| BlackRock, Inc. |
$246636382 |
5747760 |
7.34% |
股份
|
| Avoro Capital Advisors LLC |
$245612034 |
5723888 |
7.31% |
股份
|
| VANGUARD GROUP INC |
$180805107 |
3570401 |
5.38% |
股份
|
| STATE STREET CORP |
$178024407 |
4148786 |
5.30% |
股份
|
| Deep Track Capital, LP |
$171640000 |
4000000 |
5.11% |
股份
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$168052724 |
3916400 |
5.00% |
股份
|
| Kynam Capital Management, LP |
$124012432 |
2890059 |
3.69% |
股份
|
| MORGAN STANLEY |
$120124806 |
2799459 |
3.57% |
股份
|
| Sofinnova Investments, Inc. |
$119889982 |
2793987 |
3.57% |
股份
|
| FMR LLC |
$119035323 |
2774070 |
3.54% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$118234772 |
2755413 |
3.52% |
股份
|
| Eversept Partners, LP |
$94949961 |
2212770 |
2.82% |
股份
|
| Logos Global Management LP |
$94402000 |
2200000 |
2.81% |
股份
|
| Integral Health Asset Management, LLC |
$75092500 |
1750000 |
2.23% |
股份
|
| Bellevue Group AG |
$73410771 |
1710808 |
2.18% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$72637914 |
1692442 |
2.16% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$64007660 |
1591043 |
1.90% |
股份
|
| GOLDMAN SACHS GROUP INC |
$59251630 |
1380835 |
1.76% |
股份
|
| FRONTIER CAPITAL MANAGEMENT CO LLC |
$55585829 |
1295405 |
1.65% |
股份
|
| Pictet Asset Management Holding SA |
$53625486 |
1249414 |
1.60% |
股份
|
| DEUTSCHE BANK AG\ |
$47291369 |
1102106 |
1.41% |
股份
|
| Qube Research & Technologies Ltd |
$46479211 |
1083179 |
1.38% |
股份
|
| Woodline Partners LP |
$42954498 |
1001037 |
1.28% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$37170604 |
866243 |
1.11% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$27585680 |
642873 |
0.82% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$27572336 |
642562 |
0.82% |
股份
|
| GREAT POINT PARTNERS LLC |
$25781873 |
600836 |
0.77% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$25321319 |
590103 |
0.75% |
股份
|
| NORTHERN TRUST CORP |
$24936117 |
581126 |
0.74% |
股份
|
| BRAIDWELL LP |
$24232307 |
564724 |
0.72% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$23386508 |
545013 |
0.70% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$22650172 |
527853 |
0.67% |
股份
|
| SCHRODER INVESTMENT MANAGEMENT GROUP |
$22040459 |
510787 |
0.66% |
股份
|
| Davern Capital Partners, LP |
$21404881 |
498832 |
0.64% |
股份
|
| Candriam S.C.A. |
$20066803 |
468099 |
0.60% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$19987778 |
465807 |
0.59% |
股份
|
| Elmind Capital, LP |
$18730987 |
436518 |
0.56% |
股份
|
| Rock Springs Capital Management LP |
$18347629 |
427584 |
0.55% |
股份
|
| Balyasny Asset Management L.P. |
$16089147 |
374951 |
0.48% |
股份
|
| ORBIMED ADVISORS LLC |
$15859364 |
369596 |
0.47% |
股份
|
| Ikarian Capital, LLC |
$13302100 |
310000 |
0.40% |
股份
|
| ARMISTICE CAPITAL, LLC |
$12873000 |
300000 |
0.38% |
股份
|
| Nuveen, LLC |
$12804773 |
298410 |
0.38% |
股份
|
| READYSTATE ASSET MANAGEMENT LP |
$12663342 |
295114 |
0.38% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$11994546 |
279528 |
0.36% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$11957215 |
278658 |
0.36% |
股份
|
| CITIGROUP INC |
$11446585 |
266758 |
0.34% |
股份
|
| UBS Group AG |
$10906950 |
254182 |
0.32% |
股份
|
| Affinity Asset Advisors, LLC |
$10727500 |
250000 |
0.32% |
股份
|
| Alphabet Inc. |
$10352638 |
241264 |
0.31% |
股份
|
| BARCLAYS PLC |
$9659813 |
225118 |
0.29% |
股份
|
| PFM Health Sciences, LP |
$9624241 |
224289 |
0.29% |
股份
|
| TimesSquare Capital Management, LLC |
$9351986 |
232463 |
0.28% |
股份
|
| Bank of New York Mellon Corp |
$8483039 |
197694 |
0.25% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$7956246 |
197769 |
0.24% |
股份
|
| CenterBook Partners LP |
$7700929 |
179467 |
0.23% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$6901516 |
160837 |
0.21% |
股份
|
