About Bicycle Therapeutics plc - American Depositary Shares Company overview from Wikipedia

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BCYC Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price

$4.13

Market Cap

$288M

P/E (TTM)

-1.3

EPS (TTM)

$-3.16

Revenue (TTM)

$73M

Div Yield

—

ROE

-34.2%

Debt/Equity

—

52W Range

$4 – $9

BCYC Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $73M

2017-12-31 → 2025-12-31

EPS $-3.16

2019-12-31 → 2025-12-31

Free Cash Flow $-252M

2019-12-31 → 2025-12-31

Margins -301.7%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric

5Y trend

BCYC

Peer Median

P/E (TTM)

-1.3

—

P/S (TTM)

4.0

5.1

P/B

0.5

4.5

Price / FCF

-1.1

—

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric

5Y trend

BCYC

Peer Median

Operating Margin

-340.4%

—

Net Profit Margin

-301.7%

-328.5%

ROA

-26.2%

-37.9%

ROE

-34.2%

-82.2%

ROIC

-40.5%

—

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric

5Y trend

BCYC

Peer Median

Current Ratio

12.0

5.0

Quick Ratio

11.0

—

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric

5Y trend

BCYC

Peer Median

Revenue YoY

105.8%

—

Revenue CAGR 3Y

71.2%

—

Revenue CAGR 5Y

47.5%

—

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric

5Y trend

BCYC

Peer Median

EPS (Diluted)

$-3.16

—

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric

5Y trend

BCYC

Peer Median

BCYC Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 16 analysts

Strong Buy 5 31.2%
Buy 7 43.8%
Hold 4 25.0%
Sell 0 0.0%
Strong Sell 0 0.0%

12-Month Price Target

6 analysts · 2026-08-17

Median $9.50

← Below all targets $4.13

Low $5.00

High $14.00

Median target $9.50 +130.0%

Mean target $9.50 +130.0%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise

0.06%

Period	EPS Actual	EPS Est	Surprise
June 30, 2026	$-0.72	$-0.59	-0.13%
March 31, 2026	$-0.87	$-0.63	-0.24%
Dec. 31, 2025	$-0.29	$-0.96	0.67%
Sept. 30, 2025	$-0.85	$-1.10	0.25%
June 30, 2025	$-1.14	$-0.97	-0.17%
March 31, 2025	$-0.88	$-0.86	-0.02%
Dec. 31, 2024	$-0.82	$-0.88	0.06%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker	Market Cap	P/E	Rev YoY	Net Margin	ROE	Gross Margin
BCYC	$491M	-2.2	105.8%	-301.7%	-34.2%	—
AUTL	—	-1.8	644.9%	-381.4%	-109.6%	—
TLSA	—	—	—	—	—	—
OKYO	—	—	—	—	—	—
ROIV	$19.95B	-51.3	-71.6%	-3629.2%	-6.5%	—

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 15

Annual Income Statement data for BCYC
Metric	2025	2024	2023	2022	2021	2020	2019	2018
Revenue	$73M	$35M	$27M	$14M	$12M	$10M	$14M	$7M
R&D Expense	$240M	$173M	$156M	$82M	$45M	$33M	$26M	$21M
SG&A Expense	$79M	$72M	$60M	$50M	$32M	$29M	$15M	$8M
Operating Expenses	$320M	$245M	$217M	$131M	$77M	$62M	$40M	$29M
Operating Income	$-247M	$-210M	$-190M	$-117M	$-66M	$-52M	$-26M	$-22M
Interest Expense	·	·	$3M	$3M	$3M	$457.0K	·	·
Other Non-op	$28M	$36M	$11M	$2M	$-3M	$226.0K	$-5M	$-665.0K
Pretax Income	$-219M	$-174M	$-179M	$-114M	$-68M	$-52M	$-31M	$-22M
Income Tax	$152.0K	$-5M	$1M	$-2M	$-2M	$-724.0K	$-254.0K	$-396.0K
Net Income	$-219M	$-169M	$-181M	$-113M	$-67M	$-51M	$-31M	$-22M
EPS (Basic)	$-3.16	$-2.90	$-5.08	$-3.80	$-2.67	$-2.66	$-2.77	·
EPS (Diluted)	$-3.16	$-2.90	$-5.08	$-3.80	$-2.67	$-2.66	$-2.77	·
Shares (Basic)	69,279,838	58,207,593	35,592,362	29,660,659	25,061,734	19,145,938	11,045,370	·
Shares (Diluted)	69,279,838	58,207,593	35,592,362	29,660,659	25,061,734	19,145,938	11,045,370	·
EBITDA	$-241M	$-203M	$-183M	$-113M	$-64M	$-51M	$-25M	·

