PMN ProMIS Neurosciences Inc. - Common Shares
$14.93
Price · Aug 19, 2026
Fundamentals as of Aug 13, 2026
52W Range
$0–$27
54% of range
Analyst Rating
BUY
12 analysts
Price Target
$40
+167% upside
P/E (TTM)
-0.7
ROE
4840.3%
Net Profit Margin
—
PMN Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range
Price
$14.93
Market Cap
$32M
P/E (TTM)
-0.7
EPS (TTM)
$-22.61
Revenue (TTM)
—
Div Yield
—
ROE
4840.3%
Debt/Equity
—
52W Range
$0 – $27
PMN Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view
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10-Year Performance Revenue, net income, margins and EPS trends
Revenue & Net Income
—
EPS
$-22.61
2021-12-31
→
2025-12-31
Free Cash Flow
—
Margins
—
Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?
Metric
5Y trend
PMN
Peer Median
P/E (TTM)
-0.7
—
P/B
-25.5
2.3
Profitability Gross, operating and net margins; ROE, ROA, ROIC
Metric
5Y trend
PMN
Peer Median
ROA
-282.8%
-41.8%
ROE
4840.3%
-54.1%
Financial Health Debt, liquidity, solvency — balance sheet strength
Metric
5Y trend
PMN
Peer Median
Current Ratio
0.9
12.6
Quick Ratio
0.6
—
Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR
Metric
5Y trend
PMN
Peer Median
Capital Efficiency Asset turnover, inventory turnover, receivables turnover
Metric
5Y trend
PMN
Peer Median
PMN Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside
BUY
12 analysts
- Strong Buy 2 16.7%
- Buy 9 75.0%
- Hold 1 8.3%
- Sell 0 0.0%
- Strong Sell 0 0.0%
12-Month Price Target
7 analysts · 2026-08-14
Median
$35.52
Mean
$39.81
← Below all targets
$14.93
Low
$18.22
High
$70.13
Median target
$35.52
+137.9%
Mean target
$39.81
+166.6%
Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date
Avg Surprise
-0.42%
| Period | EPS Actual | EPS Est | Surprise |
|---|---|---|---|
| June 30, 2026 | $-1.28 | $-1.39 | 0.11% |
| March 31, 2026 | $-1.26 | $-1.49 | 0.23% |
| Dec. 31, 2025 | $-6.57 | $-4.93 | -1.6% |
| Sept. 30, 2025 | $-6.00 | $-6.14 | 0.14% |
| June 30, 2025 | $-7.25 | $-4.42 | -2.8% |
| March 31, 2025 | $-5.25 | $-3.03 | -2.2% |
| Dec. 31, 2024 | $-0.25 | $-3.54 | 3.3% |
Peer comparison (GICS sub-industry) Key metrics vs sector peers
| Ticker | Market Cap | P/E | Rev YoY | Net Margin | ROE | Gross Margin |
|---|---|---|---|---|---|---|
| PMN | $15M | -0.3 | — | — | 4840.3% | — |
| ZYME | $1.97B | -24.4 | 38.9% | -76.6% | -26.9% | — |
| ACOG | $141M | -5.5 | — | -202.2% | -43.8% | — |
| ENGN | — | — | — | — | — | — |
| XENE | $3.59B | -10.3 | — | -4612.1% | -56.9% | — |
Full Fundamentals All metrics by year — income statement, balance sheet, cash flow
Income Statement 12
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 |
|---|---|---|---|---|---|---|
| R&D Expense | $33M | $11M | $8M | $16M | $5M | |
| SG&A Expense | $7M | $6M | $6M | $7M | $4M | |
| Operating Expenses | $40M | $17M | $14M | $23M | $8M | |
| Operating Income | $-40M | $-17M | $-14M | $-23M | $-8M | |
| Other Non-op | $442.6K | $626.2K | $384.9K | $115.5K | $12.9K | |
| Income Tax | · | $0 | $0 | $0 | · | |
| Net Income | $-40M | $3M | $-13M | $-18M | $-10M | |
