| NEA Management Company, LLC |
$246594552 |
13222228 |
8.67% |
股份
|
| FMR LLC |
$234296949 |
12562839 |
8.24% |
股份
|
| BlackRock, Inc. |
$208041234 |
11155026 |
7.32% |
股份
|
| Frazier Life Sciences Management, L.P. |
$185370687 |
9939447 |
6.52% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$106017642 |
5684592 |
3.73% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$103147089 |
5530675 |
3.63% |
股份
|
| Vivo Capital, LLC |
$95015558 |
5094668 |
3.34% |
股份
|
| VANGUARD GROUP INC |
$80561880 |
6434655 |
2.83% |
股份
|
| Woodline Partners LP |
$76116860 |
4081333 |
2.68% |
股份
|
| Vestal Point Capital, LP |
$57815000 |
3100000 |
2.03% |
股份
|
| MPM BIOIMPACT LLC |
$57322211 |
3073577 |
2.02% |
股份
|
| FRONTIER CAPITAL MANAGEMENT CO LLC |
$57269301 |
3070740 |
2.01% |
股份
|
| STATE STREET CORP |
$56459425 |
3027315 |
1.99% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$54619528 |
2928068 |
1.92% |
股份
|
| MARSHALL WACE, LLP |
$49872655 |
2674137 |
1.75% |
股份
|
| EVENTIDE ASSET MANAGEMENT, LLC |
$49609000 |
2660000 |
1.74% |
股份
|
| Rubric Capital Management LP |
$46709167 |
2504513 |
1.64% |
股份
|
| Artia Global Partners LP |
$41232390 |
2210852 |
1.45% |
股份
|
| ACORN CAPITAL ADVISORS, LLC |
$40001341 |
2144844 |
1.41% |
股份
|
| First Light Asset Management, LLC |
$39113060 |
2097215 |
1.38% |
股份
|
| Pictet Asset Management Holding SA |
$37557109 |
2013786 |
1.32% |
股份
|
| Logos Global Management LP |
$35062000 |
1880000 |
1.23% |
股份
|
| Affinity Asset Advisors, LLC |
$33573208 |
1800172 |
1.18% |
股份
|
| EMERALD ADVISERS, LLC |
$33525445 |
1797611 |
1.18% |
股份
|
| Siren, L.L.C. |
$33325070 |
1786867 |
1.17% |
股份
|
| Pivotal bioVenture Partners Investment Advisor LLC |
$32500833 |
1742672 |
1.14% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$30038753 |
1610657 |
1.06% |
股份
|
| VIKING GLOBAL INVESTORS LP |
$28807611 |
1544644 |
1.01% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$28588381 |
1532889 |
1.01% |
股份
|
| Assenagon Asset Management S.A. |
$28447106 |
1525314 |
1.00% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$28100554 |
2355453 |
0.99% |
股份
|
| ORBIMED ADVISORS LLC |
$26674964 |
1430293 |
0.94% |
股份
|
| Jones Hill Capital LP |
$24976304 |
1339212 |
0.88% |
股份
|
| NAN FUNG TRINITY (HK) LTD |
$22634013 |
1213620 |
0.80% |
股份
|
| EMERALD MUTUAL FUND ADVISERS TRUST |
$22584497 |
1210965 |
0.79% |
股份
|
| GOLDMAN SACHS GROUP INC |
$22426998 |
1202520 |
0.79% |
股份
|
| Soleus Capital Management, L.P. |
$21999876 |
1179618 |
0.77% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$21948663 |
1176872 |
0.77% |
股份
|
| BARCLAYS PLC |
$21299737 |
1142077 |
0.75% |
股份
|
| Saturn V Capital Management LP |
$19620602 |
1052043 |
0.69% |
股份
|
| FLPUTNAM INVESTMENT MANAGEMENT CO |
$19359763 |
1038057 |
0.68% |
股份
|
| NORTHERN TRUST CORP |
$18762609 |
1006038 |
0.66% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$18138990 |
972600 |
0.64% |
买入期权
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$18004747 |
965402 |
0.63% |
股份
|
| Candriam S.C.A. |
$18002647 |
966219 |
0.63% |
股份
|
| Balyasny Asset Management L.P. |
$15760873 |
845087 |
0.55% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$15685750 |
841059 |
0.55% |
股份
|
| MORGAN STANLEY |
$14928673 |
800465 |
0.53% |
股份
|
| Nuveen, LLC |
$14270533 |
765176 |
0.50% |
股份
|
| Burkehill Global Management, LP |
$13521250 |
725000 |
0.48% |
股份
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$12646472 |
678095 |
0.44% |
股份
|
| AMERIPRISE FINANCIAL INC |
$11607406 |
622381 |
0.41% |
股份
|
| SUPERSTRING CAPITAL MANAGEMENT LP |
$9776778 |
524224 |