| AXA Investment Managers S.A. |
$6673338 |
229640 |
0.20% |
股份
|
| WELLS FARGO & COMPANY/MN |
$6311480 |
147086 |
0.19% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$6309057 |
147030 |
0.19% |
股份
|
| Jump Financial, LLC |
$6011219 |
140089 |
0.18% |
股份
|
| TD Asset Management Inc |
$5495484 |
128070 |
0.16% |
股份
|
| Ghisallo Capital Management LLC |
$5363750 |
125000 |
0.16% |
股份
|
| PLATINUM INVESTMENT MANAGEMENT LTD |
$4878309 |
113687 |
0.15% |
股份
|
| FIFTH THIRD BANCORP |
$4733110 |
110303 |
0.14% |
股份
|
| Engineers Gate Manager LP |
$4640244 |
108139 |
0.14% |
股份
|
| HighVista Strategies LLC |
$4544470 |
105907 |
0.14% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$4518123 |
105293 |
0.13% |
股份
|
| Squarepoint Ops LLC |
$4502847 |
104937 |
0.13% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$4469935 |
104170 |
0.13% |
股份
|
| XTX Topco Ltd |
$4445776 |
103607 |
0.13% |
股份
|
| Ensign Peak Advisors, Inc |
$4402480 |
102598 |
0.13% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$4332451 |
100966 |
0.13% |
股份
|
| Exome Asset Management LLC |
$4174113 |
97276 |
0.12% |
股份
|
| ALGERT GLOBAL LLC |
$3958447 |
92250 |
0.12% |
股份
|
| Swiss National Bank |
$3685969 |
85900 |
0.11% |
股份
|
| RHUMBLINE ADVISERS |
$3403051 |
79307 |
0.10% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$3361440 |
78337 |
0.10% |
股份
|
| D. E. Shaw & Co., Inc. |
$3197182 |
74509 |
0.10% |
股份
|
| Rafferty Asset Management, LLC |
$3152555 |
73469 |
0.09% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$3149594 |
73400 |
0.09% |
买入期权
|
| ALPS ADVISORS INC |
$3113421 |
72557 |
0.09% |
股份
|
| Ikarian Capital, LLC |
$3076647 |
71700 |
0.09% |
买入期权
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2982245 |
69500 |
0.09% |
卖出期权
|
| GROUP ONE TRADING LLC |
$2922085 |
68098 |
0.09% |
股份
|
| Cubist Systematic Strategies, LLC |
$2815059 |
96871 |
0.08% |
股份
|
| Odyssean, LLC |
$2574815 |
60005 |
0.08% |
股份
|
| AMERIPRISE FINANCIAL INC |
$2484275 |
57895 |
0.07% |
股份
|
| Birchview Capital, LP |
$2478396 |
57758 |
0.07% |
股份
|
| DIADEMA PARTNERS LP |
$2471959 |
57608 |
0.07% |
股份
|
| EASTERN BANK |
$2405106 |
56050 |
0.07% |
股份
|
| Trexquant Investment LP |
$2343229 |
54608 |
0.07% |
股份
|
| JPMORGAN CHASE & CO |
$2297047 |
50780 |
0.07% |
股份
|
| Invesco Ltd. |
$2181845 |
50847 |
0.06% |
股份
|
| CITADEL ADVISORS LLC |
$2162664 |
50400 |
0.06% |
买入期权
|
| Man Group plc |
$2160346 |
50346 |
0.06% |
股份
|
| Swedbank AB |
$2145500 |
50000 |
0.06% |
股份
|
| DIADEMA PARTNERS LP |
$2145500 |
50000 |
0.06% |
卖出期权
|
| Russell Investments Group, Ltd. |
$2134128 |
49735 |
0.06% |
股份
|
| Neo Ivy Capital Management |
$2099886 |
48937 |
0.06% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$2074999 |
48357 |
0.06% |
股份
|
| J. Safra Sarasin Holding AG |
$2045176 |
47662 |
0.06% |
股份
|
| Point72 Asset Management, L.P. |
$1740558 |
40563 |
0.05% |
股份
|
| E. Ohman J:or Asset Management AB |
$1729488 |
42990 |
0.05% |
股份
|
| LMR Partners LLP |
$1716400 |
40000 |
0.05% |
股份
|
| JANE STREET GROUP, LLC |
$1686363 |
39300 |
0.05% |
买入期权
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$1625934 |
37844 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$1604963 |
37403 |
0.05% |
股份
|
| PROFUND ADVISORS LLC |
$1590330 |
37062 |
0.05% |
股份
|
| CITADEL ADVISORS LLC |
$1527596 |
35600 |
0.05% |
卖出期权
|
| Legal & General Group Plc |
$1501765 |
34998 |
0.04% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$1409895 |
32857 |
0.04% |
股份
|
| COMERICA BANK |
$1404298 |
27731 |
0.04% |
股份
|
| KVP Capital Advisors, LP |
$1403157 |
32700 |
0.04% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$1363122 |
31767 |
0.04% |
股份
|
| SBI Okasan Asset Management Co.Ltd. |
$1130530 |
26200 |
0.03% |
股份
|
| Knott David M Jr |
$1115660 |
26000 |
0.03% |
股份
|
| SECTORAL ASSET MANAGEMENT INC |
