NBIX Neurocrine Biosciences, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$155.47
Price · Aug 19, 2026
Fundamentals as of Jul 31, 2026

About Neurocrine Biosciences, Inc. - Common Stock Company overview from Wikipedia

Neurocrine Biosciences, Inc. is an American biopharmaceutical company founded in 1992. It is headquartered in San Diego, California, and led by CEO Kyle Gano as of October 11, 2024. Neurocrine develops treatments for neurological and endocrine-related diseases and disorders. In 2017, the company's drug valbenazine (Ingrezza) was approved in the US to treat adults with tardive dyskinesia (TD).

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Neurocrine Biosciences, Inc. is an American biopharmaceutical company founded in 1992. It is headquartered in San Diego, California, and led by CEO Kyle Gano as of October 11, 2024. Neurocrine develops treatments for neurological and endocrine-related diseases and disorders. In 2017, the company's drug valbenazine (Ingrezza) was approved in the US to treat adults with tardive dyskinesia (TD).

The company is also developing treatments that are in various stages of clinical research for Parkinson's disease, Tourette syndrome, and congenital adrenal hyperplasia and with a partner for endometriosis and uterine fibroids.

History

Neurocrine was founded in San Diego, California, in 1992. The company's academic founders were Wylie Vale of the Salk Institute for Biological Studies, and Lawrence Steinman of Stanford University. The company was backed and organized by Larry Bock of Avalon Ventures among others.

In 1995, the company collaborated with Belgium-based Janssen Pharmaceutica N.V. to develop treatments for psychiatric disorders utilizing corticotropin releasing factor (CRF) antagonists, a class of compounds to treat psychiatric, neurological and gastrointestinal diseases including anxiety, depression and irritable bowel syndrome. The company underwent an IPO in May 1996, listing on the NASDAQ exchange under the symbol NBIX and raising $34.2 million.

In October 1996, Eli Lilly and Company agreed to pay Neurocrine $74 million over five years to develop drugs for obesity and Alzheimer's disease based on its research of CRF-binding protein-ligand inhibitors.

In July 2001, Neurocrine and GlaxoSmithKline entered into a worldwide research, development and commercialization agreement, including a collaborative research program for up to five years to identify and develop CRF-R antagonist compounds. The collaboration also included worldwide development and commercialization of NBI-34041 as well as potential backup candidates resulting from the research program. Neurocrine received upfront fees and early milestone payments totaling $25.5 million.

In December 2002, Neurocrine reached an agreement with Pfizer for the rights to its experimental insomnia drug, indiplon. The deal paid Neurocrine $100 million initially with a possible $300 million more if the drug met regulatory and sales goals. In May 2006, the FDA issued a non-approvable letter for a modified-release 15 mg formulation of indiplon and an approvable letter with stipulations for 5 mg and 10 mg immediate-release formulations. As a result, Pfizer terminated its agreement with Neurocrine. Following a resubmission of the 5 mg and 10 mg formulations in December 2007, Neurocrine's new drug application was deemed 'approvable' but the FDA requested additional studies. The company discontinued development of the drug in the United States. In 2007, Neurocrine partnered with Dainippon Sumitomo Pharma to develop and commercialize indiplon in Japan. The deal paid Neurocrine $20 million up front with the ability to receive milestone payments and royalties based on the commercialization of indiplon in Japan.

Kevin Gorman replaced Gary Lyons as CEO of the company in January 2008. Lyons was CEO and president of the company since its founding and maintained a role on the company's board of directors.

On June 16, 2010, Neurocrine agreed to a deal with AbbVie Inc. (previously Abbott Laboratories) worth up to $575 million with Neurocrine granting AbbVie the worldwide rights to develop and commercialize elagolix, an oral gonadotropin-releasing hormone (GnRH) antagonist to treat endometriosis and uterine fibroids. The deal paid Neurocrine $75 million up front.

In April 2017, the FDA approved valbenazine for the treatment of TD. At the time of approval, it was the first and only drug approved for adults with TD. Neurocrine is also studying valbenazine in clinical trials for the treatment of Tourette Syndrome. In October 2017, Neurocrine announced that it had been granted orphan drug designation status from the FDA for valbenazine for the treatment of pediatric patients with Tourette syndrome.

In February 2017, Neurocrine announced an exclusive licensing agreement for the development and commercialization of the Parkinson's disease drug, opicapone, in North America with the Portugal-based pharmaceutical company Bial. As part of the agreement, Neurocrine provided an upfront payment of $30 million and agreed to fund development activities for FDA approval in the United States. Bial is eligible to receive additional milestone payments of up to $115 million and a percentage of net sales.

In September 2017, AbbVie submitted a NDA to the FDA for elagolix for the management of endometriosis and associated pain. The submission was supported by two similar Phase 3 clinical studies involving 1,700 women. In October 2017, AbbVie and Neurocrine announced that the FDA granted priority review for the elagolix NDA. A final regulatory decision on the drug will come during the third quarter of 2018. The companies are also developing elagolix for the treatment of uterine fibroids which is in Phase III development.

In 2021,Nexera Pharmain Japan licensed out its investigational schizophrenia drug, NBI-1117568, to Neurocrine Biosciences for development.

In August 2024, Neurocrine announced the results of a Phase II clinical trial of NBI-1117568 . The drug demonstrated a 7.5-point improvement in the Positive and Negative Syndrome Scale (PANSS), which was lower than the 8.4-point improvement seen with KarXT (developed by Karuna Therapeutics) and the 12.7-point improvement seen with Emraclidine (developed by Cerevel Therapeutics), both of which were also in clinical trials at the time. Additionally, the study found no dose-dependent response to NBI-1117568. As a result, Neurocrine's stock price fell 19% the following day as investors were disappointed by the results.

