CRIS Curis, Inc. - Common Stock
$1.71
Price · Aug 19, 2026
Fundamentals as of Aug 14, 2026
52W Range
$0–$9
17% of range
Analyst Rating
BUY
10 analysts
Price Target
$43
+2401% upside
P/E (TTM)
-0.1
ROE
177.9%
Net Profit Margin
-80.3%
CRIS Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range
Price
$1.71
Market Cap
$1M
P/E (TTM)
-0.1
EPS (TTM)
$-0.58
Revenue (TTM)
$9M
Div Yield
—
ROE
177.9%
Debt/Equity
0.0
52W Range
$0 – $9
CRIS Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view
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10-Year Performance Revenue, net income, margins and EPS trends
Revenue & Net Income
$9M
2016-12-31
→
2025-12-31
EPS
$-0.58
2019-12-31
→
2025-12-31
Free Cash Flow
—
2016-12-31
→
2023-12-31
Margins
-80.3%
Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?
Metric
5Y trend
CRIS
Peer Median
P/E (TTM)
-0.1
—
P/S (TTM)
0.1
2.9
P/B
0.2
1.1
EV / EBITDA
0.7
—
Profitability Gross, operating and net margins; ROE, ROA, ROIC
Metric
5Y trend
CRIS
Peer Median
Operating Margin
-60.5%
—
Net Profit Margin
-80.3%
-4409.1%
ROA
-24.8%
-111.4%
ROE
177.9%
-169.4%
Financial Health Debt, liquidity, solvency — balance sheet strength
Metric
5Y trend
CRIS
Peer Median
Debt / Equity
0.0
0.0
Current Ratio
0.5
1.9
Quick Ratio
0.4
—
Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR
Metric
5Y trend
CRIS
Peer Median
Revenue YoY
-13.4%
—
Revenue CAGR 3Y
-2.4%
—
Revenue CAGR 5Y
-2.7%
—
Capital Efficiency Asset turnover, inventory turnover, receivables turnover
Metric
5Y trend
CRIS
Peer Median
CRIS Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside
BUY
10 analysts
- Strong Buy 2 20.0%
- Buy 7 70.0%
- Hold 1 10.0%
- Sell 0 0.0%
- Strong Sell 0 0.0%
12-Month Price Target
3 analysts · 2026-08-16
Median
$43.00
← Below all targets
$1.71
Low
$20.00
High
$65.00
Median target
$43.00
+2420.8%
Mean target
$42.67
+2401.3%
Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date
Avg Surprise
-1.8%
| Period | EPS Actual | EPS Est | Surprise |
|---|---|---|---|
| March 31, 2026 | $-25.00 | $-8.16 | -16.8% |
| Dec. 31, 2025 | $-10.00 | $-9.18 | -0.82% |
| Sept. 30, 2025 | $-9.80 | $-11.79 | 2.0% |
| June 30, 2025 | $-13.60 | $-18.16 | 4.6% |
| March 31, 2025 | $-1.25 | $-1.21 | -0.04% |
| Dec. 31, 2024 | $-1.25 | $-1.39 | 0.14% |
Peer comparison (GICS sub-industry) Key metrics vs sector peers
| Ticker | Market Cap | P/E | Rev YoY | Net Margin | ROE | Gross Margin |
|---|---|---|---|---|---|---|
| CRIS | $13M | -1.7 | -13.4% | -80.3% | 177.9% | — |
| HCWB | — | -0.1 | -97.9% | -14677.1% | -586.8% | 20.0% |
| REVB | — | — | — | — | — | — |
| SILO | $5M | -0.7 | 0.00% | -5863.5% | -75.3% | 38.6% |
| VIVS | $4M | -0.3 | -9.0% | -10567.2% | -294.8% | — |
| RNAZ | — | -0.1 | — | — | — | — |
| ONCO | $2M | -0.1 | -67.7% | -1721.0% | -129.5% | 77.6% |
| BIAF | — | — | — | — | — | — |
Full Fundamentals All metrics by year — income statement, balance sheet, cash flow
Income Statement 15
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $9M | $11M | $10M | $10M | $11M | $11M | $10M | $10M | $10M | $8M | $8M | $10M | |
| R&D Expense | · | · | · | · | · | · | · | · | · | $18M | · | $14M | |
| SG&A Expense | $14M | $17M | $19M | $20M | $17M | $12M | $12M | $15M | $14M | $16M | $13M | $12M | |
| Operating Expenses | $42M | $55M | $58M | $63M | $53M | $36M | $34M | $40M | $60M | $66M | $64M | $26M | |
| Operating Income | $-6M | $-45M | $-48M | $-53M | $-42M | $-25M | $-24M | $-29M | $-50M | $-58M | $-56M | $-16M | |
