TNGX Tango Therapeutics, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$26.08
Price · Aug 19, 2026
Fundamentals as of Aug 11, 2026

About Tango Therapeutics, Inc. - Common Stock Company overview from Wikipedia

TNGX Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$26.07
Market Cap
$3.54B
P/E (TTM)
-30.0
EPS (TTM)
$-0.87
Revenue (TTM)
$62M
Div Yield
ROE
-42.2%
Debt/Equity
52W Range
$6 – $34

TNGX Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $62M
6-point trend, +714.8%
2020-12-31 2025-12-31
EPS $-0.87
5-point trend, +7.4%
2021-12-31 2025-12-31
Free Cash Flow $-140M
5-point trend, -128.0%
2021-12-31 2025-12-31
Margins -162.8%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
TNGX
Peer Median
P/E (TTM)
5-point trend, +12.5%
-30.0
13.2
P/S (TTM)
5-point trend, -25.4%
56.8
55.3
P/B
5-point trend, +25.2%
10.2
3.5
Price / FCF
5-point trend, +44.9%
-25.3

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
TNGX
Peer Median
Operating Margin
5-point trend, -13.6%
-178.4%
Net Profit Margin
5-point trend, -3.6%
-162.8%
-151.2%
ROA
5-point trend, -72.6%
-28.4%
-42.2%
ROE
5-point trend, -157.5%
-42.2%
-52.8%
ROIC
5-point trend, -89.6%
-32.1%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
TNGX
Peer Median
Current Ratio
5-point trend, +34.9%
16.3
10.3
Quick Ratio
5-point trend, +32.2%
15.8

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
TNGX
Peer Median
Revenue YoY
5-point trend, +68.4%
48.3%
Revenue CAGR 3Y
5-point trend, +68.4%
35.9%
Revenue CAGR 5Y
5-point trend, +68.4%
52.1%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
TNGX
Peer Median
EPS (Diluted)
5-point trend, +7.4%
$-0.87

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
TNGX
Peer Median

TNGX Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 19 analysts
  • Strong Buy 8 42.1%
  • Buy 9 47.4%
  • Hold 2 10.5%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

12 analysts · 2026-08-13
Median target $40.00 +53.4%
Mean target $44.33 +70.0%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.05%
Period EPS Actual EPS Est Surprise
March 31, 2026 $-0.32 $-0.32 -0.00%
Dec. 31, 2025 $-0.29 $-0.33 0.04%
Sept. 30, 2025 $0.14 $-0.05 0.19%
June 30, 2025 $-0.35 $-0.35 0.00%
March 31, 2025 $-0.36 $-0.36 -0.00%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
TNGX $1.20B -10.2 48.3% -162.8% -42.2%
CELC $4.81B -26.3 -244.3%
PBLS
RLAY $1.47B -5.3 53.4% -1800.6% -44.9%
LEGN
DNLI $2.58B -5.6 204.7% -50.2%
VKTX $4.04B -11.0 -47.3%
RCUS $2.99B -7.2 -4.3% -142.9% -59.8%
VCYT $3.34B 51.3 16.0% 12.8% 5.2% 70.1%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 14
Annual Income Statement data for TNGX
Metric Trend 202520242023202220212020
Revenue 6-point trend, +714.8% $62M $42M $37M $25M $37M $8M
R&D Expense 6-point trend, +164.4% $132M $144M $115M $106M $78M $50M
SG&A Expense 6-point trend, +320.8% $42M $44M $36M $30M $18M $10M
