| BlackRock, Inc. |
$219785304 |
13651261 |
15.41% |
股份
|
| PRIMECAP MANAGEMENT CO/CA/ |
$163919285 |
10181322 |
11.49% |
股份
|
| BVF INC/IL |
$114852892 |
7133720 |
8.05% |
股份
|
| VANGUARD GROUP INC |
$109703040 |
7165450 |
7.69% |
股份
|
| RTW INVESTMENTS, LP |
$109117122 |
6777461 |
7.65% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$84915811 |
5274274 |
5.95% |
股份
|
| STATE STREET CORP |
$79759658 |
4954016 |
5.59% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$52788712 |
3278802 |
3.70% |
股份
|
| TCG Crossover Management, LLC |
$39479422 |
2452138 |
2.77% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$35672609 |
2215690 |
2.50% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$30933108 |
1920859 |
2.17% |
股份
|
| MORGAN STANLEY |
$28216158 |
1752556 |
1.98% |
股份
|
| UBS Group AG |
$21029402 |
1306174 |
1.47% |
股份
|
| BAKER BROS. ADVISORS LP |
$17743907 |
1102106 |
1.24% |
股份
|
| Legal & General Group Plc |
$17567950 |
1091177 |
1.23% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$16276007 |
1011119 |
1.14% |
股份
|
| GOLDMAN SACHS GROUP INC |
$15597326 |
968778 |
1.09% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$13744200 |
853677 |
0.96% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$13194192 |
819515 |
0.93% |
股份
|
| NORTHERN TRUST CORP |
$12787893 |
794279 |
0.90% |
股份
|
| JOHNSON & JOHNSON |
$12043798 |
748062 |
0.84% |
股份
|
| Jefferies Financial Group Inc. |
$11599084 |
720440 |
0.81% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$11386596 |
707242 |
0.80% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$10950930 |
680182 |
0.77% |
股份
|
| Deep Track Capital, LP |
$9556171 |
593551 |
0.67% |
股份
|
| TORONTO DOMINION BANK |
$7905100 |
491000 |
0.55% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$7842052 |
487084 |
0.55% |
股份
|
| Seven Fleet Capital Management LP |
$7828524 |
368305 |
0.55% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$7789727 |
483834 |
0.55% |
股份
|
| TWO SIGMA ADVISERS, LP |
$7756046 |
506600 |
0.54% |
股份
|
| Bank of New York Mellon Corp |
$6613381 |
410769 |
0.46% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$5802376 |
360396 |
0.41% |
股份
|
| PRINCIPAL FINANCIAL GROUP INC |
$5767487 |
358229 |
0.40% |
股份
|
| Invesco Ltd. |
$4195854 |
260612 |
0.29% |
股份
|
| Velan Capital Investment Management LP |
$4105500 |
255000 |
0.29% |
股份
|
| Public Sector Pension Investment Board |
$4101330 |
254741 |
0.29% |
股份
|
| ADAR1 Capital Management, LLC |
$3744216 |
232560 |
0.26% |
股份
|
| Hudson Bay Capital Management LP |
$3381000 |
210000 |
0.24% |
股份
|
| BARCLAYS PLC |
$3278265 |
203619 |
0.23% |
股份
|
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
$3220000 |
200000 |
0.23% |
股份
|
| CITADEL ADVISORS LLC |
$3072299 |
190826 |
0.22% |
股份
|
| RHUMBLINE ADVISERS |
$2924017 |
181617 |
0.21% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$2901300 |
180205 |
0.20% |
股份
|
| CITIGROUP INC |
$2691743 |
167189 |
0.19% |
股份
|
| JPMORGAN CHASE & CO |
$2606588 |
167089 |
0.18% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$2569302 |
159584 |
0.18% |
股份
|
| KORNITZER CAPITAL MANAGEMENT INC /KS |
$2437701 |
151410 |
0.17% |
股份
|
| Trexquant Investment LP |
$2327336 |
144555 |
0.16% |
股份
|
| Nuveen, LLC |
$2243857 |
139370 |
0.16% |
股份
|
| Jump Financial, LLC |
$2109100 |
131000 |
0.15% |
股份
|
| HSBC HOLDINGS PLC |
$2083001 |
125482 |
0.15% |
股份
|
| AMERIPRISE FINANCIAL INC |
$2002324 |
124368 |
0.14% |
股份
|
| DEUTSCHE BANK AG\ |
$1929134 |
119822 |
0.14% |
股份
|
| FMR LLC |
$1927898 |
119745 |