| EPS (Basic) | $-22.61 | $2.68 | $-1.07 | $-2.41 | $-1.69 | |
| EPS (Diluted) | $-22.61 | $2.63 | $-1.07 | $-2.41 | $-1.69 | |
| Shares (Basic) | 1,756,844 | 1,036,799 | 12,292,707 | 7,502,609 | 5,785,617 | |
| Shares (Diluted) | 1,756,844 | 1,058,469 | 12,292,707 | 7,502,609 | 5,785,617 | |
| EBITDA | $-40M | $-17M | $-14M | · | · |
Balance Sheet 21
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 |
|---|---|---|---|---|---|---|
| Cash & Equivalents | $6M | $13M | $13M | $6M | $17M | |
| Short-term Investments | $33.8K | $33.1K | $32.4K | $31.0K | $33.2K | |
| Prepaid Expense | $3M | $6M | $988.6K | $996.7K | $737.3K | |
| Current Assets | $9M | $19M | $14M | $7M | $18M | |
| PP&E (Net) | · | · | · | $321 | $4.7K | |
| PP&E (Gross) | · | · | · | $80.3K | $84.1K | |
| Accum. Depreciation | · | · | · | $80.0K | $79.4K | |
| Intangibles | · | · | · | $20.8K | $27.6K | |
| Total Assets | $9M | $19M | $14M | $7M | $18M | |
| Accounts Payable | $3M | $2M | $8M | $3M | $409.0K | |
| Accrued Liabilities | $8M | $481.0K | $2M | $3M | $520.1K | |
| Current Liabilities | $10M | $2M | $9M | $6M | $929.1K | |
| Total Liabilities | $10M | $2M | $10M | $8M | $12M | |
| Long-term Debt | · | · | $0 | · | $4M | |
| Common Stock | · | · | · | · | $0 | |
| Paid-in Capital | $130M | $108M | $98M | $79M | $68M | |
| Retained Earnings | $-130M | $-91M | $-93M | $-80M | $-62M | |
| AOCI | $-371.2K | $-371.2K | $-371.2K | $-195.4K | $-187.9K | |
| Stockholders' Equity | $-1M | $16M | $4M | $-1M | $6M | |
| Liabilities + Equity | $9M | $19M | $14M | $7M | $18M | |
| Shares Outstanding | 2,152,397 | 1,307,520 | 18,885,254 | 8,579,284 | 7,195,529 |
Cash Flow 9
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 |
|---|---|---|---|---|---|---|
| Stock-based Comp | $857.6K | $825.8K | $271.5K | $487.6K | $515.6K | |
| Amort. of Intangibles | · | · | $20.8K | $5.1K | $5.2K | |
| Operating Cash Flow | $-28M | $-27M | $-11M | $-17M | $-9M | |
| CapEx | · | · | · | $2.0K | $6.0K | |
| Investing Cash Flow | $-702 | $-693 | $-1.3K | $-2.0K | $94.6K | |
| Stock Issued | $708.5K | $190.3K | · | $5M | $16M | |
| Net Stock Activity | $708.5K | $190.3K | · | · | · | |
| Financing Cash Flow | $21M | $28M | $18M | $6M | $26M | |
| Net Change in Cash | $-7M | $693.0K | $7M | $-11M | $16M |
Profitability 2
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 |
|---|---|---|---|---|---|---|
| ROA | -282.8% | 17.1% | -128.6% | · | · | |
| ROE | 4840.3% | 23.4% | -251.5% | · | · |
Liquidity & Solvency 2
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 |
|---|---|---|---|---|---|---|
| Current Ratio | 0.9 | 8.5 | 1.5 | · | · | |
| Quick Ratio | 0.6 | 6.0 | 1.4 | · | · |
Valuation (TTM) 7
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 |
|---|---|---|---|---|---|---|
| Net Income TTM | $-40M | $3M | $-13M | $-18M | · | |
| Market Cap | $15M | $31M | $22M | · | · | |
| P/E | -0.3 | 0.4 | -1.1 | -1.8 | · | |
| P/B | -11.7 | 1.9 | 5.8 | · | · | |
| P / Tangible Book | · | 1.9 | 5.8 | · | · | |
| P / Cash Flow | -0.5 | -1.1 | -2.0 | · | · | |
| Earnings Yield | -331.0% | 276.8% | -93.0% | -55.5% | · |