| Interest Expense | · | · | · | · | $0 | $0 | $791.0K | $4M | $4M | $3M | $3M | $4M | |
| Interest Income | $316.0K | $2M | $3M | $1M | $211.0K | $63.0K | $614.0K | $684.0K | $513.0K | $406.0K | $277.0K | $165.0K | |
| Other Non-op | $-2M | $1M | $919.0K | $-4M | $890.0K | $22.0K | $-58.0K | $0 | $-4M | $-2M | $-2M | $-3M | |
| Income Tax | $0 | $0 | · | · | · | · | · | · | · | · | · | · | |
| Net Income | $-8M | $-43M | $-47M | $-57M | $-45M | $-30M | $-32M | $-33M | $-53M | $-60M | $-59M | $-19M | |
| EPS (Basic) | $-0.58 | $-6.88 | $-8.96 | $-12.14 | $0.50 | $-0.61 | $-0.97 | · | · | · | · | · | |
| EPS (Diluted) | $-0.58 | $-6.88 | $-8.96 | $-12.14 | $0.50 | $-0.61 | $-0.97 | · | · | · | · | · | |
| Shares (Basic) | 13,164,032 | 6,306,284 | 5,293,294 | 4,669,626 | 91,569,154 | 48,670,381 | 33,180,516 | · | · | · | · | · | |
| Shares (Diluted) | 13,164,032 | 6,306,284 | 5,293,294 | 4,669,626 | 91,569,154 | 48,670,381 | 33,180,516 | · | · | · | · | · | |
| EBITDA | $-6M | $-45M | $-48M | · | $-42M | $-25M | $-24M | $-29M | $-50M | $-58M | $-56M | $-16M |
Balance Sheet 27
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $5M | $20M | $27M | $20M | $40M | $130M | $15M | $24M | $38M | $26M | $33M | $8M | |
| Short-term Investments | · | $0 | $30M | $66M | $76M | $39M | $5M | $634.0K | $22M | $18M | $49M | $42M | |
| Receivables | $0 | $3M | $3M | $3M | $3M | $3M | $3M | $3M | $3M | $2M | $2M | $2M | |
| Prepaid Expense | $2M | $3M | $2M | $4M | $3M | $1M | $1M | $827.0K | $989.0K | $1M | $1M | $489.8K | |
| Current Assets | $7M | $26M | $61M | $92M | $122M | $173M | $25M | $28M | $64M | $48M | $86M | $52M | |
| PP&E (Net) | $62.0K | $231.0K | $434.0K | $689.0K | $505.0K | $663.0K | $154.0K | $267.0K | $400.0K | $400.0K | $300.0K | $407.7K | |
| PP&E (Gross) | $913.0K | $1M | $2M | $3M | $3M | $3M | $2M | $2M | $2M | $2M | $2M | $2M | |
| Accum. Depreciation | $851.0K | $1M | $2M | $2M | $2M | $2M | $2M | $2M | $2M | $2M | $2M | $2M | |
| Goodwill | $9M | $9M | $9M | $9M | $9M | $9M | $9M | $9M | $9M | $9M | $9M | $9M | |
| Other Non-current Assets | $2M | $2M | $3M | $2M | $0 | $3.0K | $3.0K | $2.0K | $3.0K | $3.0K | $51.0K | $67.5K | |
| Total Assets | $20M | $41M | $77M | $109M | $162M | $204M | $35M | $37M | $74M | $58M | $95M | $63M | |
| Accounts Payable | $6M | $3M | $3M | $3M | $6M | $4M | $4M | $3M | $5M | $6M | $4M | $2M | |
| Accrued Liabilities | $7M | $7M | $9M | $6M | $6M | $4M | $2M | $3M | $3M | $3M | $2M | $2M | |
| Current Liabilities | $14M | $19M | $22M | $10M | $13M | $10M | $7M | $13M | $14M | $14M | $11M | $10M | |
| Capital Leases | $428.0K | $2M | $1M | $3M | $4M | $5M | $0 | · | · | · | · | · | |
| Other Non-current Liabilities | · | · | · | · | $0 | $334.0K | $0 | $11.0K | $34.0K | $18.0K | $139.0K | $174.0K | |
| Total Liabilities | $15M | $47M | $58M | $62M | $72M | $74M | $69M | $42M | $50M | $28M | $30M | $33M | |
| Long-term Debt | · | · | · | · | · | $891.0K | $0 | $35M | $42M | $20M | $24M | $28M | |
| Total Debt | $0 | $8M | · | · | $0 | $557.0K | $0 | $35M | $42M | $20M | $24M | $28M | |
| Common Stock | $6.0K | $85.0K | $59.0K | $48.0K | $916.0K | $915.0K | $332.0K | $332.0K | $331.0K | $1M | $1M | $872.5K | |
| Paid-in Capital | · | · | · | · | · | · | · | · | · | · | · | $810M | |
| Retained Earnings | $-1.25B | $-1.24B | $-1.20B | $-1.15B | $-1.09B | $-1.05B | $-1.02B | $-985M | $-952M | $-899M | $-839M | $-780M | |
| Treasury Stock | · | · | · | · | · | · | · | $0 | $2M | $2M | $2M | $2M | |