Operating Expenses 6-point trend, +190.2% $174M $188M $151M $136M $95M $60M
Operating Income 6-point trend, -113.2% $-111M $-146M $-114M $-111M $-58M $-52M
Other Non-op 6-point trend, +3290.8% $4M $8M $6M $1M $-248.0K $120.0K
Pretax Income 6-point trend, -95.5% $-102M $-130M $-102M $-108M $-58M $-52M
Income Tax 6-point trend, +4000.00 $4.0K $208.0K $134.0K $54.0K $292.0K $0
Net Income 6-point trend, -95.5% $-102M $-130M $-102M $-108M $-58M $-52M
EPS (Basic) 5-point trend, +7.4% $-0.87 $-1.19 $-1.08 $-1.23 $-0.94 ·
EPS (Diluted) 5-point trend, +7.4% $-0.87 $-1.19 $-1.08 $-1.23 $-0.94 ·
Shares (Basic) 5-point trend, +87.0% 116,166,187 109,226,731 94,572,448 87,820,037 62,108,032 ·
Shares (Diluted) 5-point trend, +87.0% 116,166,187 109,226,731 94,572,448 87,820,037 62,108,032 ·
EBITDA 5-point trend, -91.3% $-111M $-146M $-114M $-111M $-58M ·
Balance Sheet 23
Annual Balance Sheet data for TNGX
Metric Trend 202520242023202220212020
Cash & Equivalents 6-point trend, +295.6% $112M $70M $66M $60M $143M $28M
Short-term Investments 6-point trend, +42.6% $231M $188M $270M $306M $343M $162M
Receivables Flat — no change across 3 periods · · · $2M $2M $2M
Prepaid Expense 6-point trend, +676.7% $10M $8M $9M $7M $5M $1M
Current Assets 6-point trend, +82.7% $354M $266M $347M $375M $492M $194M
PP&E (Net) 6-point trend, +79.6% $7M $8M $10M $11M $5M $4M
PP&E (Gross) 6-point trend, +216.1% $17M $16M $16M $15M $7M $6M
Accum. Depreciation 6-point trend, +525.8% $11M $8M $6M $4M $3M $2M
Other Non-current Assets 6-point trend, +697.4% $303.0K $4.0K $46.0K $5.0K $19.0K $38.0K
Total Assets 6-point trend, +92.4% $399M $316M $403M $436M $500M $207M
Accounts Payable 6-point trend, -35.8% $1M $2M $3M $4M $3M $2M
Accrued Liabilities · · · · · $74.9K
Current Liabilities 6-point trend, -47.0% $22M $38M $46M $56M $41M $41M
Capital Leases 5-point trend, +345.2% $31M $34M $37M $39M · $7M
Other Non-current Liabilities · · · · · $5.0K
Total Liabilities 6-point trend, -68.9% $53M $117M $149M $187M $155M $169M
Common Stock 6-point trend, +240.0% $136.0K $108.0K $102.0K $88.0K $88.0K $40.0K
Paid-in Capital 6-point trend, +570.0% $949M $701M $624M $523M $507M $142M
Retained Earnings 6-point trend, -485.0% $-603M $-502M $-371M $-270M $-161M $-103M
AOCI 6-point trend, +1217.6% $224.0K $336.0K $186.0K $-4M $-765.0K $17.0K
Stockholders' Equity 6-point trend, +796.8% $346M $200M $253M $249M $345M $39M
Liabilities + Equity 6-point trend, +92.4% $399M $316M $403M $436M $500M $207M
Shares Outstanding 6-point trend, +236.7% 135,940,454 107,729,343 102,202,759 88,179,374 87,598,184 40,372,133
Cash Flow 8
Annual Cash Flow data for TNGX
Metric Trend 202520242023202220212020
Stock-based Comp 6-point trend, +1398.3% $26M $29M $19M $14M $8M $2M
Operating Cash Flow 6-point trend, -298.2% $-139M $-132M $-118M $-109M $-60M $70M
CapEx 6-point trend, -5.2% $1M $754.0K $2M $8M $2M $1M
