DAFNA Capital Management LLC
CIK 1389933 · View on SEC EDGAR ↗
- Portfolio value
- $524.4M
- Positions
- 88
- As of
- June 30, 2026
#3,663 of 9,443 by 13F value · top 38.8%
Portfolio value QoQ: +19.3% 13F does not disclose cash
- Top 10 holdings weight
- 56.21%
- Top 25 holdings weight
- 79.78%
- Positions above 1%
- 27
- Effective number of positions
- 16.4
Based on 13F long-equity holdings only (cash, bonds, shorts not disclosed)
Turnover Q2 2026: 15.79% Est. buys $76,086,447 · sells $108,771,659
Median holding: 4.0 quarters Tracked Q4 2024–Q2 2026 · 65.7% still held
- New positions
- 17
- Increased
- 17
- Decreased
- 26
- Closed
- 11
On this page
- Performance vs S&P How this manager's 13F portfolio performed against the S&P 500.
- Sector breakdown How the portfolio splits across market sectors.
- Portfolio Every stock this institution reports holding, from its latest 13F.
- High-conviction bets The holdings this manager is most concentrated in.
- Biggest new bets Brand-new positions opened in the latest quarter.
- Top moves The biggest position increases and decreases this quarter.
- Exited positions Positions the manager fully sold out of last quarter.
Performance vs S&P 500
Annualized: +113.9% · S&P 500: +17.7%
Approximates a buy-and-hold portfolio built from quarterly SEC 13F snapshots. Excludes cash, short positions, options/derivatives, and non-13(f) securities — reflects the disclosed long-equity book only, not total fund AUM. SEC filing lag is up to 45 days; this is not a real-time-copyable timing.
Priceable coverage: 88.2% · Options excluded: 0.0%
Sector breakdown
Healthcare
83.9%
Other/Unmapped
16.1%
Full portfolio 88 positions
| Type | Streak | 8Q trend | |||||
|---|---|---|---|---|---|---|---|
| RVMD Revolution Medicines, Inc. - Common Stock | $105,369,346 | 20.09% | 562,630 | $48,898,410 | Down ×4 | ||
| XBI XBI | $31,096,916 | 5.93% | 196,505 | $-9,585,728 | Down ×4 | ||
| CMPS COMPASS Pathways Plc - American Depository Shares | $28,469,121 | 5.43% | 2,011,952 | $15,092,704 | Down ×1 | ||
| STXS | $23,530,553 | 4.49% | 13,680,554 | $-1,641,666 | |||
| NKTR Nektar Therapeutics - Common Stock | $22,226,108 | 4.24% | 318,380 | $10,341,551 | Up ×4 | ||
| DNLI Denali Therapeutics Inc. - Common Stock | $19,007,440 | 3.62% | 739,014 | $12,892,240 | Up ×1 | ||
| IDYA IDEAYA Biosciences, Inc. - Common Stock | $18,532,135 | 3.53% | 497,240 | $2,647,158 | Up ×1 | ||
| ATRC AtriCure, Inc. - Common Stock | $16,716,119 | 3.19% | 597,431 | $-328,587 | |||
| XENE Xenon Pharmaceuticals Inc. - Common Shares | $15,136,598 | 2.89% | 250,772 | $554,206 | |||
| CYTK Cytokinetics, Incorporated - Common Stock | $14,652,510 | 2.79% | 171,998 | $317,283 | Down ×4 | ||
| RCUS Arcus Biosciences, Inc. Common Stock | $13,621,588 | 2.60% | 441,829 | $4,034,882 | Down ×1 | ||
| Unknown issuer (CUSIP: K08588103) | $12,927,652 | 2.47% | 48,469 | Up ×1 | |||
| NBIX Neurocrine Biosciences, Inc. - Common Stock | $9,736,098 | 1.86% | 57,769 | $433,278 | Down ×1 | ||