0.34% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$9306891 |
499029 |
0.33% |
股份
|
| PEREGRINE CAPITAL MANAGEMENT LLC |
$8286382 |
444310 |
0.29% |
股份
|
| KVP Capital Advisors, LP |
$7721100 |
414000 |
0.27% |
股份
|
| Ensign Peak Advisors, Inc |
$7388626 |
396173 |
0.26% |
股份
|
| Octagon Capital Advisors LP |
$5874750 |
315000 |
0.21% |
股份
|
| Invesco Ltd. |
$5814119 |
311749 |
0.20% |
股份
|
| Opaleye Management Inc. |
$5781500 |
310000 |
0.20% |
股份
|
| Bank of New York Mellon Corp |
$5719601 |
306681 |
0.20% |
股份
|
| D. E. Shaw & Co., Inc. |
$5259225 |
281996 |
0.18% |
股份
|
| UBS Group AG |
$5044788 |
270498 |
0.18% |
股份
|
| Informed Momentum Co LLC |
$4935368 |
264631 |
0.17% |
股份
|
| FIFTH THIRD BANCORP |
$4861011 |
260644 |
0.17% |
股份
|
| Rock Springs Capital Management LP |
$4849000 |
260000 |
0.17% |
股份
|
| Trexquant Investment LP |
$4523315 |
242537 |
0.16% |
股份
|
| Walleye Capital LLC |
$4513058 |
241987 |
0.16% |
股份
|
| F/m Investments LLC |
$4367979 |
234208 |
0.15% |
股份
|
| JANE STREET GROUP, LLC |
$3761705 |
201700 |
0.13% |
买入期权
|
| Integral Health Asset Management, LLC |
$3730000 |
200000 |
0.13% |
股份
|
| Swiss National Bank |
$3586395 |
192300 |
0.13% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$3398683 |
182235 |
0.12% |
股份
|
| SEVEN GRAND MANAGERS, LLC |
$2797500 |
150000 |
0.10% |
股份
|
| RHUMBLINE ADVISERS |
$2470423 |
132463 |
0.09% |
股份
|
| TRUST CO OF TOLEDO NA /OH/ |
$2312637 |
124002 |
0.08% |
股份
|
| CITADEL ADVISORS LLC |
$2170860 |
116400 |
0.08% |
买入期权
|
| Harvest Investment Services, LLC |
$2146690 |
115104 |
0.08% |
股份
|
| WELLS FARGO & COMPANY/MN |
$2139286 |
114707 |
0.08% |
股份
|
| DEUTSCHE BANK AG\ |
$2135183 |
114487 |
0.08% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$2014275 |
108004 |
0.07% |
股份
|
| WINTON GROUP Ltd |
$1992790 |
106852 |
0.07% |
股份
|
| Qube Research & Technologies Ltd |
$1906515 |
102226 |
0.07% |
股份
|
| LMR Partners LLP |
$1865000 |
100000 |
0.07% |
股份
|
| OPPENHEIMER & CO INC |
$1860729 |
99771 |
0.07% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$1839225 |
154168 |
0.06% |
股份
|
| SIMPLEX TRADING, LLC |
$1819438 |
97557 |
0.06% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$1744931 |
93562 |
0.06% |
股份
|
| Russell Investments Group, Ltd. |
$1695768 |
90926 |
0.06% |
股份
|
| WEXFORD CAPITAL LP |
$1692525 |
90752 |
0.06% |
股份
|
| Erste Asset Management GmbH |
$1676700 |
90000 |
0.06% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$1543343 |
82753 |
0.05% |
股份
|
| Campbell & CO Investment Adviser LLC |
$1526950 |
81874 |
0.05% |
股份
|
| J. Goldman & Co LP |
$1510613 |
80998 |
0.05% |
股份
|
| Legal & General Group Plc |
$1477453 |
79220 |
0.05% |
股份
|
| PFS Partners, LLC |
$1473350 |
79000 |
0.05% |
股份
|
| CITIGROUP INC |
$1444890 |
77474 |
0.05% |
股份
|
| Schonfeld Strategic Advisors LLC |
$1416838 |
75970 |
0.05% |
股份
|
| Checkpoint Capital L.P. |
$1398750 |
75000 |
0.05% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$1379690 |
73978 |
0.05% |
股份
|
| JPMORGAN CHASE & CO |
$1365076 |
73273 |
0.05% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$1348320 |
72296 |
0.05% |
股份
|
| SEI INVESTMENTS CO |
$1277224 |
68484 |
0.04% |
股份
|
| FRED ALGER MANAGEMENT, LLC |
$1240039 |
66490 |
0.04% |
股份
|
| SECTORAL ASSET MANAGEMENT INC |
$1223365 |
65596 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$1198785 |
64278 |
0.04% |
股份
|
| Steward Partners Investment Advisory, LLC |
$1186140 |
63600 |
0.04% |
股份
|
| LPL Financial LLC |
$1183324 |
63449 |
0.04% |
股份
|
| KENNEDY CAPITAL MANAGEMENT LLC |
$1176964 |
63108 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$1165494 |
