EXEL Exelixis, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$54.24
Price · Aug 19, 2026
Fundamentals as of Aug 5, 2026

About Exelixis, Inc. - Common Stock Company overview from Wikipedia

Exelixis, Inc. is a genomics-based drug discovery company located in Alameda, California, and the producer of Cometriq, a treatment approved by the U.S. Food and Drug Administration (FDA) for medullary thyroid cancer with clinical activity in several other types of metastatic cancer.

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Exelixis, Inc. is a genomics-based drug discovery company located in Alameda, California, and the producer of Cometriq, a treatment approved by the U.S. Food and Drug Administration (FDA) for medullary thyroid cancer with clinical activity in several other types of metastatic cancer.

History

Exelixis was founded in 1994; the scientific founders were Spyridon Artavanis–Tsakonas, at Yale at that time, and Corey Goodman and Gerry Rubin who were then at the University of California, Berkeley. George Scangos joined the company as CEO in 1996. The business plan was to use model organisms (fruit flies, nematodes, and zebrafish) and functional genomics to identify pathways and biological targets that could be exploited in the fields of agriculture and medicine. It eventually set up a subsidiary, Exelixis Plant Sciences, for the agricultural work.

By 2000, Exelixis had left the radical exploratory phase behind and became focused on drug discovery and had a chemical library of 4 million compounds. The company went public that year, after withdrawing its offering the week before; it raised $118 million in a down market.

In 2002, the company signed a broad alliance with GSK to discover new drugs in the fields of cancer, inflammatory diseases, and vascular conditions; GSK paid it $30 million in cash, bought $14 million in stock at twice the market rate, and committed to providing Exelixis with $90 million in research funding; it also offered loan financing of up to $85 million.

By 2002, the company had limited its internal efforts to cancer, and had settled its strategy on discovering and developing drugs that could inhibit targeted small sets of tyrosine kinases that are needed for cancer formation, growth, and metastasis. The sets of TKs had been identified by means of its prior functional genomics work. This approach was controversial at the time; most companies try to selectively target just one protein in their discovery efforts.

In 2006, Exelixis partnered with Daiichi Sankyo on compounds that targeted mineralocorticoid receptors; esaxerenone was part of this collaboration. In 2007, the company partnered its MEK inhibitor program with Genentech; cobimetinib (at that time XL-518) was part of this collaboration. Exelixis had filed an IND on XL-518 prior to the partnership, committed to funding and running the Phase I trial, and retained rights to co-market it in the US.

In 2008, the company partnered its lead cancer drug candidate, XL-184 (which would become called cabozantinib) and another cancer candidate, XL-281, with Bristol Myers Squibb; BMS returned the rights to XL-184 to Exelixis in 2010 and returned the rights to other drug candidate in 2011.

In 2010, Scangos departed as CEO to take over at Biogen and the company appointed Michael M. Morrissey as president and CEO; Morrissey had joined the company in 2000 as Vice President of Discovery Research. At that time the company had eight drugs in clinical trials.

Exelixis' first drug approval came in 2012, when cabozantinib was approved for medullary thyroid cancer, an orphan indication. It was approved in Europe in 2014.

Exelixis invested heavily in exploring cabozantinib in other cancers, betting the future of the company on the drug. In 2014 the drug failed a Phase III trial in prostate cancer, and the company laid off 70% of its employees.

In 2015, Genentech and Exelixis won FDA approval for cobimetinib for certain forms of melanoma.

In March 2016, Exelixis licensed to Ipsen worldwide rights (outside the US, Canada, and Japan) to market cabozantinib.

In April 2016, the FDA granted approval for marketing the tablet formulation as a second line treatment for kidney cancer and the same was approved in Europe in October of that year.

In December 2017, the FDA granted approval for the use of cabozantinib for first line treatment of kidney cancer and in 2018 approval for first-line treatment was approved in Europe.

Finance

Pricing

Cabometyx (cabozantinib)

In 2023, the Institute for Clinical and Economic Review (ICER) identified Cabometyx (cabozantinib) as one of five high-expenditure drugs that experienced significant net price increases without new clinical evidence to justify the hikes. Specifically, Cabometyx's wholesale acquisition cost rose by 7.5%, leading to an additional $86 million in costs to U.S. payers.

Source: Wikipedia, CC BY-SA 4.0 · View on Wikipedia ↗

Wikidata ↗

EXEL Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$54.24
Market Cap
$13.76B
P/E (TTM)
18.9
EPS (TTM)
$2.78
Revenue (TTM)
$2.32B
Div Yield
ROE
37.3%
Debt/Equity
52W Range
$34 – $58

EXEL Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $2.32B
10-point trend, +1111.8%
2016-12-31 2026-01-02
EPS $2.78
9-point trend, +467.3%
2017-12-29 2026-01-02
Free Cash Flow $876M
9-point trend, +506.3%
2017-12-29 2026-01-02
Margins 33.7%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
EXEL
Peer Median
P/E (TTM)
5-point trend, -38.3%
18.9
28.5
P/S (TTM)
5-point trend, +21.4%
5.9
20.1
P/B
5-point trend, +100.7%
6.4
12.9
Price / FCF
5-point trend, -24.6%
15.7

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
EXEL
Peer Median
Operating Margin
5-point trend, +88.1%
37.6%
Net Profit Margin
5-point trend, +109.5%
33.7%
-48.4%
ROA
5-point trend, +178.0%
27.0%
-28.4%
ROE
5-point trend, +249.0%
37.3%
-49.2%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
EXEL
Peer Median
Current Ratio
5-point trend, -34.5%
3.6
5.0
Quick Ratio
5-point trend, -36.0%
3.3