Balance Sheet 24

Annual Balance Sheet data for BCYC
Metric	2025	2024	2023	2022	2021	2020	2019	2018
Cash & Equivalents	$628M	$880M	$526M	$339M	$439M	$136M	$0	$0
Receivables	$0	$0	$0	$2M	$1M	$5M	$201.0K	$5M
Prepaid Expense	$19M	$13M	$11M	$9M	$8M	$5M	$5M	$2M
Current Assets	$683M	$929M	$562M	$369M	$459M	$156M	$104M	$77M
PP&E (Net)	$6M	$10M	$15M	$19M	$3M	$2M	$2M	$2M
PP&E (Gross)	·	·	$28M	$27M	$8M	$6M	$5M	$4M
Accum. Depreciation	·	·	$13M	$8M	$5M	$4M	$3M	$2M
Other Non-current Assets	$13M	$11M	$6M	$8M	$3M	$2M	$2M	$3M
Total Assets	$718M	$957M	$595M	$411M	$480M	$161M	$110M	$82M
Accounts Payable	$10M	$16M	$13M	$6M	$3M	$1M	$2M	$2M
Accrued Liabilities	$44M	$41M	$32M	$26M	$14M	$12M	$6M	$7M
Current Liabilities	$57M	$67M	$70M	$53M	$36M	$23M	$9M	$9M
Capital Leases	$14M	$4M	$9M	$11M	$12M	$426.0K	$1M	·
Other Non-current Liabilities	$1M	$1M	$5M	$4M	$3M	$3M	$2M	$897.0K
Total Liabilities	$108M	$164M	$224M	$140M	$134M	$66M	$17M	$29M
Long-term Debt	·	·	$31M	$30M	$30M	$15M	·	·
Total Debt	·	·	$31M	$30M	$30M	$15M	·	·
Common Stock	$894.0K	$890.0K	$550.0K	$387.0K	$384.0K	$266.0K	$227.0K	$10.0K
Paid-in Capital	$1.51B	$1.47B	$883M	$601M	$568M	$250M	$195M	$2M
Retained Earnings	$-900M	$-681M	$-512M	$-331M	$-218M	$-152M	$-101M	$-70M
AOCI	$-4M	$119.0K	$-1M	$387.0K	$-3M	$-3M	$-2M	$-2M
Stockholders' Equity	$610M	$793M	$371M	$271M	$346M	$95M	$93M	$-70M
Liabilities + Equity	$718M	$957M	$595M	$411M	$480M	$161M	$110M	$82M
Shares Outstanding	69,367,896	69,061,418	42,431,766	29,873,893	29,579,364	21,094,557	17,993,701	814,728

Cash Flow 16

Annual Cash Flow data for BCYC
Metric	2025	2024	2023	2022	2021	2020	2019	2018
D&A	$6M	$7M	$7M	$4M	$1M	$1M	$960.0K	$712.0K
Stock-based Comp	$39M	$38M	$32M	$27M	$12M	$7M	$3M	$1M
Deferred Tax	$-850.0K	$-5M	$3M	$-5M	$-2M	$-673.0K	$-364.0K	$-378.0K
Restructuring	·	$2M	·	·	·	·	·	·
Other Non-cash	$-76M	$-36M	$78M	$1M	$40M	$26M	$-2M	·
Operating Cash Flow	$-250M	$-165M	$-61M	$-86M	$-15M	$-18M	$-29M	$-26M
CapEx	$2M	$1M	$3M	$19M	$2M	$1M	$2M	$1M
Investing Cash Flow	$-2M	$-1M	$-3M	$-19M	$-2M	$-1M	$-2M	$-1M
Net Debt Issued	·	$-32M	·	·	·	·	·	·
Stock Issued	·	$544M	$249M	$6M	$291M	$48M	·	·
Net Stock Activity	·	$544M	$249M	$6M	$8M	·	·	·
Financing Cash Flow	$-131.0K	$520M	$250M	$7M	$321M	$63M	$58M	$25M
Net Change in Cash	$-251M	$353M	$188M	$-100M	$303M	$44M	$29M	$-4M
Taxes Paid	$-717.0K	$792.0K	$562.0K	$2M	$73.0K	$124.0K	$117.0K	$73.0K
Free Cash Flow	$-252M	$-166M	$-64M	$-105M	$-17M	$-19M	$-30M	·
Levered FCF	·	·	$-67M	$-108M	$-20M	$-19M	·	·

Profitability 7

Annual Profitability data for BCYC
Metric	2025	2024	2023	2022	2021	2020	2019	2018
Operating Margin	-340.4%	-595.0%	-704.1%	-806.6%	-561.0%	-500.1%	-190.6%	·
Net Margin	-301.7%	-479.2%	-669.7%	-779.4%	-571.2%	-490.9%	-221.8%	·
Pretax Margin	-301.4%	-492.7%	-664.3%	-789.9%	-585.5%	-497.9%	-223.6%	·
EBITDA Margin	-331.5%	-574.6%	-679.9%	-781.1%	-548.9%	-487.8%	-183.6%	·
ROA	-26.2%	-21.8%	-35.9%	-25.3%	-20.8%	-37.6%	-31.9%	·
ROE	-34.2%	-20.8%	-45.9%	-40.2%	-25.8%	-49.8%	-32.5%	·
ROIC	-40.5%	-25.7%	-47.7%	-38.2%	-17.0%	-46.6%	-28.0%	·

Liquidity & Solvency 5

Annual Liquidity & Solvency data for BCYC
Metric	2025	2024	2023	2022	2021	2020	2019	2018
Current Ratio	12.0	13.8	8.1	6.9	12.7	6.7	11.8	·
Quick Ratio	11.0	13.1	7.6	6.4	12.1	0.2	0.0	·
Debt / Equity	·	·	0.1	0.1	0.1	0.2	·	·
LT Debt / Equity	·	·	0.1	0.1	0.1	0.2	·	·
Interest Coverage	·	·	-58.2	-34.9	-22.0	-113.7	·	·

Efficiency 2

Annual Efficiency data for BCYC
Metric	Trend	2025	2024	2023	2022	2021	2020	2019	2018
Asset Turnover		0.1	0.0	0.1	0.0	0.0	0.1	0.1	·
Receivables Turnover		·	·	26.4	9.5	3.6	3.7	5.3	·