Product pipeline

Elagolix – gonadotropin-releasing hormone receptor antagonist undergoing FDA review for the treatment of endometriosis and in clinical trials for uterine fibroids

Opicapone – A once daily catechol-O-methyl transferase inhibitor in trials for Parkinson's disease

NBI-74788 – Corticotropin-releasing factor (CRF) receptor antagonist

NBI-1117568 - A drug that stimulates muscarinic receptors and is used to treat schizophrenia.

Source: Wikipedia, CC BY-SA 4.0 · View on Wikipedia ↗

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NBIX Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$155.47
Market Cap
$15.56B
P/E (TTM)
33.3
EPS (TTM)
$4.67
Revenue (TTM)
$2.86B
Div Yield
ROE
16.1%
Debt/Equity
52W Range
$123 – $186

NBIX Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $2.86B
10-point trend, +18970.0%
2016-12-31 2025-12-31
EPS $4.67
10-point trend, +386.5%
2016-12-31 2025-12-31
Free Cash Flow $749M
10-point trend, +778.9%
2016-12-31 2025-12-31
Margins 16.7%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
NBIX
Peer Median
P/E (TTM)
5-point trend, -67.2%
33.3
16.9
P/S (TTM)
5-point trend, -30.4%
5.4
9.6
P/B
5-point trend, -25.8%
4.8
7.7
Price / FCF
5-point trend, -45.3%
20.8

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
NBIX
Peer Median
Operating Margin
5-point trend, +139.4%
21.6%
Net Profit Margin
5-point trend, +111.8%
16.7%
-36.9%
ROA
5-point trend, +143.3%
11.5%
-21.8%
ROE
5-point trend, +144.2%
16.1%
-47.3%
ROIC
5-point trend, +95.9%
12.9%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
NBIX
Peer Median
Current Ratio
5-point trend, -14.3%
3.4
3.5
Quick Ratio
5-point trend, -48.4%
1.9

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
NBIX
Peer Median
Revenue YoY
5-point trend, +152.4%
21.4%
Revenue CAGR 3Y
5-point trend, +152.4%
24.3%
Revenue CAGR 5Y
5-point trend, +152.4%
22.3%
EPS YoY
5-point trend, +407.6%
41.9%
Net Income YoY
5-point trend, +434.2%
40.2%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
NBIX
Peer Median
EPS (Diluted)
5-point trend, +407.6%
$4.67

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
NBIX
Peer Median

NBIX Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 36 analysts
  • Strong Buy 14 38.9%
  • Buy 17 47.2%
  • Hold 5 13.9%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