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
EXEL
Peer Median
Revenue YoY
5-point trend, +61.7%
7.0%
Revenue CAGR 3Y
5-point trend, +61.7%
12.9%
Revenue CAGR 5Y
5-point trend, +61.7%
18.6%
EPS YoY
5-point trend, +286.1%
58.0%
Net Income YoY
5-point trend, +238.7%
50.1%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
EXEL
Peer Median
EPS (Diluted)
5-point trend, +286.1%
$2.78

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
EXEL
Peer Median

EXEL Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 26 analysts
  • Strong Buy 5 19.2%
  • Buy 8 30.8%
  • Hold 12 46.2%
  • Sell 1 3.8%
  • Strong Sell 0 0.0%

12-Month Price Target

16 analysts · 2026-08-13
Median target $52.00 -4.1%
Mean target $52.94 -2.4%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.08%
Period EPS Actual EPS Est Surprise
June 30, 2026 $0.82 $0.80 0.02%
March 31, 2026 $0.79 $0.72 0.07%
Dec. 31, 2025 $0.88 $0.82 0.06%
Sept. 30, 2025 $0.69 $0.63 0.06%
June 30, 2025 $0.65 $0.57 0.08%
March 31, 2025 $0.55 $0.37 0.18%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
EXEL $11.44B 15.7 7.0% 33.7% 37.3%
UTHR $21.27B 17.5 10.6% 41.9% 18.7% 87.9%
NBIX $14.20B 30.4 21.4% 16.7% 16.1%
BBIO $14.90B -20.2 126.3% -146.0% 41.2%
BMRN $11.43B 33.0 12.9% 10.8% 5.8%
ARWR $4.68B -3449.0 23258.2% -0.20% -0.50%
MDGL $13.30B -45.3 432.1% -30.1% -44.4%
HALO $7.93B 26.3 37.5% 22.7% 166.1%
PRAX $7.43B -21.9 249.5% -47.3%
CYTK $7.81B -9.7 376.6% -891.6% 152.7%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 16
Annual Income Statement data for EXEL
Metric Trend 20252024202320222021202020192018201720162015
Revenue 11-point trend, +6141.6% $2.32B $2.17B $1.83B $1.61B $1.43B $988M $968M $854M $452M $191M $37M
Cost of Revenue 11-point trend, +2048.8% $84M $76M $73M $58M $53M $36M $33M $26M $15M $7M $4M
R&D Expense 11-point trend, +756.2% $825M $910M $1.04B $892M $694M $548M $337M $182M $112M $96M $96M
SG&A Expense 11-point trend, +805.2% $519M $492M $543M $460M $402M $293M $228M $206M $159M $116M $57M
Operating Expenses 11-point trend, +813.0% $1.45B $1.56B $1.66B $1.41B $1.15B $877M $598M $415M $287M $220M $159M
Operating Income 11-point trend, +818.3% $872M $605M $171M $201M $287M $110M $369M $439M $166M $-28M $-121M
Interest Expense 5-point trend, -100.0% · · · · · · $0 $0 $9M $33M $41M
Other Non-op 11-point trend, +48.0% $-198.0K $-133.0K $93.0K $-197.0K $-184.0K $912.0K $680.0K $397.0K $-4M $5M $-381.0K
Pretax Income 6-point trend, +180.9% · · · · · $131M $398M $452M $159M $-70M $-162M
Income Tax 11-point trend, +288329.1% $159M $160M $50M $52M $63M $19M $77M $-238M $4M $0 $55.0K
Net Income 11-point trend, +583.8% $783M $521M $208M $182M $231M $112M $321M $690M $154M $-70M $-162M
EPS (Basic) 10-point trend, +474.0% $2.88 $1.80 $0.65 $0.57 $0.73 $0.36 $1.06 $2.32 $0.52 · $-0.77
EPS (Diluted) 10-point trend, +461.0% $2.78 $1.76 $0.65 $0.56 $0.72 $0.35 $1.02 $2.21 $0.49 · $-0.77
Shares (Basic) 10-point trend, +29.8% 271,567,000 290,030,000 318,151,000 321,526,000 314,884,000 308,271,000 302,584,000 297,892,000 293,588,000 · 209,227,000
Shares (Diluted) 10-point trend, +34.7% 281,863,000 296,132,000 321,464,000 324,556,000 322,359,000 318,001,000 315,009,000 312,803,000 312,003,000 · 209,227,000
EBITDA 9-point trend, +439.4% $901M $633M $197M $222M $300M $119M $378M $444M $167M · ·
Balance Sheet 27
Annual Balance Sheet data for EXEL
Metric Trend 20252024202320222021202020192018201720162015
Cash & Equivalents 11-point trend, +240.7% $482M $217M $263M $501M $647M $319M $267M $315M $183M $152M $142M
Short-term Investments 10-point trend, +115.1% $577M $894M $732M $807M $820M $887M $586M $379M $205M $268M ·
Receivables 10-point trend, +609.4% $287M $265M $237M $215M $283M $161M $119M $163M $77M $40M ·
Inventory 10-point trend, +549.7% $22M $22M $17M $33M $27M $21M $13M $10M $7M $3M ·