Per Share 6

Annual Per Share data for BCYC
Metric	2025	2024	2023	2022	2021	2020	2019	2018
Book Value / Share	$8.79	$11.48	$8.74	$9.06	$11.71	$4.53	$5.18	·
Revenue / Share	$1.05	$0.61	$0.76	$0.49	$0.47	·	·	·
Cash Flow / Share	$-3.60	$-2.83	$-1.70	$-2.90	$-0.59	·	·	·
Cash / Share	$9.05	$12.74	$12.41	$11.35	$14.83	$0.00	$0.00	·
Dividend / Share	$0	$0	$0	$0	$0	·	·	·
EPS (TTM)	$-3.16	$-2.90	$-5.08	$-3.80	$-2.67	$-2.66	$-2.77	·

Growth Rates 3

Annual Growth Rates data for BCYC
Metric	2025	2024	2023	2022	2021	2020	2019	2018
Revenue YoY	105.8%	30.8%	86.5%	23.6%	12.6%	·	·	·
Revenue CAGR 3Y	71.2%	44.5%	37.4%	·	·	·	·	·
Revenue CAGR 5Y	47.5%	·	·	·	·	·	·	·

Valuation (TTM) 14

Annual Valuation (TTM) data for BCYC
Metric	2025	2024	2023	2022	2021	2020	2019	2018
Revenue TTM	$73M	$35M	$27M	$14M	$12M	$10M	$14M	·
Net Income TTM	$-219M	$-169M	$-181M	$-113M	$-67M	$-51M	$-31M	·
Market Cap	$491M	$967M	$767M	$884M	$1.80B	$379M	$170M	·
Enterprise Value	·	·	$271M	$575M	$1.39B	$393M	·	·
P/E	-2.2	-4.8	-3.6	-7.8	-22.8	-6.7	-3.4	·
P/S	6.8	27.4	28.4	61.1	153.9	36.4	12.3	·
P/B	0.8	1.2	2.1	3.3	5.2	4.0	1.8	·
P / Tangible Book	0.8	1.2	2.1	3.3	5.2	4.0	·	·
P / Cash Flow	-2.0	-5.9	-12.7	-10.3	-121.7	-21.3	-5.9	·
P / FCF	-1.9	-5.8	-12.1	-8.4	-107.0	-19.9	-5.6	·
EV / EBITDA	·	·	-1.5	-5.1	-21.7	-7.8	·	·
EV / FCF	·	·	-4.3	-5.5	-82.7	-20.7	·	·
EV / Revenue	·	·	10.1	39.8	119.0	37.8	·	·
Earnings Yield	-44.6%	-20.7%	-28.1%	-12.8%	-4.4%	-14.8%	-29.4%	·

Income Statement 15

Quarterly Income Statement data for BCYC
Metric	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Revenue	$629.0K	$887.0K	$48M	$12M	$3M	$10M	$4M	$3M	$9M	$20M	$5M	$5M	$11M	$5M	$3M	$3M
R&D Expense	$41M	$49M	$52M	$58M	$71M	$59M	$50M	$48M	$40M	$35M	$45M	$40M	$40M	$32M	$25M	$23M
SG&A Expense	$14M	$17M	$21M	$19M	$18M	$21M	$22M	$18M	$16M	$16M	$15M	$16M	$15M	$14M	$11M	$10M
Operating Expenses	$55M	$66M	$73M	$77M	$90M	$80M	$71M	$67M	$56M	$51M	$60M	$56M	$55M	$47M	$35M	$33M
Operating Income	$-55M	$-65M	$-25M	$-66M	$-87M	$-70M	$-68M	$-64M	$-47M	$-32M	$-54M	$-51M	$-43M	$-42M	$-32M	$-30M
Interest Expense	·	·	·	·	·	·	·	·	·	$821.0K	·	$814.0K	$821.0K	$808.0K	·	$817.0K
Other Non-op	$4M	$5M	$6M	$7M	$7M	$8M	$15M	$10M	$7M	$5M	$5M	$3M	$-9.0K	$2M	$2M	$1M
Pretax Income	$-50M	$-61M	$-19M	$-59M	$-79M	$-62M	$-53M	$-54M	$-40M	$-27M	$-49M	$-48M	$-43M	$-40M	$-30M	$-29M
Income Tax	$90.0K	$172.0K	$1M	$205.0K	$-231.0K	$-1M	$-1M	$-3M	$115.0K	$-350.0K	$320.0K	$2M	$-517.0K	$-618.0K	$-420.0K	$-238.0K
Net Income	$-50M	$-61M	$-20M	$-59M	$-79M	$-61M	$-52M	$-51M	$-40M	$-27M	$-49M	$-50M	$-43M	$-39M	$-30M	$-28M
EPS (Basic)	$-0.72	$-0.87	$-0.29	$-0.85	$-1.14	$-0.88	$-0.77	$-0.74	$-0.77	$-0.62	$-1.11	$-1.26	$-1.41	$-1.30	$-1.01	$-0.96
EPS (Diluted)	$-0.72	$-0.87	$-0.29	$-0.85	$-1.14	$-0.88	$-0.77	$-0.74	$-0.77	$-0.62	$-1.11	$-1.26	$-1.41	$-1.30	$-1.01	$-0.96
Shares (Basic)	69,804,828	69,683,471	-138,472,862	69,303,746	69,252,009	69,196,945	-105,333,390	68,988,858	51,992,034	42,560,091	-64,177,523	39,576,467	30,191,693	30,001,725	-59,269,069	29,676,021
Shares (Diluted)	69,804,828	69,683,471	-138,472,862	69,303,746	69,252,009	69,196,945	-105,333,390	68,988,858	51,992,034	42,560,091	-64,177,523	39,576,467	30,191,693	30,001,725	-59,269,069	29,676,021
EBITDA	$-55M	$-64M	·	$-66M	$-87M	$-69M	·	$-64M	$-47M	$-30M	·	$-51M	$-43M	$-40M	·	$-30M