| AOCI | · | $0 | $229.0K | $-186.0K | $-109.0K | $-3.0K | $0 | $0 | $-2.0K | $-4.0K | $28.0K | $-11.0K | |
| Stockholders' Equity | $5M | $-6M | $20M | $47M | $91M | $131M | $-34M | $-4M | $24M | $29M | $65M | $30M | |
| Liabilities + Equity | $20M | $41M | $77M | $109M | $162M | $204M | $35M | $37M | $74M | $58M | $95M | $63M | |
| Shares Outstanding | 646,537 | 8,487,818 | 5,894,085 | 4,830,464 | 91,645,369 | 91,502,461 | 33,241,793 | 33,159,253 | 32,831,380 | 141,124,025 | 128,990,378 | 86,030,811 |
Cash Flow 10
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $169.0K | $203.0K | $255.0K | $233.0K | $158.0K | $144.0K | $125.0K | $177.0K | $235.0K | $193.0K | $200.0K | $200.0K | |
| Stock-based Comp | $4M | $6M | $6M | $7M | $5M | $3M | $3M | $4M | $5M | $4M | $4M | $3M | |
| Operating Cash Flow | $-27M | $-40M | $-38M | $-54M | $-38M | $-26M | $-26M | $-30M | $-48M | $-36M | $-30M | $-17M | |
| CapEx | · | · | $0 | $416.0K | $0 | $677.0K | $41.0K | $85.0K | $188.0K | $329.0K | $48.0K | $92.0K | |
| Investing Cash Flow | $2M | $29M | $38M | $33M | $-48M | $-49M | $-4M | $21M | $-4M | $30M | $-6M | $16M | |
| Stock Issued | $15M | $12M | $14M | $6M | $0 | $159M | $0 | $0 | $42M | $0 | $65M | $0 | |
| Net Stock Activity | $15M | $12M | $14M | · | $0 | $159M | · | $0 | $42M | $0 | $65M | $282.8K | |
| Financing Cash Flow | $10M | $3M | $8M | $867.0K | $-4M | $189M | $23M | $-6M | $64M | $-1M | $62M | $-1M | |
| Net Change in Cash | $-15M | $-7M | $7M | $-20M | $-90M | $114M | $-7M | $-15M | $12M | $-7M | $25M | $-2M | |
| Free Cash Flow | · | · | $-38M | · | $-38M | $-26M | $-26M | $-30M | $-49M | $-36M | $-30M | $-17M |
Profitability 5
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | -60.5% | -408.3% | -482.2% | · | -395.0% | -229.8% | -243.5% | -281.3% | -502.7% | -771.1% | -716.9% | -161.1% | |
| Net Margin | -80.3% | -397.8% | -473.0% | · | -426.7% | -276.0% | -320.9% | -312.6% | -538.7% | -802.6% | -748.6% | -190.3% | |
| EBITDA Margin | -60.5% | -408.3% | -482.2% | · | -395.0% | -229.8% | -243.5% | -281.3% | -502.7% | -771.1% | -716.9% | -161.1% | |
| ROA | -24.8% | -73.2% | -50.9% | · | -24.8% | -25.0% | -88.6% | -58.7% | -81.1% | -79.1% | -74.9% | -26.2% | |
| ROE | 177.9% | 589.0% | -192.5% | · | -46.9% | -58.6% | 107.1% | 1755.5% | -199.5% | -128.8% | -125.1% | -50.0% |
Liquidity & Solvency 5
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 0.5 | 1.4 | 4.5 | · | 9.1 | 17.1 | 3.8 | 2.1 | 4.6 | 3.6 | 7.9 | 5.2 | |
| Quick Ratio | 0.4 | 1.2 | 4.4 | · | 8.9 | 17.0 | 3.6 | 2.0 | 4.5 | 3.5 | 7.8 | 5.1 | |
| Debt / Equity | 0.0 | -1.3 | · | · | 0.0 | 0.0 | 0.0 | -7.9 | 1.7 | 0.7 | 0.4 | 1.0 | |
| LT Debt / Equity | · | · | · | · | · | · | 0.0 | -6.4 | 1.5 | 0.5 | 0.3 | 0.8 | |
| Interest Coverage | · | · | · | · | · | · | -30.8 | -7.5 | -12.5 | -20.9 | -17.0 | -4.2 |
Efficiency 2
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.3 | 0.2 | 0.1 | · | 0.1 | 0.1 | 0.3 | 0.2 | 0.2 | 0.1 | 0.1 | 0.1 | |
| Receivables Turnover | 5.6 | 3.6 | 3.5 | · | 3.4 | 3.4 | 3.3 | 3.5 | 3.6 | 3.3 | 3.9 | 5.7 |
Growth Rates 3
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue YoY | -13.4% | 8.8% | -1.4% | -4.6% | -1.7% | · | · | · | · | · | · | · | |
| Revenue CAGR 3Y | -2.4% | 0.80% | -2.6% | · | · | · | · | · | · | · | · | · | |
| Revenue CAGR 5Y | -2.7% | · | · | · | · | · | · | · | · | · | · | · |
Valuation (TTM) 14
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $9M | $11M | $10M | $10M | $11M | $11M | $10M | $10M | $10M | $8M | $8M | $10M | |