Investing Cash Flow 6-point trend, +71.9% $-41M $86M $41M $26M $-183M $-145M
Financing Cash Flow 6-point trend, +175.1% $222M $48M $82M $2M $357M $81M
Net Change in Cash 6-point trend, +678.4% $43M $2M $6M $-81M $114M $5M
Taxes Paid $12.0K · · · · ·
Free Cash Flow 5-point trend, -128.0% $-140M $-132M $-120M $-117M $-61M ·
Profitability 7
Annual Profitability data for TNGX
Metric Trend 202520242023202220212020
Operating Margin 5-point trend, -13.6% -178.4% -346.1% -312.6% -446.8% -157.1% ·
Net Margin 5-point trend, -3.6% -162.8% -309.7% -278.5% -435.1% -157.2% ·
Pretax Margin 5-point trend, -4.1% -162.8% -309.2% -278.2% -434.9% -156.4% ·
EBITDA Margin 5-point trend, -13.6% -178.4% -346.1% -312.6% -446.8% -157.1% ·
ROA 5-point trend, -72.6% -28.4% -36.2% -24.2% -23.1% -16.5% ·
ROE 5-point trend, -157.5% -42.2% -60.8% -38.4% -41.4% -16.4% ·
ROIC 5-point trend, -89.6% -32.1% -73.1% -45.2% -44.5% -17.0% ·
Liquidity & Solvency 2
Annual Liquidity & Solvency data for TNGX
Metric Trend 202520242023202220212020
Current Ratio 6-point trend, +24.6% 16.3 7.0 7.5 6.8 12.1 13.1
Quick Ratio 6-point trend, +37.7% 15.8 6.8 7.3 6.6 12.0 11.5
Efficiency 2
Annual Efficiency data for TNGX
Metric Trend 202520242023202220212020
Asset Turnover 5-point trend, +66.7% 0.2 0.1 0.1 0.1 0.1 ·
Receivables Turnover 2-point trend, -32.9% · · · 12.4 18.5 ·
Per Share 5
Annual Per Share data for TNGX
Metric Trend 202520242023202220212020
Book Value / Share 6-point trend, +187.3% $2.55 $1.85 $2.48 $2.83 $3.94 $0.89
Revenue / Share 4-point trend, +89.7% $0.54 $0.39 $0.39 $0.28 · ·
Cash Flow / Share 4-point trend, +3.7% $-1.20 $-1.20 $-1.25 $-1.24 · ·
Cash / Share 6-point trend, +254.5% $0.83 $0.65 $0.65 $0.68 $1.63 $0.23
EPS (TTM) 5-point trend, +7.4% $-0.87 $-1.19 $-1.08 $-1.23 $-0.94 ·
Growth Rates 3
Annual Growth Rates data for TNGX
Metric Trend 202520242023202220212020
Revenue YoY 5-point trend, -87.4% 48.3% 15.2% 46.9% -32.9% 383.8% ·
Revenue CAGR 3Y 3-point trend, -47.5% 35.9% 4.3% 68.3% · · ·
Revenue CAGR 5Y 52.1% · · · · ·
Valuation (TTM) 10
Annual Valuation (TTM) data for TNGX
Metric Trend 202520242023202220212020
Revenue TTM 6-point trend, +714.8% $62M $42M $37M $25M $37M $8M
Net Income TTM 6-point trend, -95.5% $-102M $-130M $-102M $-108M $-58M $-52M
Market Cap 6-point trend, +1766.4% $1.20B $333M $1.01B $639M $958M $65M
P/E 5-point trend, +12.5% -10.2 -2.6 -9.2 -5.9 -11.6 ·
P/S 6-point trend, +129.0% 19.3 7.9 27.7 25.7 25.9 8.4
P/B 6-point trend, -73.0% 3.5 1.7 4.0 2.6 2.8 12.9
P / Tangible Book 6-point trend, +108.1% 3.5 1.7 4.0 2.6 2.8 1.7
P / Cash Flow 5-point trend, +46.1% -8.7 -2.5 -8.6 -5.9 -16.1 ·
P / FCF 5-point trend, +44.9% -8.6 -2.5 -8.5 -5.5 -15.6 ·
Earnings Yield 5-point trend, -14.3% -9.8% -38.5% -10.9% -17.0% -8.6% ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $62M$42M$37M$25M$37M