Balance Sheet 24

Quarterly Balance Sheet data for BCYC
Metric	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Cash & Equivalents	$510M	$559M	$628M	$648M	$721M	$793M	$880M	$891M	$961M	$457M	$526M	$572M	$340M	$294M	$339M	$361M
Receivables	·	·	$0	·	·	$136.0K	$0	·	$233.0K	·	·	$0	$45M	$50M	·	$0
Prepaid Expense	$18M	$19M	$19M	$23M	$22M	$17M	$13M	$17M	$20M	$20M	·	$14M	$10M	$11M	·	$8M
Current Assets	$575M	$619M	$683M	$739M	$804M	$856M	$929M	$966M	$1.03B	$516M	·	$603M	$408M	$381M	·	$381M
PP&E (Net)	$5M	$6M	$6M	$7M	$8M	$9M	$10M	$12M	$12M	$13M	·	$16M	$18M	$18M	·	$16M
PP&E (Gross)	·	·	·	·	·	·	·	·	$28M	$28M	·	$27M	$28M	$27M	·	$22M
Accum. Depreciation	·	·	·	·	·	·	·	·	$17M	$15M	·	$11M	$10M	$9M	·	$6M
Other Non-current Assets	$13M	$13M	$13M	$14M	$14M	$12M	$11M	$10M	$7M	$6M	·	$5M	$12M	$11M	·	$6M
Total Assets	$607M	$652M	$718M	$764M	$832M	$884M	$957M	$997M	$1.06B	$547M	·	$639M	$454M	$429M	·	$417M
Accounts Payable	$6M	$6M	$10M	$13M	$18M	$11M	$16M	$6M	$7M	$7M	·	$8M	$5M	$3M	·	$7M
Accrued Liabilities	$39M	$40M	$44M	$44M	$45M	$34M	$41M	$39M	$28M	$26M	·	$34M	$37M	$25M	·	$18M
Current Liabilities	$48M	$49M	$57M	$69M	$77M	$58M	$67M	$56M	$70M	$50M	·	$70M	$72M	$53M	·	$42M
Capital Leases	$14M	$14M	$14M	$981.0K	$2M	$3M	$4M	$6M	$7M	$8M	·	$10M	$12M	$14M	·	$11M
Other Non-current Liabilities	$931.0K	$973.0K	$1M	$1M	$1M	$1M	$1M	$6M	$5M	$5M	·	$4M	$4M	$4M	·	$3M
Total Liabilities	$96M	$98M	$108M	$145M	$163M	$144M	$164M	$166M	$184M	$191M	·	$223M	$234M	$186M	·	$128M
Long-term Debt	·	·	·	·	·	·	·	·	$31M	$31M	·	$31M	$31M	$30M	·	$30M
Total Debt	·	·	·	·	·	·	·	·	$31M	$31M	·	$31M	$31M	$30M	·	$30M
Common Stock	$900.0K	$899.0K	$894.0K	$894.0K	$893.0K	$892.0K	$890.0K	$890.0K	$889.0K	$553.0K	·	$550.0K	$396.0K	$389.0K	·	$385.0K
Paid-in Capital	$1.53B	$1.52B	$1.51B	$1.50B	$1.49B	$1.48B	$1.47B	$1.46B	$1.45B	$895M	·	$875M	$633M	$613M	·	$590M
Retained Earnings	$-1.01B	$-961M	$-900M	$-880M	$-820M	$-742M	$-681M	$-629M	$-578M	$-538M	·	$-463M	$-413M	$-370M	·	$-301M
AOCI	$-5M	$-5M	$-4M	$-3M	$-3M	$-1M	$119.0K	$-3M	$-1M	$-778.0K	·	$3M	$-877.0K	$71.0K	·	$528.0K
Stockholders' Equity	$510M	$554M	$610M	$618M	$669M	$740M	$793M	$831M	$874M	$356M	$371M	$416M	$220M	$243M	$271M	$289M
Liabilities + Equity	$607M	$652M	$718M	$764M	$832M	$884M	$957M	$997M	$1.06B	$547M	·	$639M	$454M	$429M	·	$417M
Shares Outstanding	69,814,145	69,707,026	69,367,896	69,306,511	69,253,944	69,202,355	69,061,418	69,015,971	68,941,242	42,632,597	42,431,766	42,384,799	30,585,940	30,031,758	29,873,893	29,678,431