| Net Income TTM | $-8M | $-43M | $-47M | $-57M | $-45M | $-30M | $-32M | $-33M | $-53M | $-60M | $-59M | $-19M | |
| Market Cap | $13M | $26M | $75M | · | $8.72B | $14.99B | $1.13B | $458M | $11.49B | $43.47B | $37.54B | $12.90B | |
| Enterprise Value | $8M | $14M | · | · | $8.61B | $14.82B | $1.11B | $469M | $11.47B | $43.44B | $37.48B | $12.88B | |
| P/E | -1.7 | -0.4 | -1.4 | -0.9 | 190.4 | -268.5 | -35.1 | · | · | · | · | · | |
| P/S | 1.4 | 2.4 | 7.5 | · | 819.3 | 1383.3 | 113.0 | 43.9 | 1160.9 | 5774.7 | 4764.7 | 1311.0 | |
| P/B | 2.3 | -4.3 | 3.8 | · | 96.2 | 114.7 | -33.3 | -101.8 | 478.9 | 1485.2 | 581.9 | 433.3 | |
| P / Tangible Book | · | · | 7.0 | 28.3 | 106.8 | 123.2 | · | · | · | · | · | · | |
| P / Cash Flow | -0.5 | -0.7 | -2.0 | · | -231.9 | -582.3 | -43.1 | -15.2 | -237.6 | -1213.8 | -1255.8 | -767.5 | |
| P / FCF | · | · | -2.0 | · | -231.9 | -567.4 | -43.1 | -15.2 | -236.7 | -1202.7 | -1253.8 | -763.4 | |
| EV / EBITDA | -1.4 | -0.3 | · | · | -204.7 | -595.2 | -45.6 | -16.0 | -230.6 | -748.5 | -663.6 | -812.2 | |
| EV / FCF | · | · | · | · | -228.8 | -561.0 | -42.3 | -15.5 | -236.3 | -1202.0 | -1251.8 | -762.1 | |
| EV / Revenue | 0.8 | 1.2 | · | · | 808.4 | 1367.8 | 110.9 | 45.0 | 1159.1 | 5771.4 | 4757.3 | 1308.9 | |
| Earnings Yield | -58.6% | -224.8% | -70.3% | -110.4% | 0.53% | -0.37% | -2.9% | · | · | · | · | · |
Income Statement 12
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $0 | $0 | $1M | $3M | $3M | $2M | $3M | $3M | $3M | $2M | $3M | $3M | $2M | $2M | $3M | $3M | |
| SG&A Expense | $3M | $5M | $3M | $4M | $4M | $4M | $3M | $4M | $5M | $5M | $5M | $5M | $4M | $5M | $4M | $5M | |
| Operating Expenses | $10M | $12M | $9M | $10M | $11M | $13M | $12M | $13M | $15M | $15M | $15M | $15M | $14M | $14M | $13M | $15M | |
| Operating Income | $-10M | $-12M | $20M | $-7M | $-8M | $-10M | $-9M | $-11M | $-13M | $-12M | $-12M | $-12M | $-12M | $-12M | $-10M | $-13M | |
| Interest Income | $62.0K | $77.0K | $51.0K | $80.0K | $92.0K | $93.0K | $227.0K | $325.0K | $701.0K | $515.0K | $665.0K | $806.0K | $815.0K | $652.0K | $542.0K | $335.0K | |
| Other Non-op | $1M | $-13M | $-263.0K | $-805.0K | $-342.0K | $-459.0K | $-624.0K | $475.0K | $709.0K | $593.0K | $487.0K | $187.0K | $177.0K | $68.0K | $-1M | $-688.0K | |
| Net Income | $-9M | $-24M | $19M | $-8M | $-9M | $-11M | $-10M | $-10M | $-12M | $-12M | $-12M | $-12M | $-12M | $-12M | $-11M | $-13M | |
| EPS (Basic) | $-4.02 | $-1.25 | $1.84 | $-0.49 | $-13.61 | $-1.25 | $-1.10 | $-1.70 | $-2.03 | $-2.05 | $-1.97 | $-2.13 | $-2.47 | $-2.39 | $-8.96 | $-2.83 | |
| EPS (Diluted) | $-4.02 | $-1.25 | $1.84 | $-0.49 | $-13.61 | $-1.25 | $-1.10 | $-1.70 | $-2.03 | $-2.05 | $-1.97 | $-2.13 | $-2.47 | $-2.39 | $-8.96 | $-2.83 | |
| Shares (Basic) | 2,135,906 | 19,363,478 | -23,637,672 | 15,680,178 | 631,475 | 8,493,886 | -11,236,641 | 5,940,924 | 5,818,416 | 5,783,585 | -10,092,639 | 5,720,789 | 4,834,381 | 4,830,763 | -183,316,252 | 4,689,559 | |
| Shares (Diluted) | 2,135,906 | 19,363,478 | -23,637,672 | 15,680,178 | 631,475 | 8,493,886 | -11,236,641 | 5,940,924 | 5,818,416 | 5,783,585 | -10,092,639 | 5,720,789 | 4,834,381 | 4,830,763 | -183,316,252 | 4,689,559 | |
| EBITDA | $-10M | $-12M | · | $-7M | $-8M | $-10M | · | $-11M | $-13M | $-12M | · | $-12M | $-12M | $-12M | · | $-13M |
Balance Sheet 23
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $5M | $15M | $5M | $9M | $10M | $20M | $20M | $21M | $10M | $30M | $27M | $24M | $20M | $32M | $20M | $30M | |