27 analysts · 2026-08-15
Median target $215.00 +38.3%
Mean target $211.57 +36.1%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.24%
Period EPS Actual EPS Est Surprise
June 30, 2026 $1.39 $1.37 0.02%
March 31, 2026 $1.91 $1.20 0.71%
Dec. 31, 2025 $1.91 $1.20 0.71%
Sept. 30, 2025 $2.04 $1.62 0.42%
June 30, 2025 $1.06 $0.99 0.07%
March 31, 2025 $0.08 $0.56 -0.48%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
NBIX $14.20B 30.4 21.4% 16.7% 16.1%
INCY $19.60B 15.4 21.2% 25.0% 27.6%
MRNA $11.62B -4.1 -39.9% -145.2% -31.3%
UTHR $21.27B 17.5 10.6% 41.9% 18.7% 87.9%
BBIO $14.90B -20.2 126.3% -146.0% 41.2%
BMRN $11.43B 33.0 12.9% 10.8% 5.8%
EXEL $11.44B 15.7 7.0% 33.7% 37.3%
ARWR $4.68B -3449.0 23258.2% -0.20% -0.50%
MDGL $13.30B -45.3 432.1% -30.1% -44.4%
HALO $7.93B 26.3 37.5% 22.7% 166.1%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 17
Annual Income Statement data for NBIX
Metric Trend 202520242023202220212020201920182017201620152014
Revenue 12-point trend, +2860500000.00 $2.86B $2.36B $1.89B $1.49B $1.13B $1.05B $788M $451M $162M $15M $20M $0
Cost of Revenue 10-point trend, +52100000.00 $52M $34M $40M $23M $14M $10M · $5M $1M $0 $0 ·
R&D Expense 5-point trend, +245.8% · · · · · · · $161M $122M $94M $81M $46M
SG&A Expense 12-point trend, +6328.3% $1.16B $1.01B $888M $753M $583M $433M $354M $249M $170M $68M $32M $18M
Operating Expenses 12-point trend, +3379.8% $2.24B $1.78B $1.64B $1.24B $1.03B $883M $716M $414M $293M $162M $114M $64M
Operating Income 12-point trend, +1061.2% $619M $570M $251M $249M $102M $163M $72M $37M $-131M $-147M $-94M $-64M
Interest Expense 9-point trend, +4600000.00 · · $5M $7M $26M $33M $32M $30M $20M $0 $0 ·
Interest Income 3-point trend, +351.2% · · · · · · · · · $3M $2M $629.0K
Other Non-op 12-point trend, +479344.4% $86M $-84M $81M $-35M $-1M $-56M $-26M $-15M $-11M $6M $20.0K $18.0K
Pretax Income 10-point trend, +600.0% $705M $486M $332M $214M $101M $107M $46M $22M $-143M $-141M · ·
Income Tax 12-point trend, +226800000.00 $227M $145M $82M $59M $12M $-301M $10M $700.0K $0 $0 $0 $0
Net Income 12-point trend, +890.5% $479M $341M $250M $154M $90M $407M $37M $21M $-143M $-141M $-89M $-61M
EPS (Basic) 12-point trend, +693.8% $4.81 $3.40 $2.56 $1.61 $0.95 $4.38 $0.40 $0.23 $-1.62 $-1.63 $-1.05 $-0.81
EPS (Diluted) 12-point trend, +676.5% $4.67 $3.29 $2.47 $1.56 $0.92 $4.16 $0.39 $0.22 $-1.62 $-1.63 $-1.05 $-0.81
Shares (Basic) 12-point trend, +33.4% 99,500,000 100,400,000 97,700,000 95,800,000 94,600,000 93,100,000 91,600,000 90,200,000 88,089,000 86,713,000 84,496,000 74,577,000
Shares (Diluted) 12-point trend, +37.4% 102,500,000 103,700,000 101,000,000 98,900,000 97,900,000 97,800,000 95,700,000 95,400,000 88,089,000 86,713,000 84,496,000 74,577,000
EBITDA 11-point trend, +1061.2% $619M $570M $251M $249M $102M $163M $72M $37M $-131M $-147M · $-64M
Balance Sheet 28
Annual Balance Sheet data for NBIX
Metric Trend 202520242023202220212020201920182017201620152014
Cash & Equivalents 12-point trend, +2199.0% $713M $233M $251M $263M $341M $187M $112M $142M $255M $83M $74M $31M
Short-term Investments 8-point trend, +127.6% · · · · $370M $614M $558M $509M $261M $224M $305M $163M
Receivables 10-point trend, +686800000.00 $687M $479M $439M $350M $186M $157M $127M $57M $31M $0 · ·
Inventory 10-point trend, +69000000.00 $69M $57M $38M $35M $30M $28M $17M $11M $1M $0 · ·
Prepaid Expense 2-point trend, +252.0% $171M $48M · · · · · · · · · ·
Other Current Assets 12-point trend, +2535.4% $116M $64M $98M $79M $46M $30M $17M $19M $7M $3M $5M $4M
Current Assets 12-point trend, +1172.8% $2.52B $1.72B $1.61B $1.45B $973M $1.02B $831M $738M $555M $310M $384M $198M
PP&E (Net) 12-point trend, +3482.0% $90M $83M $71M $59M $59M $45M $42M $34M $11M $6M $3M $3M