Cash Flow 15

Quarterly Cash Flow data for BCYC
Metric	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
D&A	$1M	$1M	$1M	$2M	$2M	$2M	$2M	$2M	$2M	$2M	$2M	$2M	$2M	$2M	$1M	$1M
Stock-based Comp	$6M	$7M	$12M	$9M	$9M	$10M	$10M	$9M	$9M	$9M	$8M	$7M	$8M	$9M	$6M	$5M
Deferred Tax	$326.0K	$-241.0K	$843.0K	$-46.0K	$-331.0K	$-1M	$-1M	$-3M	$-110.0K	$-767.0K	$-282.0K	$7M	$-2M	$-2M	$-2M	$-1M
Restructuring	·	·	·	·	·	·	·	$2M	·	·	·	·	·	·	·	·
Other Non-cash	·	$-13M	·	·	·	$-36M	·	·	·	$-54M	·	·	·	$-16M	·	·
Operating Cash Flow	$-50M	$-66M	$-19M	$-71M	$-73M	$-86M	$-9M	$-40M	$-45M	$-71M	$-47M	$-1M	$34M	$-46M	$-30M	$-6M
CapEx	$265.0K	$713.0K	$574.0K	$674.0K	$498.0K	$604.0K	$368.0K	$435.0K	$420.0K	$12.0K	$51.0K	$502.0K	$277.0K	$2M	$1M	$3M
Investing Cash Flow	$-265.0K	$-713.0K	$-574.0K	$-674.0K	$-498.0K	$-604.0K	$-368.0K	$-435.0K	$-420.0K	$-12.0K	$-51.0K	$-502.0K	$-277.0K	$-2M	$-1M	$-3M
Stock Issued	·	·	·	·	·	·	$0	$-979.0K	·	·	$10.0K	$234M	$12M	$3M	·	·
Net Stock Activity	·	·	·	·	·	·	·	·	·	·	·	·	·	$3M	·	·
Financing Cash Flow	$-50.0K	$-54.0K	$-15.0K	$-30.0K	$-45.0K	$-41.0K	$203.0K	$-32M	$550M	$2M	$386.0K	$235M	$12M	$3M	$6M	$159.0K
Net Change in Cash	$-50M	$-69M	$-20M	$-73M	$-72M	$-87M	$-11M	$-71M	$504M	$-69M	$-46M	$232M	$47M	$-45M	$-22M	$-11M
Taxes Paid	·	·	$171.0K	$233.0K	·	·	$0	$0	·	·	$-102.0K	$0	·	·	$1M	$454.0K
Free Cash Flow	·	$-67M	·	·	·	$-87M	·	·	·	$-71M	·	·	·	$-49M	·	·
Levered FCF	·	·	·	·	·	·	·	·	·	$-72M	·	·	·	$-49M	·	·

Profitability 7

Quarterly Profitability data for BCYC
Metric	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Operating Margin	-8673.9%	-7382.4%	·	-558.6%	-2965.8%	-703.7%	·	-2385.9%	-498.3%	-162.4%	·	·	·	-853.8%	·	-978.9%
Net Margin	-8002.1%	-6857.4%	·	-503.7%	-2703.8%	-608.9%	·	-1898.4%	-425.3%	-136.0%	·	·	·	-797.9%	·	-932.5%
Pretax Margin	-7987.8%	-6838.0%	·	-501.9%	-2711.8%	-619.8%	·	-2027.3%	-424.1%	-137.8%	·	·	·	-810.5%	·	-940.3%
EBITDA Margin	-8673.9%	-7255.1%	·	-558.6%	-2965.8%	-687.3%	·	-2385.9%	-498.3%	-153.9%	·	·	·	-822.0%	·	-978.9%
ROA	-7.0%	-7.9%	·	-6.7%	-8.4%	-8.5%	·	-6.2%	-5.3%	-5.4%	·	-9.4%	-9.5%	-8.8%	·	-8.1%
ROE	-8.5%	-9.4%	·	-8.2%	-10.2%	-11.1%	·	-8.2%	-7.3%	-8.9%	·	-14.1%	-16.0%	-13.6%	·	-12.3%
ROIC	-10.7%	-11.8%	·	-10.6%	-12.9%	-9.3%	·	-7.2%	-5.2%	-8.1%	·	-11.9%	-17.0%	-15.0%	·	-9.2%

Liquidity & Solvency 5

Quarterly Liquidity & Solvency data for BCYC
Metric	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Current Ratio	12.1	12.7	·	10.7	10.4	14.9	·	17.1	14.8	10.4	·	8.6	5.7	7.2	·	9.2
Quick Ratio	10.7	11.4	·	9.4	9.3	13.8	·	15.8	13.8	9.2	·	8.2	5.3	6.5	·	8.7
Debt / Equity	·	·	·	·	·	·	·	·	0.0	0.1	·	0.1	0.1	0.1	·	0.1
LT Debt / Equity	·	·	·	·	·	·	·	·	0.0	0.1	·	0.1	0.1	0.1	·	0.1
Interest Coverage	·	·	·	·	·	·	·	·	·	-38.6	·	-62.4	-52.5	-51.7	·	-36.4

Efficiency 2

Quarterly Efficiency data for BCYC
Metric	Trend	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Asset Turnover		0.0	0.0	·	0.0	0.0	0.0	·	0.0	0.0	0.0	·	·	·	0.0	·	0.0
Receivables Turnover		·	·	·	·	·	0.4	·	·	0.4	·	·	·	·	0.2	·	2.1

Per Share 6

Quarterly Per Share data for BCYC
Metric	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Book Value / Share	$7.31	$7.95	·	$8.92	$9.66	$10.70	·	$12.04	$12.67	$8.35	·	$9.82	$7.20	$8.10	·	$9.75
Revenue / Share	$0.01	$0.01	·	$0.17	$0.04	$0.14	·	$0.04	$0.18	$0.46	·	·	·	$0.16	·	$0.10
Cash Flow / Share	·	$-0.95	·	·	·	$-1.25	·	·	·	$-1.67	·	·	·	$-1.55	·	·
Cash / Share	$7.31	$8.03	·	$9.35	$10.42	$11.46	·	$12.91	$13.94	$10.72	·	$13.50	$11.13	$9.78	·	$12.18
Dividend / Share	$0	$0	$0	$0	$0	$0	$0	$0	$0	$0	·	$0	$0	$0	·	$0
EPS (TTM)	$-3.58	$-3.74	·	$-3.61	$-3.53	$-3.01	·	$-3.39	$-4.06	$-4.59	·	$-4.93	$-4.57	$-4.09	·	$-3.38