| Short-term Investments | · | · | · | · | · | · | · | $0 | $18M | $11M | $30M | $44M | $44M | $40M | $66M | $69M | |
| Receivables | · | · | $0 | $3M | $3M | $2M | $3M | $3M | $3M | $2M | $3M | $3M | $2M | $2M | $3M | $3M | |
| Prepaid Expense | $1M | $2M | $2M | $2M | $2M | $2M | $3M | $3M | $4M | $3M | $2M | $2M | $2M | $4M | $4M | $4M | |
| Current Assets | $7M | $17M | $7M | $14M | $14M | $25M | $26M | $27M | $35M | $46M | $61M | $73M | $68M | $78M | $92M | $106M | |
| PP&E (Net) | $46.0K | $54.0K | $62.0K | $98.0K | $130.0K | $172.0K | $231.0K | $246.0K | $308.0K | $370.0K | $434.0K | $497.0K | $561.0K | $625.0K | $689.0K | $780.0K | |
| PP&E (Gross) | · | · | $913.0K | · | · | · | $1M | · | · | · | $2M | · | · | · | $3M | · | |
| Accum. Depreciation | · | · | $851.0K | · | · | · | $1M | · | · | · | $2M | · | · | · | $2M | · | |
| Goodwill | $9M | $9M | $9M | $9M | $9M | $9M | $9M | $9M | $9M | $9M | $9M | $9M | $9M | $9M | $9M | $9M | |
| Other Non-current Assets | $2M | $2M | $2M | $2M | $3M | $2M | $2M | $2M | $2M | $3M | $3M | $3M | $3M | $2M | $2M | $2M | |
| Total Assets | $19M | $30M | $20M | $28M | $29M | $39M | $41M | $42M | $50M | $62M | $77M | $90M | $84M | $95M | $109M | $123M | |
| Accounts Payable | $5M | $7M | $6M | $4M | $4M | $5M | $3M | $4M | $2M | $4M | $3M | $5M | $3M | $3M | $3M | $6M | |
| Accrued Liabilities | $7M | $7M | $7M | $7M | $7M | $6M | $7M | $8M | $7M | $6M | $9M | $7M | $6M | $4M | $6M | $7M | |
| Current Liabilities | $14M | $15M | $14M | $20M | $19M | $20M | $19M | $22M | $19M | $11M | $22M | $14M | $10M | $8M | $10M | $14M | |
| Capital Leases | $0 | $108.0K | $428.0K | $740.0K | $1M | $1M | $2M | $2M | $2M | $1M | $1M | $2M | $2M | $2M | $3M | $3M | |
| Total Liabilities | $14M | $17M | $15M | $42M | $43M | $46M | $47M | $51M | $51M | $53M | $58M | $60M | $58M | $58M | $62M | $67M | |
| Total Debt | · | · | · | $7M | $7M | $7M | · | · | · | · | · | · | · | · | · | · | |
| Common Stock | $19.0K | $400.0K | $129.0K | $127.0K | $107.0K | $105.0K | $85.0K | $60.0K | $59.0K | $59.0K | $59.0K | $59.0K | $993.0K | $966.0K | $48.0K | $964.0K | |
| Retained Earnings | $-1.28B | $-1.27B | $-1.25B | $-1.27B | $-1.26B | $-1.25B | $-1.24B | $-1.23B | $-1.22B | $-1.21B | $-1.20B | $-1.18B | $-1.17B | $-1.16B | $-1.15B | $-1.14B | |
| AOCI | · | · | · | · | · | · | · | $0 | $42.0K | $338.0K | $229.0K | $103.0K | $2.0K | $9.0K | $-186.0K | $-479.0K | |
| Stockholders' Equity | $5M | $13M | $5M | $-15M | $-14M | $-7M | $-6M | $-9M | $-694.0K | $9M | $20M | $30M | $26M | $37M | $47M | $56M | |
| Liabilities + Equity | $19M | $30M | $20M | $28M | $29M | $39M | $41M | $42M | $50M | $62M | $77M | $90M | $84M | $95M | $109M | $123M | |
| Shares Outstanding | 1,949,041 | 39,978,693 | 12,928,853 | 12,733,853 | 10,708,393 | 10,462,250 | 8,487,818 | 6,020,259 | 5,904,278 | 5,894,085 | 5,894,085 | 5,885,313 | 99,344,798 | 96,617,898 | 4,830,464 | 96,398,360 |
Cash Flow 10
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $8.0K | $8.0K | $36.0K | $32.0K | $42.0K | $59.0K | $16.0K | $61.0K | $62.0K | $64.0K | $64.0K | $63.0K | $64.0K | $64.0K | $92.0K | $61.0K | |
| Stock-based Comp | $569.0K | $575.0K | $795.0K | $924.0K | $1M | $1M | $1M | $1M | $2M | $2M | $2M | $2M | $1M | $1M | $2M | $1M | |
| Operating Cash Flow | $-10M | $-9M | $-6M | $-6M | $-8M | $-7M | $-9M | $-6M | $-11M | $-13M | $-10M | $-8M | $-8M | $-12M | $-12M | $-13M | |