$1097337 |
25573 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$1083177 |
25243 |
0.03% |
股份
|
| Verdad Advisers, LP |
$1007827 |
23487 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$996756 |
23229 |
0.03% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$986501 |
22990 |
0.03% |
股份
|
| Verition Fund Management LLC |
$971568 |
22642 |
0.03% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$908448 |
21171 |
0.03% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$901110 |
21000 |
0.03% |
买入期权
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$865752 |
20176 |
0.03% |
股份
|
| NOMURA HOLDINGS INC |
$862491 |
20100 |
0.03% |
买入期权
|
| NOMURA HOLDINGS INC |
$858200 |
20000 |
0.03% |
卖出期权
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$844640 |
19684 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$808982 |
18853 |
0.02% |
股份
|
| ADAR1 Capital Management, LLC |
$786197 |
18322 |
0.02% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$738095 |
17201 |
0.02% |
股份
|
| JANUS HENDERSON GROUP PLC |
$710293 |
17658 |
0.02% |
股份
|
| Persistent Asset Partners Ltd |
$707372 |
16485 |
0.02% |
股份
|
| TWINBEECH CAPITAL LP |
$695142 |
16200 |
0.02% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$693983 |
16173 |
0.02% |
股份
|
| Perigon Wealth Management, LLC |
$680124 |
15850 |
0.02% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$660428 |
15391 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$636312 |
14829 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$594003 |
13843 |
0.02% |
股份
|
| GC Wealth Management RIA, LLC |
$572977 |
13353 |
0.02% |
股份
|
| Cinctive Capital Management LP |
$532170 |
12402 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$517323 |
12056 |
0.02% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$510629 |
11900 |
0.02% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$506896 |
11813 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$490204 |
11424 |
0.01% |
股份
|
| STRS OHIO |
$480592 |
11200 |
0.01% |
股份
|
| ExodusPoint Capital Management, LP |
$480206 |
11191 |
0.01% |
股份
|
| Quantinno Capital Management LP |
$479519 |
11175 |
0.01% |
股份
|
| JANE STREET GROUP, LLC |
$463428 |
10800 |
0.01% |
卖出期权
|
| Nebula Research & Development LLC |
$462577 |
19634 |
0.01% |
股份
|
| ProShare Advisors LLC |
$460081 |
10722 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$451413 |
10520 |
0.01% |
股份
|
| Allianz Asset Management GmbH |
$450555 |
10500 |
0.01% |
股份
|
| E Fund Management Co., Ltd. |
$444505 |
10359 |
0.01% |
股份
|
| Ishara Investments LP |
$439828 |
10250 |
0.01% |
股份
|
| Jasper Ridge Partners, L.P. |
$435708 |
10154 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$421419 |
9821 |
0.01% |
股份
|
| Creative Planning |
$416785 |
9713 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$416227 |
9700 |
0.01% |
股份
|
| Virtus Investment Advisers, LLC |
$409791 |
9550 |
0.01% |
股份
|
| NINE MASTS CAPITAL Ltd |
$404813 |
9434 |
0.01% |
股份
|
| MML INVESTORS SERVICES, LLC |
$392755 |
9153 |
0.01% |
股份
|
| NEUBERGER BERMAN GROUP LLC |
$337272 |
7860 |
0.01% |
股份
|
| MARSHALL WACE, LLP |
$323156 |
7531 |
0.01% |
股份
|
| EntryPoint Capital, LLC |
$310883 |
7245 |
0.01% |
股份
|
| Corton Capital Inc. |
$306932 |
10562 |
0.01% |
股份
|
| PSP Research LLC |
$300370 |
7000 |
0.01% |
股份
|
| Magnetar Financial LLC |
$299812 |
6987 |
0.01% |
股份
|
| Financiere des Professionnels - Fonds d'investissement inc. |
$298182 |
6949 |
0.01% |
股份
|
| VARCOV Co. |
$283893 |
6616 |
0.01% |
股份
|
| SEI INVESTMENTS CO |
$273119 |
6365 |
0.01% |
股份
|
| XPONANCE LLC |
$269518 |
6281 |
0.01% |
股份
|
| ALLSTATE CORP |
$268745 |
6263 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$248921 |
5801 |
0.01% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$232014 |
5407 |
0.01% |
股份
|
| Fiduciary Trust Co |