Prepaid Expense 10-point trend, +1295.8% $76M $68M $68M $62M $58M $57M $27M $31M $9M $5M ·
Current Assets 10-point trend, +207.7% $1.44B $1.47B $1.32B $1.62B $1.83B $1.45B $1.01B $897M $485M $469M ·
PP&E (Net) 10-point trend, +4678.4% $99M $119M $129M $111M $104M $67M $49M $51M $26M $2M ·
PP&E (Gross) 10-point trend, +757.7% $231M $220M $209M $171M $145M $102M $74M $68M $49M $27M ·
Accum. Depreciation 10-point trend, +431.4% $132M $101M $80M $61M $41M $35M $26M $17M $23M $25M ·
Goodwill Flat — no change across 10 periods $64M $64M $64M $64M $64M $64M $64M $64M $64M $64M ·
Other Non-current Assets 6-point trend, +10533.3% · · · · $131M $73M $53M $8M $12M $1M ·
Total Assets 10-point trend, +377.5% $2.84B $2.95B $2.94B $3.07B $2.62B $2.14B $1.89B $1.42B $655M $596M ·
Accounts Payable 10-point trend, +351.2% $30M $38M $34M $33M $24M $24M $12M $11M $10M $7M ·
Short-term Debt 2-point trend, -100.0% · · · · · · · · $0 $80M ·
Current Liabilities 10-point trend, +50.9% $406M $404M $394M $324M $338M $205M $143M $105M $115M $269M ·
Capital Leases 9-point trend, +1090.9% $173M $191M $190M $190M $51M $49M $48M $12M $15M · ·
Other Non-current Liabilities 10-point trend, +19201.7% $104M $109M $94M $69M $8M $721.0K $2M $1M $2M $541.0K ·
Total Liabilities 10-point trend, +34.9% $683M $703M $678M $583M $406M $258M $200M $135M $370M $506M ·
Long-term Debt 2-point trend, -100.0% · · · · · · · · $0 $189M ·
Total Debt · · · · · · · · $0 · ·
Common Stock 10-point trend, -9.7% $262.0K $282.0K $303.0K $324.0K $319.0K $312.0K $305.0K $300.0K $296.0K $290.0K ·
Paid-in Capital 10-point trend, +7.8% $2.23B $2.34B $2.44B $2.54B $2.43B $2.32B $2.24B $2.17B $2.11B $2.07B ·
Retained Earnings 10-point trend, +96.1% $-77M $-99M $-173M $-34M $-217M $-448M $-559M $-880M $-1.83B $-1.98B ·
AOCI 10-point trend, +935.6% $3M $-1M $-4M $-15M $-758.0K $4M $3M $-701.0K $-347.0K $-416.0K ·
Stockholders' Equity 11-point trend, +1635.0% $2.16B $2.24B $2.26B $2.49B $2.21B $1.88B $1.69B $1.29B $285M $89M $-141M
Liabilities + Equity 10-point trend, +377.5% $2.84B $2.95B $2.94B $3.07B $2.62B $2.14B $1.89B $1.42B $655M $596M ·
Shares Outstanding 11-point trend, +15.1% 262,483,000 281,732,000 302,793,000 323,951,000 318,842,000 311,627,000 304,831,000 299,876,000 296,209,000 289,923,798 227,960,943
Cash Flow 17
Annual Cash Flow data for EXEL
Metric Trend 20252024202320222021202020192018201720162015
D&A 11-point trend, +1966.5% $29M $29M $26M $21M $14M $9M $8M $5M $1M $1M $1M
Stock-based Comp 11-point trend, +414.1% $113M $94M $106M $108M $120M $105M $57M $41M $24M $23M $22M
Deferred Tax 11-point trend, +126237000.00 $126M $-59M $-133M $-60M $47M $15M $71M $-244M $0 $0 $0
Restructuring 8-point trend, +1868.3% $21M $34M $0 $0 · · · $0 $-32.0K $63M $1M
Other Non-cash 9-point trend, -1112.3% $-167M $116M $127M $112M $-10M $-32M $70M $-76M $-14M · ·
Operating Cash Flow 11-point trend, +726.9% $884M $700M $333M $363M $401M $209M $527M $416M $166M $206M $-141M
CapEx 11-point trend, +1785.7% $8M $28M $40M $28M $54M $30M $13M $33M $21M $2M $447.0K
Investing Cash Flow 11-point trend, +599.8% $350M $-117M $-27M $-524M $-43M $-131M $-587M $-298M $37M $-216M $50M
Net Debt Issued 3-point trend, +100.0% · · · · · · $0 $0 $-186M · ·
Stock Issued 3-point trend, -100.0% · · · · · · · · $0 $0 $146M
Stock Repurchased 5-point trend, +947511000.00 $948M $652M $550M $0 $0 · · · · · ·
Net Stock Activity 4-point trend, -947511000.00 $-948M $-652M $-550M · · · · · $0 · ·
Financing Cash Flow 11-point trend, -737.0% $-970M $-629M $-546M $586.0K $-15M $-25M $13M $10M $-170M $20M $152M
Net Change in Cash 11-point trend, +332.9% $265M $-46M $-240M $-161M $343M $53M $-48M $128M $32M $10M $61M
Taxes Paid 9-point trend, +28765.4% $155M $170M $186M $128M $13M $4M $8M $11M $538.0K · ·
Free Cash Flow 9-point trend, +506.3% $876M $672M $293M $335M $337M $179M $514M $382M $144M · ·