Valuation (TTM) 14

Quarterly Valuation (TTM) data for BCYC
Metric	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Revenue TTM	$16M	$26M	·	$27M	$25M	$42M	·	$37M	$46M	$41M	·	$25M	$24M	$16M	·	$16M
Net Income TTM	$-249M	$-260M	·	$-250M	$-230M	$-178M	·	$-167M	$-159M	$-158M	·	$-160M	$-137M	$-122M	·	$-97M
Market Cap	$296M	$323M	·	$536M	$481M	$588M	·	$1.56B	$1.40B	$1.06B	·	$852M	$781M	$639M	·	$690M
Enterprise Value	·	·	·	·	·	·	·	·	$465M	$635M	·	$310M	$471M	$375M	·	$359M
P/E	-1.2	-1.2	·	-2.1	-2.0	-2.8	·	-6.7	-5.0	-5.4	·	-4.1	-5.6	-5.2	·	-6.9
P/S	18.3	12.7	·	19.6	19.3	14.1	·	42.3	30.6	25.8	·	34.5	32.9	39.5	·	44.2
P/B	0.6	0.6	·	0.9	0.7	0.8	·	1.9	1.6	3.0	·	2.0	3.5	2.6	·	2.4
P / Tangible Book	0.6	0.6	·	0.9	0.7	0.8	·	1.9	1.6	3.0	·	2.0	3.5	2.6	·	2.4
P / Cash Flow	·	-4.9	·	·	·	-6.8	·	·	·	-15.0	·	·	·	-13.8	·	·
P / FCF	·	-4.9	·	·	·	-6.8	·	·	·	-15.0	·	·	·	-13.2	·	·
EV / EBITDA	·	·	·	·	·	·	·	·	-10.0	-21.1	·	-6.1	-10.9	-9.3	·	-12.1
EV / FCF	·	·	·	·	·	·	·	·	·	-9.0	·	·	·	-7.7	·	·
EV / Revenue	·	·	·	·	·	·	·	·	10.2	15.4	·	12.6	19.8	23.2	·	23.0
Earnings Yield	-84.4%	-80.6%	·	-46.6%	-50.8%	-35.4%	·	-15.0%	-20.1%	-18.4%	·	-24.5%	-17.9%	-19.2%	·	-14.5%

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement

	2025-12-31	2024-12-31	2023-12-31	2022-12-31	2021-12-31
Revenue	$73M	$35M	$27M	$14M	$12M
Operating Margin %	-340.4%	-595.0%	-704.1%	-806.6%	-561.0%
Net Income	$-219M	$-169M	$-181M	$-113M	$-67M
Diluted EPS	$-3.16	$-2.90	$-5.08	$-3.80	$-2.67

Balance Sheet

	2025-12-31	2024-12-31	2023-12-31	2022-12-31	2021-12-31
Debt / Equity	—	—	0.1	0.1	0.1
Current Ratio	12.0	13.8	8.1	6.9	12.7
Quick Ratio	11.0	13.1	7.6	6.4	12.1

Cash Flow

	2025-12-31	2024-12-31	2023-12-31	2022-12-31	2021-12-31
Free Cash Flow	$-252M	$-166M	$-64M	$-105M	$-17M

Latest News Recent headlines mentioning this company

Morgan Stanley Updates Bicycle Therapeutics plc (BCYC) Outlook Amid Pipeline Refocus Yahoo Finance · 4 months ago
RBC Capital Lowers its Price Target on Bicycle Therapeutics plc (BCYC) to $7 from $11 Yahoo Finance · 4 months, 2 weeks ago

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Institutional owners (13F) 115 filers · $141.9M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter

New positions	Exited positions	Increased	Decreased	Net shares change
23 (+7 vs prior Q)	12 (-13 vs prior Q)	36 (-8 vs prior Q)	19 (+2 vs prior Q)	-669K

