ATYR aTyr Pharma, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$0.53
Price · Aug 19, 2026
Fundamentals as of Aug 7, 2026

About aTyr Pharma, Inc. - Common Stock Company overview from Wikipedia

aTyr Pharma is a public biotherapeutics company that is focused on researching the extracellular functionality and signaling pathways of tRNA synthetases.

Read more

aTyr Pharma is a public biotherapeutics company (Nasdaq: LIFE) that is focused on researching the extracellular functionality and signaling pathways of tRNA synthetases.

The company's lead product candidate, ATYR1923, is a selective modulator of Neuropilin-2 (NRP2) that downregulates both the innate and adaptive immune responses in inflammatory disease states. aTyr is developing ATYR1923 as a potential disease-modifying therapy for patients with interstitial lung disease (ILD), a group of rare immune-mediated disorders that cause progressive fibrosis of the lung interstitium and remain a high unmet medical need. ATYR1923 is currently being investigated in a clinical trial in pulmonary sarcoidosis patients.

The company was founded in 2005 and is headquartered in San Diego, California, and led by CEO Sanjay S. Shukla.

History

In 2005, aTyr was founded by Paul Schimmel, and Xiang-Lei Yang, two aminoacyl tRNA synthetase scientists at The Scripps Research Institute. In 2009, Bruce Beutler, recipient of the 2011 Nobel Prize in Physiology or Medicine, joined aTyr as a member of the scientific advisory board.

In April 2007, Polaris Partners and Alta Partners co-led a $10.5 million Series B financing. In October 2010, Series C financing totaled $23 million and was led by Domain Associates. This round was followed by a $49 million Series D in August 2013.

aTyr was a winner of the 2011 Red Herring 100 North America Award for discovering and developing innovative medicines based on Physiocrine biology.

In April 2015, aTyr raised $76 million in a Series E, led by Sofinnova Ventures, and filed for an IPO. The company began trading as LIFE on the Nasdaq stock exchange.

ATyr's primary focus is on ATYR1923, a clinical stage product candidate which binds to the NRP2 receptor and is designed to down regulate immune engagement in interstitial lung diseases (ILDs). ATYR1923 is currently being investigated in a clinical trial in patients with pulmonary sarcoidosis. In January 2020, ATyr entered into a license with Kyorin Pharmaceutical Co., Ltd. for the development and commercialization of ATYR1923 for ILDs in Japan. Under the license agreement, Kyorin received an exclusive right to develop and commercialize ATYR1923 in Japan for all forms of ILDs including, sarcoidosis, chronic hypersensitivity pneumonitis (CHP) and connective tissue disease ILD (CTD-ILD). aTyr recently initiated a clinical trial for ATYR1923 in patients with severe respiratory complications related to COVID-19.

Therapeutic concept

Homeostasis, or the coordinated regulation of tissues within the body, is fundamental to the maintenance of the overall health of an organism. Lack of homeostasis can lead to disease and death. The process of homeostasis was first described in 1865 by the French physiologist Claude Bernard and Walter Cannon later coined the term. In the 150 years since this discovery, many proteins associated with homeostatic pathways have been discovered, ranging from insulin to erythropoietin.

aTyr was founded after Dr. Schimmel discovered several nontranslational functions of aminoacyl tRNA synthetases, which are primarily responsible for the production of a vital component of protein synthesis, aminoacyl-tRNAs. [23] These nontranslational functions have since been shown to play an important role in maintaining homeostasis. [23] One of these nontranslational functions is modulation and regulation of the immune response. [23] This modulatory activity is a result of Physiocrines, a novel class of proteins that are present as biologically active signaling regions of the tRNA synthetases. aTyr's research is based on the premise that Physiocrines are involved in orchestrating homeostatic activities to help the body restore diseased or damaged tissue to a healthier state.

By researching and understanding the role of Physiocrines in immune modulation, aTyr has developed two IND candidates.