Income Statement 12
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R&D Expense | $10M | $7M | $9M | $10M | $9M | $5M | $4M | $3M | $2M | $2M | $2M | $1M | $1M | $4M | $6M | $5M | |
| SG&A Expense | $3M | $2M | $1M | $2M | $1M | $2M | $2M | $2M | $1M | $2M | $2M | $1M | $2M | $1M | $2M | $1M | |
| Operating Expenses | $12M | $9M | $11M | $12M | $10M | $7M | $6M | $4M | $3M | $4M | $4M | $3M | $3M | $5M | $9M | $6M | |
| Operating Income | $-12M | $-9M | $-11M | $-12M | $-10M | $-7M | $-6M | $-4M | $-3M | $-4M | $-4M | $-3M | $-3M | $-5M | $-9M | $-6M | |
| Interest Expense | · | · | · | · | · | · | · | $1 | $-1 | $76.8K | · | $75.4K | $49.2K | · | · | $0 | |
| Other Non-op | $536.7K | $400.5K | $92.4K | $170.3K | $67.6K | $112.2K | $-13M | $14M | $90.0K | $41.6K | $144.2K | $156.9K | $30.9K | $52.9K | $52.6K | $35.9K | |
| Net Income | $-12M | $-8M | $-11M | $-12M | $-10M | $-7M | $-238.2K | $9M | $-3M | $-4M | $-4M | $-2M | $-2M | $-5M | $-7M | $-6M | |
| EPS (Basic) | $-1.28 | $-1.26 | $-21.87 | $-0.24 | $-7.26 | $-5.27 | $2.69 | $0.31 | $-0.13 | $-0.19 | $-0.03 | $-0.19 | $-0.27 | $-0.58 | $-0.91 | $-0.83 | |
| EPS (Diluted) | $-1.28 | $-1.26 | $-21.87 | $-0.24 | $-7.26 | $-5.27 | $2.64 | $0.31 | $-0.13 | $-0.19 | $-0.03 | $-0.19 | $-0.27 | $-0.58 | $-0.91 | $-0.83 | |
| Shares (Basic) | 9,142,366 | 6,527,779 | -116,779,361 | 48,833,799 | 1,394,048 | 1,394,048 | -68,291,591 | 30,023,675 | 19,770,739 | 19,533,976 | -17,236,691 | 12,370,830 | 8,579,284 | 8,579,284 | -14,083,978 | 7,195,529 | |
| Shares (Diluted) | 9,142,366 | 6,527,779 | -116,779,361 | 48,833,799 | 1,394,048 | 1,394,048 | -68,313,341 | 30,067,095 | 19,770,739 | 19,533,976 | -17,236,691 | 12,370,830 | 8,579,284 | 8,579,284 | -14,083,978 | 7,195,529 | |
| EBITDA | $-12M | $-9M | · | $-12M | $-10M | $-7M | · | $-4M | $-3M | $-4M | · | $-3M | $-3M | $-5M | · | $-6M |
Balance Sheet 20
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $53M | $64M | $6M | $15M | $5M | $8M | $13M | $22M | $992.5K | $2M | $13M | $17M | $1M | $3M | $6M | $4M | |
| Short-term Investments | $33.8K | $33.8K | $33.8K | $33.1K | $33.1K | $33.1K | $33.1K | $32.4K | $32.4K | $32.4K | $32.4K | $31.8K | $31.8K | $31.1K | $31.0K | $30.5K | |
| Prepaid Expense | $3M | $2M | $3M | $6M | $5M | $5M | $6M | $3M | $384.8K | $1M | $988.6K | $957.8K | $224.7K | $1M | $996.7K | $1M | |
| Current Assets | $57M | $66M | $9M | $21M | $10M | $14M | $19M | $25M | $1M | $4M | $14M | $18M | $1M | $4M | $7M | $5M | |
| PP&E (Net) | · | · | · | · | · | · | · | · | · | · | · | · | · | · | $321 | $788 | |
| PP&E (Gross) | · | · | · | · | · | · | · | · | · | · | · | · | · | · | · | $79.1K | |
| Accum. Depreciation | · | · | · | · | · | · | · | · | · | · | · | · | · | · | · | $78.3K | |
| Intangibles | · | · | · | · | · | · | · | · | · | · | · | $18.0K | $18.8K | $19.7K | $20.8K | $21.7K | |
| Total Assets | $57M | $67M | $9M | $21M | $10M | $14M | $19M | $25M | $1M | $4M | $14M | $18M | $1M | $4M | $7M | $5M | |
| Accounts Payable | $2M | $2M | $3M | $4M | $3M | $1M | $2M | $2M | $2M | $1M | $8M | $8M | $8M | $7M | $3M | $2M | |
