2830 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$21149 |
2736 |
0.01% |
股份
|
| FMR LLC |
$20407 |
2640 |
0.01% |
股份
|
| Quantbot Technologies LP |
$17802 |
2303 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$15792 |
2043 |
0.00% |
股份
|
| NFSG Corp |
$11595 |
1500 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$9353 |
1210 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$7790 |
1000 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$6563 |
849 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$6254 |
809 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$3239 |
419 |
0.00% |
股份
|
| Rialto Wealth Management, LLC |
$2776 |
359 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$2451 |
317 |
0.00% |
股份
|
| Quarry LP |
$989 |
128 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$904 |
117 |
0.00% |
股份
|
| Arax Advisory Partners |
$889 |
115 |
0.00% |
股份
|
| FNY Investment Advisers, LLC |
$844 |
109250 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$378 |
48883 |
0.00% |
股份
|
| Point72 Europe (London) LLP |
$357 |
52 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$8 |
1 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$4 |
456 |
0.00% |
股份
|