== References ==

Source: Wikipedia, CC BY-SA 4.0 · View on Wikipedia ↗

Wikidata ↗

ATYR Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$0.53
Market Cap
$52M
P/E (TTM)
-0.7
EPS (TTM)
$-0.80
Revenue (TTM)
$190.0K
Div Yield
ROE
-107.8%
Debt/Equity
52W Range
$0 – $7

ATYR Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $190.0K
7-point trend, -55.0%
2019-12-31 2025-12-31
EPS $-0.80
6-point trend, +54.8%
2020-12-31 2025-12-31
Free Cash Flow $-62M
10-point trend, -16.1%
2016-12-31 2025-12-31
Margins -39009.5%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
ATYR
Peer Median
P/E (TTM)
5-point trend, +76.8%
-0.7
P/S (TTM)
5-point trend, +9779.2%
272.2
165.8
P/B
5-point trend, -40.1%
0.8
1.6
Price / FCF
5-point trend, +80.2%
-0.8

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
ATYR
Peer Median
Operating Margin
5-point trend, -26745.6%
-40856.3%
Net Profit Margin
5-point trend, -25038.2%
-39009.5%
-2229.6%
ROA
5-point trend, -78.4%
-78.1%
-64.3%
ROE
5-point trend, -125.0%
-107.8%
-102.1%
ROIC
5-point trend, -269.7%
-115.0%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
ATYR
Peer Median
Current Ratio
5-point trend, -72.0%
5.3
4.8
Quick Ratio
5-point trend, +82.5%
0.7

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
ATYR
Peer Median
Revenue YoY
5-point trend, +190000.00
-19.1%
Revenue CAGR 3Y
5-point trend, +190000.00
-73.7%
Revenue CAGR 5Y
5-point trend, +190000.00
-55.1%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
ATYR
Peer Median
EPS (Diluted)
5-point trend, +54.8%
$-0.80

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
ATYR
Peer Median

ATYR Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 15 analysts
  • Strong Buy 3 20.0%
  • Buy 6 40.0%
  • Hold 6 40.0%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