Levered FCF 3-point trend, +278.0% · · · · · · $514M $382M $136M · ·
Profitability 7
Annual Profitability data for EXEL
Metric Trend 20252024202320222021202020192018201720162015
Operating Margin 9-point trend, +2.5% 37.6% 27.9% 9.3% 12.5% 20.0% 11.1% 38.2% 51.4% 36.7% · ·
Net Margin 9-point trend, -1.1% 33.7% 24.0% 11.3% 11.3% 16.1% 11.3% 33.2% 80.8% 34.1% · ·
Pretax Margin 4-point trend, -62.2% · · · · · 13.2% 41.1% 52.9% 35.0% · ·
EBITDA Margin 9-point trend, +5.2% 38.8% 29.2% 10.7% 13.8% 20.9% 12.1% 39.0% 52.0% 36.9% · ·
ROA 9-point trend, +9.6% 27.0% 17.7% 6.9% 6.4% 9.7% 5.6% 19.4% 66.4% 24.7% · ·
ROE 9-point trend, -54.7% 37.3% 23.1% 9.0% 7.3% 10.7% 6.0% 19.5% 62.6% 82.4% · ·
ROIC 4-point trend, -91.2% · · · · · 5.0% 17.7% 52.0% 56.6% · ·
Liquidity & Solvency 4
Annual Liquidity & Solvency data for EXEL
Metric Trend 20252024202320222021202020192018201720162015
Current Ratio 9-point trend, -15.5% 3.6 3.6 3.3 5.0 5.4 7.1 7.1 8.5 4.2 · ·
Quick Ratio 9-point trend, -18.5% 3.3 3.4 3.1 4.7 5.2 6.7 6.8 8.1 4.1 · ·
Debt / Equity · · · · · · · · 0.0 · ·
Interest Coverage · · · · · · · · 19.1 · ·
Efficiency 3
Annual Efficiency data for EXEL
Metric Trend 20252024202320222021202020192018201720162015
Asset Turnover 9-point trend, +10.7% 0.8 0.7 0.6 0.6 0.6 0.5 0.6 0.8 0.7 · ·
Inventory Turnover 9-point trend, +26.0% 3.8 3.8 2.9 1.9 2.2 2.1 2.9 3.2 3.0 · ·
Receivables Turnover 9-point trend, +12.9% 8.4 8.6 8.1 6.5 6.5 7.1 6.9 9.8 7.4 · ·
Per Share 5
Annual Per Share data for EXEL
Metric Trend 20252024202320222021202020192018201720162015
Book Value / Share 9-point trend, +755.9% $8.23 $7.97 $7.48 $7.68 $6.93 $6.03 $5.53 $4.29 $0.96 · ·
Revenue / Share 9-point trend, +467.6% $8.23 $7.32 $5.69 $4.96 $4.45 $3.11 $3.07 $2.73 $1.45 · ·
Cash Flow / Share 9-point trend, +491.0% $3.14 $2.36 $1.04 $1.12 $1.24 $0.66 $1.67 $1.33 $0.53 · ·
Cash / Share 9-point trend, +197.3% $1.84 $0.77 $0.87 $1.55 $2.03 $1.02 $0.87 $1.05 $0.62 · ·
EPS (TTM) 10-point trend, +461.0% $2.78 $1.76 $0.65 $0.56 $0.72 $0.35 $1.02 $2.21 $0.49 · $-0.77
Growth Rates 9
Annual Growth Rates data for EXEL
Metric Trend 20252024202320222021202020192018201720162015
Revenue YoY 5-point trend, -84.6% 7.0% 18.5% 13.6% 12.3% 45.3% · · · · · ·
Revenue CAGR 3Y 3-point trend, -43.4% 12.9% 14.8% 22.8% · · · · · · · ·
Revenue CAGR 5Y 18.6% · · · · · · · · · ·
EPS YoY 5-point trend, -45.2% 58.0% 170.8% 16.1% -22.2% 105.7% · · · · · ·
EPS CAGR 3Y 3-point trend, +208.0% 70.6% 34.7% 22.9% · · · · · · · ·
EPS CAGR 5Y 51.3% · · · · · · · · · ·
Net Income YoY 5-point trend, -53.0% 50.1% 150.9% 14.0% -21.1% 106.7% · · · · · ·
Net Income CAGR 3Y 3-point trend, +172.5% 62.5% 31.1% 22.9% · · · · · · · ·
Net Income CAGR 5Y 47.6% · · · · · · · · · ·
Valuation (TTM) 14
Annual Valuation (TTM) data for EXEL
Metric Trend 20252024202320222021202020192018201720162015
Revenue TTM 10-point trend, +6141.6% $2.32B $2.17B $1.83B $1.61B $1.43B $988M $968M $854M $452M · $37M
Net Income TTM 10-point trend, +583.8% $783M $521M $208M $182M $231M $112M $321M $690M $154M · $-162M
Market Cap 9-point trend, +27.0% $11.44B $9.57B $7.26B $5.20B $5.83B $6.25B $5.19B $5.83B $9.00B · ·
Enterprise Value · · · · · · · · $8.62B · ·
P/E 10-point trend, +314.0% 15.7 19.3 36.9 28.6 25.4 57.3 16.7 8.8 62.0 · -7.3
P/S 9-point trend, -75.2% 4.9 4.4 4.0 3.2 4.1 6.3 5.4 6.8 19.9 · ·
P/B 9-point trend, -83.3% 5.3 4.3 3.2 2.1 2.6 3.3 3.1 4.5 31.6 · ·
P / Tangible Book 6-point trend, +58.3% 5.5 4.4 3.3 2.1 2.7 3.4 · · · · ·
P / Cash Flow 9-point trend, -76.2% 12.9 13.7 21.8 14.3 14.5 29.9 9.8 14.0 54.4 · ·
P / FCF 9-point trend, -79.0% 13.1 14.3 24.8 15.5 17.3 35.0 10.1 15.2 62.3 · ·
EV / EBITDA · · · · · · · · 51.6 · ·
EV / FCF · · · · · · · · 59.6 · ·
EV / Revenue · · · · · · · · 19.0 · ·
Earnings Yield 10-point trend, +146.7% 6.4% 5.2% 2.7% 3.5% 3.9% 1.7% 6.0% 11.4% 1.6% · -13.7%