| AXGN Axogen, Inc. - Common Stock | $9,651,862 | 1.84% | 208,960 | $1,370,687 | Down ×3 | ||
| PODD Insulet Corporation - Common Stock | $9,419,708 | 1.80% | 61,870 | $7,138,747 | Up ×2 | ||
| EWTX Edgewise Therapeutics, Inc. - Common Stock | $9,215,656 | 1.76% | 226,819 | $5,680,222 | Up ×1 | ||
| BCAX Bicara Therapeutics Inc. - Common Stock | $8,460,314 | 1.61% | 284,955 | $72,045 | Down ×1 | ||
| IBB IBB | $8,101,143 | 1.54% | 42,595 | $-2,383,598 | Down ×3 | ||
| SNDX Syndax Pharmaceuticals, Inc. - Common Stock | $7,328,674 | 1.40% | 335,255 | $2,251,261 | Up ×1 | ||
| MPLT MapLight Therapeutics, Inc. - Common Stock | $6,128,855 | 1.17% | 171,006 | $2,652,303 | |||
| LRMR Larimar Therapeutics, Inc. - Common Stock | $6,124,900 | 1.17% | 2,008,164 | $-3,006,338 | Down ×1 | ||
| IPSC Century Therapeutics, Inc. - Common Stock | $5,881,122 | 1.12% | 2,400,458 | $379,484 | Down ×2 | ||
| DXCM DexCom, Inc. - Common Stock | $5,810,891 | 1.11% | 86,279 | $392,570 | |||
| IMVT Immunovant, Inc. - Common Stock | $5,761,160 | 1.10% | 149,524 | $2,022,144 | Down ×1 | ||
| INGN Inogen, Inc - Common Stock | $5,451,405 | 1.04% | 845,179 | $228,199 | |||
| TNDM Tandem Diabetes Care, Inc. - Common Stock | $5,360,089 | 1.02% | 355,208 | $-1,449,248 | |||
| ALKS Alkermes plc - Ordinary Shares | $5,305,832 | 1.01% | 101,266 | $373,748 | Down ×1 | ||
| STOK Stoke Therapeutics, Inc. - Common Stock | $4,282,230 | 0.82% | 130,875 | $20,940 | |||
| ALLO Allogene Therapeutics, Inc. - Common Stock | $4,160,000 | 0.79% | 2,000,000 | $816,912 | Up ×1 | ||
| BCRX BioCryst Pharmaceuticals, Inc. - Common Stock | $4,002,480 | 0.76% | 400,248 | $-93,481 | Down ×1 | ||
| GLPG Galapagos NV - American Depositary Shares | $3,902,647 | 0.74% | 130,175 | $-2,603 | |||
| KIDS OrthoPediatrics Corp. - Common Stock | $3,618,057 | 0.69% | 189,130 | $2,099,949 | Up ×1 | ||
| HELP Cybin Inc. - Common Stock | $3,397,943 | 0.65% | 514,061 | $1,005,810 | Up ×2 | ||
| RAPP Rapport Therapeutics, Inc. - Common Stock | $3,125,250 | 0.60% | 75,000 | $778,500 | |||
| KYMR Kymera Therapeutics, Inc. - Common Stock | $3,096,090 | 0.59% | 27,000 | Up ×1 | |||
| PRQR ProQR Therapeutics N.V. - Ordinary Shares | $2,846,471 | 0.54% | 1,530,361 | $307,022 | Down ×1 | ||
| NGNE Neurogene Inc. - Common Stock | $2,800,056 | 0.53% | 89,032 | $1,658,294 | Up ×2 | ||
| ANL Adlai Nortye Ltd. - American Depositary Shares | $2,754,860 | 0.53% | 239,553 | Up ×1 | |||
| PRCT PROCEPT BioRobotics Corporation - Common Stock | $2,709,600 | 0.52% | 120,000 | $-291,600 | |||
| AQST Aquestive Therapeutics, Inc. - Common Stock | $2,687,006 | 0.51% | 645,915 | $1,158,084 | Up ×1 | ||
| CLDX Celldex Therapeutics, Inc. - Common Stock | $2,549,555 | 0.49% | 68,518 | $376,164 | |||
| GPCR Structure Therapeutics Inc. - American Depositary Shares | $2,495,655 | 0.48% | 46,500 | $254,355 | |||
| ALGN Align Technology, Inc. - Common Stock | $2,361,240 | 0.45% | 14,000 | $-210,210 | Down ×2 | ||