7 analysts · 2026-08-13
Median target $3.00 +468.7%
Mean target $2.86 +441.6%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.01%
Period EPS Actual EPS Est Surprise
June 30, 2026 $-0.11 $-0.12 0.01%
March 31, 2026 $-0.11 $-0.14 0.03%
Dec. 31, 2025 $-0.14 $-0.19 0.05%
Sept. 30, 2025 $-0.26 $-0.19 -0.07%
June 30, 2025 $-0.22 $-0.19 -0.03%
March 31, 2025 $-0.17 $-0.19 0.02%
Dec. 31, 2024 $-0.18 $-0.23 0.05%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
ATYR $77M -1.0 -19.1% -39009.5% -107.8%
TCRX -1.0 266.7% -1256.8% -86.6%
APLM
TIL $75M -1.0 -58.1%
MGX $61M -0.7 -51.8% -348.5% -49.6%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 14
Annual Income Statement data for ATYR
Metric Trend 2025202420232022202120202019
Revenue 7-point trend, -55.0% $190.0K $235.0K $353.0K $10M $0 $10M $422.0K
R&D Expense 7-point trend, +328.7% $60M $54M $42M $43M $23M $17M $14M
SG&A Expense 7-point trend, +88.2% $18M $14M $13M $14M $11M $9M $9M
Operating Expenses 7-point trend, +232.6% $78M $68M $55M $57M $34M $26M $23M
Operating Income 7-point trend, -237.8% $-78M $-68M $-55M $-46M $-34M $-16M $-23M
Other Non-op 7-point trend, +546.4% $4M $4M $5M $1M $238.0K $-319.0K $-785.0K
Pretax Income 7-point trend, -211.9% $-74M $-64M $-50M $-45M $-34M $-16M $-24M
Income Tax Flat — no change across 7 periods $0 $0 $0 $0 $0 $0 $0
Net Income 7-point trend, -356.8% $-74M $-64M $-50M $-45M $-34M $-16M $-16M
EPS (Basic) 6-point trend, +54.8% $-0.80 $-0.86 $-0.94 $-1.60 $-1.77 $-1.77 ·
EPS (Diluted) 6-point trend, +54.8% $-0.80 $-0.86 $-0.94 $-1.60 $-1.77 $-1.77 ·
Shares (Basic) 6-point trend, +915.1% 92,985,359 74,261,265 53,606,488 28,419,569 19,080,878 9,160,269 ·
Shares (Diluted) 6-point trend, +915.1% 92,985,359 74,261,265 53,606,488 28,419,569 19,080,878 9,160,269 ·
EBITDA 7-point trend, -244.5% $-77M $-67M $-54M $-46M $-34M $-15M $-22M
Balance Sheet 20
Annual Balance Sheet data for ATYR
Metric Trend 2025202420232022202120202019
Cash & Equivalents 7-point trend, +16.6% $11M $11M $23M $10M $2M $17M $9M
Prepaid Expense 7-point trend, -0.6% $677.0K $8M $2M $3M $5M $2M $681.0K
Current Assets 7-point trend, +151.3% $80M $82M $103M $81M $114M $36M $32M
PP&E (Net) 7-point trend, +235.7% $4M $5M $6M $3M $543.0K $899.0K $1M
PP&E (Gross) 7-point trend, +21.5% $9M $9M $10M $9M $7M $8M $7M
Accum. Depreciation 7-point trend, -22.3% $5M $5M $5M $6M $6M $7M $6M
Other Non-current Assets 7-point trend, -14.0% $148.0K $66.0K $131.0K $193.0K $158.0K $213.0K $172.0K
Total Assets 7-point trend, +157.0% $93M $97M $121M $96M $116M $39M $36M
Accounts Payable 7-point trend, +359.4% $4M $4M $4M $3M $1M $1M $847.0K
Accrued Liabilities 7-point trend, +312.1% $10M $9M $12M $10M $4M $4M $2M
Current Liabilities 7-point trend, +17.2% $15M $15M $16M $14M $6M $6M $13M
Capital Leases 7-point trend, +360.4% $10M $11M $12M $10M $398.0K $1M $2M
Total Debt · · · · · · $9M
Common Stock 7-point trend, +2350.0% $98.0K $84.0K $63.0K $29.0K $28.0K $11.0K $4.0K
Paid-in Capital 7-point trend, +96.1% $674M $602M $559M $490M $482M $370M $344M
Retained Earnings 7-point trend, -88.1% $-606M $-532M $-468M $-418M $-372M $-339M $-322M
AOCI 7-point trend, +80.0% $-8.0K $-40.0K $-74.0K $-433.0K $-263.0K $-43.0K $-40.0K
Stockholders' Equity 7-point trend, +218.5% $67M $70M $91M $71M $109M $32M $21M
Liabilities + Equity 7-point trend, +157.0% $93M $97M $121M $96M $116M $39M $36M
Shares Outstanding 7-point trend, +2418.9% 98,031,014 84,038,922 63,286,404 29,498,488 27,793,035 11,018,954 3,891,787
Cash Flow 8
Annual Cash Flow data for ATYR
Metric Trend 2025202420232022202120202019
D&A 7-point trend, +4.6% $664.0K $708.0K $592.0K $232.0K $475.0K $569.0K $635.0K