$225664 |
5259 |
0.01% |
股份
|
| TEACHER RETIREMENT SYSTEM OF TEXAS |
$214850 |
5007 |
0.01% |
股份
|
| NOMURA HOLDINGS INC |
$214550 |
5000 |
0.01% |
股份
|
| PRINCIPAL FINANCIAL GROUP INC |
$209744 |
4888 |
0.01% |
股份
|
| SIMPLEX TRADING, LLC |
$201977 |
4707 |
0.01% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$172196 |
4012936 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$160000 |
3738 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$147053 |
3427 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$137741 |
3210 |
0.00% |
股份
|
| Sandia Investment Management LP |
$126600 |
2500 |
0.00% |
股份
|
| Bayforest Capital Ltd |
$122465 |
2854 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$116241 |
2709 |
0.00% |
股份
|
| Point72 (DIFC) Ltd |
$108542 |
3735 |
0.00% |
股份
|
| AlphaQuest LLC |
$81277 |
1605 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$64880 |
1512 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$64450 |
1502 |
0.00% |
股份
|
| Quarry LP |
$62650 |
1460 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$50076 |
1167 |
0.00% |
股份
|
| NFSG Corp |
$42910 |
1000 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$41709 |
972 |
0.00% |
股份
|
| Allworth Financial LP |
$39092 |
911 |
0.00% |
股份
|
| Point72 Europe (London) LLP |
$35746 |
1230 |
0.00% |
股份
|
| GAMMA Investing LLC |
$30638 |
714 |
0.00% |
股份
|
| Persistent Asset Partners Ltd |
$28439 |
127 |
0.00% |
卖出期权
|
| HAP Trading, LLC |
$25875 |
45000 |
0.00% |
买入期权
|
| Kemnay Advisory Services Inc. |
$24330 |
567 |
0.00% |
股份
|
| Redwood Park Advisors LLC |
$21455 |
500 |
0.00% |
股份
|
| HUNTINGTON NATIONAL BANK |
$20039 |
467 |
0.00% |
股份
|
| CWM, LLC |
$15086 |
375 |
0.00% |
股份
|
| Graticule Asia Macro Advisors LLC |
$11157 |
260 |
0.00% |
股份
|
| SMA Capital LLC |
$10255 |
239 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$9612 |
224 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$5178 |
120 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$4978 |
116 |
0.00% |
股份
|
| GW&K Investment Management, LLC |
$4837 |
112722 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$4671 |
110 |
0.00% |
股份
|
| US BANCORP \DE\ |
$4205 |
98 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$3261 |
76 |
0.00% |
股份
|
| Arax Advisory Partners |
$2875 |
67 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$2746 |
64 |
0.00% |
股份
|
| Sankala Group LLC |
$1957 |
61 |
0.00% |
股份
|
| Larson Financial Group LLC |
$1931 |
45 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$1889 |
44 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$1088 |
25358 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$944 |
22 |
0.00% |
股份
|
| Handelsbanken Fonder AB |
$797 |
19800 |
0.00% |
股份
|
| LRI Investments, LLC |
$772 |
18 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$678 |
21 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$673 |
28 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$644 |
15 |
0.00% |
股份
|
| Ameritas Advisory Services, LLC |
$300 |
7 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$300 |
7 |
0.00% |
股份
|
| Essential Partners LLC |
$215 |
5 |
0.00% |
股份
|
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO |
$160 |
3718 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$129 |
3 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$129 |
3 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$129 |
3 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$86 |
2 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$86 |
2 |
0.00% |
股份
|
| KBC Group NV |
$55 |
1282 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$53 |
1227 |
0.00% |
股份
|
| GHP Investment Advisors, Inc. |
$41 |
1 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$38 |
896 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
15 |
0.00% |
股份
|