Operating Margin % -178.4%-346.1%-312.6%-446.8%-157.1%
Net Income $-102M$-130M$-102M$-108M$-58M
Diluted EPS $-0.87$-1.19$-1.08$-1.23$-0.94
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio 16.37.07.56.812.1
Quick Ratio 15.86.87.36.612.0
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-140M$-132M$-120M$-117M$-61M

Latest News Recent headlines mentioning this company

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Institutional owners (13F) 262 filers · $5.3B total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
84 (+30 vs prior Q) 21 (-9 vs prior Q) 92 (+28 vs prior Q) 59 (+3 vs prior Q) +34.6M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
RTW INVESTMENTS, LP $434,533,381 13,900,620 8.13% Shares
FARALLON CAPITAL MANAGEMENT, L.L.C. $383,779,020 12,277,000 7.18% Shares
Boxer Capital Management, LLC $339,990,606 10,876,219 6.36% Shares
GOLDMAN SACHS GROUP INC $301,599,366 9,648,092 5.64% Shares
TCG Crossover Management, LLC $283,878,343 9,081,201 5.31% Shares
FMR LLC $252,410,308 8,074,546 4.72% Shares
Paradigm Biocapital Advisors LP $198,736,169 6,357,523 3.72% Shares
Siren, L.L.C. $193,166,919 6,179,364 3.61% Shares
STATE STREET CORP $186,928,736 5,979,806 3.50% Shares
VANGUARD CAPITAL MANAGEMENT LLC $186,226,699 5,957,348 3.48% Shares
ADAGE CAPITAL PARTNERS GP, L.L.C. $175,056,000 5,600,000 3.28% Shares
Deep Track Capital, LP $131,292,000 4,200,000 2.46% Shares
DEERFIELD MANAGEMENT COMPANY, L.P. $130,998,500 4,190,611 2.45% Shares
Woodline Partners LP $125,057,724 4,000,567 2.34% Shares
TRV GP IV, LLC $120,181,383 6,374,574 2.25% Shares
PERCEPTIVE ADVISORS LLC $105,565,020 3,377,000 1.97% Shares
GEODE CAPITAL MANAGEMENT, LLC $101,978,756 3,261,580 1.91% Shares
Logos Global Management LP $89,091,000 2,850,000 1.67% Shares
Caligan Partners LP $78,153,220 2,500,103 1.46% Shares
Holocene Advisors, LP $75,365,953 2,410,939 1.41% Shares
Commodore Capital LP $70,335,000 2,250,000 1.32% Shares
Balyasny Asset Management L.P. $63,032,008 2,016,379 1.18% Shares
Jefferies Financial Group Inc. $62,849,293 2,010,534 1.18% Shares
Seven Fleet Capital Management LP $54,443,081 1,909,593 1.02% Shares
Candriam S.C.A. $50,922,046 1,630,553 0.95% Shares
JANUS HENDERSON GROUP PLC $49,579,803 2,371,672 0.93% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $49,550,570 1,585,111 0.93% Shares
Polar Capital Holdings Plc $46,287,932 1,480,740 0.87% Shares
Vivo Capital, LLC $43,131,579 1,379,769 0.81% Shares
DV EQUITIES, LLC $41,217,904 1,318,551 0.77% Shares
Cormorant Asset Management, LP $40,638,000 1,300,000 0.76% Shares
STEMPOINT CAPITAL LP $38,231,574 1,223,019 0.72% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $33,512,564 1,072,059 0.63% Shares
AMERICAN CENTURY COMPANIES INC $31,691,245 1,013,794 0.59% Shares
Integral Health Asset Management, LLC $31,260,000 1,000,000 0.58% Shares