Other Non-cash 7-point trend, +288.1% $11M $-6M $17M $3M $218.0K $354.0K $3M
Operating Cash Flow 7-point trend, -209.7% $-62M $-69M $-33M $-42M $-33M $-15M $-20M
CapEx 7-point trend, -2.5% $77.0K $65.0K $4M $2M $192.0K $202.0K $79.0K
Investing Cash Flow 7-point trend, -202.6% $-5M $17M $-20M $47M $-92M $7M $5M
Financing Cash Flow 7-point trend, +4840.9% $66M $40M $66M $5M $110M $16M $1M
Net Change in Cash 7-point trend, +92.5% $-1M $-12M $13M $11M $-15M $8M $-14M
Free Cash Flow 7-point trend, -208.9% $-62M $-69M $-37M $-44M $-33M $-16M $-20M
Profitability 7
Annual Profitability data for ATYR
Metric Trend 2025202420232022202120202019
Operating Margin 6-point trend, -650.3% -40856.3% -28899.6% -15557.8% -446.8% · -152.2% -5445.0%
Net Margin 6-point trend, -597.5% -39009.5% -27243.8% -14274.5% -436.5% · -155.2% -5593.1%
Pretax Margin 6-point trend, -592.8% -39012.1% -27243.4% -14276.2% -436.6% · -155.2% -5631.0%
EBITDA Margin 6-point trend, -665.1% -40506.8% -28598.3% -15390.1% -444.6% · -146.7% -5294.6%
ROA 7-point trend, -47.1% -78.1% -58.9% -46.6% -42.9% -43.8% -43.3% -53.1%
ROE 7-point trend, -9.4% -107.8% -79.7% -62.2% -50.2% -47.9% -61.4% -98.5%
ROIC 6-point trend, -128.8% -115.0% -97.0% -60.6% -64.9% -31.1% -50.3% ·
Liquidity & Solvency 3
Annual Liquidity & Solvency data for ATYR
Metric Trend 2025202420232022202120202019
Current Ratio 7-point trend, +114.4% 5.3 5.5 6.3 5.8 18.9 6.1 2.5
Quick Ratio 7-point trend, -0.5% 0.7 0.7 1.4 0.7 0.4 2.9 0.7
Debt / Equity · · · · · · 0.4
Efficiency 1
Annual Efficiency data for ATYR
Metric Trend 2025202420232022202120202019
Asset Turnover 6-point trend, -78.9% 0.0 0.0 0.0 0.1 · 0.3 0.0
Per Share 5
Annual Per Share data for ATYR
Metric Trend 2025202420232022202120202019
Book Value / Share 7-point trend, -87.4% $0.69 $0.83 $1.43 $2.42 $3.93 $2.87 $5.44
Revenue / Share 4-point trend, -99.5% $0.00 $0.00 $0.01 $0.37 · · ·
Cash Flow / Share 4-point trend, +54.8% $-0.67 $-0.93 $-0.62 $-1.47 · · ·
Cash / Share 7-point trend, -95.4% $0.11 $0.13 $0.36 $0.34 $0.08 $1.54 $2.37
EPS (TTM) 6-point trend, +54.8% $-0.80 $-0.86 $-0.94 $-1.60 $-1.77 $-1.77 ·
Growth Rates 3
Annual Growth Rates data for ATYR
Metric Trend 2025202420232022202120202019
Revenue YoY 3-point trend, +80.2% -19.1% -33.4% -96.6% · · · ·
Revenue CAGR 3Y 2-point trend, -8.8% -73.7% · -67.7% · · · ·
Revenue CAGR 5Y -55.1% · · · · · ·
Valuation (TTM) 14
Annual Valuation (TTM) data for ATYR
Metric Trend 2025202420232022202120202019
Revenue TTM 7-point trend, -55.0% $190.0K $235.0K $353.0K $10M $0 $10M $422.0K
Net Income TTM 7-point trend, -356.8% $-74M $-64M $-50M $-45M $-34M $-16M $-16M
Market Cap 7-point trend, +373.0% $77M $304M $89M $65M $208M $43M $16M
Enterprise Value · · · · · · $16M
P/E 6-point trend, +55.3% -1.0 -4.2 -1.5 -1.4 -4.2 -2.2 ·
P/S 6-point trend, +950.5% 404.0 1294.6 252.8 6.2 · 4.1 38.5
P/B 7-point trend, +48.5% 1.1 4.3 1.0 0.9 1.9 1.4 0.8
P / Tangible Book 6-point trend, -15.8% 1.1 4.3 1.0 0.9 1.9 1.4 ·
P / Cash Flow 7-point trend, -52.7% -1.2 -4.4 -2.7 -1.5 -6.3 -2.8 -0.8
P / FCF 7-point trend, -53.1% -1.2 -4.4 -2.4 -1.5 -6.2 -2.8 -0.8
EV / EBITDA · · · · · · -0.7
EV / FCF · · · · · · -0.8
EV / Revenue · · · · · · 37.3
Earnings Yield 6-point trend, -124.0% -102.2% -23.8% -66.7% -73.1% -23.7% -45.6% ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $190.0K$235.0K$353.0K$10M$0
Operating Margin % -40856.3%-28899.6%-15557.8%-446.8%
Net Income $-74M$-64M$-50M$-45M$-34M
Diluted EPS $-0.80$-0.86$-0.94$-1.60$-1.77
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio 5.35.56.35.818.9
Quick Ratio 0.70.71.40.70.4
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-62M$-69M$-37M$-44M$-33M