| CapEx | · | · | · | · | · | · | · | · | · | · | · | $0 | $0 | $0 | $0 | $52.0K | |
| Investing Cash Flow | $0 | $0 | $2M | $0 | $0 | $0 | $-428.0K | $18M | $-7M | $19M | $15M | $180.0K | $-3M | $26M | $3M | $4M | |
| Stock Issued | $-282.0K | $19M | $-119.0K | $6M | $-578.0K | $10M | $11M | $696.0K | $291.0K | $0 | $118.0K | $14M | $178.0K | $7.0K | $179.0K | · | |
| Net Stock Activity | · | $19M | · | · | · | $10M | · | · | · | $0 | · | · | · | · | · | · | |
| Financing Cash Flow | $-282.0K | $19M | $-119.0K | $4M | $-2M | $8M | $9M | $-2M | $-1M | $-2M | $-2M | $13M | $-852.0K | $-2M | $-1M | $5M | |
| Net Change in Cash | $-10M | $10M | $-4M | $-1M | $-10M | $285.0K | $-857.0K | $11M | $-20M | $3M | $2M | $5M | $-12M | $12M | $-10M | $-4M | |
| Free Cash Flow | · | · | · | · | · | · | · | · | · | · | · | · | · | $-12M | · | · |
Profitability 5
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | · | · | · | -218.0% | -300.1% | -426.8% | · | -360.5% | -491.4% | -597.8% | · | -436.6% | -552.5% | -506.2% | · | -446.2% | |
| Net Margin | · | · | · | -243.4% | -312.6% | -446.0% | · | -344.3% | -463.6% | -569.3% | · | -430.0% | -544.4% | -503.2% | · | -470.6% | |
| EBITDA Margin | · | · | · | -218.0% | -300.1% | -426.8% | · | -360.5% | -491.4% | -597.8% | · | -436.6% | -552.5% | -506.2% | · | -446.2% | |
| ROA | -35.6% | -70.1% | · | -22.1% | -21.6% | -20.9% | · | -15.2% | -17.5% | -15.2% | · | -11.5% | -11.2% | -9.8% | · | -9.0% | |
| ROE | 184.7% | -793.4% | · | 66.0% | 117.1% | -743.7% | · | -96.8% | -92.5% | -51.6% | · | -28.5% | -27.1% | -20.5% | · | -16.8% |
Liquidity & Solvency 3
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 0.5 | 1.1 | · | 0.7 | 0.7 | 1.2 | · | 1.2 | 1.8 | 4.1 | · | 5.4 | 7.0 | 9.7 | · | 7.7 | |
| Quick Ratio | 0.4 | 1.0 | · | 0.6 | 0.7 | 1.1 | · | 1.1 | 1.6 | 3.8 | · | 5.2 | 6.8 | 9.2 | · | 7.4 | |
| Debt / Equity | · | · | · | -0.5 | -0.5 | -1.1 | · | · | · | · | · | · | · | · | · | · |
Efficiency 2
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.0 | 0.0 | · | 0.1 | 0.1 | 0.0 | · | 0.0 | 0.0 | 0.0 | · | 0.0 | 0.0 | 0.0 | · | 0.0 | |
| Receivables Turnover | · | · | · | 1.0 | 1.0 | 1.1 | · | 1.0 | 1.0 | 0.9 | · | 1.0 | 0.9 | 1.1 | · | 1.0 |
Valuation (TTM) 13
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $6M | $8M | · | $11M | $11M | $10M | · | $10M | $10M | $9M | · | $10M | $10M | $10M | · | $10M | |
| Net Income TTM | $-49M | $-51M | · | $-37M | $-41M | $-44M | · | $-46M | $-48M | $-48M | · | $-49M | $-53M | $-57M | · | $-56M | |
| Market Cap | $1M | $22M | · | $21M | $25M | $22M | · | $32M | $41M | $64M | · | $39M | $1.65B | $1.16B | · | $1.35B | |
| Enterprise Value | · | · | · | $19M | $22M | $9M | · | · | · | · | · | · | · | · | · | · | |
| P/E | -0.0 | -0.1 | · | -0.4 | -0.4 | -0.3 | · | -0.7 | -0.8 | -1.2 | · | -0.7 | -2.1 | -2.2 | · | -4.2 | |
| P/S | 0.2 | 2.6 | · | 1.9 | 2.3 | 2.2 | · | 3.1 | 4.2 | 6.8 | · | 3.8 | 169.8 | 121.1 | · | 130.8 | |
| P/B | 0.2 | 1.7 | · | -1.4 | -1.8 | -3.3 | · | -3.7 | -58.7 | 6.8 | · | 1.3 | 62.9 | 31.7 | · | 24.2 | |
| P / Tangible Book | · | 5.9 | · | · | · | · | · | · | · | 133.5 | · | 1.9 | 95.6 | 42.0 | · | 28.9 | |
| P / Cash Flow | · | -2.4 | · | · | · | -3.0 | · | · | · | -4.8 | · | · | · | -95.0 | · | · | |
| P / FCF | · | · | · | · | · | · | · | · | · | · | · | · | · | -95.0 | · | · | |
| EV / EBITDA | · | · | · | -2.7 | -2.7 | -0.9 | · | · | · | · | · | · | · | · | · | · | |