PP&E (Gross) 12-point trend, +565.9% $208M $189M $154M $125M $110M $86M $76M $62M $38M $32M $30M $31M
Accum. Depreciation 12-point trend, +311.5% $118M $106M $83M $66M $52M $42M $34M $28M $28M $26M $27M $29M
Goodwill 5-point trend, +6100000.00 $6M $6M $6M $5M $0 · · · · · · ·
Intangibles 5-point trend, +4700000.00 $5M $36M $36M $37M $0 · · · · · · ·
Other Non-current Assets 7-point trend, +48700000.00 $49M $52M $50M $25M $4M $6M $0 · · · · ·
Total Assets 12-point trend, +1805.7% $4.63B $3.72B $3.25B $2.37B $2.07B $1.73B $1.31B $993M $818M $365M $475M $243M
Accounts Payable 12-point trend, +274005.7% $674M $462M $449M $348M $226M $169M $141M $86M $6M $5M $3M $246.0K
Accrued Liabilities 3-point trend, +83.3% · · · · · · · · · $21M $19M $12M
Current Liabilities 12-point trend, +4645.9% $743M $508M $655M $538M $246M $186M $565M $88M $54M $30M $26M $16M
Capital Leases 8-point trend, +415300000.00 $415M $455M $258M $94M $105M $94M $87M $0 · · · ·
Deferred Tax $0 · · · · · · · · · · ·
Other Non-current Liabilities 12-point trend, +84400.0% $220M $166M $106M $30M $12M $10M $17M $36M $0 $113.0K $221.0K $260.0K
Total Liabilities 12-point trend, +3914.7% $1.38B $1.13B $1.02B $661M $698M $608M $669M $512M $445M $50M $50M $34M
Common Stock 12-point trend, +31.6% $100.0K $100.0K $100.0K $100.0K $100.0K $100.0K $100.0K $91.0K $89.0K $87.0K $86.0K $76.0K
Paid-in Capital · · · · · · · · · · · $1.04B
Retained Earnings 12-point trend, +154.2% $448M $29M $-157M $-407M $-636M $-725M $-1.13B $-1.18B $-1.20B $-1.06B $-915M $-826M
AOCI 12-point trend, +4829.2% $13M $6M $7M $-8M $-2M $2M $1M $-2M $-2M $-318.0K $-977.0K $-277.0K
Stockholders' Equity 12-point trend, +1458.8% $3.25B $2.59B $2.23B $1.71B $1.37B $1.13B $637M $481M $372M $315M $424M $209M
Liabilities + Equity 12-point trend, +1805.7% $4.63B $3.72B $3.25B $2.37B $2.07B $1.73B $1.31B $993M $818M $365M $475M $243M
Shares Outstanding 12-point trend, +30.9% 100,100,000 99,400,000 98,700,000 96,500,000 94,900,000 93,500,000 92,300,000 90,797,000 88,793,903 86,883,300 86,262,594 76,465,942
Cash Flow 15
Annual Cash Flow data for NBIX
Metric Trend 202520242023202220212020201920182017201620152014
D&A 5-point trend, +386.6% · · · · · · · $4M $2M $1M $1M $827.0K
Stock-based Comp 12-point trend, +1998.8% $218M $196M $194M $173M $134M $100M $75M $58M $43M $28M $28M $10M
Deferred Tax 8-point trend, +164200000.00 $164M $-123M $-61M $22M $6M $-311M $0 $0 · · · ·
Amort. of Intangibles 6-point trend, +4100000.00 $4M $4M $4M $500.0K $0 $0 · · · · · ·
Operating Cash Flow 12-point trend, +1760.4% $783M $595M $390M $339M $256M $228M $147M $101M $-94M $-106M $-38M $-47M
CapEx 12-point trend, +2009.2% $34M $38M $28M $16M $23M $11M $15M $25M $7M $4M $2M $2M
Investing Cash Flow 10-point trend, -334.1% $-264M $-127M $-467M $-177M $-130M $4M $-211M $-243M $-251M $113M · ·
Stock Issued 12-point trend, -6.7% $129M $122M $65M $45M $28M $29M $32M $30M $14M $2M $277M $139M
Stock Repurchased 4-point trend, +167700000.00 $168M $300M $0 $0 · · · · · · · ·
Net Stock Activity 11-point trend, -127.6% $-38M $-178M $65M $45M $28M $29M $27M $30M $14M $2M · $139M
Financing Cash Flow 10-point trend, -1702.5% $-38M $-487M $65M $-234M $27M $-158M $32M $30M $517M $2M · ·
Net Change in Cash 12-point trend, +3584.6% $480M $-18M $-12M $-73M $154M $75M $-32M $-112M $171M $9M $43M $-14M
Taxes Paid $81M · · · · · · · · · · ·
Free Cash Flow 11-point trend, +1635.7% $749M $557M $362M $323M $233M $218M $137M $77M $-101M $-110M · $-49M
Levered FCF 6-point trend, +661.3% · · $358M $318M $210M $92M $112M $47M · · · ·
Profitability 7
Annual Profitability data for NBIX
Metric Trend 202520242023202220212020201920182017201620152014
Operating Margin 10-point trend, +102.2% 21.6% 24.2% 13.3% 16.7% 9.0% 15.6% 9.2% 8.2% -81.3% -982.5% · ·
