CRIS Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

03
Price $0.80
Market Cap (MRQ) $2M
P/E (TTM) -0.2
EPS (TTM) $-3.92
Revenue (TTM) $4M
ROE (TTM) 455.3%
Debt/Equity 0.0
52W Range $1–$34

CRIS Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

04
range
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Stock splits 3
Ex-date Split Type
July 6, 2026 1-for-20 Reverse
Sept. 29, 2023 1-for-20 Reverse
May 30, 2018 1-for-5 Reverse

10-Year Performance Revenue, net income, margins and EPS trends

06
Revenue$9M
2016-12-31 → 2025-12-31
EPS$-0.58
2019-12-31 → 2025-12-31
Free Cash Flow·
2016-12-31 → 2023-12-31
Net margin-490.3%
2016-12-31 → 2025-12-31
Valuation & Ratios 07–12

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric 5Y trend CRIS 5Y avg Peer Median Verdict
P/E (TTM) -0.25Y avg ≈37.2 ≈37.2 · ·
P/S (TTM) 0.45Y avg ≈207.6 ≈207.6 · ·
P/B (MRQ) 0.35Y avg ≈24.5 ≈24.5 · ·
EV / EBITDA 0.85Y avg ≈-68.8 ≈-68.8 · ·
Price / Cash Flow -0.05Y avg ≈-58.8 ≈-58.8 · ·
EV / Revenue -0.55Y avg ≈270.2 ≈270.2 · ·
Price / Tangible Book 0.35Y avg ≈47.4 ≈47.4 · ·

Peer median is calculated on a standardized basis per metric and may not always match the TTM/MRQ basis shown for this stock.

value · ≈ 5Y avg · industry median · verdict relative to median

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

14
Avg Surprise -16.7%
Next Report Nov 04, 2026
PeriodReportEPS ActualEPS EstSurprise
June 30, 2026 Aug 14, 2026 $-4.02 $-8.00 49.7%
March 31, 2026 $-25.00 $-8.16 -206.4%
Dec. 31, 2025 $-10.00 $-9.18 -8.9%
Sept. 30, 2025 $-9.80 $-11.79 16.9%
June 30, 2025 $-13.60 $-18.16 25.1%
March 31, 2025 $-1.25 $-1.21 -3.2%
Dec. 31, 2024 $-1.25 $-1.39 9.9%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

