your badges 52W Range $12–$27 19% of range Analyst Rating BUY 21 analysts Price Target $36 +137% upside P/E -4.4 ROE -57.8% Net Profit Margin ·

DYN Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

03
Price $15.20
Market Cap (MRQ) $2.52B
P/E -4.4
EPS $-3.47
ROE -57.8%
52W Range $12–$27

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04
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10-Year Performance Revenue, net income, margins and EPS trends

06
EPS$-3.47
2021-12-31 → 2025-12-31
Free Cash Flow$-405M
2020-12-31 → 2025-12-31
Valuation & Ratios 07–12

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric 5Y trend DYN 5Y avg Peer Median Verdict
P/E -4.45Y avg ≈-4.7 ≈-4.7 · ·
P/B (MRQ) 3.65Y avg ≈4.1 ≈4.1 4.6 Overvalued
Price / FCF (TTM) -5.25Y avg ≈-5.9 ≈-5.9 · ·
Price / Cash Flow (TTM) -5.35Y avg ≈-6.0 ≈-6.0 · ·
Price / Tangible Book 2.65Y avg ≈4.1 ≈4.1 · ·

Peer median is calculated on a standardized basis per metric and may not always match the TTM/MRQ basis shown for this stock.

value · ≈ 5Y avg · industry median · verdict relative to median

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

14
Avg Surprise -7.1%
Next Report Nov 02, 2026
PeriodReportEPS ActualEPS EstSurprise
June 30, 2026 Jul 27, 2026 $-1.08 $-0.76 -42.4%
March 31, 2026 $-0.73 $-0.78 6.5%
Dec. 31, 2025 $-0.76 $-0.78 2.3%
Sept. 30, 2025 $-0.76 $-0.85 10.1%
June 30, 2025 $-0.97 $-0.96 -0.60%
March 31, 2025 $-1.05 $-0.89 -18.2%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