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2026-01-022025-01-032023-12-292022-12-302021-12-31
Revenue $2.32B$2.17B$1.83B$1.61B$1.43B
Operating Margin % 37.6%27.9%9.3%12.5%20.0%
Net Income $783M$521M$208M$182M$231M
Diluted EPS $2.78$1.76$0.65$0.56$0.72
Balance Sheet
2026-01-022025-01-032023-12-292022-12-302021-12-31
Current Ratio 3.63.63.35.05.4
Quick Ratio 3.33.43.14.75.2
Cash Flow
2026-01-022025-01-032023-12-292022-12-302021-12-31
Free Cash Flow $876M$672M$293M$335M$337M

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Trading Signals Recent buy/sell signals with entry price and risk/reward ratio

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Institutional owners (13F) 811 filers · $9.1B total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
135 (+27 vs prior Q) 61 (-13 vs prior Q) 240 (-1 vs prior Q) 274 (+16 vs prior Q) +39.8M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
FARALLON CAPITAL MANAGEMENT, L.L.C. $732,794,424 13,468,010 8.04% Shares
RENAISSANCE TECHNOLOGIES LLC $730,617,099 13,427,993 8.01% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $655,266,268 12,043,122 7.19% Shares
VANGUARD CAPITAL MANAGEMENT LLC $595,843,747 10,950,997 6.53% Shares
STATE STREET CORP $542,471,563 9,970,071 5.95% Shares
FULLER & THALER ASSET MANAGEMENT, INC. $485,848,030 8,929,389 5.33% Shares
GEODE CAPITAL MANAGEMENT, LLC $362,702,104 6,664,894 3.98% Shares
D. E. Shaw & Co., Inc. $281,389,313 5,171,647 3.09% Shares
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP $237,550,034 4,365,926 2.60% Shares
TWO SIGMA INVESTMENTS, LP $229,058,537 4,209,861 2.51% Shares
DIMENSIONAL FUND ADVISORS LP $221,832,835 4,077,060 2.43% Shares
ASSETMARK, INC $186,834,364 3,433,824 2.05% Shares
Stephens Investment Management Group LLC $147,451,698 2,710,011 1.62% Shares
NORGES BANK $146,301,199 2,688,866 1.60% Shares
FIRST TRUST ADVISORS LP $138,383,701 2,543,353 1.52% Shares
Caisse de depot et placement du Quebec $113,950,809 2,094,299 1.25% Shares
GOLDMAN SACHS GROUP INC $106,578,308 1,958,800 1.17% Shares
AMERICAN CENTURY COMPANIES INC $97,484,439 1,791,664 1.07% Shares
VANGUARD FIDUCIARY TRUST CO $86,563,209 1,590,943 0.95% Shares
Caligan Partners LP $84,512,985 1,553,262 0.93% Shares
MILLENNIUM MANAGEMENT LLC $66,309,793 1,218,706 0.73% Shares
LOS ANGELES CAPITAL MANAGEMENT LLC $63,086,055 1,159,457 0.69% Shares
BANK OF AMERICA CORP /DE/ $58,788,318 1,080,469 0.64% Shares
Robeco Institutional Asset Management B.V. $56,032,453 1,029,819 0.61% Shares
ENVESTNET ASSET MANAGEMENT INC $51,671,488 949,669 0.57% Shares
FMR LLC $48,839,667 897,623 0.54% Shares
Gotham Asset Management, LLC $48,569,794 892,663 0.53% Shares
Swedbank AB $45,801,141 841,778 0.50% Shares
Allspring Global Investments Holdings, LLC $44,544,520 825,510 0.49% Shares
Retirement Systems of Alabama $44,107,739 810,655 0.48% Shares
BOOTHBAY FUND MANAGEMENT, LLC $43,750,809 804,095 0.48% Shares
RAYMOND JAMES FINANCIAL INC $41,924,320 770,526 0.46% Shares
Capital Impact Advisors, LLC $41,061,268 754,664 0.45% Shares
BlackRock, Inc. $40,753,525 749,008 0.45% Shares
RHUMBLINE ADVISERS $35,723,294 656,559 0.39% Shares
CANADA PENSION PLAN INVESTMENT BOARD $35,464,438 651,800 0.39% Shares
SCHRODER INVESTMENT MANAGEMENT GROUP $34,721,830 639,680 0.38% Shares
MARSHALL WACE, LLP $34,322,590 630,814 0.38% Shares
SYSTEMATIC FINANCIAL MANAGEMENT LP $34,315,027 630,675 0.38% Shares
AMERIPRISE FINANCIAL INC $32,255,716 592,827 0.35% Shares
BARCLAYS PLC $31,502,574 578,985 0.35% Shares
VOLORIDGE INVESTMENT MANAGEMENT, LLC $31,496,480 578,873 0.35% Shares
Arbejdsmarkedets Tillaegspension $30,855,911 567,100 0.34% Shares