| VKTX Viking Therapeutics, Inc. - Common Stock | $2,321,719 | 0.44% | 59,516 | $385,068 | |||
| NGEN NervGen Pharma Corp. - Common stock | $2,163,000 | 0.41% | 1,050,000 | Up ×1 | |||
| BHVN Biohaven Ltd. Common Shares | $2,047,384 | 0.39% | 137,593 | $-5,107,534 | Down ×2 | ||
| MAZE Maze Therapeutics, Inc. - Common Stock | $1,939,600 | 0.37% | 65,000 | $894,850 | Up ×1 | ||
| ALEC Alector, Inc. - Common Stock | $1,825,786 | 0.35% | 908,351 | $-127,169 | |||
| LXEO Lexeo Therapeutics, Inc. - Common Stock | $1,755,210 | 0.33% | 377,059 | $-409,109 | |||
| PROF Profound Medical Corp. - common stock | $1,731,394 | 0.33% | 260,360 | $27,122 | Down ×2 | ||
| Unknown issuer (CUSIP: 04965N104) | $1,721,600 | 0.33% | 128,000 | Up ×1 | |||
| ANNX Annexon, Inc. - common stock | $1,700,507 | 0.32% | 297,812 | $1,047,829 | Up ×1 | ||
| CTMX CytomX Therapeutics, Inc. - Common Stock | $1,644,026 | 0.31% | 438,407 | $563,026 | Up ×1 | ||
| RARE Ultragenyx Pharmaceutical Inc. - Common Stock | $1,572,669 | 0.30% | 47,100 | $292,624 | Down ×1 | ||
| EPRX Eupraxia Pharmaceuticals Inc. - Common Stock | $1,491,216 | 0.28% | 225,600 | Up ×1 | |||
| DSGN Design Therapeutics, Inc. - Common Stock | $1,484,622 | 0.28% | 102,600 | Up ×1 | |||
| FATE Fate Therapeutics, Inc. - Common Stock | $1,417,500 | 0.27% | 525,000 | $757,500 | Down ×1 | ||
| MDWD MediWound Ltd. - Ordinary Shares | $1,387,754 | 0.26% | 94,405 | $-133,111 | |||
| KURA Kura Oncology, Inc. - Common Stock | $1,322,631 | 0.25% | 120,568 | $-594,976 | Down ×1 | ||
| SPRY ARS Pharmaceuticals, Inc. - Common Stock | $1,315,923 | 0.25% | 164,285 | $197,464 | Up ×1 | ||
| MLYS Mineralys Therapeutics, Inc. - Common Stock | $1,200,340 | 0.23% | 44,490 | $157,646 | Up ×1 | ||
| IMTX Immatics N.V. - Ordinary Shares | $1,184,805 | 0.23% | 116,960 | $-1,037,657 | Down ×2 | ||
| TELA TELA Bio, Inc. - Common stock | $1,080,772 | 0.21% | 1,441,029 | $187,334 | |||
| PYPD PolyPid Ltd. - Ordinary Shares | $1,056,132 | 0.20% | 207,900 | $145,530 | |||
| CRBP Corbus Pharmaceuticals Holdings, Inc. - Common Stock | $1,010,911 | 0.19% | 107,773 | Up ×1 | |||
| INSP Inspire Medical Systems, Inc. Common Stock | $811,902 | 0.15% | 18,200 | $-126,854 | |||
| ACET Adicet Bio, Inc. - Common Stock | $810,536 | 0.15% | 93,812 | $171,676 | |||
| Unknown issuer (CUSIP: 81221K108) | $703,728 | 0.13% | 32,400 | Up ×1 | |||
| MBX MBX Biosciences, Inc. - Common Stock | $651,857 | 0.12% | 11,809 | $-4,585,773 | Down ×1 | ||
| BNTX BioNTech SE - American Depositary Shares | $651,350 | 0.12% | 7,000 | $29,190 | |||
| ARTV Artiva Biotherapeutics, Inc. - Common Stock | $650,880 | 0.12% | 67,101 | Up ×1 | |||
| PLRX Pliant Therapeutics, Inc. - Common Stock | $555,180 | 0.11% | 487,000 | $-58,440 | |||
| Unknown issuer (CUSIP: 811292309) | $552,983 | 0.11% | 135,868 | Up ×1 | |||
| EDIT Editas Medicine, Inc. - Common Stock | $552,323 | 0.11% | 170,470 | Up ×1 | |||
| OBIO Orchestra BioMed Holdings, Inc. - Ordinary Shares | $547,319 | 0.10% | 126,841 | $8,245 | |||