15
Income Statement 15
Metric Trend 202520242023202220212020201920182017201620152014
Revenue $9M$11M$10M$10M$11M$11M$10M$10M$10M$8M$8M$10M
R&D Expense ·········$18M·$14M
SG&A Expense $14M$17M$19M$20M$17M$12M$12M$15M$14M$16M$13M$12M
Operating Expenses $42M$55M$58M$63M$53M$36M$34M$40M$60M$66M$64M$26M
Operating Income $-6M$-45M$-48M$-53M$-42M$-25M$-24M$-29M$-50M$-58M$-56M$-16M
Interest Expense ····$0$0$791.0K$4M$4M$3M$3M$4M
Interest Income $316.0K$2M$3M$1M$211.0K$63.0K$614.0K$684.0K$513.0K$406.0K$277.0K$165.0K
Other Non-op $-2M$1M$919.0K$-4M$890.0K$22.0K$-58.0K$0$-4M$-2M$-2M$-3M
Income Tax $0$0··········
Net Income $-8M$-43M$-47M$-57M$-45M$-30M$-32M$-33M$-53M$-60M$-59M$-19M
EPS (Basic) $-0.58$-6.88$-8.96$-12.14$0.50$-0.61$-0.97·····
EPS (Diluted) $-0.58$-6.88$-8.96$-12.14$0.50$-0.61$-0.97·····
Shares (Basic) 13,164,0326,306,2845,293,2944,669,62691,569,15448,670,38133,180,516·····
Shares (Diluted) 13,164,0326,306,2845,293,2944,669,62691,569,15448,670,38133,180,516·····
EBITDA $-6M$-45M$-48M·$-42M$-25M$-24M$-29M$-50M$-58M$-56M$-16M
Balance Sheet 27
Metric Trend 202520242023202220212020201920182017201620152014
Cash & Equivalents $5M$20M$27M$20M$40M$130M$15M$24M$38M$26M$33M$8M
Short-term Investments ·$0$30M$66M$76M$39M$5M$634.0K$22M$18M$49M$42M
Receivables $0$3M$3M$3M$3M$3M$3M$3M$3M$2M$2M$2M
Prepaid Expense $2M$3M$2M$4M$3M$1M$1M$827.0K$989.0K$1M$1M$489.8K
Current Assets $7M$26M$61M$92M$122M$173M$25M$28M$64M$48M$86M$52M
PP&E (Net) $62.0K$231.0K$434.0K$689.0K$505.0K$663.0K$154.0K$267.0K$400.0K$400.0K$300.0K$407.7K
PP&E (Gross) $913.0K$1M$2M$3M$3M$3M$2M$2M$2M$2M$2M$2M
Accum. Depreciation $851.0K$1M$2M$2M$2M$2M$2M$2M$2M$2M$2M$2M
Goodwill $9M$9M$9M$9M$9M$9M$9M$9M$9M$9M$9M$9M
Other Non-current Assets $2M$2M$3M$2M$0$3.0K$3.0K$2.0K$3.0K$3.0K$51.0K$67.5K
Total Assets $20M$41M$77M$109M$162M$204M$35M$37M$74M$58M$95M$63M
Accounts Payable $6M$3M$3M$3M$6M$4M$4M$3M$5M$6M$4M$2M
Accrued Liabilities $7M$7M$9M$6M$6M$4M$2M$3M$3M$3M$2M$2M
Current Liabilities $14M$19M$22M$10M$13M$10M$7M$13M$14M$14M$11M$10M
Capital Leases $428.0K$2M$1M$3M$4M$5M$0·····
Other Non-current Liabilities ····$0$334.0K$0$11.0K$34.0K$18.0K$139.0K$174.0K
Total Liabilities $15M$47M$58M$62M$72M$74M$69M$42M$50M$28M$30M$33M
Long-term Debt ·····$891.0K$0$35M$42M$20M$24M$28M
Total Debt $0$8M··$0$557.0K$0$35M$42M$20M$24M$28M
Common Stock $6.0K$85.0K$59.0K$48.0K$916.0K$915.0K$332.0K$332.0K$331.0K$1M$1M$872.5K
Paid-in Capital ···········$810M
Retained Earnings $-1.25B$-1.24B$-1.20B$-1.15B$-1.09B$-1.05B$-1.02B$-985M$-952M$-899M$-839M$-780M
Treasury Stock ·······$0$2M$2M$2M$2M
AOCI ·$0$229.0K$-186.0K$-109.0K$-3.0K$0$0$-2.0K$-4.0K$28.0K$-11.0K
Stockholders' Equity $5M$-6M$20M$47M$91M$131M$-34M$-4M$24M$29M$65M$30M
Liabilities + Equity $20M$41M$77M$109M$162M$204M$35M$37M$74M$58M$95M$63M
Shares Outstanding 646,5378,487,8185,894,0854,830,46491,645,36991,502,46133,241,79333,159,25332,831,380141,124,025128,990,37886,030,811
Cash Flow 10
Metric Trend 202520242023202220212020201920182017201620152014
D&A $169.0K$203.0K$255.0K$233.0K$158.0K$144.0K$125.0K$177.0K$235.0K$193.0K$200.0K$200.0K
Stock-based Comp $4M$6M$6M$7M$5M$3M$3M$4M$5M$4M$4M$3M