| Accrued Liabilities | $5M | $5M | $8M | $8M | $7M | $3M | $481.0K | $1M | $1M | $1M | $2M | $1M | $775.9K | $2M | $3M | $1M | |
| Current Liabilities | $7M | $7M | $10M | $12M | $10M | $4M | $2M | $3M | $3M | $3M | $9M | $10M | $9M | $9M | $6M | $3M | |
| Total Liabilities | $7M | $7M | $10M | $12M | $10M | $4M | $2M | $17M | $4M | $3M | $10M | $11M | $10M | $11M | $8M | $5M | |
| Common Stock | · | · | · | · | · | · | · | · | · | · | · | · | · | · | · | $0 | |
| Paid-in Capital | $200M | $200M | $130M | $129M | $108M | $108M | $108M | $98M | $98M | $98M | $98M | $97M | $79M | $79M | $79M | $74M | |
| Retained Earnings | $-150M | $-139M | $-130M | $-120M | $-108M | $-98M | $-91M | $-90M | $-100M | $-97M | $-93M | $-90M | $-88M | $-85M | $-80M | $-73M | |
| AOCI | $-371.2K | $-371.2K | $-371.2K | $-371.2K | $-371.2K | $-371.2K | $-371.2K | $-371.2K | $-371.2K | $-371.2K | $-371.2K | $-371.2K | $-371.2K | $-199.7K | $-195.4K | $-270.3K | |
| Stockholders' Equity | $49M | $61M | $-1M | $9M | $-382.6K | $9M | $16M | $7M | $-2M | $77.1K | $4M | $7M | $-9M | $-6M | $-1M | $729.8K | |
| Liabilities + Equity | $57M | $67M | $9M | $21M | $10M | $14M | $19M | $25M | $1M | $4M | $14M | $18M | $1M | $4M | $7M | $5M | |
| Shares Outstanding | 8,967,693 | 8,967,693 | 2,152,397 | 53,811,110 | 32,689,190 | 32,689,190 | 1,307,520 | 32,689,190 | 18,961,116 | 18,961,116 | 18,885,254 | 18,525,254 | 8,579,284 | 8,579,284 | 8,579,284 | 7,195,529 |
Cash Flow 9
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stock-based Comp | $408.9K | $189.4K | $203.2K | $197.1K | $212.0K | $245.3K | $623.2K | $121.0K | $18.0K | $63.6K | $4.8K | $0 | $134.2K | $132.5K | $138.8K | $108.6K | |
| Amort. of Intangibles | · | · | · | · | · | · | · | · | · | · | $18.0K | $345 | $1.2K | $1.2K | $1.2K | $1.3K | |
| Operating Cash Flow | $-10M | $-12M | $-9M | $-10M | $-4M | $-5M | $-9M | $-7M | $-2M | $-10M | $-4M | $-2M | $-2M | $-3M | $-5M | $-5M | |
| CapEx | · | · | · | · | · | · | · | · | · | · | · | · | · | · | $-43 | $-24 | |
| Investing Cash Flow | · | · | · | · | · | · | · | · | · | · | · | · | · | · | $43 | $24 | |
| Stock Issued | · | · | $0 | · | · | · | $0 | $0 | $0 | $190.3K | · | · | · | · | · | · | |
| Net Stock Activity | · | · | · | · | · | · | · | · | · | $190.3K | · | · | · | · | · | · | |
| Financing Cash Flow | $0 | $70M | $-1 | · | · | · | $470.0K | $27M | $0 | $190.3K | $-510.6K | · | · | · | · | · | |
| Net Change in Cash | $-10M | $58M | $-9M | $11M | $-4M | $-5M | $-8M | $21M | $-2M | $-10M | $-4M | $16M | $-2M | $-3M | $2M | $-5M |
Profitability 2
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROA | -35.4% | -20.3% | · | -50.4% | -185.3% | -85.5% | · | 43.8% | -180.5% | -91.1% | · | -20.3% | -39.6% | -224.0% | · | -221.4% | |
| ROE | -47.9% | -23.5% | · | -140.7% | 760.8% | -153.9% | · | 132.2% | 48.6% | 119.2% | · | -63.1% | 254.3% | 160.5% | · | -1632.6% |
Liquidity & Solvency 3
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 7.9 | 9.9 | · | 1.8 | 1.0 | 3.4 | · | 9.3 | 0.4 | 1.3 | · | 1.8 | 0.2 | 0.5 | · | 1.7 | |