Net Margin 10-point trend, +101.8% 16.7% 14.5% 13.2% 10.4% 7.9% 38.9% 4.7% 4.7% -88.2% -940.6% · ·
Pretax Margin 8-point trend, +409.5% 24.7% 20.6% 17.6% 14.4% 8.9% 10.2% 5.9% 4.8% · · · ·
EBITDA Margin 10-point trend, +102.2% 21.6% 24.2% 13.3% 16.7% 9.0% 15.6% 9.2% 8.2% -81.3% -982.5% · ·
ROA 11-point trend, +137.6% 11.5% 9.8% 8.9% 7.0% 4.7% 26.8% 3.2% 2.3% -24.1% -33.6% · -30.4%
ROE 11-point trend, +143.7% 16.1% 12.9% 11.8% 9.5% 6.6% 42.2% 6.1% 4.5% -41.5% -38.2% · -36.8%
ROIC 8-point trend, +74.0% 12.9% 15.5% 8.5% 10.5% 6.6% 55.2% 9.0% 7.4% · · · ·
Liquidity & Solvency 3
Annual Liquidity & Solvency data for NBIX
Metric Trend 202520242023202220212020201920182017201620152014
Current Ratio 11-point trend, -73.2% 3.4 3.4 2.5 2.7 4.0 5.4 1.5 8.4 10.2 10.2 · 12.7
Quick Ratio 11-point trend, -84.8% 1.9 1.4 1.1 1.1 3.6 5.1 1.4 2.2 10.1 10.1 · 12.4
Interest Coverage 7-point trend, +910.6% · · 54.5 35.1 4.0 5.0 2.3 1.2 -6.7 · · ·
Efficiency 3
Annual Efficiency data for NBIX
Metric Trend 202520242023202220212020201920182017201620152014
Asset Turnover 11-point trend, +0.69 0.7 0.7 0.7 0.7 0.6 0.7 0.7 0.5 0.3 0.0 · 0.0
Inventory Turnover 5-point trend, +0.2% 0.8 0.7 1.1 0.7 · · · 0.8 · · · ·
Receivables Turnover 9-point trend, -52.7% 4.9 5.1 4.8 5.6 6.6 7.4 8.6 10.3 10.4 · · ·
Per Share 5
Annual Per Share data for NBIX
Metric Trend 202520242023202220212020201920182017201620152014
Book Value / Share 11-point trend, +1090.7% $32.50 $26.05 $22.61 $17.70 $14.48 $12.04 $6.90 $5.29 $4.19 $3.62 · $2.73
Revenue / Share 11-point trend, +27.91 $27.91 $22.71 $18.68 $15.05 $11.58 $10.69 $8.23 $4.73 $1.83 $0.17 · $0.00
Cash Flow / Share 11-point trend, +1308.1% $7.64 $5.74 $3.86 $3.43 $2.62 $2.34 $1.59 $1.06 $-1.07 $-1.22 · $-0.63
Cash / Share 11-point trend, +1656.1% $7.12 $2.34 $2.54 $2.72 $3.59 $2.00 $1.22 $1.56 $2.87 $0.96 · $0.41
EPS (TTM) 12-point trend, +676.5% $4.67 $3.29 $2.47 $1.56 $0.92 $4.16 $0.39 $0.22 $-1.62 $-1.63 $-1.05 $-0.81
Growth Rates 9
Annual Growth Rates data for NBIX
Metric Trend 202520242023202220212020201920182017201620152014
Revenue YoY 5-point trend, +156.0% 21.4% 24.8% 26.8% 31.3% 8.4% · · · · · · ·
Revenue CAGR 3Y 3-point trend, +11.9% 24.3% 27.6% 21.7% · · · · · · · · ·
Revenue CAGR 5Y 22.3% · · · · · · · · · · ·
EPS YoY 5-point trend, +153.9% 41.9% 33.2% 58.3% 69.6% -77.9% · · · · · · ·
EPS CAGR 3Y 3-point trend, +376.6% 44.1% 52.9% -16.0% · · · · · · · · ·
EPS CAGR 5Y 2.3% · · · · · · · · · · ·
Net Income YoY 5-point trend, +151.6% 40.2% 36.7% 61.6% 72.4% -78.0% · · · · · · ·
Net Income CAGR 3Y 3-point trend, +404.1% 45.8% 56.2% -15.0% · · · · · · · · ·
Net Income CAGR 5Y 3.3% · · · · · · · · · · ·
Valuation (TTM) 10
Annual Valuation (TTM) data for NBIX
Metric Trend 202520242023202220212020201920182017201620152014
Revenue TTM 12-point trend, +2860500000.00 $2.86B $2.36B $1.89B $1.49B $1.13B $1.05B $788M $451M $162M $15M $20M $0
Net Income TTM 12-point trend, +890.5% $479M $341M $250M $154M $90M $407M $37M $21M $-143M $-141M $-89M $-61M
Market Cap 11-point trend, +731.1% $14.20B $13.57B $13.00B $11.53B $8.08B $8.96B $9.92B $6.48B $6.89B $3.36B · $1.71B
P/E 12-point trend, +210.1% 30.4 41.5 53.3 76.6 92.6 23.0 275.6 324.6 -47.9 -23.7 -53.9 -27.6
P/S 10-point trend, -97.8% 5.0 5.8 6.9 7.7 7.1 8.6 12.6 14.4 42.6 224.2 · ·
P/B 11-point trend, -46.7% 4.4 5.2 5.8 6.7 5.9 8.0 15.6 13.5 18.5 10.7 · 8.2
P / Tangible Book 6-point trend, -45.2% 4.4 5.3 5.9 6.9 5.9 8.0 · · · · · ·
P / Cash Flow 11-point trend, +150.1% 18.1 22.8 33.4 34.0 31.5 39.2 65.2 64.0 -73.0 -31.7 · -36.2
P / FCF 11-point trend, +154.1% 19.0 24.4 36.0 35.7 34.7 41.2 72.2 84.7 -68.0 -30.5 · -35.0
Earnings Yield 12-point trend, +190.6% 3.3% 2.4% 1.9% 1.3% 1.1% 4.3% 0.36% 0.31% -2.1% -4.2% -1.9% -3.6%

