DNLI logo
DNLI NASDAQ US

Denali Therapeutics Inc. - Common Stock

Healthcare · Biotechnology Website · IPO Dec 2017
$20.65
▲ +$0.97 (+4.93%)
Vol 1.6M
3
Quality Score
fail
Mkt Cap
$2.6B
ROE
-40.8%
Margin
-36.5%
D/E
0.60
Beta
0.98
52W
$11–$24

Wall Street Consensus

25 analysts · Apr 2026
11
Strong Buy
12
Buy
2
Hold
0
Sell
0
Strong Sell
92.0%
Buy Rating

Price Chart

Earnings

Beat rate: 75.0%
Quarter EPS Est EPS Act Surprise
Dec 2025 $-0.76 $-0.73 +$0.03
Sep 2025 $-0.77 $-0.74 +$0.03
Jun 2025 $-0.73 $-0.72 +$0.01
Mar 2025 $-0.70 $-0.78 $-0.08

Quarterly Revenue & Earnings

Quarter 2024-1… 2025-0… 2025-0… 2025-0… 2025-1…
Revenue
Net Income -$114.8M -$133.0M -$124.1M -$126.9M -$128.5M

Fundamentals Trend

Metric 2025-06-30 2025-09-02 2025-10-02 2025-11-03 2025-12-03 2026-01-02
ROE (TTM) -40.8% -31.4% -31.4% -31.4% -40.8% -40.8%
P/E (TTM)
Net Margin -36.5% -36.5% -36.5% -36.5% -36.5%
Gross Margin
D/E Ratio 0.54 0.54 0.54 0.54 0.60 0.60
Current Ratio 10.27 10.27 10.27 10.27 9.79 9.79

Key Ratios

ROA (TTM)
-36.4%
P/S (TTM)
7.57
P/B
2.4
EPS (TTM)
$-2.81
CF/Share
$-0.77
52W High
$24.35
52W Low
$10.57
$10.57 52-Week Range $24.35

Financial Health

Free Cash Flow
-$100.1M
Net Debt
-$168.6M
Cash
$205.3M
Total Debt
$36.8M
As of Dec 31, 2025

How does DNLI compare to Biotechnology peers?

Peer group: Micro-cap Biotechnology (All) · 528 companies

DNLI AAPG ABEO ABOS ABP

DNLI valuation vs Biotechnology peers

P/E ratio
0% below peers (18.8)
vs Peers
vs Industry
Undervalued
P/S ratio
7.6
41% below peers (12.9)
vs Peers
vs Industry
Undervalued
P/B ratio
2.4
3% below peers (2.5)
vs Peers
vs Industry
Fair value
Div yield
0% below peers (0.0%)
vs Peers
vs Industry
Low yield

DNLI profitability vs Biotechnology peers

ROE
-40.8%
39% above peers (-67.3%)
vs Peers
vs Industry
Below avg
Net margin
-36.5%
87% above peers (-286.8%)
vs Peers
vs Industry
Below avg
Gross margin
0% below peers (78.6%)
vs Peers
vs Industry
In line
ROA
-36.4%
22% above peers (-46.7%)
vs Peers
vs Industry
Below avg

DNLI financial health vs Biotechnology peers

D/E ratio
0.6
0% below peers (0.0)
vs Peers
vs Industry
In line
Current ratio
9.8
121% above peers (4.4)
vs Peers
vs Industry
Strong liquidity
Beta
1.0
1% above peers (1.0)
vs Peers
vs Industry
Less volatile

DNLI fundamentals radar

DNLI Peer median Industry

DNLI profitability vs leverage

Bubble size = market cap · X = net margin · Y = D/E ratio

DNLI vs peers: key metrics

Insider Activity

Neutral
Buys
0
Sells
0
WATTS RYAN J
Chief Executive Officer · Jan 06
35198 shs
SCHUTH ALEXANDER O
Chief Financial Officer · Jan 06
17218 shs
Last 90 days

Top Holders

Top 5: 33.0%
Vanguard Group Inc
8.23%
$237.1M
Blackrock Inc.
8.02%
$230.9M
BAILLIE GIFFORD & CO
7.76%
$223.6M
T. Rowe Price Investment Ma…
4.57%
$131.7M
Temasek Holdings (Private) …
4.42%
$127.4M
As of Dec 31, 2025

Latest News

No related news yet