15
Income Statement 10
Metric Trend 2025202420232022202120202019
R&D Expense $398M$281M$211M$143M$121M$45M$11M
SG&A Expense $70M$62M$31M$28M$29M$13M$3M
Operating Expenses $468M$344M$242M$171M$150M$59M$14M
Operating Income $-468M$-344M$-242M$-171M$-150M$-59M$-14M
Other Non-op $22M$26M$6M$3M$734.0K$-790.0K$-1M
Income Tax $0$0$0····
Net Income $-446M$-317M$-236M$-168M$-149M$-59M$-15M
EPS (Basic) $-3.47$-3.37$-3.95$-3.23$-2.93··
EPS (Diluted) $-3.47$-3.37$-3.95$-3.23$-2.93··
EBITDA $-466M$-342M$-240M$-169M$-149M$-58M·
Balance Sheet 20
Metric Trend 2025202420232022202120202019
Cash & Equivalents $893M$435M$122M$172M$201M$301M$15M
Prepaid Expense $16M$17M$6M$10M$6M$4M$127.0K
Current Assets $1.13B$659M$129M$266M$382M$349M$15M
PP&E (Net) $24M$5M$5M$6M$5M$2M$1M
PP&E (Gross) $33M$12M$10M$10M$7M$3M$2M
Accum. Depreciation $9M$7M$5M$4M$2M$995.0K$295.0K
Other Non-current Assets ······$191.0K
Total Assets $1.19B$691M$165M$306M$426M$353M$16M
Accounts Payable $8M$7M$23M$5M$4M$3M$1M
Current Liabilities $51M$42M$51M$28M$29M$11M$2M
Capital Leases $15M$19M$23M$26M$29M$0·
Total Liabilities $215M$61M$74M$54M$57M$11M$2M
Long-term Debt $149M$0·····
Common Stock $16.0K$10.0K$6.0K$6.0K$6.0K$5.0K$1.0K
Paid-in Capital $2.37B$1.58B$724M$650M$597M$422M$6M
Retained Earnings $-1.40B$-950M$-633M$-397M$-228M$-79M$-20M
AOCI $475.0K$6.0K$0$-571.0K$-269.0K$-27.0K·
Stockholders' Equity $972M$630M$91M$252M$368M$342M$14M
Liabilities + Equity $1.19B$691M$165M$306M$426M$353M$16M
Shares Outstanding 164,950,540102,318,62961,468,74355,636,50551,569,38145,076,5742,586,535
Cash Flow 13
Metric Trend 2025202420232022202120202019
D&A $2M$2M$2M$2M$1M$700.0K$271.0K
Stock-based Comp $46M$46M$20M$15M$18M$7M$26.0K
Other Non-cash $-5M$-22M$26M$-2M$11M$6M·
Operating Cash Flow $-403M$-292M$-188M$-154M$-120M$-47M$-12M
CapEx $2M$2M$729.0K$3M$4M$1M$2M
Investing Cash Flow $-29M$-204M$83M$87M$-138M$-46M$-2M
Debt Issued $148M$0$0··$10M·
Net Debt Issued $148M····$10M·
Stock Issued $141M$98M$52M$37M···
Net Stock Activity $141M$98M·····
Financing Cash Flow $890M$810M$54M$37M$158M$381M$20M
Net Change in Cash $458M$313M$-51M$-29M$-100M$289M$7M
Free Cash Flow $-405M$-295M$-189M$-157M$-123M$-48M·
Profitability 2
Metric Trend 2025202420232022202120202019
ROA -47.5%-74.1%-100.1%-45.9%-38.3%-32.1%·
ROE -57.8%-47.5%-193.9%-67.0%-38.2%-16.8%·
Liquidity & Solvency 2
Metric Trend 2025202420232022202120202019
Current Ratio 22.315.62.59.513.331.8·
Quick Ratio 17.610.32.46.17.027.4·
Per Share 3
Metric Trend 2025202420232022202120202019
Book Value / Share $5.89$6.16$1.49$4.54$7.14$7.60·
Cash / Share $5.42$4.26$1.98$3.09$3.89$6.67·
EPS (TTM) $-3.47$-3.37$-3.95$-3.23$-2.93··
Valuation (TTM) 8
Metric Trend 2025202420232022202120202019
Net Income TTM $-446M$-317M$-236M$-168M$-149M$-59M·
Market Cap $3.23B$2.41B$818M$645M$613M$947M·
P/E -5.6-7.0-3.4-3.6-4.1··
P/B 3.33.89.02.61.72.8·
P / Tangible Book 3.33.89.02.61.72.8·
P / Cash Flow -8.0-8.2-4.3-4.2-5.1-20.4·
P / FCF -8.0-8.2-4.3-4.1-5.0-19.9·
Earnings Yield -17.7%-14.3%-29.7%-27.9%-24.6%··

Most recent period on the left · null values shown as ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

16
Metric 2025-12-312024-12-312023-12-312022-12-312021-12-31
Net Income $-446M $-317M $-236M $-168M $-149M
Diluted EPS $-3.47 $-3.37 $-3.95 $-3.23 $-2.93