My Metrics Your personal watchlist — selected rows from Full Fundamentals

📊

Pick the metrics that matter to you — click the ➕ next to any row in Full Fundamentals above.

Your selection is saved and follows you across all tickers.

Institutional owners (13F) 110 filers · $19.3M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
21 (-14 vs prior Q) 32 (+24 vs prior Q) 33 (+9 vs prior Q) 29 (-7 vs prior Q) -3.0M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
FEDERATED HERMES, INC. $5,078,576 8,509,678 26.25% Shares
VANGUARD CAPITAL MANAGEMENT LLC $2,273,430 3,808,091 11.75% Shares
AQR CAPITAL MANAGEMENT LLC $1,546,546 2,591,397 7.99% Shares
FMR LLC $1,474,942 2,471,418 7.62% Shares
Kalehua Capital Management LLC $1,067,178 1,788,167 5.52% Shares
UBS Group AG $794,476 1,330,780 4.11% Shares
TWO SIGMA INVESTMENTS, LP $743,104 1,245,147 3.84% Shares
TWO SIGMA ADVISERS, LP $658,861 841,350 3.41% Shares
GEODE CAPITAL MANAGEMENT, LLC $574,771 962,604 2.97% Shares
VANGUARD GROUP INC $508,386 649,280 2.63% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $445,833 747,039 2.30% Shares
MILLENNIUM MANAGEMENT LLC $391,531 656,051 2.02% Shares
JANE STREET GROUP, LLC $368,177 616,918 1.90% Shares
VANGUARD FIDUCIARY TRUST CO $343,947 576,125 1.78% Shares
STATE STREET CORP $295,387 494,951 1.53% Shares
H D Vest Advisory Services $292,382 57,669 1.51% Shares
GOLDMAN SACHS GROUP INC $226,657 379,788 1.17% Shares
WOLVERINE TRADING, LLC $163,096 205,100 0.84% Call option
CITADEL ADVISORS LLC $148,603 249,000 0.77% Call option
XTX Topco Ltd $135,281 226,678 0.70% Shares
NORTHERN TRUST CORP $131,380 220,141 0.68% Shares
WOLVERINE TRADING, LLC $110,453 138,900 0.57% Put option
BANK OF AMERICA CORP /DE/ $108,971 182,838 0.56% Shares
JANE STREET GROUP, LLC $106,588 178,600 0.55% Call option
RENAISSANCE TECHNOLOGIES LLC $98,604 165,222 0.51% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $92,880 154,800 0.48% Call option
JPMORGAN CHASE & CO $83,679 147,739 0.43% Shares
GROUP ONE TRADING LLC $82,882 138,878 0.43% Shares
Qube Research & Technologies Ltd $75,791 126,996 0.39% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $69,900 116,500 0.36% Put option
WOLVERINE TRADING, LLC $42,961 54,026 0.22% Shares
HSBC HOLDINGS PLC $38,361 66,185 0.20% Shares
BlackRock, Inc. $35,972 60,274 0.19% Shares
Mariner, LLC $34,998 58,658 0.18% Shares
CITADEL ADVISORS LLC $34,137 57,200 0.18% Put option
HOHIMER WEALTH MANAGEMENT, LLC $32,824 55,000 0.17% Shares
MERCER GLOBAL ADVISORS INC /ADV $31,947 53,531 0.17% Shares
KINGSWOOD WEALTH ADVISORS, LLC $31,034 52,000 0.16% Shares
Schonfeld Strategic Advisors LLC $30,364 50,880 0.16% Shares
ADAR1 Capital Management, LLC $30,249 50,685 0.16% Shares
Alpha Wealth Funds, LLC $29,890 50,000 0.15% Shares
CWM, LLC $28,088 36,010 0.15% Shares
Creative Planning $24,823 41,593 0.13% Shares
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC $23,925 43,948 0.12% Shares