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $2.86B$2.36B$1.89B$1.49B$1.13B
Operating Margin % 21.6%24.2%13.3%16.7%9.0%
Net Income $479M$341M$250M$154M$90M
Diluted EPS $4.67$3.29$2.47$1.56$0.92
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio 3.43.42.52.74.0
Quick Ratio 1.91.41.11.13.6
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $749M$557M$362M$323M$233M

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Institutional owners (13F) 827 filers · $10.1B total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
153 (+61 vs prior Q) 62 (-37 vs prior Q) 300 (+11 vs prior Q) 223 (+8 vs prior Q) +9.4M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
Dodge & Cox $941,218,594 5,584,707 9.32% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $838,307,078 4,974,083 8.30% Shares
VANGUARD CAPITAL MANAGEMENT LLC $766,048,708 4,545,339 7.59% Shares
STATE STREET CORP $739,126,759 4,385,598 7.32% Shares
RENAISSANCE TECHNOLOGIES LLC $393,680,402 2,335,897 3.90% Shares
TWO SIGMA INVESTMENTS, LP $349,922,479 2,076,260 3.47% Shares
Vestal Point Capital, LP $316,845,800 1,880,000 3.14% Shares
GEODE CAPITAL MANAGEMENT, LLC $294,151,210 1,750,392 2.91% Shares
RTW INVESTMENTS, LP $213,689,740 1,267,925 2.12% Shares
NORGES BANK $164,132,866 973,880 1.63% Shares
FIRST TRUST ADVISORS LP $155,578,851 923,125 1.54% Shares
JACOBS LEVY EQUITY MANAGEMENT, INC $122,375,286 726,112 1.21% Shares
TWO SIGMA ADVISERS, LP $119,504,823 842,592 1.18% Shares
Swedbank AB $109,730,107 651,082 1.09% Shares
VANGUARD FIDUCIARY TRUST CO $109,170,737 647,763 1.08% Shares
DIMENSIONAL FUND ADVISORS LP $109,070,816 647,171 1.08% Shares
VICTORY CAPITAL MANAGEMENT INC $104,238,729 618,499 1.03% Shares
Caisse de depot et placement du Quebec $91,002,327 539,961 0.90% Shares
ARMISTICE CAPITAL, LLC $90,307,457 535,838 0.89% Shares
PRIMECAP MANAGEMENT CO/CA/ $82,807,988 491,340 0.82% Shares
AMERIPRISE FINANCIAL INC $79,666,260 472,708 0.79% Shares
Hood River Capital Management LLC $79,082,184 469,233 0.78% Shares
ROYAL BANK OF CANADA $73,348,000 435,207 0.73% Shares
Pictet Asset Management Holding SA $72,751,030 430,635 0.72% Shares
Gotham Asset Management, LLC $62,622,213 371,568 0.62% Shares
Fiera Capital Corp $61,558,083 365,254 0.61% Shares
BlackRock, Inc. $61,129,161 362,709 0.61% Shares
ALLIANCEBERNSTEIN L.P. $60,767,710 461,270 0.60% Shares
Vinva Investment Management Ltd $58,838,530 346,109 0.58% Shares
AustralianSuper Pty Ltd $58,817,535 348,993 0.58% Shares
GOLDMAN SACHS GROUP INC $58,206,259 345,366 0.58% Shares
BRAIDWELL LP $56,656,579 336,171 0.56% Shares
RHUMBLINE ADVISERS $52,723,054 312,832 0.52% Shares
Clearbridge Investments, LLC $47,391,031 281,194 0.47% Shares
SEIZERT CAPITAL PARTNERS, LLC $46,740,991 277,337 0.46% Shares
Swiss National Bank $45,319,062 268,900 0.45% Shares
BARCLAYS PLC $44,228,304 262,428 0.44% Shares
ENVESTNET ASSET MANAGEMENT INC $44,187,600 262,192 0.44% Shares
WORLDQUANT MILLENNIUM ADVISORS LLC $44,038,027 261,299 0.44% Shares
Candriam S.C.A. $43,932,854 260,926 0.44% Shares
BNP PARIBAS FINANCIAL MARKETS $43,921,064 260,605 0.43% Shares
FMR LLC $40,551,501 240,612 0.40% Shares
PRINCIPAL FINANCIAL GROUP INC $40,285,595 239,034 0.40% Shares
California Public Employees Retirement System $39,090,345 231,942 0.39% Shares
RENAISSANCE GROUP LLC $38,589,515 228,970 0.38% Shares
Assenagon Asset Management S.A. $37,516,902 222,606 0.37% Shares
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. $37,508,000 222,554 0.37% Shares
Sumitomo Mitsui Trust Group, Inc. $36,317,270 215,488 0.36% Shares
Carmignac Gestion $36,083,344 214,100 0.36% Shares
PFM Health Sciences, LP $35,966,549 213,407 0.36% Shares
Bridgewater Associates, LP $34,663,773 205,677 0.34% Shares
LOS ANGELES CAPITAL MANAGEMENT LLC $34,304,966 203,548 0.34% Shares
Nantahala Capital Management, LLC $33,707,000 200,000 0.33% Call option
BANK OF AMERICA CORP /DE/ $32,143,164 190,721 0.32% Shares
MORGAN STANLEY $32,058,612 190,219 0.32% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $31,213,608 185,200 0.31% Put option
FULLER & THALER ASSET MANAGEMENT, INC. $30,192,001 179,149 0.30% Shares
PRUDENTIAL FINANCIAL INC $29,909,064 177,465 0.30% Shares
SEB Asset Management AB $29,789,208 176,754 0.30% Shares
Ensign Peak Advisors, Inc $29,653,059 175,946 0.29% Shares
IEQ CAPITAL, LLC $29,628,432 175,800 0.29% Shares
MACKENZIE FINANCIAL CORP $29,609,071 175,685 0.29% Shares
NEW YORK STATE COMMON RETIREMENT FUND $29,573,511 175,474 0.29% Shares
Korea Investment CORP $29,154,701 172,989 0.29% Shares
PKO BP BANKOWY Universal Pension Society JSC $28,786,115 170,802 0.29% Shares
Zurich Insurance Group Ltd/FI $28,618,254 169,806 0.28% Shares
Impax Asset Management Group plc $26,965,600 160,000 0.27% Shares
Nearwater Capital Markets, Ltd $26,122,925 155,000 0.26% Shares
Mariner, LLC $25,627,342 152,055 0.25% Shares
Integral Health Asset Management, LLC $25,281,000 150,000 0.25% Shares
Rock Springs Capital Management LP $24,395,441 144,750 0.24% Shares
Zurcher Kantonalbank (Zurich Cantonalbank) $23,738,829 140,854 0.24% Shares
Fisher Asset Management, LLC $22,769,751 135,104 0.23% Shares
Aware Super Pty Ltd as trustee of Aware Super $22,056,175 130,870 0.22% Shares
RAYMOND JAMES FINANCIAL INC $22,009,323 130,592 0.22% Shares
Hudson Bay Capital Management LP $21,909,550 130,000 0.22% Shares
Life Cycle Investment Partners Ltd $21,287,319 126,308 0.21% Shares
VIRGINIA RETIREMENT SYSTEMS ET Al $20,937,370 147,623 0.21% Shares
DNB Asset Management AS $20,280,996 120,337 0.20% Shares
JANE STREET GROUP, LLC $20,072,518 119,100 0.20% Put option
Sarissa Capital Management LP $19,639,889 116,533 0.19% Shares
Andra AP-fonden $19,522,682 148,191 0.19% Shares
AMERICAN CENTURY COMPANIES INC $19,061,140 113,099 0.19% Shares
DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main $18,885,863 112,059 0.19% Shares
Man Group plc $18,859,404 111,902 0.19% Shares
Mitsubishi UFJ Asset Management Co., Ltd. $18,788,956 111,484 0.19% Shares
UBS Group AG $18,243,577 108,248 0.18% Shares
Robeco Institutional Asset Management B.V. $18,197,736 107,976 0.18% Shares
LOOMIS SAYLES & CO L P $18,108,412 107,446 0.18% Shares
Retirement Systems of Alabama $17,527,134 103,997 0.17% Shares
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $17,474,389 132,643 0.17% Shares
ING GROEP NV $17,224,277 102,200 0.17% Shares
Legal & General Group Plc $17,176,748 101,918 0.17% Shares
RICE HALL JAMES & ASSOCIATES, LLC $16,886,364 100,195 0.17% Shares
Universal- Beteiligungs- und Servicegesellschaft mbH $16,827,572 99,912 0.17% Shares
CWM, LLC $16,696,728 126,740 0.17% Shares
CAPITAL FUND MANAGEMENT S.A. $16,536,148 98,117 0.16% Shares
Clark Capital Management Group, Inc. $15,629,612 92,738 0.15% Shares
Distillate Capital Partners LLC $15,604,993 92,592 0.15% Shares
LAZARD ASSET MANAGEMENT LLC $15,399,211 91,371 0.15% Shares