Pictet Asset Management Holding SA $30,153,926 555,438 0.33% Shares
California Public Employees Retirement System $29,366,600 539,728 0.32% Shares
CAPITAL FUND MANAGEMENT S.A. $28,686,856 527,235 0.31% Shares
BNP PARIBAS FINANCIAL MARKETS $28,655,734 526,663 0.31% Shares
JANUS HENDERSON GROUP PLC $26,675,806 621,814 0.29% Shares
Woodline Partners LP $26,411,049 485,408 0.29% Shares
Driehaus Capital Management LLC $26,025,500 478,322 0.29% Shares
EULAV Asset Management $25,901,500 476,043 0.28% Shares
Squarepoint Ops LLC $25,774,398 473,707 0.28% Shares
Swiss National Bank $25,648,874 471,400 0.28% Shares
MASSACHUSETTS FINANCIAL SERVICES CO /MA/ $25,156,355 462,348 0.28% Shares
Universal- Beteiligungs- und Servicegesellschaft mbH $24,600,555 452,133 0.27% Shares
IEQ CAPITAL, LLC $24,580,697 451,768 0.27% Shares
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND $23,831,580 438,000 0.26% Shares
Baird Financial Group, Inc. $23,565,461 433,109 0.26% Shares
FRANKLIN RESOURCES INC $23,480,472 431,547 0.26% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $23,347,331 429,100 0.26% Call option
Assenagon Asset Management S.A. $23,324,098 428,673 0.26% Shares
BANK OF NOVA SCOTIA $22,837,676 419,730 0.25% Shares
JACOBS LEVY EQUITY MANAGEMENT, INC $22,615,516 415,650 0.25% Shares
South Street Advisors LLC $22,275,019 409,392 0.24% Shares
Bridgewater Associates, LP $21,810,738 400,859 0.24% Shares
VICTORY CAPITAL MANAGEMENT INC $21,480,143 394,783 0.24% Shares
ROYAL BANK OF CANADA $20,031,000 368,153 0.22% Shares
SEI INVESTMENTS CO $19,897,640 365,698 0.22% Shares
LAZARD ASSET MANAGEMENT LLC $18,664,208 343,029 0.20% Shares
Nuveen, LLC $18,299,226 336,321 0.20% Shares
Nuveen Asset Management, LLC $18,252,629 548,127 0.20% Shares
NFJ INVESTMENT GROUP, LLC $17,880,160 328,619 0.20% Shares
SAWGRASS ASSET MANAGEMENT LLC $17,808,447 327,301 0.20% Shares
WORLDQUANT MILLENNIUM ADVISORS LLC $17,565,616 322,838 0.19% Shares
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC $17,472,485 407,379 0.19% Shares
ING GROEP NV $16,943,274 311,400 0.19% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $16,529,758 303,800 0.18% Put option
Brandywine Global Investment Management, LLC $16,490,117 376,229 0.18% Shares
CAPTRUST FINANCIAL ADVISORS $16,488,532 303,042 0.18% Shares
INTECH INVESTMENT MANAGEMENT LLC $16,262,224 298,883 0.18% Shares
HighTower Advisors, LLC $15,842,121 291,162 0.17% Shares
SEIZERT CAPITAL PARTNERS, LLC $15,411,796 283,253 0.17% Shares
Trexquant Investment LP $14,974,122 275,209 0.16% Shares
Clark Capital Management Group, Inc. $14,792,882 271,878 0.16% Shares
ALLIANCEBERNSTEIN L.P. $14,763,381 344,215 0.16% Shares
VAN ECK ASSOCIATES CORP $14,270,709 262,281 0.16% Shares
GLOBEFLEX CAPITAL L P $13,874,169 254,993 0.15% Shares
Sofinnova Investments, Inc. $13,831,022 254,200 0.15% Put option
JANE STREET GROUP, LLC $13,815,570 253,916 0.15% Shares
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM $13,724,052 252,234 0.15% Shares
Voleon Capital Management LP $13,682,047 251,462 0.15% Shares
BLAIR WILLIAM & CO/IL $13,233,352 243,215 0.15% Shares
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. $13,027,000 239,418 0.14% Shares
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $12,745,021 297,156 0.14% Shares
MERITAGE PORTFOLIO MANAGEMENT $12,679,099 289,279 0.14% Shares
VANGUARD ASSET MANAGEMENT, Ltd $12,516,694 230,044 0.14% Shares
Susquehanna Portfolio Strategies, LLC $12,500,643 229,749 0.14% Shares
MILLENNIUM MANAGEMENT LLC $12,035,492 221,200 0.13% Call option
Illinois Municipal Retirement Fund $11,750,764 215,967 0.13% Shares
CWM, LLC $11,300,486 263,476 0.12% Shares