| EV / Revenue | · | · | · | 1.7 | 2.1 | 0.9 | · | · | · | · | · | · | · | · | · | · | |
| Earnings Yield | -3725.0% | -667.3% | · | -248.2% | -244.0% | -334.8% | · | -146.8% | -125.8% | -83.2% | · | -149.0% | -47.3% | -46.4% | · | -23.6% |
Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years
Income Statement
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Revenue | $9M | $11M | $10M | $10M | $11M |
| Operating Margin % | -60.5% | -408.3% | -482.2% | — | -395.0% |
| Net Income | $-8M | $-43M | $-47M | $-57M | $-45M |
| Diluted EPS | $-0.58 | $-6.88 | $-8.96 | $-12.14 | $0.50 |
Balance Sheet
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Debt / Equity | 0.0 | -1.3 | — | — | 0.0 |
| Current Ratio | 0.5 | 1.4 | 4.5 | — | 9.1 |
| Quick Ratio | 0.4 | 1.2 | 4.4 | — | 8.9 |
Cash Flow
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Free Cash Flow | — | — | $-38M | — | $-38M |
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Institutional owners (13F) 39 filers · $7.0M total · As of June 30, 2026
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
Institutional activity — Q2 2026 vs prior quarter
| New positions | Exited positions | Increased | Decreased | Net shares change |
|---|---|---|---|---|
| 9 (+1 vs prior Q) | 12 (+4 vs prior Q) | 5 (-8 vs prior Q) | 7 (+1 vs prior Q) | -3.9M |
Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| Bleichroeder LP | $1,985,196 | 3,802,329 | 28.49% | Shares |
| Stonepine Capital Management, LLC | $1,729,292 | 3,312,185 | 24.82% | Shares |
| SPHERA FUNDS MANAGEMENT LTD. | $1,033,717 | 98,996 | 14.84% | Shares |
| Cable Car Capital, LP | $696,134 | 1,333,334 | 9.99% | Shares |
| CM Management, LLC | $287,155 | 550,000 | 4.12% | Shares |
| MORGAN STANLEY | $263,290 | 504,291 | 3.78% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $179,486 | 343,842 | 2.58% | Shares |
| M28 Capital Management LP | $148,741 | 284,889 | 2.13% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $142,044 | 272,044 | 2.04% | Shares |
| FLPUTNAM INVESTMENT MANAGEMENT CO | $128,306 | 245,750 | 1.84% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $74,123 | 141,972 | 1.06% | Shares |
| VANGUARD GROUP INC | $60,862 | 61,664 | 0.87% | Shares |
| XTX Topco Ltd | $56,470 | 108,160 | 0.81% | Shares |
| NORTHERN TRUST CORP | $50,054 | 95,870 | 0.72% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $32,189 | 61,664 | 0.46% | Shares |
| BlackRock, Inc. | $27,846 | 53,334 | 0.40% | Shares |
| Focused Wealth Management, Inc | $26,131 | 50,049 | 0.38% | Shares |
| STATE STREET CORP | $10,990 | 21,049 | 0.16% | Shares |
| FRANKLIN STREET ADVISORS INC /NC | $10,442 | 20,000 | 0.15% | Shares |
| LPL Financial LLC | $7,819 | 14,977 | 0.11% | Shares |
| MAVERICK CAPITAL LTD | $6,194 | 49,554 | 0.09% | Shares |
| Dauntless Investment Group, LLC | $5,222 | 10,001 | 0.07% | Shares |
| BARCLAYS PLC | $3,641 | 6,973 | 0.05% | Shares |
| Steward Partners Investment Advisory, LLC | $1,356 | 2,597 | 0.02% | Shares |
| OSAIC HOLDINGS, INC. | $785 | 1,510 | 0.01% | Shares |
| GROUP ONE TRADING LLC | $235 | 450 | 0.00% | Shares |
| Axiom Investment Management LLC | $52 | 100 | 0.00% | Shares |
| JPMORGAN CHASE & CO | $48 | 108 | 0.00% | Shares |
| JONES FINANCIAL COMPANIES LLLP | $39 | 120 | 0.00% | Shares |
| WELLS FARGO & COMPANY/MN | $29 | 55 | 0.00% | Shares |
| CWM, LLC | $28 | 51 | 0.00% | Shares |
| UBS Group AG | $16 | 31 | 0.00% | Shares |
| GSA CAPITAL PARTNERS LLP | $12 | 22,760 | 0.00% | Shares |