62493 |
0.04% |
股份
|
| XTX Topco Ltd |
$1154360 |
61896 |
0.04% |
股份
|
| WealthTrust Axiom LLC |
$1146975 |
61500 |
0.04% |
股份
|
| Creative Planning |
$1073792 |
57576 |
0.04% |
股份
|
| MAI Capital Management |
$1046825 |
56130 |
0.04% |
股份
|
| COMERICA BANK |
$1039498 |
83027 |
0.04% |
股份
|
| HighVista Strategies LLC |
$989065 |
53033 |
0.03% |
股份
|
| Ghisallo Capital Management LLC |
$932500 |
50000 |
0.03% |
股份
|
| FRANKLIN RESOURCES INC |
$931866 |
49966 |
0.03% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$925245 |
49611 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$916517 |
49143 |
0.03% |
股份
|
| CITADEL ADVISORS LLC |
$841115 |
45100 |
0.03% |
卖出期权
|
| BIT Capital GmbH |
$839250 |
45000 |
0.03% |
股份
|
| Seven Fleet Capital Management LP |
$833430 |
45598 |
0.03% |
股份
|
| Z3 Capital Partners, LLC |
$732013 |
39250 |
0.03% |
股份
|
| Harbour Capital Advisors, LLC |
$717168 |
40200 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$702452 |
37665 |
0.02% |
股份
|
| ROYAL BANK OF CANADA |
$668000 |
35804 |
0.02% |
股份
|
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. |
$658345 |
35300 |
0.02% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$644433 |
34554 |
0.02% |
股份
|
| OPTIMIZE FINANCIAL INC. |
$592697 |
31780 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$589545 |
31611 |
0.02% |
股份
|
| UNITED BANK |
$581880 |
31200 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$577702 |
30976 |
0.02% |
股份
|
| PSP Research LLC |
$559500 |
30000 |
0.02% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$492994 |
26434 |
0.02% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$480293 |
25753 |
0.02% |
股份
|
| Persistent Asset Partners Ltd |
$477459 |
25601 |
0.02% |
股份
|
| Vanguard Investments Australia, Ltd. |
$468488 |
25120 |
0.02% |
股份
|
| STIFEL FINANCIAL CORP |
$468156 |
25102 |
0.02% |
股份
|
| Brevan Howard Capital Management LP |
$459648 |
24646 |
0.02% |
股份
|
| AlphaCentric Advisors LLC |
$453512 |
24317 |
0.02% |
股份
|
| JANUS HENDERSON GROUP PLC |
$442554 |
37127 |
0.02% |
股份
|
| DIVERSIFIED TRUST CO |
$438200 |
23496 |
0.02% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$435478 |
23350 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$432605 |
23196 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$430852 |
23102 |
0.02% |
股份
|
| KLP KAPITALFORVALTNING AS |
$404705 |
21700 |
0.01% |
股份
|
| Cerity Partners LLC |
$402428 |
21578 |
0.01% |
股份
|
| PROFUND ADVISORS LLC |
$393627 |
21106 |
0.01% |
股份
|
| CHAPIN DAVIS, INC. |
$374865 |
20100 |
0.01% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$371694 |
19930 |
0.01% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$350000 |
50000 |
0.01% |
买入期权
|
| ProShare Advisors LLC |
$348588 |
18691 |
0.01% |
股份
|
| Graham Capital Management, L.P. |
$334712 |
17947 |
0.01% |
股份
|
| COWA, LLC |
$334544 |
17938 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$324715 |
17411 |
0.01% |
股份
|
| STRS OHIO |
$302130 |
16200 |
0.01% |
股份
|
| Kingsview Wealth Management, LLC |
$296442 |
15895 |
0.01% |
股份
|
| Bridgefront Capital, LLC |
$282753 |
15161 |
0.01% |
股份
|
| Rafferty Asset Management, LLC |
$276468 |
14824 |
0.01% |
股份
|
| Marex Group Ltd |
$261100 |
14000 |
0.01% |
股份
|
| CIBC Bancorp USA Inc. |
$237470 |
12733 |
0.01% |
股份
|
| TEACHER RETIREMENT SYSTEM OF TEXAS |
$207313 |
11116 |
0.01% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$199648 |
10705 |
0.01% |
股份
|
| HSBC HOLDINGS PLC |
$199278 |
10516 |
0.01% |
股份
|
| Maltin Wealth Management, Inc. |
$196944 |
10560 |
0.01% |
股份
|
| Amundi |
$192170 |
10304 |
0.01% |
股份
|
| XPONANCE LLC |
