| BAKER BROS. ADVISORS LP |
$37335293 |
5072730 |
14.70% |
股份
|
| 5AM Venture Management, LLC |
$29854949 |
4056379 |
11.76% |
股份
|
| MPM ASSET MANAGEMENT LLC |
$25410160 |
4381062 |
10.01% |
股份
|
| BlackRock, Inc. |
$19013332 |
2583333 |
7.49% |
股份
|
| VANGUARD GROUP INC |
$16781689 |
1632460 |
6.61% |
股份
|
| Merck & Co., Inc. |
$12804692 |
1739768 |
5.04% |
股份
|
| StepStone Group LP |
$9607316 |
761277 |
3.78% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$9344506 |
1269634 |
3.68% |
股份
|
| MPM BIOIMPACT LLC |
$9222470 |
1253053 |
3.63% |
股份
|
| TCG Crossover Management, LLC |
$7803293 |
1060230 |
3.07% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$7024524 |
954419 |
2.77% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$5622738 |
763959 |
2.21% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$5281368 |
717430 |
2.08% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$5148591 |
699537 |
2.03% |
股份
|
| STATE STREET CORP |
$4391543 |
596677 |
1.73% |
股份
|
| JPMORGAN CHASE & CO |
$3827683 |
496457 |
1.51% |
股份
|
| CITADEL ADVISORS LLC |
$2902217 |
394323 |
1.14% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$2769577 |
376136 |
1.09% |
股份
|
| NORTHERN TRUST CORP |
$2281173 |
309942 |
0.90% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$2233458 |
303459 |
0.88% |
股份
|
| Nantahala Capital Management, LLC |
$2212232 |
300575 |
0.87% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$1870397 |
254130 |
0.74% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1450921 |
197136 |
0.57% |
股份
|
| Longaeva Partners L.P. |
$1436944 |
195237 |
0.57% |
股份
|
| MORGAN STANLEY |
$1410544 |
191650 |
0.56% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$1405760 |
191000 |
0.55% |
股份
|
| Quantinno Capital Management LP |
$1389855 |
188839 |
0.55% |
股份
|
| Lynx1 Capital Management LP |
$1314540 |
178606 |
0.52% |
股份
|
| GOLDMAN SACHS GROUP INC |
$1305247 |
177343 |
0.51% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$1233875 |
167646 |
0.49% |
股份
|
| Woodline Partners LP |
$1071616 |
145600 |
0.42% |
股份
|
| Trexquant Investment LP |
$1031452 |
140143 |
0.41% |
股份
|
| MOORE CAPITAL MANAGEMENT, LP |
$772800 |
105000 |
0.30% |
股份
|
| Cubist Systematic Strategies, LLC |
$711521 |
122676 |
0.28% |
股份
|
| XTX Topco Ltd |
$701680 |
95337 |
0.28% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$699524 |
95044 |
0.28% |
股份
|
| Allspring Global Investments Holdings, LLC |
$688440 |
93538 |
0.27% |
股份
|
| ROYCE & ASSOCIATES LP |
$610159 |
82902 |
0.24% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$586599 |
79701 |
0.23% |
股份
|
| Bank of New York Mellon Corp |
$581955 |
79070 |
0.23% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$533747 |
72520 |
0.21% |
股份
|
| AMERIPRISE FINANCIAL INC |
$518107 |
70395 |
0.20% |
股份
|
| Qube Research & Technologies Ltd |
$448018 |
60872 |
0.18% |
股份
|
| CANTOR FITZGERALD, L. P. |
$441600 |
60000 |
0.17% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$426343 |
57927 |
0.17% |
股份
|
| Nuveen, LLC |
$417879 |
56777 |
0.16% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$399297 |
31640 |
0.16% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$398272 |
54113 |
0.16% |
股份
|
| TD Asset Management Inc |
$394408 |
53588 |
0.16% |
股份
|
| ExodusPoint Capital Management, LP |
$388365 |
52767 |
0.15% |
股份
|
| Nan Fung Group Holdings Ltd |
$361244 |
49082 |
0.14% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$341519 |
46402 |
0.13% |
股份
|
| Invesco Ltd. |
$326372 |
44344 |
0.13% |
股份
|
| UBS Group AG |
$305911 |
41564 |
0.12% |
股份
|
| GREAT LAKES ADVISORS, LLC |
$283441 |
38511 |
0.11% |
股份
|
| MARTINGALE ASSET MANAGEMENT L P |
$281616 |
38263 |
0.11% |
股份
|
| HSBC HOLDINGS PLC |
$278266 |
36470 |
0.11% |
股份
|
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
$276015 |
37502 |
0.11% |
股份
|
| RHUMBLINE ADVISERS |
$270421 |
36743 |
0.11% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$255296 |
34687 |
0.10% |
股份
|
| Brevan Howard Capital Management LP |
$250012 |
33969 |
0.10% |
股份
|
| Graham Capital Management, L.P. |
$246244 |
33457 |
0.10% |
股份
|
| D. E. Shaw & Co., Inc. |
$238442 |
32397 |
0.09% |
股份
|
| Odyssean, LLC |
$230405 |
31305 |
0.09% |
股份
|
| Corton Capital Inc. |
$225324 |
38849 |
0.09% |
股份
|
| IEQ CAPITAL, LLC |