| CIBC Private Wealth Group LLC | $10 | 6 | 0.00% | Shares |
| WR Wealth Planners, LLC | $3 | 1 | 0.00% | Shares |
| Blue Trust, Inc. | $2 | 4 | 0.00% | Shares |
| VIMA LLC | $2 | 3 | 0.00% | Shares |
| MPWM ADVISORY SOLUTIONS, LLC | $1 | 2 | 0.00% | Shares |
| ROYAL BANK OF CANADA | $0 | 63 | 0.00% | Shares |
Company insiders 33 insiders · 17 officers · 16 directors
| Insider | Role | Last activity | Shares owned | Buys 12m | Sells 12m | Net 12m |
|---|---|---|---|---|---|---|
| James E Dentzer | President & CEO | July 7, 2026 A | 148,730 | 0 | 0 | $0 |
| Ali Fattaey Ph.D. | President & CEO | May 15, 2018 A | 322,140 | 0 | 0 | $0 |
| Diantha Duvall | CFO | July 7, 2026 A | 77,707 | 0 | 0 | $0 |
| William Steinkrauss | Chief Financial Officer | Jan. 29, 2022 A | — | 0 | 0 | $0 |
| Michael Gray | CFO | May 27, 2015 A | 107,304 | 0 | 0 | $0 |
| Mitchell Keegan | Vice-President | Jan. 7, 2011 A | — | 0 | 0 | $0 |
| Jonathan B. Zung | CDO | July 7, 2026 A | 66,667 | 0 | 0 | $0 |
| Ahmed Hamdy MD | CMO | March 20, 2026 C | 66,667 | 0 | 0 | $0 |
| Robert Martell | Head of Research & Development | Jan. 20, 2023 A | 23,027 | 0 | 0 | $0 |
| David Tuck | Chief Medical Officer | May 15, 2018 A | 169,424 | 0 | 0 | $0 |
| Mani Mohindru | Chief Strategy Officer | Feb. 14, 2017 A | — | 0 | 0 | $0 |
| Jaye Viner | Chief Medical Officer | May 27, 2015 A | — | 0 | 0 | $0 |
| Mark Noel | VP, Tech Management | May 2, 2013 M | 27,540 | 0 | 0 | $0 |
| Changgeng Qian | VP, Research & Preclinical Dev | Jan. 7, 2011 A | — | 0 | 0 | $0 |
| Mary Elizabeth Potthoff | VP and General Counsel | May 31, 2006 A | 0 | 0 | 0 | $0 |
| Lee L Rubin | VP of Research | June 1, 2005 A | 9,814 | 0 | 0 | $0 |
| Christopher U Missling | Sr. VP, Strategic Planning | Jan. 16, 2004 M | 0 | 0 | 0 | $0 |
| Anne Elizabeth Borgman | Director | July 7, 2026 A | — | 0 | 0 | $0 |
| John Hohneker | Director | July 7, 2026 A | — | 0 | 0 | $0 |
| Marc Rubin | Director | July 7, 2026 A | 28,108 | 0 | 0 | $0 |
| Kenneth I Kaitin | Director | July 7, 2026 A | 11,407 | 1 | 0 | $5,500 |
| Martyn D Greenacre | Director | July 7, 2026 A | 26,089 | 0 | 0 | $0 |
| Lori Anne Kunkel | Director | Jan. 31, 2022 A | 22,200 | 0 | 0 | $0 |
| James R Mcnab | Director | May 5, 2017 S | 50,000 | 0 | 0 | $0 |
| Kenneth Pienta | Director | Feb. 28, 2017 A | 30,000 | 0 | 0 | $0 |
| James R Tobin | Director | Jan. 26, 2015 A | 144,921 | 0 | 0 | $0 |
| Susan B Bayh | Director | Jan. 17, 2013 A | 25,000 | 0 | 0 | $0 |
| Joseph Davie MD PHD | Director | Jan. 7, 2011 A | — | 0 | 0 | $0 |
| Stephen Carter | Director | Jan. 25, 2008 A | — | 0 | 0 | $0 |
| Joseph M Davie | Director | June 6, 2007 A | 20,000 | 0 | 0 | $0 |
| Douglas Melton | Director | Aug. 23, 2006 A | 173,499 | 0 | 0 | $0 |
| Daniel R Passeri | — | Jan. 19, 2016 A | 211,798 | 0 | 0 | $0 |
| Maurizio Voi | — | Jan. 17, 2013 A | — | 0 | 0 | $0 |
Insiders from SEC Form 3/4/5 filings; net = open-market P/S only
Activists & 5%+ owners 3 positions
Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.
| Filer | Filed | Stake | Status | Purpose | Filing |
|---|---|---|---|---|---|
| Undisclosed reporting person | March 4, 2004 | — | Initial filing | — | SEC |
| Undisclosed reporting person | Jan. 29, 2004 | — | Initial filing | Passive investment | SEC |
| Undisclosed reporting person | June 4, 2003 | — | Initial filing | — | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
ETF ownership Held by 2 ETFs
Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.