Operating Cash Flow $-27M$-40M$-38M$-54M$-38M$-26M$-26M$-30M$-48M$-36M$-30M$-17M
CapEx ··$0$416.0K$0$677.0K$41.0K$85.0K$188.0K$329.0K$48.0K$92.0K
Investing Cash Flow $2M$29M$38M$33M$-48M$-49M$-4M$21M$-4M$30M$-6M$16M
Stock Issued $15M$12M$14M$6M$0$159M$0$0$42M$0$65M$0
Net Stock Activity $15M$12M$14M·$0$159M·$0$42M$0$65M$282.8K
Financing Cash Flow $10M$3M$8M$867.0K$-4M$189M$23M$-6M$64M$-1M$62M$-1M
Net Change in Cash $-15M$-7M$7M$-20M$-90M$114M$-7M$-15M$12M$-7M$25M$-2M
Free Cash Flow ··$-38M·$-38M$-26M$-26M$-30M$-49M$-36M$-30M$-17M
Profitability 5
Metric Trend 202520242023202220212020201920182017201620152014
Operating Margin -60.5%-408.3%-482.2%·-395.0%-229.8%-243.5%-281.3%-502.7%-771.1%-716.9%-161.1%
Net Margin -80.3%-397.8%-473.0%·-426.7%-276.0%-320.9%-312.6%-538.7%-802.6%-748.6%-190.3%
EBITDA Margin -60.5%-408.3%-482.2%·-395.0%-229.8%-243.5%-281.3%-502.7%-771.1%-716.9%-161.1%
ROA -24.8%-73.2%-50.9%·-24.8%-25.0%-88.6%-58.7%-81.1%-79.1%-74.9%-26.2%
ROE 177.9%589.0%-192.5%·-46.9%-58.6%107.1%1755.5%-199.5%-128.8%-125.1%-50.0%
Liquidity & Solvency 5
Metric Trend 202520242023202220212020201920182017201620152014
Current Ratio 0.51.44.5·9.117.13.82.14.63.67.95.2
Quick Ratio 0.41.24.4·8.917.03.62.04.53.57.85.1
Debt / Equity 0.0-1.3··0.00.00.0-7.91.70.70.41.0
LT Debt / Equity ······0.0-6.41.50.50.30.8
Interest Coverage ······-30.8-7.5-12.5-20.9-17.0-4.2
Efficiency 2
Metric Trend 202520242023202220212020201920182017201620152014
Asset Turnover 0.30.20.1·0.10.10.30.20.20.10.10.1
Receivables Turnover 5.63.63.5·3.43.43.33.53.63.33.95.7
Per Share 5
Metric Trend 202520242023202220212020201920182017201620152014
Book Value / Share $0.42$-0.71$3.34·$0.99$1.43$-1.02$-0.14$0.15$0.21$0.50$0.35
Revenue / Share $0.72$1.73$1.89·$0.12·······
Cash Flow / Share $-2.07$-6.27$-7.26·$-0.41·······
Cash / Share $0.39$2.36$4.53·$0.44$1.42$0.46$0.71$0.23$0.18$0.26$0.09
EPS (TTM) $-0.58$-6.88$-8.96$-12.14$0.50$-0.61$-0.97·····
Growth Rates 3
Metric Trend 202520242023202220212020201920182017201620152014
Revenue YoY -13.4%8.8%-1.4%-4.6%-1.7%·······
Revenue CAGR 3Y -2.4%0.80%-2.6%·········
Revenue CAGR 5Y -2.7%···········
Valuation (TTM) 14
Metric Trend 202520242023202220212020201920182017201620152014
Revenue TTM $9M$11M$10M$10M$11M$11M$10M$10M$10M$8M$8M$10M
Net Income TTM $-8M$-43M$-47M$-57M$-45M$-30M$-32M$-33M$-53M$-60M$-59M$-19M
Market Cap $13M$26M$75M·$8.72B$14.99B$1.13B$458M$11.49B$43.47B$37.54B$12.90B
Enterprise Value $8M$14M··$8.61B$14.82B$1.11B$469M$11.47B$43.44B$37.48B$12.88B
P/E -1.7-0.4-1.4-0.9190.4-268.5-35.1·····
P/S 1.42.47.5·819.31383.3113.043.91160.95774.74764.71311.0
P/B 2.3-4.33.8·96.2114.7-33.3-101.8478.91485.2581.9433.3
P / Tangible Book ··7.028.3106.8123.2······
P / Cash Flow -0.5-0.7-2.0·-231.9-582.3-43.1-15.2-237.6-1213.8-1255.8-767.5
P / FCF ··-2.0·-231.9-567.4-43.1-15.2-236.7-1202.7-1253.8-763.4
EV / EBITDA -1.4-0.3··-204.7-595.2-45.6-16.0-230.6-748.5-663.6-812.2
EV / FCF ····-228.8-561.0-42.3-15.5-236.3-1202.0-1251.8-762.1
EV / Revenue 0.81.2··808.41367.8110.945.01159.15771.44757.31308.9
Earnings Yield -58.6%-224.8%-70.3%-110.4%0.53%-0.37%-2.9%·····