| FHTX Foghorn Therapeutics Inc. - Common Stock | $545,872 | 0.10% | 111,859 | $11,186 | |||
| ARAY Accuray Incorporated - Common Stock | $433,235 | 0.08% | 1,680,508 | $-218,970 | |||
| QTTB Q32 Bio Inc. - Common Stock | $419,095 | 0.08% | 32,896 | Up ×1 | |||
| NVCT Nuvectis Pharma, Inc. - Common Stock | $367,800 | 0.07% | 20,000 | Up ×1 | |||
| CGEN Compugen Ltd. - Ordinary Shares | $360,016 | 0.07% | 168,232 | $-189,062 | Down ×2 | ||
| IBIO iBio, Inc. - Common Stock | $297,593 | 0.06% | 170,053 | $-70,319 | Down ×1 | ||
| AUTL Autolus Therapeutics plc - American Depositary Shares | $286,906 | 0.05% | 179,316 | $39,450 | |||
| BCYC Bicycle Therapeutics plc - American Depositary Shares | $273,446 | 0.05% | 64,492 | $-25,797 | |||
| TNYA Tenaya Therapeutics, Inc. - Common Stock | $221,730 | 0.04% | 300,000 | ||||
| VRCA Verrica Pharmaceuticals Inc. - Common Stock | $145,350 | 0.03% | 23,750 | $-667,786 | Down ×2 | ||
| Unknown issuer (CUSIP: 29286X101) | $129,145 | 0.02% | 74,650 | Up ×1 | |||
| Unknown issuer (CUSIP: 485925101) | $119,250 | 0.02% | 5,000 | Up ×1 | |||
| ADCT ADC Therapeutics SA Common Shares | $82,477 | 0.02% | 77,081 | $-187,827 | Up ×1 | ||
| No matches | |||||||
Conviction holdings
Positions increased for 3+ consecutive quarters.
Share counts are as reported in 13F filings (not split-adjusted)
| Security | Value | % of portfolio | Streak |
|---|---|---|---|
| NKTR | $22,226,108 | 4.24% | up ×4 |
Biggest new bets
New positions opened this quarter, largest first.
| Security | Value | Shares | % of portfolio |
|---|---|---|---|
| Unknown issuer (CUSIP: K08588103) | $12,927,652 | 48,469 | 2.47% |
| KYMR | $3,096,090 | 27,000 | 0.59% |
| ANL | $2,754,860 | 239,553 | 0.53% |
| NGEN | $2,163,000 | 1,050,000 | 0.41% |
| Unknown issuer (CUSIP: 04965N104) | $1,721,600 | 128,000 | 0.33% |
| EPRX | $1,491,216 | 225,600 | 0.28% |
| DSGN | $1,484,622 | 102,600 | 0.28% |
| CRBP | $1,010,911 | 107,773 | 0.19% |
| Unknown issuer (CUSIP: 81221K108) | $703,728 | 32,400 | 0.13% |
| ARTV | $650,880 | 67,101 | 0.12% |
| Unknown issuer (CUSIP: 811292309) | $552,983 | 135,868 | 0.11% |
| EDIT | $552,323 | 170,470 | 0.11% |
| QTTB | $419,095 | 32,896 | 0.08% |
| NVCT | $367,800 | 20,000 | 0.07% |
| TNYA | $221,730 | 300,000 | 0.04% |
Top movers (QoQ)
| Security | Action | Shares Δ | Value Δ |
|---|---|---|---|
| RVMD | Trimmed | -18K | +$48.9M |
| CMPS | Trimmed | -407K | +$15.1M |
| DNLI | Bought more | +421K | +$12.9M |
| NKTR | Bought more | +153K | +$10.3M |
| XBI | Trimmed | -122K | -$9.6M |
| PODD | Bought more | +51K | +$7.1M |
| EWTX | Bought more | +115K | +$5.7M |
| BHVN | Trimmed | -708K | -$5.1M |
| RCUS | Trimmed | -2K | +$4.0M |
| LRMR | Trimmed | -21K | -$3.0M |
1 position hidden (data completeness check)
Exited positions
Includes corporate events (mergers, delistings) — not all exits are sells
Closed positions reflect 13F reporting changes; for index managers these are often mechanical (delisting, M&A, index rebalancing), not active decisions.