Institutional owners (13F) 259 filers · $3.7B total · As of Sept. 30, 2026

17

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Holders 259
Value held $3.7B
New positions 46
Exited positions 27
Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
46 (+4 vs prior Q) 27 (-14 vs prior Q) 90 (-12 vs prior Q) 76 (+14 vs prior Q) -9.6M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
BlackRock, Inc. $275,500,169 12,404,330 7.51% Shares
FMR LLC $248,907,468 11,207,000 6.79% Shares
JANUS HENDERSON GROUP PLC $247,426,927 13,647,376 6.75% Shares
VANGUARD GROUP INC $219,376,451 11,215,565 5.98% Shares
STATE STREET CORP $165,648,021 7,458,263 4.52% Shares
Orbis Allan Gray Ltd $155,615,298 7,006,542 4.24% Shares
Atlas Venture Life Science Advisors, LLC $151,030,199 6,800,099 4.12% Shares
VANGUARD CAPITAL MANAGEMENT LLC $140,166,621 6,310,969 3.82% Shares
TCG Crossover Management, LLC $102,502,348 4,615,144 2.80% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $89,915,586 4,048,428 2.45% Shares
FCPM III SERVICES B.V. $85,469,766 3,848,256 2.33% Shares
GEODE CAPITAL MANAGEMENT, LLC $83,158,757 3,743,427 2.27% Shares
Vestal Point Capital, LP $74,958,750 3,375,000 2.04% Shares
ORBIMED ADVISORS LLC $71,864,542 3,235,684 1.96% Shares
Frazier Life Sciences Management, L.P. $70,029,951 3,153,082 1.91% Shares
ARMISTICE CAPITAL, LLC $68,567,289 3,087,226 1.87% Shares
JPMORGAN CHASE & CO $67,154,494 3,151,656 1.83% Shares
PERCEPTIVE ADVISORS LLC $59,727,909 2,689,235 1.63% Shares
Logos Global Management LP $56,635,500 2,550,000 1.54% Shares
BANK OF AMERICA CORP /DE/ $49,603,770 2,233,398 1.35% Shares
Venrock Adviser, LLC $48,282,608 2,173,913 1.32% Shares
GOLDMAN SACHS GROUP INC $47,911,301 2,157,195 1.31% Shares
Siren, L.L.C. $47,287,866 2,129,125 1.29% Shares
FRANKLIN RESOURCES INC $45,104,481 2,030,819 1.23% Shares
DIMENSIONAL FUND ADVISORS LP $43,221,836 1,946,479 1.18% Shares
MPM BIOIMPACT LLC $42,689,686 1,922,093 1.16% Shares
SAMLYN CAPITAL, LLC $38,972,065 1,754,708 1.06% Shares
Sofinnova Investments, Inc. $36,832,709 1,658,384 1.00% Shares
Palo Alto Investors LP $36,591,441 1,647,521 1.00% Shares
Vivo Capital, LLC $34,591,320 1,557,466 0.94% Shares
Aberdeen Group plc $34,190,829 1,539,434 0.93% Shares
Deep Track Capital, LP $33,315,000 1,500,000 0.91% Shares
MARSHALL WACE, LLP $33,068,847 1,488,917 0.90% Shares
Polar Capital Holdings Plc $28,580,072 1,286,811 0.78% Shares
NORTHERN TRUST CORP $28,386,180 1,278,081 0.77% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $26,700,929 1,202,203 0.73% Shares
CITADEL ADVISORS LLC $25,407,307 1,143,958 0.69% Shares
Saturn V Capital Management LP $23,486,920 1,057,493 0.64% Shares
VANGUARD FIDUCIARY TRUST CO $21,964,557 988,949 0.60% Shares
NOVO HOLDINGS A/S $21,330,351 960,394 0.58% Shares
Rock Springs Capital Management LP $20,925,240 942,154 0.57% Shares
BRAIDWELL LP $20,468,692 921,598 0.56% Shares
FRONTIER CAPITAL MANAGEMENT CO LLC $19,414,605 874,138 0.53% Shares
BAKER BROS. ADVISORS LP $18,066,702 813,449 0.49% Shares
Fiera Capital Corp $17,545,656 789,989 0.48% Shares
MORGAN STANLEY $16,573,116 746,200 0.45% Shares
Artisan Partners Limited Partnership $14,653,847 659,786 0.40% Shares
RAYMOND JAMES FINANCIAL INC $12,800,733 576,350 0.35% Shares
TD Asset Management Inc $12,173,568 548,112 0.33% Shares
ALGERT GLOBAL LLC $11,244,323 506,273 0.31% Shares

Show all 259 institutional owners →

Activists & 5%+ owners 1 position

18

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Vida Ventures II, LLC, Vida Ventures II-A, LLC, VV Manager II, LLC ×2 filings Feb. 10, 2023 · Initial filing · SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Company insiders 26 insiders · 11 officers · 12 directors