Point72 Asset Management, L.P. $22,248 37,278 0.11% Shares
Hobbs Group Advisors, LLC $21,480 35,992 0.11% Shares
LPL Financial LLC $21,216 35,549 0.11% Shares
CITADEL ADVISORS LLC $20,884 34,994 0.11% Shares
CAPTRUST FINANCIAL ADVISORS $20,259 33,946 0.10% Shares
Vanguard Global Advisers, LLC $19,948 33,414 0.10% Shares
RHUMBLINE ADVISERS $18,155 30,412 0.09% Shares
Rockefeller Capital Management L.P. $16,781 28,118 0.09% Shares
DIMENSIONAL FUND ADVISORS LP $16,657 27,911 0.09% Shares
BNP PARIBAS FINANCIAL MARKETS $14,953 25,055 0.08% Shares
BARCLAYS PLC $14,382 24,099 0.07% Shares
Balyasny Asset Management L.P. $13,735 23,015 0.07% Shares
Y-Intercept (Hong Kong) Ltd $13,352 22,373 0.07% Shares
Abel Hall, LLC $13,199 22,117 0.07% Shares
Steward Partners Investment Advisory, LLC $11,697 19,600 0.06% Shares
Tower Research Capital LLC (TRC) $10,893 18,252 0.06% Shares
MAI Capital Management $10,054 16,846 0.05% Shares
TRUST CO OF TOLEDO NA /OH/ $9,931 16,640 0.05% Shares
Arax Advisory Partners $9,882 16,557 0.05% Shares
JANE STREET GROUP, LLC $8,952 15,000 0.05% Put option
Vanguard Personalized Indexing Management, LLC $8,892 14,899 0.05% Shares
RAYMOND JAMES FINANCIAL INC $7,861 13,172 0.04% Shares
Cerity Partners LLC $7,624 12,775 0.04% Shares
DIADEMA PARTNERS LP $7,460 12,500 0.04% Put option
TORONTO DOMINION BANK $7,281 12,200 0.04% Call option
BRIGHTON JONES LLC $6,839 11,458 0.04% Shares
Gladstone Institutional Advisory LLC $6,744 11,300 0.03% Shares
My Portfolio Guide, LLC $5,460 7,000 0.03% Shares
MARSHALL WACE, LLP $5,339 8,899 0.03% Shares
Persistent Asset Partners Ltd $5,213 27 0.03% Put option
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $4,048 5,190 0.02% Shares
Integrated Wealth Concepts LLC $3,577 5,995 0.02% Shares
WELLS FARGO & COMPANY/MN $2,984 5,000 0.02% Shares
MORGAN STANLEY $2,461 4,123 0.01% Shares
Allworth Financial LP $2,158 3,615 0.01% Shares
GSA CAPITAL PARTNERS LLP $2,062 3,454,863 0.01% Shares
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC $1,569 2,011 0.01% Shares
Ares Financial Consulting, LLC $1,194 2,000 0.01% Shares
NFSG Corp $1,181 1,979 0.01% Shares
Vision Retirement, LLC $895 1,500 0.00% Shares
MCF Advisors LLC $836 1,400 0.00% Shares
JONES FINANCIAL COMPANIES LLLP $791 1,500 0.00% Shares
PNC Financial Services Group, Inc. $762 1,276 0.00% Shares
CITIGROUP INC $537 900 0.00% Shares
ROTHSCHILD INVESTMENT LLC $528 885 0.00% Shares
Clearstead Advisors, LLC $515 861 0.00% Shares
Essential Partners LLC $486 815 0.00% Shares
GAMMA Investing LLC $393 659 0.00% Shares
True Wealth Design, LLC $277 464 0.00% Shares
Farther Finance Advisors, LLC $222 372 0.00% Shares
SJS Investment Consulting Inc. $125 208 0.00% Shares
Larson Financial Group LLC $90 150 0.00% Shares
EverSource Wealth Advisors, LLC $88 148 0.00% Shares
IFP Advisors, Inc $85 143 0.00% Shares
HRT FINANCIAL LP $75 126,681 0.00% Shares
CALDWELL SUTTER CAPITAL, INC. $31 52 0.00% Shares