VANGUARD FIDUCIARY TRUST CO $28,620,562 915,565 0.54% Shares
FEDERATED HERMES, INC. $26,956,373 862,328 0.50% Shares
RENAISSANCE TECHNOLOGIES LLC $23,391,858 748,300 0.44% Shares
Soleus Capital Management, L.P. $22,163,340 709,000 0.41% Shares
ArrowMark Colorado Holdings LLC $22,144,115 708,385 0.41% Shares
Bellevue Group AG $21,700,129 694,182 0.41% Shares
Alyeska Investment Group, L.P. $21,604,067 691,109 0.40% Shares
Connor, Clark & Lunn Investment Management Ltd. $19,871,576 635,687 0.37% Shares
Pictet Asset Management Holding SA $18,343,379 582,262 0.34% Shares
Fisher Asset Management, LLC $18,073,218 578,158 0.34% Shares
Nextech Invest Ltd. $17,099,998 5,533,980 0.32% Shares
FIRST TRUST ADVISORS LP $15,920,999 509,309 0.30% Shares
Nantahala Capital Management, LLC $15,650,600 500,659 0.29% Shares
BOOTHBAY FUND MANAGEMENT, LLC $15,645,536 500,497 0.29% Shares
MILLENNIUM MANAGEMENT LLC $15,506,085 496,036 0.29% Shares
DIMENSIONAL FUND ADVISORS LP $14,536,650 465,024 0.27% Shares
Rock Springs Capital Management LP $14,271,784 456,551 0.27% Shares
BOONE CAPITAL MANAGEMENT LLC $14,242,212 455,605 0.27% Shares
Longaeva Partners L.P. $12,969,837 414,902 0.24% Shares
BANK OF AMERICA CORP /DE/ $12,604,469 403,214 0.24% Shares
EVENTIDE ASSET MANAGEMENT, LLC $12,504,000 400,000 0.23% Shares
ACUTA CAPITAL PARTNERS, LLC $12,221,066 390,949 0.23% Shares
CONGRESS ASSET MANAGEMENT CO $11,902,120 380,746 0.22% Shares
Mass General Brigham, Inc $11,072,042 354,192 0.21% Shares
Assenagon Asset Management S.A. $10,789,577 345,156 0.20% Shares
BAKER BROS. ADVISORS LP $10,419,990 333,333 0.19% Shares
PFM Health Sciences, LP $10,192,229 326,047 0.19% Shares
AMERIPRISE FINANCIAL INC $9,576,345 306,345 0.18% Shares
JANE STREET GROUP, LLC $9,354,993 299,264 0.18% Shares
Point72 Asset Management, L.P. $9,326,077 298,339 0.17% Shares
SAMLYN CAPITAL, LLC $9,145,519 292,563 0.17% Shares
SCHRODER INVESTMENT MANAGEMENT GROUP $9,068,318 278,511 0.17% Shares
ALGERT GLOBAL LLC $8,489,278 271,570 0.16% Shares
HighVista Strategies LLC $8,129,788 260,070 0.15% Shares
SPHERA FUNDS MANAGEMENT LTD. $7,947,855 254,250 0.15% Shares
TWO SIGMA INVESTMENTS, LP $7,558,137 241,783 0.14% Shares
KVP Capital Advisors, LP $7,198,053 230,264 0.13% Shares
TD Asset Management Inc $6,938,720 221,968 0.13% Shares
BlackRock, Inc. $6,844,940 218,968 0.13% Shares
Sio Capital Management, LLC $6,517,710 208,500 0.12% Shares
Atle Fund Management AB $6,206,891 198,557 0.12% Shares
TRV GP VI, LLC $6,069,879 194,174 0.11% Shares
Walleye Capital LLC $6,010,360 192,270 0.11% Shares
Swiss National Bank $5,858,124 187,400 0.11% Shares
VANGUARD GROUP INC $5,714,806 645,012 0.11% Shares
MANUFACTURERS LIFE INSURANCE COMPANY, THE $5,664,687 181,212 0.11% Shares
VICTORY CAPITAL MANAGEMENT INC $5,525,142 176,748 0.10% Shares
RHUMBLINE ADVISERS $5,474,643 175,133 0.10% Shares