Company insiders 43 insiders · 22 officers · 10 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Michael Morrissey President and CEO May 18, 2026 G 2,004,327 0 0 $0
Christopher J. Senner EVP and CFO May 18, 2026 S 952,317 0 3 $-4,556,048
Deborah Burke SVP & Chief Financial Officer Nov. 15, 2014 M 18,156 0 0 $0
Frank Karbe EVP and CFO Feb. 15, 2014 M 93,990 0 0 $0
Kristine M Ball Controller & Interim CFO Dec. 10, 2003 A 4,913 0 0 $0
Patrick J. Haley EVP, Commercial May 20, 2026 S 357,638 0 7 $-7,597,268
Brenda Hefti SVP and General Counsel May 18, 2026 S 106,762 0 2 $-1,154,264
Amy C. Peterson EVP Prod Dev & Med Aff & CMO May 16, 2025 M 465,393 0 0 $0
Jeffrey Hessekiel EVP & General Counsel May 15, 2025 S 693,396 0 0 $0
Vicki L Goodman EVP, Prod Dev & Med Aff &CMO April 3, 2023 A 307,654 0 0 $0
Peter Lamb EVP, Scientific Strategy & CSO Dec. 15, 2022 M 410,958 0 0 $0
Gisela Schwab Pres, Prod Dev & Med Aff & CMO July 26, 2021 M 689,078 0 0 $0
Pamela A Simonton EVP and General Counsel Nov. 15, 2013 M 17,139 0 0 $0
Lupe M Rivera EVP, Operations Aug. 15, 2011 M 19,219 0 0 $0
Frances K Heller EVP, Business Development May 15, 2011 M 17,125 0 0 $0
Ian D Malcolm VP, STRATEGIC MARKETING Dec. 8, 2006 A 0 0 $0
Christoph Pereira VP, Legal Affairs & Secretary Dec. 8, 2006 A 0 0 $0
Jeffrey Latts Executive VP, Development Dec. 8, 2006 A 0 0 $0
Gregory Plowman Sr VP, CSO Dec. 13, 2004 A 0 0 $0
Steven P James Sr VP, Commercial Ops Dec. 10, 2003 A 0 0 $0
Jane M Green VP, Corp Communications Dec. 10, 2003 A 0 0 $0
Geoffrey M Duyk Pres R&D & CSO Nov. 4, 2003 S 941,355 0 0 $0
Alan M Garber Director March 21, 2024 M 35,703 0 0 $0
Jacqueline Wright Director June 1, 2023 A 51,756 0 0 $0
Carl B Feldbaum Director Feb. 9, 2023 M 18,701 0 0 $0
Lance Willsey Director May 26, 2022 A 424,415 0 0 $0
Vincent T Marchesi Director May 26, 2022 A 93,989 0 0 $0
Charles Cohen Director July 6, 2021 M 261,375 0 0 $0
George A Scangos Director May 18, 2020 S 714,717 0 0 $0
FORMELA JEAN FRANCOIS Director Sept. 7, 2005 S 584,519 0 0 $0
Mary C Beckerle Aug. 10, 2026 S 16,079 0 4 $-1,932,572
Sue Gail Eckhardt June 1, 2026 S 16,079 0 2 $-660,828
Jack L Wyszomierski June 1, 2026 S 284,384 0 2 $-4,580,661
Tomas J. Heyman May 27, 2026 A 50,649 0 0 $0
Bob Oliver May 27, 2026 A 29,487 0 2 $-1,325,340
Julie Smith May 27, 2026 A 28,957 0 3 $-4,687,346
Maria C Freire May 27, 2026 A 109,186 0 1 $-949,164
Stelios Papadopoulos May 27, 2026 A 1,197,595 0 1 $-4,355,000
George Poste May 27, 2026 A 127,199 0 1 $-2,742,600
Dana Aftab May 26, 2026 S 594,741 0 4 $-7,701,255
Frank Mccormick Dec. 6, 2013 A 0 0 $0
Scott J. Garland Sept. 18, 2013 A 0 0 $0
Jason S Fisherman Sept. 8, 2005 S 7,881 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 4 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Farallon Capital Management, L.L.C., Farallon Capital Partners, L.P., Farallon Capital Institutional Partners, L.P., Farallon Capital Institutional Partners II, L.P., Farallon Capital Institutional Partners III, L.P., Four Crossings Institutional Partners V, L.P., Farallon Capital Offshore Investors II, L.P., Farallon Capital (AM) Investors, L.P., Farallon Capital F5 Master I, L.P., Farallon Healthcare Partners Master, L.P., Farallon Partners, L.L.C., Farallon Institutional (GP) V, L.L.C., Farallon F5 (GP), L.L.C., Farallon Healthcare Partners (GP), L.L.C., Dapice Joshua J., Dreyfuss, Philip D., Dunn Hannah E., Gehani, Varun N., Giauque, Nicolas, Husen, Avner A., Kim, David T., Linn, Michael G., Luo Patrick (Cheng), Roberts, Jr., Thomas G., Saito Edric C., Short Daniel S., Spokes, Andrew J. M., Warren, John R., Wehrly, Mark C. Aug. 14, 2026 5.60% Amendment SEC