Company insiders 42 insiders · 21 officers · 15 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Kyle Gano Chief Executive Officer Feb. 13, 2025 M 139,907 0 0 $0
Matt Abernethy Chief Financial Officer Feb. 13, 2025 M 35,810 0 0 $0
Timothy Coughlin Chief Financial Officer Feb. 6, 2017 S 137,961 0 0 $0
David-Alexandre C Gros President & COO Feb. 6, 2017 A 0 0 $0
Ingrid Delaet Chief Regulatory Officer July 10, 2026 M 16,225 0 5 $-3,747,962
Darin Lippoldt Chief Legal Officer July 9, 2026 M 54,729 0 4 $-3,497,443
Sanjay Chandru Keswani Chief Medical Officer June 2, 2026 F 1,479 0 0 $0
Julie Cooke Chief Human Resources Officer June 2, 2026 M 22,374 0 1 $-2,200,685
David W. Boyer Chief Corp. Affairs Officer Feb. 13, 2025 M 3,565 0 0 $0
Eiry Roberts Chief Medical Officer Feb. 13, 2025 M 35,640 0 0 $0
Eric Benevich Chief Commercial Officer Feb. 13, 2025 M 44,689 0 0 $0
Malcolm Lloyd-Smith Chief Integration Officer Feb. 8, 2023 S 42,337 0 0 $0
Dimitri E. Grigoriadis Chief Research Officer Jan. 31, 2022 A 82,273 0 0 $0
Haig P. Bozigian Chief Development Officer Feb. 8, 2021 A 157,651 0 0 $0
Christopher Flint Obrien Former Chief Medical Officer Feb. 5, 2018 A 55,946 0 0 $0
VALEUR JENSEN MARGARET E EVP and General Counsel Aug. 31, 2011 A 118,256 0 0 $0
Richard J Ranieri Sr. VP, Human Resources Feb. 27, 2008 A 9,667 0 0 $0
Wendall Wierenga EVP, Research & Development Jan. 19, 2006 A 5,023 0 0 $0
Henry Pan Executive VP and CMO June 3, 2005 A 11,216 0 0 $0
Robert J Little SVP, Commercial Operations Feb. 18, 2005 A 0 0 $0
SAUNDERS JOHN Vice President Research (Chem) Dec. 18, 2003 S 7,966 0 0 $0
Leslie V Norwalk Director July 29, 2026 M 2,430 0 2 $-437,584
SHERWIN STEPHEN A Director June 5, 2026 M 15,860 0 5 $-4,132,990
William H Rastetter Director May 27, 2026 A 43,678 0 1 $-2,732,760
Kevin Charles Gorman Director May 27, 2026 A 511,293 0 1 $-37,824,431
Christine A Poon Director May 27, 2026 A 4,753 0 0 $0
POPS RICHARD F Director May 27, 2026 A 37,798 0 1 $-2,364,750
LYONS GARY A Director May 27, 2026 A 122,141 0 1 $-2,289,150
MORROW GEORGE J Director May 27, 2026 A 10,386 0 1 $-2,150,550
Johanna Mercier Director May 22, 2025 M 3,535 0 0 $0
Alfred Sandrock Director May 22, 2019 A 0 0 $0
Corinne H Nevinny Director May 24, 2018 A 43,283 0 0 $0
Thomas W Mitchell Director May 28, 2015 A 1,000 0 0 $0
VALE WYLIE W Director May 25, 2011 A 231,372 0 0 $0
Adrian Adams Director June 30, 2006 A 0 0 $0
NEUROCRINE BIOSCIENCES INC 10% owner Feb. 23, 2023 P 8,575,316 0 0 $0
Jude Onyia Aug. 4, 2026 G 20,996 0 1 $-1,762,710
Shalini Sharp May 27, 2026 A 4,088 0 0 $0
MOLLICA JOSEPH A May 22, 2017 A 56,042 0 0 $0
HAWRAN PAUL W Sept. 18, 2006 J 132,000 0 0 $0
Lawrence Steinman March 2, 2005 S 15,500 0 0 $0
CONLON PAUL J Dec. 16, 2003 S 57,335 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 1 position