VOYA INVESTMENT MANAGEMENT LLC $4,897,973 156,685 0.09% Shares
Burkehill Global Management, LP $4,689,000 150,000 0.09% Shares
SEVEN GRAND MANAGERS, LLC $4,689,000 150,000 0.09% Shares
Ghisallo Capital Management LLC $4,689,000 150,000 0.09% Shares
CITIGROUP INC $4,497,626 143,878 0.08% Shares
Informed Momentum Co LLC $4,189,278 134,014 0.08% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $3,888,744 124,400 0.07% Call option
XTX Topco Ltd $3,697,589 118,285 0.07% Shares
PRUDENTIAL FINANCIAL INC $3,622,565 115,885 0.07% Shares
ALLIANCEBERNSTEIN L.P. $3,347,409 160,010 0.06% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $3,313,091 105,985 0.06% Shares
WELLINGTON MANAGEMENT GROUP LLP $3,161,042 101,121 0.06% Shares
Monashee Investment Management LLC $3,126,000 100,000 0.06% Shares
Balyasny Asset Management L.P. $3,126,000 100,000 0.06% Call option
ExodusPoint Capital Management, LP $3,063,949 98,015 0.06% Shares
CITADEL ADVISORS LLC $2,991,582 95,700 0.06% Call option
SUSQUEHANNA INTERNATIONAL GROUP, LLP $2,935,314 93,900 0.05% Put option

Company insiders 20 insiders · 7 officers · 10 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Malte Peters President & CEO Jan. 8, 2026 A 367,500 0 0 $0
Matthew Gall Chief Financial Officer May 1, 2026 A 40,000 0 0 $0
Daniella Beckman Chief Financial Officer Feb. 2, 2026 A 184,297 0 2 $-126,559
Barbara Weber Director, Executive Chair Feb. 2, 2026 A 1,629,254 0 2 $-374,376
Douglas Barry General Counsel Feb. 5, 2025 S 66,014 0 0 $0
Alan Huang Chief Scientific Officer March 1, 2023 A 167,584 0 0 $0
Marc Rudoltz Chief Medical Officer Nov. 1, 2021 A 0 0 $0
Robert Azelby Director June 19, 2026 A 5,740 0 0 $0
John B Ketchum Director June 5, 2026 A 24,937 0 0 $0
Mace Rothenberg Director June 5, 2026 A 41,500 0 0 $0
Sung Lee Director June 5, 2026 A 22,870 0 0 $0
Lesley Ann Calhoun Director June 5, 2026 A 16,500 0 0 $0
Alexis Borisy Director June 5, 2025 A 17,500 0 0 $0
Reid M Huber Director June 6, 2023 A 5,000 0 0 $0
Tango Therapeutics, Inc. Director Dec. 8, 2021 A 3,400 0 0 $0
EcoR1 Capital, LLC 10% owner Nov. 7, 2024 S 10,630,736 0 0 $0
Adam Crystal Aug. 3, 2026 M 115,743 0 15 $-5,724,378
Davis Aaron I. Sept. 3, 2024 J 5,000 0 0 $0
Aaron Weitzman Dec. 1, 2022 A 0 0 $0
BCTG Holdings, LLC Nov. 20, 2020 S 4,488,450 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 5 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Third Rock Ventures IV, L.P., Third Rock Ventures GP IV, L.P., TRV GP IV, LLC ×3 filings Feb. 10, 2026 4.74% Amendment SEC
BCTG Holdings, LLC, MVA Investors, LLC, Davis Aaron I., Boxer Capital Management, LLC ×7 filings Jan. 2, 2025 10.00% Amendment SEC
Boxer Asset Management Inc., Braslyn Ltd., Joe Lewis Oct. 15, 2024 Initial filing SEC
Boxer Capital Management, LLC, Boxer Capital, LLC, MVA Investors, LLC, Aaron I. Davis Oct. 15, 2024 Initial filing SEC