0.14% |
股份
|
| OP Asset Management Ltd |
$1771886 |
110055 |
0.12% |
股份
|
| XTX Topco Ltd |
$1728770 |
107377 |
0.12% |
股份
|
| WINTON GROUP Ltd |
$1710577 |
106247 |
0.12% |
股份
|
| DCF Advisers, LLC |
$1670150 |
103736 |
0.12% |
股份
|
| Essex LLC |
$1588442 |
98661 |
0.11% |
股份
|
| Swiss National Bank |
$1481200 |
92000 |
0.10% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$1463384 |
121342 |
0.10% |
股份
|
| Quinn Opportunity Partners LLC |
$1449000 |
90000 |
0.10% |
股份
|
| Erste Asset Management GmbH |
$1438320 |
92200 |
0.10% |
股份
|
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
$1299850 |
80736 |
0.09% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$1209191 |
75105 |
0.08% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$1205407 |
74870 |
0.08% |
股份
|
| ALPS ADVISORS INC |
$1201801 |
74646 |
0.08% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$1179347 |
97790 |
0.08% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$1173964 |
72917 |
0.08% |
股份
|
| Cubist Systematic Strategies, LLC |
$1171859 |
99902 |
0.08% |
股份
|
| Point72 Asset Management, L.P. |
$1152309 |
71572 |
0.08% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$1130880 |
70241 |
0.08% |
股份
|
| TD Asset Management Inc |
$1001001 |
62174 |
0.07% |
股份
|
| WELLS FARGO & COMPANY/MN |
$979476 |
60837 |
0.07% |
股份
|
| Man Group plc |
$939918 |
58380 |
0.07% |
股份
|
| TEMA ETFS LLC |
$925597 |
60457 |
0.06% |
股份
|
| Rafferty Asset Management, LLC |
$868112 |
53920 |
0.06% |
股份
|
| Quantinno Capital Management LP |
$861253 |
53494 |
0.06% |
股份
|
| D. E. Shaw & Co., Inc. |
$812648 |
50475 |
0.06% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$800106 |
49696 |
0.06% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$745881 |
46328 |
0.05% |
股份
|
| Russell Investments Group, Ltd. |
$730631 |
45380 |
0.05% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$714888 |
44403 |
0.05% |
股份
|
| FRANKLIN RESOURCES INC |
$705840 |
43841 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$653885 |
40614 |
0.05% |
股份
|
| Cerity Partners LLC |
$642858 |
39929 |
0.05% |
股份
|
| CIBC Private Wealth Group LLC |
$616564 |
52563 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$611776 |
38193 |
0.04% |
股份
|
| Palumbo Wealth Management LLC |
$604394 |
37540 |
0.04% |
股份
|
| EntryPoint Capital, LLC |
$527307 |
32752 |
0.04% |
股份
|
| Louisiana State Employees Retirement System |
$523250 |
32500 |
0.04% |
股份
|
| Inspire Investing, LLC |
$512898 |
42529 |
0.04% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$505427 |
31393 |
0.04% |
股份
|
| LPL Financial LLC |
$496508 |
30839 |
0.03% |
股份
|
| PROFUND ADVISORS LLC |
$476818 |
29616 |
0.03% |
股份
|
| State of Tennessee, Department of Treasury |
$472745 |
29363 |
0.03% |
股份
|
| Squarepoint Ops LLC |
$458963 |
28507 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$444779 |
27626 |
0.03% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$435940 |
27077 |
0.03% |
股份
|
| HighVista Strategies LLC |
$431834 |
26822 |
0.03% |
股份
|
| Virtus Investment Advisers, LLC |
$427246 |
26537 |
0.03% |
股份
|
| Creative Planning |
$416459 |
25867 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$415203 |
25789 |
0.03% |
股份
|
| BANK OF MONTREAL /CAN/ |
$365727 |
22716 |
0.03% |
股份
|
| DIVERSIFIED TRUST CO |
$362089 |
22490 |
0.03% |
股份
|
| Mitsubishi UFJ Asset Management Co., Ltd. |
$352284 |
21881 |
0.02% |
股份
|
| Rockefeller Capital Management L.P. |
$334076 |
20750 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$333721 |
20728 |
0.02% |
股份