Most recent period on the left · null values shown as ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

16
Metric 2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $9M $11M $10M $10M $11M
Operating Margin % -60.5% -408.3% -482.2% · -395.0%
Net Income $-8M $-43M $-47M $-57M $-45M
Diluted EPS $-0.58 $-6.88 $-8.96 $-12.14 $0.50

Institutional owners (13F) 39 filers · $8.3M total · As of June 30, 2026

17

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Holders 39
Value held $8.3M
New positions 7
Exited positions 12
Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
7 (-4 vs prior Q) 12 (+4 vs prior Q) 5 (-9 vs prior Q) 10 (+4 vs prior Q) -2.4M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
Bleichroeder LP $1,985,196 3,802,329 23.88% Shares
Stonepine Capital Management, LLC $1,729,292 3,312,185 20.80% Shares
SPHERA FUNDS MANAGEMENT LTD. $1,033,717 98,996 12.43% Shares
Nantahala Capital Management, LLC $1,033,171 1,978,876 12.43% Shares
Cable Car Capital, LP $696,134 1,333,334 8.37% Shares
VANGUARD GROUP INC $361,347 366,107 4.35% Shares
CM Management, LLC $287,155 550,000 3.45% Shares
MORGAN STANLEY $263,291 504,292 3.17% Shares
VANGUARD CAPITAL MANAGEMENT LLC $179,486 343,842 2.16% Shares
GEODE CAPITAL MANAGEMENT, LLC $153,036 293,097 1.84% Shares
M28 Capital Management LP $148,741 284,889 1.79% Shares
FLPUTNAM INVESTMENT MANAGEMENT CO $128,306 245,750 1.54% Shares
RENAISSANCE TECHNOLOGIES LLC $74,123 141,972 0.89% Shares
XTX Topco Ltd $56,470 108,160 0.68% Shares
NORTHERN TRUST CORP $50,054 95,870 0.60% Shares
VANGUARD FIDUCIARY TRUST CO $32,189 61,664 0.39% Shares
BlackRock, Inc. $27,846 53,334 0.33% Shares
Focused Wealth Management, Inc $26,131 50,049 0.31% Shares
STATE STREET CORP $10,990 21,049 0.13% Shares
FRANKLIN STREET ADVISORS INC /NC $10,442 20,000 0.13% Shares
LPL Financial LLC $7,819 14,977 0.09% Shares
MAVERICK CAPITAL LTD $6,194 49,554 0.07% Shares
Dauntless Investment Group, LLC $5,222 10,001 0.06% Shares
BARCLAYS PLC $3,641 6,973 0.04% Shares
Steward Partners Investment Advisory, LLC $1,356 2,597 0.02% Shares
OSAIC HOLDINGS, INC. $785 1,510 0.01% Shares
Axiom Investment Management LLC $574 1,100 0.01% Shares
GROUP ONE TRADING LLC $235 450 0.00% Shares
JPMORGAN CHASE & CO $48 108 0.00% Shares
JONES FINANCIAL COMPANIES LLLP $39 120 0.00% Shares
WELLS FARGO & COMPANY/MN $29 55 0.00% Shares
CWM, LLC $28 51 0.00% Shares
UBS Group AG $24 46 0.00% Shares
GSA CAPITAL PARTNERS LLP $12 22,760 0.00% Shares
CIBC Private Wealth Group LLC $10 6 0.00% Shares
Blue Trust, Inc. $2 4 0.00% Shares
VIMA LLC $2 3 0.00% Shares
MPWM ADVISORY SOLUTIONS, LLC $1 2 0.00% Shares
ROYAL BANK OF CANADA $0 63 0.00% Shares