Third Rock Ventures IV, L.P. (2), Third Rock Ventures GP IV, L.P. (2), TRV GP IV, LLC (2) ×2 filings Sept. 4, 2024 Initial filing SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 40 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
PTH · Invesco Exchange-Traded Fund Trust 2.07% 188,550 SH Aug. 8, 2026 Daily
BBC · ETFis Series Trust I 1.71% 29,518 NS April 30, 2026 N-PORT
DWAS · Invesco Exchange-Traded Fund Trust … 1.26% 208,730 SH Aug. 8, 2026 Daily
FYC · First Trust Exchange-Traded AlphaDE… 0.58% 278,656 NS April 30, 2026 N-PORT
LABU · Direxion Shares ETF Trust 0.47% 112,975 NS April 30, 2026 N-PORT
FYX · First Trust Exchange-Traded AlphaDE… 0.30% 165,931 NS April 30, 2026 N-PORT
IBB · iShares Trust 0.27% 877,490 SH Aug. 8, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.27% 7,871 SH Aug. 8, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.26% 150,730 SH Aug. 8, 2026 Daily
IWO · iShares Trust 0.25% 1,280,778 SH Aug. 8, 2026 Daily
VFMO · VANGUARD WELLINGTON FUND 0.23% 146,692 SH Aug. 8, 2026 Daily
BIB · ProShares Trust 0.15% 4,978 NS May 31, 2026 N-PORT
VTWO · VANGUARD SCOTTSDALE FUNDS 0.13% 810,623 SH Aug. 8, 2026 Daily
IWM · iShares Trust 0.13% 3,593,320 SH Aug. 8, 2026 Daily
FAD · First Trust Exchange-Traded AlphaDE… 0.12% 25,999 NS April 30, 2026 N-PORT
ISCG · iShares Trust 0.09% 29,437 SH Aug. 8, 2026 Daily
RSSL · Global X Funds 0.07% 48,104 NS April 30, 2026 N-PORT
GSSC · Goldman Sachs ETF Trust 0.07% 32,613 NS May 31, 2026 N-PORT
PRFZ · Invesco Exchange-Traded Fund Trust 0.07% 75,650 SH Aug. 8, 2026 Daily
ESML · iShares Trust 0.07% 65,532 SH Aug. 8, 2026 Daily
ITWO · ProShares Trust 0.06% 5,226 NS May 31, 2026 N-PORT
SCHA · SCHWAB STRATEGIC TRUST 0.05% 471,380 NS May 31, 2026 N-PORT
ISCB · iShares Trust 0.04% 4,243 SH Aug. 8, 2026 Daily
VXF · VANGUARD INDEX FUNDS 0.04% 1,418,754 SH Aug. 8, 2026 Daily
VHT · VANGUARD WORLD FUND 0.04% 281,272 SH Aug. 8, 2026 Daily
UWM · ProShares Trust 0.04% 4,088 NS May 31, 2026 N-PORT
WSML · iShares Trust 0.03% 6,197 SH Aug. 8, 2026 Daily
URTY · ProShares Trust 0.03% 4,138 NS May 31, 2026 N-PORT
FHLC · FIDELITY COVINGTON TRUST 0.02% 20,381 NS April 30, 2026 N-PORT
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.01% 3,996 NS May 31, 2026 N-PORT
HDG · ProShares Trust 0.01% 104 NS May 31, 2026 N-PORT
VTI · VANGUARD INDEX FUNDS 0.01% 4,396,603 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.01% 11,571 SH Aug. 8, 2026 Daily
DFAS · Dimensional ETF Trust 0.01% 61,068 NS April 30, 2026 N-PORT
ONEQ · Fidelity Commonwealth Trust 0.01% 36,046 NS May 31, 2026 N-PORT
IWV · iShares Trust 0.01% 39,761 SH Aug. 8, 2026 Daily
ITOT · iShares Trust 0.00% 151,725 SH Aug. 8, 2026 Daily
SCHB · SCHWAB STRATEGIC TRUST 0.00% 60,195 NS May 31, 2026 N-PORT
DFAU · Dimensional ETF Trust 0.00% 4,480 NS April 30, 2026 N-PORT
DFUS · Dimensional ETF Trust 0.00% 5,276 NS April 30, 2026 N-PORT