Farallon Capital Partners, L.P., Farallon Capital Institutional Partners, L.P., Farallon Capital Institutional Partners II, L.P., Farallon Capital Institutional Partners III, L.P., Four Crossings Institutional Partners V, L.P., Farallon Capital Offshore Investors II, L.P., Farallon Capital (AM) Investors, L.P., Farallon Capital F5 Master I, L.P., Farallon Healthcare Partners Master, L.P., Farallon Partners, L.L.C., Farallon Institutional (GP) V, L.L.C., Farallon F5 (GP), L.L.C., Farallon Healthcare Partners (GP), L.L.C., Dapice Joshua J., Dreyfuss, Philip D., Dunn Hannah E., Fried, Richard B, Gehani, Varun N., Giauque, Nicolas, Husen, Avner A., Kim, David T., Linn, Michael G., Luo Patrick (Cheng), Patel, Rajiv A., Roberts, Jr., Thomas G., Saito Edric C., Seybold, William, Short Daniel S., Spokes, Andrew J. M., Warren, John R., Wehrly, Mark C. ×8 filings Jan. 5, 2026 5.90% Amendment SEC
Caligan Partners LP, David Johnson ×3 filings June 2, 2023 Initial filing SEC
Undisclosed reporting person Nov. 29, 2001 Initial filing M&A / sale SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 152 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
IDNA · iShares Trust 3.47% 131,275 SH Aug. 8, 2026 Daily
SAWG · ETF Series Solutions 2.82% 1,599 NS April 30, 2026 N-PORT
CANC · Tema ETF Trust 2.78% 96,885 NS May 31, 2026 N-PORT
XMHQ · Invesco Exchange-Traded Fund Trust 2.67% 2,774,135 SH Aug. 8, 2026 Daily
PBE · Invesco Exchange-Traded Fund Trust 2.59% 173,519 SH Aug. 8, 2026 Daily
MCOW · Pacer Funds Trust 2.38% 528 NS April 30, 2026 N-PORT
FXH · First Trust Exchange-Traded AlphaDE… 2.24% 441,186 NS April 30, 2026 N-PORT
LYLD · Cambria ETF Trust 2.01% 2,722 NS April 30, 2026 N-PORT
AZTD · Tidal Trust I 1.92% 18,950 NS April 30, 2026 N-PORT
GRPM · Invesco Exchange-Traded Fund Trust 1.84% 172,947 SH Aug. 8, 2026 Daily
BBP · ETFis Series Trust I 1.74% 23,148 NS April 30, 2026 N-PORT
ABOT · Abacus FCF ETF Trust 1.61% 1,596 NS April 30, 2026 N-PORT
BUL · Pacer Funds Trust 1.45% 41,520 NS April 30, 2026 N-PORT
JSMD · Janus Detroit Street Trust 1.39% 306,870 NS April 30, 2026 N-PORT
JMID · Janus Detroit Street Trust 1.36% 5,563 NS April 30, 2026 N-PORT
RFG · Invesco Exchange-Traded Fund Trust 1.30% 86,397 SH Aug. 8, 2026 Daily
PTH · Invesco Exchange-Traded Fund Trust 1.29% 58,887 SH Aug. 8, 2026 Daily
COWG · Pacer Funds Trust 1.26% 616,432 NS April 30, 2026 N-PORT
TAX · EA Series Trust 1.13% 5,692 NS May 29, 2026 N-PORT
CALF · Pacer Funds Trust 1.07% 829,382 NS April 30, 2026 N-PORT
AFMC · First Trust Exchange-Traded Fund VI… 1.03% 32,938 NS May 31, 2026 N-PORT
LABU · Direxion Shares ETF Trust 1.00% 116,281 NS April 30, 2026 N-PORT
IBB · iShares Trust 0.98% 1,788,613 SH Aug. 8, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.93% 13,681 SH Aug. 8, 2026 Daily
AGNG · Global X Funds 0.92% 14,988 NS May 31, 2026 N-PORT
OASC · Unified Series Trust 0.91% 15,171 NS May 31, 2026 N-PORT
SMDX · Tidal Trust III 0.90% 25,550 NS April 30, 2026 N-PORT
FLOW · Global X Funds 0.90% 5,093 NS May 31, 2026 N-PORT
VAMO · Cambria ETF Trust 0.88% 16,470 NS April 30, 2026 N-PORT
IVOG · VANGUARD ADMIRAL FUNDS 0.72% 248,016 SH Aug. 8, 2026 Daily
FLRG · FIDELITY COVINGTON TRUST 0.72% 45,672 NS April 30, 2026 N-PORT
IJK · iShares Trust 0.70% 1,469,020 SH Aug. 8, 2026 Daily
MMSC · First Trust Exchange-Traded Fund VI… 0.69% 7,149 NS May 31, 2026 N-PORT
CLSE · Trust for Professional Managers 0.68% 82,717 NS May 31, 2026 N-PORT
BIB · ProShares Trust 0.66% 9,600 NS May 31, 2026 N-PORT
TMFX · RBB Fund, Inc. 0.64% 4,091 NS May 31, 2026 N-PORT
VUSE · ETF Series Solutions 0.63% 85,930 NS May 31, 2026 N-PORT
LSEQ · Harbor ETF Trust 0.60% 2,080 NS April 30, 2026 N-PORT
PDP · Invesco Exchange-Traded Fund Trust 0.59% 165,207 SH Aug. 8, 2026 Daily
QGRO · AMERICAN CENTURY ETF TRUST 0.58% 255,026 NS May 31, 2026 N-PORT
SIXL · EXCHANGE TRADED CONCEPTS TRUST 0.53% 19,762 NS May 31, 2026 N-PORT
VLLU · Harbor ETF Trust 0.51% 502 NS April 30, 2026 N-PORT
VFQY · VANGUARD WELLINGTON FUND 0.49% 42,746 SH Aug. 8, 2026 Daily
LSVD · ADVISORS' INNER CIRCLE FUND 0.48% 64,828 NS April 30, 2026 N-PORT
HQGO · Lattice Strategies Trust 0.47% 5,095 NS April 30, 2026 N-PORT
PKW · Invesco Exchange-Traded Fund Trust 0.45% 147,282 SH Aug. 8, 2026 Daily
IQSM · New York Life Investments ETF Trust 0.44% 30,864 NS April 30, 2026 N-PORT
XJH · iShares Trust 0.41% 33,981 SH Aug. 8, 2026 Daily
FNY · First Trust Exchange-Traded AlphaDE… 0.41% 47,960 NS April 30, 2026 N-PORT
QVMM · Invesco Exchange-Traded Fund Trust … 0.41% 33,169 SH Aug. 8, 2026 Daily