Company insiders 33 insiders · 17 officers · 11 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Sanjay Shukla President and CEO Feb. 3, 2026 M 153,553 0 1 $-3,670
Jill Marie Broadfoot Chief Financial Officer Feb. 3, 2026 M 37,296 0 1 $-1,527
Stan Blackburn Acting Chief Financial Officer Jan. 27, 2016 A 0 0 $0
Frederic Chereau President & COO May 6, 2015 A 0 0 $0
Nancy Krueger General Counsel Feb. 3, 2026 M 33,124 0 1 $-1,096
Ashraf Amanullah Senior Vice President, Biologics Development and Manufacturing May 31, 2018 M 26,264 0 0 $0
John T Blake Senior Vice President, Finance Feb. 7, 2018 M 1,932 0 0 $0
David John King Chief Scientific Officer Feb. 6, 2018 A 0 0 $0
Sanuj K. Ravindran Chief Business Officer Feb. 7, 2017 A 0 0 $0
Andrew Cubitt VP, Product Protection Sept. 13, 2016 A 0 0 $0
Kelly Blackburn VP, Clinical Affairs March 28, 2016 A 0 0 $0
Melissa A. Ashlock SVP, Translational Medicine and Therapeutics Jan. 27, 2016 A 0 0 $0
John C. Mckew VP, Research Jan. 27, 2016 A 0 0 $0
Holly D. Chrzanowski VP, Enterprise Talent & Organization Jan. 27, 2016 A 0 0 $0
Marcy Graham VP, Investor Relations and Corporate Communications Jan. 4, 2016 A 0 0 $0
Fred Ramsdell VP, Immunology Oct. 1, 2015 A 0 0 $0
David M. Weiner Chief Medical Officer May 6, 2015 A 0 0 $0
Svetlana Lucas Director May 1, 2025 A 6,000 0 0 $0
Jane A Gross Director May 1, 2025 A 9,750 0 0 $0
Eric Benevich Director May 1, 2025 A 0 0 $0
Sara Zaknoen Director May 1, 2025 A 6,000 0 0 $0
John K Clarke Director May 22, 2024 A 19,797 0 0 $0
Jeffrey S. Hatfield Director May 6, 2020 A 0 0 $0
John Mendlein Director May 8, 2019 A 615,382 0 0 $0
BLAIR JAMES C Director May 8, 2019 A 0 0 $0
Amir Nashat Director May 15, 2018 A 17,638 0 0 $0
Kathryn E Falberg Director May 24, 2016 A 0 0 $0
EcoR1 Capital Fund Qualified, L.P. 10% owner May 16, 2018 S 0 0 0 $0
Timothy Coughlin May 11, 2026 A 56,000 0 0 $0
SCHIMMEL PAUL May 11, 2026 A 1,413,023 2 0 $912,720
Mark Alan Goldberg May 9, 2017 A 0 0 $0
Srinivas Akkaraju May 9, 2017 A 1,866,126 0 0 $0
Grove Matsuoka Feb. 7, 2017 A 12,412 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 3 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
PAUL SCHIMMEL, PAUL SCHIMMEL PROTOTYPE PSP, PAUL SCHIMMEL, TRUSTEE, FBO PAUL SCHIMMEL ×3 filings Feb. 14, 2020 Initial filing SEC
Polaris Venture Partners V, L.P. (“PVP V”), Polaris Venture Partners Entrepreneurs’ Fund V, L.P. (“PVPE V”), Polaris Venture Partners Founders’ Fund V, L.P. (“PVPFF V”), Polaris Venture Partners Special Founders’ Fund V, L.P. (“PVPSFF V”), Polaris Venture Management Co. V, L.L.C. (“PVM V”), Jonathan A. Flint, Terrance G. McGuire, Amir Nashat ×2 filings July 17, 2019 Initial filing SEC
Sofinnova Venture Partners IX, L.P. (“SVP IX”), Sofinnova Management IX, L.L.C. (“SM IX”), Dr. Michael F. Powell (“Powell”), Dr. James I. Healy (“Healy”), Dr. Anand Mehra (“Mehra”) ×3 filings Feb. 12, 2019 Initial filing Passive investment SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 8 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
ITWO · ProShares Trust 0.00% 4,514 NS May 31, 2026 N-PORT
UWM · ProShares Trust 0.00% 3,530 NS May 31, 2026 N-PORT
URTY · ProShares Trust 0.00% 3,569 NS May 31, 2026 N-PORT
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.00% 4,536 NS May 31, 2026 N-PORT
HDG · ProShares Trust 0.00% 90 NS May 31, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.00% 1,054,556 SH Aug. 8, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 2,650,788 SH Aug. 8, 2026 Daily
DFAC · Dimensional ETF Trust 0.00% 3,126 NS April 30, 2026 N-PORT