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution	Value	Shares	% of tracked 13F	Type
BAKER BROS. ADVISORS LP	$46,153,914	10,885,357	32.53%	Shares
FCPM III SERVICES B.V.	$14,706,143	3,468,430	10.37%	Shares
ARMISTICE CAPITAL, LLC	$14,407,520	3,398,000	10.16%	Shares
Long Focus Capital Management, LLC	$14,037,313	3,310,687	9.89%	Shares
RENAISSANCE TECHNOLOGIES LLC	$6,501,616	1,533,400	4.58%	Shares
GSK plc	$6,485,339	1,529,561	4.57%	Shares
Qube Research & Technologies Ltd	$3,288,404	775,567	2.32%	Shares
SCHRODER INVESTMENT MANAGEMENT GROUP	$2,555,707	615,833	1.80%	Shares
MILLENNIUM MANAGEMENT LLC	$2,348,820	553,967	1.66%	Shares
Peapod Lane Capital LLC	$2,281,027	537,978	1.61%	Shares
DIADEMA PARTNERS LP	$1,961,950	462,724	1.38%	Shares
TWO SIGMA INVESTMENTS, LP	$1,842,606	434,577	1.30%	Shares
Aquilo Capital Management, LLC	$1,457,691	171,695	1.03%	Shares
Birchview Capital, LP	$1,329,732	313,616	0.94%	Shares
MOORE CAPITAL MANAGEMENT, LP	$1,166,000	275,000	0.82%	Shares
CITADEL ADVISORS LLC	$1,129,277	266,339	0.80%	Shares
Rangeley Capital, LLC	$1,074,840	253,500	0.76%	Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP	$1,042,616	245,900	0.73%	Put option
TWO SIGMA ADVISERS, LP	$1,034,388	146,100	0.73%	Shares
JANE STREET GROUP, LLC	$888,373	209,522	0.63%	Shares
Palo Alto Investors LP	$856,014	201,890	0.60%	Shares
Sculptor Capital LP	$839,113	197,904	0.59%	Shares
Eversept Partners, LP	$808,632	190,715	0.57%	Shares
PINNACLE ASSOCIATES LTD	$805,558	189,990	0.57%	Shares
Cubist Systematic Strategies, LLC	$800,393	103,410	0.56%	Shares
FLAX POND CAPITAL, LLC	$763,565	180,086	0.54%	Shares
Jump Financial, LLC	$708,504	167,100	0.50%	Shares
Point72 Asset Management, L.P.	$635,729	149,936	0.45%	Shares
MORGAN STANLEY	$552,302	130,260	0.39%	Shares
MANUFACTURERS LIFE INSURANCE COMPANY, THE	$542,139	127,863	0.38%	Shares
GOLDMAN SACHS GROUP INC	$514,231	121,281	0.36%	Shares
Persistent Asset Partners Ltd	$497,157	117,254	0.35%	Shares
XTX Topco Ltd	$465,556	109,801	0.33%	Shares
Quadrature Capital Ltd	$441,350	104,092	0.31%	Shares
TD Asset Management Inc	$390,046	91,992	0.27%	Shares
MARSHALL WACE, LLP	$378,183	89,194	0.27%	Shares
Virtus Investment Advisers, LLC	$342,545	80,789	0.24%	Shares
NANO CAP NEW MILLENNIUM GROWTH FUND L P	$339,200	80,000	0.24%	Shares
EntryPoint Capital, LLC	$329,630	77,743	0.23%	Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP	$315,880	74,500	0.22%	Call option
Marquette Asset Management, LLC	$308,901	72,854	0.22%	Shares
DAFNA Capital Management LLC	$273,446	64,492	0.19%	Shares
State of Tennessee, Department of Treasury	$259,289	61,153	0.18%	Shares
CITADEL ADVISORS LLC	$238,288	56,200	0.17%	Put option
SEI INVESTMENTS CO	$223,804	52,784	0.16%	Shares
ALPS ADVISORS INC	$216,757	51,122	0.15%	Shares
Verdad Advisers, LP	$216,664	51,100	0.15%	Shares
ADAR1 Capital Management, LLC	$214,705	50,638	0.15%	Shares
JANE STREET GROUP, LLC	$151,792	35,800	0.11%	Call option
SIMPLEX TRADING, LLC	$149,383	35,232	0.11%	Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP	$135,498	31,957	0.10%	Shares
Trexquant Investment LP	$131,627	31,044	0.09%	Shares
STATE STREET CORP	$130,715	30,829	0.09%	Shares
WOODSTOCK CORP	$123,579	29,146	0.09%	Shares
AXQ CAPITAL, LP	$116,040	27,368	0.08%	Shares
JANE STREET GROUP, LLC	$113,632	26,800	0.08%	Put option
D. E. Shaw & Co., Inc.	$107,938	25,457	0.08%	Shares
Invesco Ltd.	$105,160	24,802	0.07%	Shares
National Philanthropic Trust	$104,826	24,723	0.07%	Shares
Forefront Analytics, LLC	$92,525	21,822	0.07%	Shares
STIFEL FINANCIAL CORP	$86,829	20,479	0.06%	Shares
State of New Jersey Common Pension Fund D	$85,245	20,105	0.06%	Shares
Vontobel Holding Ltd.	$84,800	20,000	0.06%	Shares
Aigen Investment Management, LP	$81,913	19,319	0.06%	Shares
GEODE CAPITAL MANAGEMENT, LLC	$80,708	19,035	0.06%	Shares
CITADEL ADVISORS LLC	$73,352	17,300	0.05%	Call option
RHUMBLINE ADVISERS	$67,690	15,967	0.05%	Shares
PORTLAND INVESTMENT COUNSEL INC.	$63,600	15,000	0.04%	Shares
Erste Asset Management GmbH	$58,100	14,000	0.04%	Shares
Cerity Partners LLC	$57,537	13,570	0.04%	Shares
Schonfeld Strategic Advisors LLC	$56,810	13,399	0.04%	Shares
Walleye Capital LLC	$55,120	13,000	0.04%	Shares
HORIZON KINETICS ASSET MANAGEMENT LLC	$53,356	12,584	0.04%	Shares
Aquatic Capital Management LLC	$52,334	12,343	0.04%	Shares
Jain Global LLC	$50,880	12,000	0.04%	Shares
Crossmark Global Holdings, Inc.	$48,344	11,402	0.03%	Shares
Pinnacle Wealth Management Advisory Group, LLC	$46,576	10,985	0.03%	Shares
State of Wyoming	$45,622	10,760	0.03%	Shares
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS	$42,892	10,116	0.03%	Shares
GAMMA Investing LLC	$32,665	7,704	0.02%	Shares
Walleye Capital LLC	$32,648	7,700	0.02%	Call option
China Universal Asset Management Co., Ltd.	$31,461	7,420	0.02%	Shares
UBS Group AG	$20,140	4,750	0.01%	Shares
NATIXIS	$19,997	4,645	0.01%	Shares
Tower Research Capital LLC (TRC)	$15,557	3,669	0.01%	Shares
BARCLAYS PLC	$13,352	3,149	0.01%	Shares
ROYAL BANK OF CANADA	$11,000	2,500	0.01%	Shares
Mirae Asset Global Investments Co., Ltd.	$8,840	2,085	0.01%	Shares
ACADIAN ASSET MANAGEMENT LLC	$8,319	1,968,025	0.01%	Shares
GROUP ONE TRADING LLC	$8,217	1,938	0.01%	Shares
ASSETMARK, INC	$6,733	1,588	0.00%	Shares
CITIGROUP INC	$4,982	1,175	0.00%	Shares
BNP PARIBAS FINANCIAL MARKETS	$4,308	1,016	0.00%	Shares
GF FUND MANAGEMENT CO. LTD.	$4,079	962	0.00%	Shares
PRICE T ROWE ASSOCIATES INC /MD/	$3,826	902,150	0.00%	Shares
JPMORGAN CHASE & CO	$3,598	867	0.00%	Shares
JONES FINANCIAL COMPANIES LLLP	$2,870	700	0.00%	Shares
Quarry LP	$2,277	537	0.00%	Shares
HighMark Wealth Management LLC	$1,844	435	0.00%	Shares
Arax Advisory Partners	$1,289	304	0.00%	Shares