|
| AlphaQuest LLC |
$324450 |
21192 |
0.02% |
股份
|
| CIBC Bancorp USA Inc. |
$304211 |
13895 |
0.02% |
股份
|
| Lynx1 Capital Management LP |
$292923 |
18194 |
0.02% |
股份
|
| JANUS HENDERSON GROUP PLC |
$289391 |
23986 |
0.02% |
股份
|
| Brevan Howard Capital Management LP |
$285163 |
17712 |
0.02% |
股份
|
| Mariner, LLC |
$284609 |
17681 |
0.02% |
股份
|
| IEQ CAPITAL, LLC |
$284036 |
17642 |
0.02% |
股份
|
| YOUSIF CAPITAL MANAGEMENT, LLC |
$280494 |
17422 |
0.02% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$276132 |
17151 |
0.02% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$270818 |
16821 |
0.02% |
股份
|
| OREGON PUBLIC EMPLOYEES RETIREMENT FUND |
$270673 |
16812 |
0.02% |
股份
|
| FIFTH THIRD BANCORP |
$270641 |
16810 |
0.02% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$266922 |
16579 |
0.02% |
股份
|
| AXQ CAPITAL, LP |
$261062 |
16215 |
0.02% |
股份
|
| COMERICA BANK |
$260499 |
17015 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$258261 |
16041 |
0.02% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$251647 |
28147 |
0.02% |
股份
|
| Vanguard Investments Australia, Ltd. |
$239327 |
14865 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$238618 |
14821 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$218574 |
13576 |
0.02% |
股份
|
| EP Wealth Advisors, LLC |
$218429 |
13567 |
0.02% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$207835 |
12909 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$207690 |
12900 |
0.01% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$203633 |
12648 |
0.01% |
股份
|
| Aigen Investment Management, LP |
$199930 |
12418 |
0.01% |
股份
|
| ProShare Advisors LLC |
$199866 |
12414 |
0.01% |
股份
|
| NorthCrest Asset Manangement, LLC |
$194476 |
12068 |
0.01% |
股份
|
| China Universal Asset Management Co., Ltd. |
$189980 |
11800 |
0.01% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$177470 |
11023 |
0.01% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$177293 |
11012 |
0.01% |
股份
|
| Maryland State Retirement & Pension System |
$173703 |
10789 |
0.01% |
股份
|
| Pictet Asset Management Holding SA |
$172914 |
10740 |
0.01% |
股份
|
| ALLSTATE CORP |
$169131 |
10505 |
0.01% |
股份
|
| Skopos Labs, Inc. |
$168105 |
13939 |
0.01% |
股份
|
| Jain Global LLC |
$161612 |
10038 |
0.01% |
股份
|
| Arax Advisory Partners |
$122812 |
7628 |
0.01% |
股份
|
| CWM, LLC |
$120757 |
10013 |
0.01% |
股份
|
| Corton Capital Inc. |
$117910 |
10052 |
0.01% |
股份
|
| Ensign Peak Advisors, Inc |
$113940 |
7077 |
0.01% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$111911 |
6951 |
0.01% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$96147 |
8197 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$94749 |
5885 |
0.01% |
股份
|
| PNC Financial Services Group, Inc. |
$90240 |
5605 |
0.01% |
股份
|
| Versant Capital Management, Inc |
$77694 |
3114 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$75000 |
4679 |
0.01% |
股份
|
| Pinnacle Wealth Planning Services, Inc. |
$71339 |
4431 |
0.01% |
股份
|
| GAMMA Investing LLC |
$59522 |
3697 |
0.00% |
股份
|
| Allworth Financial LP |
$55320 |
3436 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$53388 |
3316 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$48413 |
3007 |
0.00% |
股份
|
| US BANCORP \DE\ |
$39155 |
2432 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$37939 |
2356409 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$25003 |
1553 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$22588 |
1403 |
0.00% |
股份
|
| Amova Asset Management Americas, Inc. |