$191293 |
10257 |
0.01% |
股份
|
| Vontobel Holding Ltd. |
$187488 |
10053 |
0.01% |
股份
|
| ALBION FINANCIAL GROUP /UT |
$186500 |
10000 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$181409 |
9727 |
0.01% |
股份
|
| Farther Finance Advisors, LLC |
$172070 |
9226 |
0.01% |
股份
|
| Avidity Partners Management LP |
$124209 |
6660 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$118428 |
6350 |
0.00% |
股份
|
| AlphaQuest LLC |
$100010 |
7988 |
0.00% |
股份
|
| Hilton Head Capital Partners, LLC |
$81146 |
4351 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$72679 |
3897 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$71597 |
3839 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$64380 |
3452 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$56344 |
3026 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$50672 |
2717 |
0.00% |
股份
|
| Chung Wu Investment Group, LLC |
$37300 |
2000 |
0.00% |
股份
|
| LANARK FINANCIAL, INC. |
$37300 |
2000 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$31928 |
1712 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$30978 |
1661 |
0.00% |
股份
|
| Kemnay Advisory Services Inc. |
$21783 |
1168 |
0.00% |
股份
|
| Larson Financial Group LLC |
$21448 |
1150 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$18277 |
1007 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$14603 |
783 |
0.00% |
股份
|
| Allworth Financial LP |
$14286 |
766 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$14137 |
758 |
0.00% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$10351 |
555 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$9623 |
516 |
0.00% |
股份
|
| Aster Capital Management (DIFC) Ltd |
$7777 |
417 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$7012 |
376 |
0.00% |
股份
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$6397 |
343 |
0.00% |
股份
|
| CWM, LLC |
$5058 |
424 |
0.00% |
股份
|
| Optiver Holding B.V. |
$3916 |
210 |
0.00% |
股份
|
| Caption Management, LLC |
$3898 |
209 |
0.00% |
股份
|
| Arax Advisory Partners |
$3618 |
194 |
0.00% |
股份
|
| State of Wyoming |
$3469 |
186 |
0.00% |
股份
|
| FTB Advisors, Inc. |
$2735 |
500 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$2609 |
140 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$2313 |
124 |
0.00% |
股份
|
| GAMMA Investing LLC |
$1846 |
99 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$1643 |
88057 |
0.00% |
股份
|
| Cornerstone Financial Management LLC |
$1455 |
78 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$1306 |
70 |
0.00% |
股份
|
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
$933 |
50049 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$746 |
40 |
0.00% |
股份
|
| US BANCORP \DE\ |
$597 |
32 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$562 |
30146 |
0.00% |
股份
|
| Bare Financial Services, Inc |
$560 |
30 |
0.00% |
股份
|
| CoreCap Advisors, LLC |
$336 |
18 |
0.00% |
股份
|
| Stone House Investment Management, LLC |
$317 |
17 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$233 |
12520 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$224 |
12 |
0.00% |
股份
|
| Essential Partners LLC |
$205 |
11 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$118 |
6325 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$75 |
4 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$75 |
4 |
0.00% |
股份
|
| KBC Group NV |
$46 |
2464 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$37 |
2 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$19 |
1 |
0.00% |
股份
|
| Dauntless Investment Group, LLC |
$19 |
1 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
43 |
0.00% |
股份
|