| Quick Ratio | 7.4 | 9.7 | · | 1.3 | 0.5 | 2.1 | · | 8.2 | 0.3 | 1.0 | · | 1.7 | 0.1 | 0.4 | · | 1.3 | |
| Interest Coverage | · | · | · | · | · | · | · | · | · | -47.9 | · | · | · | · | · | · |
Valuation (TTM) 7
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Income TTM | $-42M | $-37M | · | $-20M | $-11M | $-4M | · | $656.4K | $-11M | $-13M | · | $-16M | $-16M | $-16M | · | $-12M | |
| Market Cap | $118M | $114M | · | $23M | $16M | $23M | · | $41M | $28M | $36M | · | $37M | $33M | $41M | · | $44M | |
| P/E | -1.3 | -1.8 | · | -1.0 | -1.5 | -3.2 | · | -6.2 | -1.9 | -1.6 | · | -1.1 | -1.9 | -2.3 | · | -3.6 | |
| P/B | 2.4 | 1.9 | · | 2.5 | -41.0 | 2.4 | · | 5.6 | -12.5 | 469.7 | · | 5.4 | -3.9 | -6.6 | · | 60.4 | |
| P / Tangible Book | 2.4 | 1.9 | · | 2.5 | · | 2.4 | · | 5.6 | · | 469.7 | · | 5.4 | · | · | · | 62.3 | |
| P / Cash Flow | · | -9.2 | · | · | · | -4.6 | · | · | · | -3.5 | · | · | · | -15.8 | · | · | |
| Earnings Yield | -76.3% | -55.6% | · | -100.0% | -66.7% | -31.4% | · | -16.0% | -52.0% | -64.4% | · | -94.4% | -53.1% | -44.0% | · | -27.7% |
Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years
Income Statement
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Net Income | $-40M | $3M | $-13M | $-18M | $-10M |
| Diluted EPS | $-22.61 | $2.63 | $-1.07 | $-2.41 | $-1.69 |
Balance Sheet
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Current Ratio | 0.9 | 8.5 | 1.5 | — | — |
| Quick Ratio | 0.6 | 6.0 | 1.4 | — | — |
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Institutional owners (13F) 29 filers · $83.8M total · As of June 30, 2026
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
Institutional activity — Q2 2026 vs prior quarter
| New positions | Exited positions | Increased | Decreased | Net shares change |
|---|---|---|---|---|
| 4 (-14 vs prior Q) | 2 (0 vs prior Q) | 7 (+5 vs prior Q) | 5 (+1 vs prior Q) | -1.0M |
Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | $16,418,014 | 1,292,757 | 19.60% | Shares |
| Deep Track Capital, LP | $10,997,220 | 835,655 | 13.13% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $9,164,334 | 696,378 | 10.94% | Shares |
| Ally Bridge Group (NY) LLC | $8,163,398 | 620,319 | 9.75% | Shares |
| Trails Edge Capital Partners, LP | $7,331,475 | 557,103 | 8.75% | Shares |
| Woodline Partners LP | $5,815,548 | 441,911 | 6.94% | Shares |
| Yu Fan | $4,339,642 | 329,760 | 5.18% | Shares |
| SPHERA FUNDS MANAGEMENT LTD. | $4,284,784 | 325,591 | 5.12% | Shares |
| Squadron Capital Management LLC | $4,276,697 | 324,977 | 5.11% | Shares |
| Ikarian Capital, LLC | $2,697,801 | 205,000 | 3.22% | Shares |
| AMERIPRISE FINANCIAL INC | $2,443,812 | 185,700 | 2.92% | Shares |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $2,161,859 | 164,275 | 2.58% | Shares |
| 683 Capital Management, LLC | $1,250,200 | 95,000 | 1.49% | Shares |
| ADAR1 Capital Management, LLC | $1,221,906 | 92,850 | 1.46% | Shares |
| GREAT POINT PARTNERS LLC | $1,133,734 | 86,150 | 1.35% | Shares |
| BOOTHBAY FUND MANAGEMENT, LLC | $816,946 | 62,078 | 0.98% | Shares |