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Neurocrine Biosciences, Inc. ×3 filings Feb. 24, 2023 Initial filing SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 129 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
IBRN · iShares Trust 3.71% 1,793 SH Aug. 8, 2026 Daily
PBE · Invesco Exchange-Traded Fund Trust 2.51% 55,704 SH Aug. 8, 2026 Daily
MCOW · Pacer Funds Trust 2.17% 162 NS April 30, 2026 N-PORT
FGSI · First Trust Exchange-Traded Fund IV 2.01% 457 NS April 30, 2026 N-PORT
POWA · Invesco Exchange-Traded Self-Indexe… 1.97% 22,094 SH Aug. 8, 2026 Daily
SMRI · EA Series Trust 1.95% 79,947 NS April 30, 2026 N-PORT
GRPM · Invesco Exchange-Traded Fund Trust 1.78% 55,458 SH Aug. 8, 2026 Daily
XMHQ · Invesco Exchange-Traded Fund Trust 1.74% 599,955 SH Aug. 8, 2026 Daily
BUL · Pacer Funds Trust 1.66% 16,032 NS April 30, 2026 N-PORT
BBP · ETFis Series Trust I 1.38% 6,192 NS April 30, 2026 N-PORT
ILDR · First Trust Exchange-Traded Fund VI… 1.29% 23,318 NS May 31, 2026 N-PORT
IBB · iShares Trust 1.22% 725,434 SH Aug. 8, 2026 Daily
RFG · Invesco Exchange-Traded Fund Trust 1.16% 25,502 SH Aug. 8, 2026 Daily
AGNG · Global X Funds 1.12% 5,792 NS May 31, 2026 N-PORT
IBBQ · Invesco Exchange-Traded Fund Trust … 1.12% 5,472 SH Aug. 8, 2026 Daily
LABU · Direxion Shares ETF Trust 0.95% 37,476 NS April 30, 2026 N-PORT
AGRW · ALLSPRING EXCHANGE-TRADED FUNDS TRU… 0.93% 7,516 NS April 30, 2026 N-PORT
IVOG · VANGUARD ADMIRAL FUNDS 0.89% 99,214 SH Aug. 8, 2026 Daily
FXH · First Trust Exchange-Traded AlphaDE… 0.87% 57,454 NS April 30, 2026 N-PORT
IJK · iShares Trust 0.86% 588,275 SH Aug. 8, 2026 Daily
COWG · Pacer Funds Trust 0.81% 132,963 NS April 30, 2026 N-PORT
BIB · ProShares Trust 0.80% 3,712 NS May 31, 2026 N-PORT
QQQJ · Invesco Exchange-Traded Fund Trust … 0.79% 57,321 SH Aug. 8, 2026 Daily
TMFX · RBB Fund, Inc. 0.76% 1,542 NS May 31, 2026 N-PORT
ABOT · Abacus FCF ETF Trust 0.72% 240 NS April 30, 2026 N-PORT
CLSE · Trust for Professional Managers 0.66% 25,529 NS May 31, 2026 N-PORT
MIDE · DBX ETF Trust 0.64% 136 NS May 29, 2026 N-PORT
JDOC · J.P. Morgan Exchange-Traded Fund Tr… 0.63% 533 NS April 30, 2026 N-PORT
IQSM · New York Life Investments ETF Trust 0.55% 13,166 NS April 30, 2026 N-PORT
SMDX · Tidal Trust III 0.55% 5,215 NS April 30, 2026 N-PORT
XJH · iShares Trust 0.51% 13,589 SH Aug. 8, 2026 Daily
ISCG · iShares Trust 0.50% 31,557 SH Aug. 8, 2026 Daily
QVMM · Invesco Exchange-Traded Fund Trust … 0.49% 13,131 SH Aug. 8, 2026 Daily
VBK · VANGUARD INDEX FUNDS 0.46% 1,331,820 SH Aug. 8, 2026 Daily
IVOO · VANGUARD ADMIRAL FUNDS 0.46% 162,408 SH Aug. 8, 2026 Daily
QLV · FlexShares Trust 0.46% 5,915 NS April 30, 2026 N-PORT
IJH · iShares Trust 0.44% 3,469,295 SH Aug. 8, 2026 Daily
SDG · iShares Trust 0.42% 4,563 SH Aug. 8, 2026 Daily
FNY · First Trust Exchange-Traded AlphaDE… 0.40% 15,614 NS April 30, 2026 N-PORT
IWP · iShares Trust 0.39% 493,090 SH Aug. 8, 2026 Daily
PTMC · Pacer Funds Trust 0.39% 11,519 NS April 30, 2026 N-PORT
USMV · iShares Trust 0.35% 534,448 SH Aug. 8, 2026 Daily
MVV · ProShares Trust 0.34% 3,468 NS May 31, 2026 N-PORT
SXQG · EXCHANGE TRADED CONCEPTS TRUST 0.34% 1,461 NS May 31, 2026 N-PORT
BKMC · BNY Mellon ETF Trust 0.34% 16,076 NS April 30, 2026 N-PORT
SCHM · SCHWAB STRATEGIC TRUST 0.29% 271,303 NS May 31, 2026 N-PORT
MIDU · Direxion Shares ETF Trust 0.26% 1,662 NS April 30, 2026 N-PORT
BBMC · J.P. Morgan Exchange-Traded Fund Tr… 0.26% 40,014 NS April 30, 2026 N-PORT
IYH · iShares Trust 0.26% 59,243 SH Aug. 8, 2026 Daily
ISCB · iShares Trust 0.25% 4,488 SH Aug. 8, 2026 Daily