| Security | Quarter | Shares before | Value before | Price since exit |
|---|---|---|---|---|
| BPMC | Sept. 30, 2025 | 168,763 | $21,632,041 | No longer tracked |
| DAWN | June 30, 2026 | 978,463 | $20,978,247 | No longer tracked |
| MRUS | Dec. 31, 2025 | 220,451 | $20,755,462 | No longer tracked |
| KALV | June 30, 2026 | 267,402 | $5,382,802 | No longer tracked |
| ASND | June 30, 2026 | 23,177 | $5,301,275 | -2.8% |
| ATXS | March 31, 2026 | 304,775 | $3,989,505 | No longer tracked |
| SLNO | Dec. 31, 2025 | 53,000 | $3,582,800 | No longer tracked |
| CMPX | Dec. 31, 2025 | 946,661 | $3,313,314 | -54.4% |
| KRRO | Dec. 31, 2025 | 60,804 | $2,911,904 | 68.7% |
| TSVT | June 30, 2025 | 429,252 | $2,120,505 | No longer tracked |
| FULC | June 30, 2026 | 205,000 | $1,572,350 | 5.7% |
| RGLS | June 30, 2025 | 847,176 | $1,482,558 | No longer tracked |
| ITOS | Sept. 30, 2025 | 140,847 | $1,404,245 | No longer tracked |
| KROS | Dec. 31, 2025 | 80,716 | $1,276,927 | -47.1% |
| ENGN | June 30, 2026 | 187,353 | $1,275,874 | 4.3% |
| SPRY | June 30, 2025 | 95,290 | $1,198,748 | -64.9% |
| BDTX | Dec. 31, 2025 | 307,070 | $1,163,795 | -11.5% |
| LCTX | June 30, 2025 | 2,511,374 | $1,134,136 | No longer tracked |
| VYNE | Sept. 30, 2025 | 636,103 | $1,049,570 | No longer tracked |
| GOSS | Sept. 30, 2025 | 849,921 | $1,045,403 | -94.1% |
| SCYX | June 30, 2026 | 1,086,956 | $996,630 | 29.2% |
| PVLA | Sept. 30, 2025 | 43,348 | $977,064 | 130.1% |
| ERAS | March 31, 2026 | 254,436 | $946,502 | 8.2% |
| ORIC | June 30, 2026 | 98,724 | $945,460 | 32.2% |
| SAGE | June 30, 2025 | 108,200 | $860,190 | No longer tracked |
| ZBIO | June 30, 2026 | 42,500 | $830,875 | 17.8% |
| CNTA | March 31, 2025 | 47,453 | $794,838 | No longer tracked |
| VIR | March 31, 2025 | 100,000 | $734,000 | 46.3% |
| TSHA | June 30, 2025 | 522,500 | $726,275 | 164.1% |
| ACRV | March 31, 2025 | 112,414 | $676,732 | 9.4% |
| NAMS | June 30, 2026 | 20,000 | $640,200 | -17.5% |
| URGN | Dec. 31, 2025 | 27,515 | $548,924 | 109.6% |
| MASI | March 31, 2025 | 3,000 | $495,900 | No longer tracked |
| CRDF | June 30, 2025 | 150,000 | $471,000 | -71.5% |
| CATX | March 31, 2025 | 130,169 | $415,239 | No longer tracked |
| STRO | Dec. 31, 2025 | 437,079 | $379,559 | 82.8% |
| ACET | Sept. 30, 2025 | 540,000 | $329,400 | 1090.9% |
| SLRN | March 31, 2025 | 87,989 | $276,285 | No longer tracked |
| KPTI | June 30, 2026 | 45,800 | $255,106 | -80.3% |
| BWAY | March 31, 2026 | 12,965 | $246,594 | 14.7% |
| CMPX | March 31, 2025 | 158,394 | $229,671 | 28.9% |
| NVRO | June 30, 2025 | 38,000 | $221,920 | No longer tracked |
| PHGE | Dec. 31, 2025 | 401,136 | $210,596 | No longer tracked |
| APRE | Dec. 31, 2025 | 137,174 | $202,332 | -21.2% |
| PRCT | Sept. 30, 2025 | 3,000 | $172,800 | -39.3% |
| IFRX | Sept. 30, 2025 | 200,000 | $158,000 | 58.2% |
| CATX | March 31, 2026 | 50,000 | $137,500 | No longer tracked |
| NMRA | June 30, 2026 | 70,000 | $136,500 | -6.5% |
| SPRO | June 30, 2025 | 125,000 | $90,000 | -56.9% |
| TNYA | June 30, 2025 | 47,319 | $26,977 | 17.6% |