Activists & 5%+ owners 3 positions

18

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Undisclosed reporting person March 4, 2004 · Initial filing · SEC
Undisclosed reporting person Jan. 29, 2004 · Initial filing Passive investment SEC
Undisclosed reporting person June 4, 2003 · Initial filing · SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Company insiders 33 insiders · 17 officers · 16 directors

19
Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
James E Dentzer President & CEO July 7, 2026 A 148,730 0 0 $0
Ali Fattaey Ph.D. President & CEO May 15, 2018 A 322,140 0 0 $0
Diantha Duvall CFO July 7, 2026 A 77,707 0 0 $0
William Steinkrauss Chief Financial Officer Jan. 29, 2022 A · 0 0 $0
Michael Gray CFO May 27, 2015 A 107,304 0 0 $0
Mitchell Keegan Vice-President Jan. 7, 2011 A · 0 0 $0
Jonathan B. Zung CDO July 7, 2026 A 66,667 0 0 $0
Ahmed Hamdy MD CMO March 20, 2026 C 66,667 0 0 $0
Robert Martell Head of Research & Development Jan. 20, 2023 A 23,027 0 0 $0
David Tuck Chief Medical Officer May 15, 2018 A 169,424 0 0 $0
Mani Mohindru Chief Strategy Officer Feb. 14, 2017 A · 0 0 $0
Jaye Viner Chief Medical Officer May 27, 2015 A · 0 0 $0
Mark Noel VP, Tech Management May 2, 2013 M 27,540 0 0 $0
Changgeng Qian VP, Research & Preclinical Dev Jan. 7, 2011 A · 0 0 $0
Mary Elizabeth Potthoff VP and General Counsel May 31, 2006 A 0 0 0 $0
Lee L Rubin VP of Research June 1, 2005 A 9,814 0 0 $0
Christopher U Missling Sr. VP, Strategic Planning Jan. 16, 2004 M 0 0 0 $0
Anne Elizabeth Borgman Director July 7, 2026 A · 0 0 $0
John Hohneker Director July 7, 2026 A · 0 0 $0
Marc Rubin Director July 7, 2026 A 28,108 0 0 $0
Kenneth I Kaitin Director July 7, 2026 A 11,407 1 0 $5,500
Martyn D Greenacre Director July 7, 2026 A 26,089 0 0 $0
Lori Anne Kunkel Director Jan. 31, 2022 A 22,200 0 0 $0
James R Mcnab Director May 5, 2017 S 50,000 0 0 $0
Kenneth Pienta Director Feb. 28, 2017 A 30,000 0 0 $0
James R Tobin Director Jan. 26, 2015 A 144,921 0 0 $0
Susan B Bayh Director Jan. 17, 2013 A 25,000 0 0 $0
Joseph Davie MD PHD Director Jan. 7, 2011 A · 0 0 $0
Stephen Carter Director Jan. 25, 2008 A · 0 0 $0
Joseph M Davie Director June 6, 2007 A 20,000 0 0 $0
Douglas Melton Director Aug. 23, 2006 A 173,499 0 0 $0
Daniel R Passeri · Jan. 19, 2016 A 211,798 0 0 $0
Maurizio Voi · Jan. 17, 2013 A · 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

ETF ownership Held by 2 ETFs

20

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
VXF · VANGUARD INDEX FUNDS 0.00% 128,243 SH Aug. 19, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 215,599 SH Aug. 19, 2026 Daily

CRIS Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

21
rating · 10 analysts BUY
Median target $43.00 +5252.3%
2 20.0% Strong Buy
7 70.0% Buy
1 10.0% Hold
0 0.0% Sell
0 0.0% Strong Sell

12-Month Price Target

3 analysts · 2026-10-01

Mean target $42.67 +5210.8%

← Below all targets Current price $0.80
Low$20.00 Mean$42.67 High$65.00

Peer comparison (GICS sub-industry) Key metrics vs sector peers

22

FY basis, prices as of each company's last fiscal year-end close.

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
CRIS $13M -1.7 -13.4% -80.3% 177.9% ·
BCAB · -0.6 · · · ·
GNPX $6M · · · -347.0% ·

My Metrics Your personal watchlist — selected rows from Full Fundamentals

26

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Source: SEC 10-Q filed Aug 14, 2026