$218437 |
29679 |
0.09% |
股份
|
| BARCLAYS PLC |
$210495 |
28600 |
0.08% |
股份
|
| Point72 Asset Management, L.P. |
$209760 |
28500 |
0.08% |
股份
|
| China Universal Asset Management Co., Ltd. |
$204446 |
27778 |
0.08% |
股份
|
| Verdad Advisers, LP |
$202400 |
27500 |
0.08% |
股份
|
| DEUTSCHE BANK AG\ |
$195452 |
26556 |
0.08% |
股份
|
| Voleon Capital Management LP |
$186385 |
25324 |
0.07% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$184000 |
25000 |
0.07% |
股份
|
| WELLS FARGO & COMPANY/MN |
$183279 |
24902 |
0.07% |
股份
|
| Jump Financial, LLC |
$177170 |
24072 |
0.07% |
股份
|
| Inscription Capital, LLC |
$176206 |
23941 |
0.07% |
股份
|
| Russell Investments Group, Ltd. |
$172591 |
23450 |
0.07% |
股份
|
| AlphaQuest LLC |
$160666 |
15629 |
0.06% |
股份
|
| Mariner, LLC |
$159779 |
21707 |
0.06% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$152006 |
20653 |
0.06% |
股份
|
| MetLife Investment Management, LLC |
$129941 |
17655 |
0.05% |
股份
|
| ADAR1 Capital Management, LLC |
$114080 |
15500 |
0.04% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$114028 |
15493 |
0.04% |
股份
|
| CITIGROUP INC |
$108854 |
14790 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$99735 |
13551 |
0.04% |
股份
|
| Cerity Partners LLC |
$99442 |
13511 |
0.04% |
股份
|
| Quadrature Capital Ltd |
$97572 |
13257 |
0.04% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$88364 |
12769 |
0.03% |
股份
|
| CWM, LLC |
$85665 |
6788 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$69707 |
9471 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$65335 |
8877 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$64856 |
8812 |
0.03% |
股份
|
| State of Wyoming |
$36903 |
5014 |
0.01% |
股份
|
| Arax Advisory Partners |
$32958 |
4478 |
0.01% |
股份
|
| Versant Capital Management, Inc |
$26702 |
4205 |
0.01% |
股份
|
| STRS OHIO |
$23552 |
3200 |
0.01% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$21874 |
2972 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$21462 |
2916 |
0.01% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$19784 |
2688 |
0.01% |
股份
|
| Legal & General Group Plc |
$18807 |
2557 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$17789 |
2417 |
0.01% |
股份
|
| FMR LLC |
$15962 |
2169 |
0.01% |
股份
|
| FEDERATED HERMES, INC. |
$14484 |
1968 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$12777 |
1736 |
0.01% |
股份
|
| PNC Financial Services Group, Inc. |
$8354 |
1135 |
0.00% |
股份
|
| Point72 (DIFC) Ltd |
$7876 |
1358 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$6000 |
882 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$5976 |
812 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$5490 |
435 |
0.00% |
股份
|
| Allworth Financial LP |
$4762 |
647 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$4724 |
642 |
0.00% |
股份
|
| Essential Partners LLC |
$4394 |
597 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$4364 |
593 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$3992 |
542316 |
0.00% |
股份
|
| GAMMA Investing LLC |
$3864 |
525 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$2945 |
400862 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$2937 |
399 |
0.00% |
股份
|
| True Wealth Design, LLC |
$2260 |
307 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$2009 |
273 |
0.00% |
股份
|
| Optiver Holding B.V. |
$1722 |
234 |
0.00% |
股份
|
| Private Wealth Management Group, LLC |
$1561 |
212 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$1435 |
195 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$1369 |
186 |
0.00% |
股份
|
| IFP Advisors, Inc |
$1259 |
171 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$1054 |
143 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$1038 |
141 |
0.00% |
股份
|
| Cornerstone Financial Management LLC |
$670 |
91 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$648 |
88005 |
0.00% |
股份
|
| ZIONS BANCORPORATION, NATIONAL ASSOCIATION /UT/ |
$640 |
87 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$523 |
71 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$339 |
46 |
0.00% |
股份
|
| Wealth Enhancement Trust Services, Inc. |
$316 |
43 |
0.00% |
股份
|
| HARBOR CAPITAL ADVISORS, INC. |
$245 |
33351 |
0.00% |
股份
|
| Quarry LP |
$184 |
25 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$15 |
2 |
0.00% |
股份
|