| MILLENNIUM MANAGEMENT LLC | $737,552 | 56,045 | 0.88% | Shares |
| BANK OF MONTREAL /CAN/ | $149,642 | 11,371 | 0.18% | Shares |
| Seven Fleet Capital Management LP | $139,496 | 10,600 | 0.17% | Shares |
| MORGAN STANLEY | $99,476 | 7,559 | 0.12% | Shares |
| Allostery Investments LP | $76,303 | 155,720 | 0.09% | Shares |
| JNB Advisors LLC | $25,561 | 52,833 | 0.03% | Shares |
| OSAIC HOLDINGS, INC. | $4,737 | 360 | 0.01% | Shares |
| ROYAL BANK OF CANADA | $3,000 | 218 | 0.00% | Shares |
| Steward Partners Investment Advisory, LLC | $1,237 | 94 | 0.00% | Shares |
| Federation des caisses Desjardins du Quebec | $131 | 10 | 0.00% | Shares |
| TD Waterhouse Canada Inc. | $66 | 5 | 0.00% | Shares |
| Caitong International Asset Management Co., Ltd | $39 | 3 | 0.00% | Shares |
| UBS Group AG | $13 | 1 | 0.00% | Shares |
Company insiders 18 insiders · 7 officers · 10 directors
| Insider | Role | Last activity | Shares owned | Buys 12m | Sells 12m | Net 12m |
|---|---|---|---|---|---|---|
| Neil K Warma | Chief Executive Officer | May 20, 2026 A | 6,183 | 0 | 0 | $0 |
| Gail M Farfel | Chief Executive Officer | Aug. 23, 2023 A | 55,192 | 0 | 0 | $0 |
| Daniel E. Geffken | Chief Financial Officer | Oct. 26, 2023 A | — | 0 | 0 | $0 |
| Gavin T. Malenfant | Chief Operating Officer | Oct. 26, 2023 A | 2,660 | 0 | 0 | $0 |
| Neil Cashman | Chief Scientific Officer | May 20, 2026 A | 4,122 | 0 | 0 | $0 |
| Max A. Milbury | Principal Accounting Officer | May 20, 2026 A | 8,409 | 0 | 0 | $0 |
| Larry Douglas Altstiel | Chief Medical Officer | Nov. 18, 2024 A | — | 0 | 0 | $0 |
| Slanix Paul Alex | Director | May 20, 2026 A | — | 0 | 0 | $0 |
| Eugene Williams | Director | May 20, 2026 A | 12,397 | 4 | 0 | $141,220 |
| Madge K. Shafmaster | Director | May 20, 2026 A | 208,333 | 0 | 0 | $0 |
| Josh Mandel-Brehm | Director | May 20, 2026 A | — | 0 | 0 | $0 |
| William W Wyman | Director | May 20, 2026 A | — | 0 | 0 | $0 |
| Patrick D. Kirwin | Director | April 22, 2026 P | 4,653 | 1 | 0 | $45,320 |
| Jeremy M. Sclar 2012 Irrevocable Family Trust | 10% owner | July 29, 2025 P | 3,710,459 | 0 | 0 | $0 |
| Jeremy M. Sclar | 10% owner | July 29, 2025 P | 3,710,459 | 0 | 0 | $0 |
| Johanne Kaplan | — | Aug. 5, 2026 P | 6,221 | 2 | 0 | $55,329 |
| Title 19 Promis | — | July 25, 2025 X | 2,435,029 | 0 | 0 | $0 |
| Michael S Gordon | — | July 25, 2025 X | 0 | 0 | 0 | $0 |
Insiders from SEC Form 3/4/5 filings; net = open-market P/S only
Activists & 5%+ owners 1 position
Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.
| Filer | Filed | Stake | Status | Purpose | Filing |
|---|---|---|---|---|---|
| ABG Management Ltd., Ally Bridge Group (NY) LLC, Ally Bridge MedAlpha Master Fund L.P., ABG V-SIV IX Limited, Ally Bridge Group Global Life Science Capital Partners V, L.P., ABG Global Life Science Capital Partners V GP, L.P., ABG Global Life Science Capital Partners V GP Limited, ABG V-SIV X Limited, Fan Yu ×3 filings | Feb. 5, 2026 | 17.00% | Amendment | — | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.