19
Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
John Cox CEO & President Sept. 8, 2026 S 357,507 0 6 $-443,688
Joshua T Brumm CEO & President March 11, 2024 M 537,998 0 0 $0
Erick Lucera Chief Financial Officer Aug. 13, 2026 S 119,766 0 4 $-228,675
Susanna Gatti High Chief Operating Officer Sept. 18, 2024 S 131,636 0 0 $0
Johanna Friedl-Naderer Chief Commercial Officer Sept. 8, 2026 S 152,897 0 7 $-43,380
Douglas Kerr Chief Medical Officer Sept. 8, 2026 S 162,564 0 7 $-233,116
Oxana Beskrovnaya Chief Scientific Officer March 11, 2025 S 195,840 0 0 $0
Richard William Scalzo SVP, Head of Finance & Admin. March 11, 2025 S 122,330 0 0 $0
Wildon Farwell Chief Medical Officer Aug. 19, 2024 S 143,222 0 0 $0
Jonathan Mcneill Chief Business Officer Aug. 19, 2024 S 132,106 0 0 $0
Romesh Subramanian Chief Scientific Officer Sept. 16, 2020 A 566,249 0 0 $0
Jason P Rhodes Director Aug. 14, 2026 S 428,946 0 79 $-129,095,799
Dirk Kersten Director July 27, 2026 S 3,586,796 0 19 $-38,570,974
Barry E Greene Director June 22, 2026 A · 0 0 $0
Carlo Incerti Director June 5, 2026 A 0 0 0 $0
Catherine Stehman-Breen Director June 5, 2026 A 115,713 0 0 $0
David Charles Lubner Director June 5, 2026 A 0 0 0 $0
Brian S Posner Director June 5, 2026 A 24,500 7 0 $274,840
Edward Hurwitz Director June 5, 2026 A 91,081 0 0 $0
Vikram Karnani Director Dec. 22, 2025 A · 0 0 $0
Lawrence Otto Klein Director July 5, 2022 A 10,725 0 0 $0
Atlas Venture Fund XI, L.P. 10% owner July 13, 2021 J 7,326,117 0 0 $0
CureDuchenne Ventures, LLC 10% owner Sept. 21, 2020 C 602,972 0 0 $0
Forbion Capital Fund IV Cooperatief U.A. 10% owner Sept. 21, 2020 C 6,131,079 0 0 $0
Logos Global Management LP 10% owner Sept. 21, 2020 C 1,504,392 0 0 $0
Wellington Biomedical Innovation Master Investors (Cayman) I L.P. 10% owner Sept. 21, 2020 C 1,608,785 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