$19030 |
1182 |
0.00% |
股份
|
| State of Wyoming |
$17533 |
1089 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$15698 |
998 |
0.00% |
股份
|
| Point72 (DIFC) Ltd |
$14388 |
1227 |
0.00% |
股份
|
| Salomon & Ludwin, LLC |
$12596 |
819 |
0.00% |
股份
|
| SUMMIT SECURITIES GROUP LLC |
$9145 |
568 |
0.00% |
股份
|
| UMB Bank, n.a. |
$8662 |
538 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$7857 |
488 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$7145 |
458 |
0.00% |
股份
|
| GHP Investment Advisors, Inc. |
$5645 |
468 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$5249 |
326 |
0.00% |
股份
|
| HUNTINGTON NATIONAL BANK |
$5184 |
322 |
0.00% |
股份
|
| HighMark Wealth Management LLC |
$4830 |
300 |
0.00% |
股份
|
| Boreal Capital Management LLC |
$4025 |
250 |
0.00% |
股份
|
| Blue Trust, Inc. |
$3574 |
222 |
0.00% |
股份
|
| Private Wealth Management Group, LLC |
$2271 |
141 |
0.00% |
股份
|
| True Wealth Design, LLC |
$2077 |
129 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$1868 |
116 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$1852 |
115 |
0.00% |
股份
|
| Quarry LP |
$1787 |
111 |
0.00% |
股份
|
| Essential Partners LLC |
$1771 |
110 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$1610 |
100 |
0.00% |
股份
|
| Cedar Mountain Advisors, LLC |
$1417 |
88 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$1201 |
74615 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$1191 |
74 |
0.00% |
股份
|
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM |
$1135 |
70526 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$1098 |
68168 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$1092 |
67854 |
0.00% |
股份
|
| Thrivent Financial for Lutherans |
$961 |
59716 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$935 |
58 |
0.00% |
股份
|
| CANADA LIFE ASSURANCE Co |
$921 |
57164 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$886 |
55 |
0.00% |
股份
|
| FARMERS & MERCHANTS INVESTMENTS INC |
$741 |
46 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$596 |
37 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$556 |
34520 |
0.00% |
股份
|
| Ankerstar Wealth, LLC |
$547 |
34 |
0.00% |
股份
|
| State of Alaska, Department of Revenue |
$393 |
24417 |
0.00% |
股份
|
| NATIXIS ADVISORS, LLC |
$390 |
24266 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$362 |
34 |
0.00% |
股份
|
| ASSETMARK, INC |
$322 |
20 |
0.00% |
股份
|
| AMALGAMATED BANK |
$310 |
19270 |
0.00% |
股份
|
| Plante Moran Financial Advisors, LLC |
$290 |
18 |
0.00% |
股份
|
| IFP Advisors, Inc |
$290 |
18 |
0.00% |
股份
|
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
$281 |
17496 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$258 |
16 |
0.00% |
股份
|
| GILPIN WEALTH MANAGEMENT, LLC |
$194 |
12 |
0.00% |
股份
|
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO |
$149 |
9276 |
0.00% |
股份
|
| JPL Wealth Management, LLC |
$113 |
7 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$113 |
7 |
0.00% |
股份
|
| Abound Wealth Management |
$73 |
6 |
0.00% |
股份
|
| Davis Capital Management |
$64 |
4 |
0.00% |
股份
|
| HANTZ FINANCIAL SERVICES, INC. |
$49 |
3036 |
0.00% |
股份
|
| Wealth Enhancement Trust Services, Inc. |
$32 |
2 |
0.00% |
股份
|
| BESSEMER GROUP INC |
$25 |
1509 |
0.00% |
股份
|
| SHELL ASSET MANAGEMENT CO |
$17 |
1424 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$16 |
1 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$16 |
1 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$15 |
901 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
21 |
0.00% |
股份
|