Company insiders 26 insiders · 13 officers · 11 directors

Insider	Role	Last activity	Shares owned	Sells 12m	Net 12m
Kevin Lee	CHIEF EXECUTIVE OFFICER	July 6, 2026 S	603,671	2	$-32,700
Travis Alvin Thompson	Chief Financial Officer	July 15, 2026 A	64,441	2	$-3,945
Alethia Young	Chief Financial Officer	Jan. 2, 2024 A	12,000	0	$0
Lee Kalowski	President and CFO	April 3, 2023 S	30,309	0	$0
Jennifer Scott Perry	Chief Operating Officer	July 15, 2026 A	91,052	3	$-6,054
Alistair Milnes	Chief Operating Officer	Jan. 2, 2024 A	73,196	0	$0
Michael Charles Ferguson Hannay	CHIEF PROD & SUPPLY CHAIN OFF	July 15, 2026 A	94,375	2	$-7,530
Michael Skynner	CHIEF SCIENTIFIC OFFICER	July 15, 2026 A	157,171	2	$-10,231
Nigel Crockett	Chief Business Officer	Jan. 2, 2024 A	48,716	0	$0
Nicholas Keen	Chief Scientific Officer	Jan. 2, 2024 A	63,593	0	$0
Santiago Arroyo	Chief Development Officer	Jan. 2, 2024 A	17,340	0	$0
Dominic Smethurst	Chief Medical Officer	Jan. 3, 2023 A	36,699	0	$0
Peter Brian Leone	Chief Business Officer	May 28, 2019 A	—	0	$0
Janice Bourque	Director	Jan. 2, 2024 A	16,750	0	$0
Gregory Paul Winter	Director	Jan. 2, 2024 A	180,677	0	$0
Jose-Carlos Gutierrez-Ramos	Director	Jan. 2, 2024 A	16,750	0	$0
Pierre Legault	Director	Jan. 2, 2024 A	33,500	0	$0
Richard N Kender	Director	Jan. 2, 2024 A	16,750	0	$0
Veronica Gh Jordan	Director	Jan. 2, 2024 A	16,750	0	$0
Kate Bingham	Director	July 14, 2021 S	38,708	0	$0
Carolyn Ng	Director	May 28, 2019 C	1,427,151	0	$0
Deborah Harland	Director	May 28, 2019 C	1,915,275	0	$0
Michael Anstey	Director	May 28, 2019 C	1,751,437	0	$0
Cambridge Innovation Capital (Jersey) Ltd	10% owner	May 28, 2019 C	1,751,437	0	$0
Vertex Global Healthcare Fund I Pte Ltd.	10% owner	May 28, 2019 C	1,621,168	0	$0
GSK plc	—	July 15, 2020 S	1,910,531	0	$0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 7 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer	Filed	Stake	Status	Purpose	Filing
Baker Bros. Advisors LP, Baker Bros. Advisors (GP) LLC, Julian C. Baker, Felix J. Baker ×3 filings	Dec. 17, 2024	—	Initial filing	—	SEC
GSK plc	July 20, 2023	—	Initial filing	—	SEC
Tybourne Capital Management (HK) Limited, Tybourne Capital Management Limited, Tybourne Kesari Limited, Viswanathan Krishnan, Aquila Investments IV ×4 filings	March 14, 2022	—	Initial filing	—	SEC
GlaxoSmithKline plc ×5 filings	Sept. 16, 2021	—	Initial filing	—	SEC
SVLSF V, LLC, SV Life Sciences Fund V, L.P., SV Life Sciences Fund V Strategic Partners, L.P., SV Life Sciences Fund V (GP), L.P. ×2 filings	Aug. 16, 2021	—	Initial filing	—	SEC
Vertex Venture Holdings Ltd., Vertex Global HC Fund I Pte. Ltd., Vertex Venture Management Pte. Ltd. ×2 filings	Jan. 20, 2021	—	Initial filing	Passive investment	SEC
Cambridge Innovation Capital (Jersey) Limited	June 7, 2019	—	Initial filing	Passive investment	SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 6 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund	Weight	Units	As of	Source
BBC · ETFis Series Trust I	0.47%	37,047 NS	April 30, 2026	N-PORT
QQQS · Invesco Exchange-Traded Fund Trust …	0.44%	23,841 SH	Aug. 8, 2026	Daily
SBIO · ALPS ETF Trust	0.15%	51,450 NS	May 31, 2026	N-PORT
IBBQ · Invesco Exchange-Traded Fund Trust …	0.01%	2,516 SH	Aug. 8, 2026	Daily
IBB · iShares Trust	0.01%	272,825 SH	Aug. 8, 2026	Daily
BIB · ProShares Trust	0.01%	1,711 NS	May 31, 2026	N-PORT

About Bicycle Therapeutics plc - American Depositary Shares Company overview from Wikipedia

BCYC Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

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Institutional owners (13F) 115 filers · $141.9M total · As of June 30, 2026

Company insiders 26 insiders · 13 officers · 11 directors

Activists & 5%+ owners 7 positions

ETF ownership Held by 6 ETFs