ETF ownership Held by 41 ETFs

20

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
IBRN · iShares Trust 2.55% 10,352 SH Sept. 11, 2026 Daily
BBC · ETFis Series Trust I 0.93% 17,087 NS July 31, 2026 N-PORT
JDOC · J.P. Morgan Exchange-Traded Fund Tr… 0.82% 2,968 NS July 31, 2026 N-PORT
LABU · Direxion Shares ETF Trust 0.72% 140,706 NS July 31, 2026 N-PORT
ESSC · Strategy Shares 0.23% 3,298 NS July 31, 2026 N-PORT
IBB · iShares Trust 0.20% 1,142,515 SH Sept. 11, 2026 Daily
PWS · Pacer Funds Trust 0.20% 1,922 NS July 31, 2026 N-PORT
IBBQ · Invesco Exchange-Traded Fund Trust … 0.20% 13,206 SH Oct. 2, 2026 Daily
BBSC · J.P. Morgan Exchange-Traded Fund Tr… 0.15% 41,341 NS July 31, 2026 N-PORT
BKSE · BNY Mellon ETF Trust 0.13% 4,624 NS July 31, 2026 N-PORT
VTWV · VANGUARD SCOTTSDALE FUNDS 0.13% 77,375 SH Aug. 19, 2026 Daily
RSSL · Global X Funds 0.12% 72,365 NS July 31, 2026 N-PORT
IWM · iShares Trust 0.09% 3,869,303 SH Sept. 11, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.09% 784,894 SH Aug. 19, 2026 Daily
DFAS · Dimensional ETF Trust 0.08% 478,626 NS July 31, 2026 N-PORT
ISCG · iShares Trust 0.07% 37,091 SH Sept. 11, 2026 Daily
IWO · iShares Trust 0.06% 494,945 SH Sept. 11, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.06% 50,849 SH Aug. 19, 2026 Daily
ESML · iShares Trust 0.06% 83,903 SH Sept. 11, 2026 Daily
FHLC · FIDELITY COVINGTON TRUST 0.05% 65,771 NS July 31, 2026 N-PORT
VFMO · VANGUARD WELLINGTON FUND 0.05% 47,064 SH Aug. 19, 2026 Daily
PRFZ · Invesco Exchange-Traded Fund Trust 0.05% 81,555 SH Oct. 2, 2026 Daily
VXF · VANGUARD INDEX FUNDS 0.04% 1,689,620 SH Aug. 19, 2026 Daily
VHT · VANGUARD WORLD FUND 0.04% 347,244 SH Aug. 19, 2026 Daily
VBR · VANGUARD INDEX FUNDS 0.03% 1,020,875 SH Aug. 19, 2026 Daily
WSML · iShares Trust 0.02% 8,555 SH Sept. 11, 2026 Daily
VB · VANGUARD INDEX FUNDS 0.02% 1,607,020 SH Aug. 19, 2026 Daily
DXUV · Dimensional ETF Trust 0.02% 3,800 NS July 31, 2026 N-PORT
TILT · FlexShares Trust 0.01% 12,166 NS July 31, 2026 N-PORT
DFAC · Dimensional ETF Trust 0.01% 217,916 NS July 31, 2026 N-PORT
DCOR · Dimensional ETF Trust 0.01% 14,680 NS July 31, 2026 N-PORT
DFAU · Dimensional ETF Trust 0.01% 37,664 NS July 31, 2026 N-PORT
ITOT · iShares Trust 0.00% 199,795 SH Sept. 11, 2026 Daily
DFUS · Dimensional ETF Trust 0.00% 31,685 NS July 31, 2026 N-PORT
IWV · iShares Trust 0.00% 39,299 SH Sept. 11, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 4,473,029 SH Aug. 19, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 11,370 SH Aug. 19, 2026 Daily
IWN · iShares Trust · 928,355 SH Sept. 11, 2026 Daily
ISCB · iShares Trust · 7,751 SH Sept. 11, 2026 Daily
ISCV · iShares Trust · 12,245 SH Sept. 11, 2026 Daily
SMLF · iShares Trust · 33,057 SH Sept. 11, 2026 Daily

DYN Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

21
rating · 21 analysts BUY
Median target $37.00 +143.4%
7 33.3% Strong Buy
12 57.1% Buy
2 9.5% Hold
0 0.0% Sell
0 0.0% Strong Sell

12-Month Price Target

15 analysts · 2026-10-03

Mean target $36.00 +136.8%

Now Current price $15.20
Low$10.00 Mean$36.00 High$50.00

Peer comparison (GICS sub-industry) Key metrics vs sector peers

22

FY basis, prices as of each company's last fiscal year-end close.

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
DYN $3.23B -5.6 · · -57.8% ·
ACAD $4.55B 11.6 11.9% 36.5% 38.1% ·
DNLI $2.58B -5.6 204.7% · -50.2% ·
ARQT $3.58B -223.4 91.3% -4.3% -9.8% ·
RCUS $2.99B -7.2 -4.3% -142.9% -59.8% ·
PGEN $1.48B -3.1 146.7% -2588.2% 3159.1% ·
PURR $1.58B 2.5 · 3229.8% 24.8% ·
CLDX $1.81B -7.0 -78.0% -16748.0% -43.8% ·
BEAM $2.82B -34.2 120.0% -57.2% -7.0% ·
IRON $3.01B -13.2 · · -31.3% ·

Latest News Recent headlines mentioning this company

23
Dyne Therapeutics (DYN) Concludes Phase 1/2 ACHIEVE Trial Enrollment Yahoo Finance · 3 months, 3 weeks ago Dyne Therapeutics Q1 Net Loss Widens Nasdaq · 4 months, 3 weeks ago

My Metrics Your personal watchlist — selected rows from Full Fundamentals

26

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Source: SEC 10-Q filed Jul 29, 2026