IONS logo
IONS NASDAQ US

Ionis Pharmaceuticals, Inc. - Common Stock

Healthcare · Biotechnology Website · IPO May 1991
$74.79
▼ $-0.34 (-0.45%)
Vol 1.8M
4
Quality Score
fail
Mkt Cap
$12.8B
ROE
-44.3%
Margin
-26.5%
D/E
198.53
Beta
0.27
52W
$24–$84

Wall Street Consensus

29 analysts · Apr 2026
9
Strong Buy
13
Buy
7
Hold
0
Sell
0
Strong Sell
75.9%
Buy Rating

Price Chart

Earnings

Beat rate: 75.0%
Quarter EPS Est EPS Act Surprise
Dec 2025 $-1.35 $-1.41 $-0.06
Sep 2025 $-1.26 $-0.80 +$0.46
Jun 2025 $-0.44 $0.70 +$1.14
Mar 2025 $-1.14 $-0.93 +$0.21

Fundamentals Trend

Metric 2025-06-30 2025-09-02 2025-10-02 2025-11-03 2025-12-03 2026-01-02
ROE (TTM) -45.5% -45.5% -45.5% -45.5% -44.3% -44.3%
P/E (TTM)
Net Margin 27.3% -28.4% -28.4% -28.4% -26.5% -26.5%
Gross Margin 99.1% 98.8% 98.8% 98.8% 98.7% 98.7%
D/E Ratio 198.76 198.76 198.76 198.76 198.53 198.53
Current Ratio 2.87 2.87 2.87 2.87 2.79 2.79

Key Ratios

ROA (TTM)
-8.7%
P/S (TTM)
13.24
P/B
9.4
EPS (TTM)
$-1.71
CF/Share
$-2.77
Rev Growth 3Y
-4.5%
52W High
$83.61
52W Low
$23.95
$23.95 52-Week Range $83.61

How does IONS compare to Biotechnology peers?

Peer group: Micro-cap Biotechnology (All) · 528 companies

IONS AAPG ABEO ABOS ABP

IONS valuation vs Biotechnology peers

P/E ratio
0% below peers (18.8)
vs Peers
vs Industry
Undervalued
P/S ratio
13.2
3% above peers (12.9)
vs Peers
vs Industry
Fair value
P/B ratio
9.4
281% above peers (2.5)
vs Peers
vs Industry
Overvalued
Div yield
0% below peers (0.0%)
vs Peers
vs Industry
Low yield

IONS profitability vs Biotechnology peers

ROE
-44.3%
34% above peers (-67.3%)
vs Peers
vs Industry
Below avg
Net margin
-26.5%
91% above peers (-286.8%)
vs Peers
vs Industry
Below avg
Gross margin
98.7%
26% above peers (78.6%)
vs Peers
vs Industry
Weak
ROA
-8.7%
81% above peers (-46.7%)
vs Peers
vs Industry
Top tier

IONS financial health vs Biotechnology peers

D/E ratio
198.5
0% below peers (0.0)
vs Peers
vs Industry
High debt
Current ratio
2.8
37% below peers (4.4)
vs Peers
vs Industry
Low liquidity
Beta
0.3
72% below peers (1.0)
vs Peers
vs Industry
More volatile

IONS fundamentals radar

IONS Peer median Industry

IONS profitability vs leverage

Bubble size = market cap · X = net margin · Y = D/E ratio

IONS vs peers: key metrics