Allostery Investments LP
CIK 1978599 · View on SEC EDGAR ↗
- Portfolio value
- $7.9M
- Positions
- 20
- As of
- June 30, 2025 Data as of Q2 2025
#8,989 of 9,443 by 13F value · top 95.2%
Portfolio value QoQ: -88.7% 13F does not disclose cash
- Top 10 holdings weight
- 82.66%
- Top 25 holdings weight
- 100.00%
- Positions above 1%
- 17
- Effective number of positions
- 11.1
Based on 13F long-equity holdings only (cash, bonds, shorts not disclosed)
Turnover Q2 2025: 3.91% Est. buys $1,507,562 · sells $65,980,393
- New positions
- 5
- Increased
- 1
- Decreased
- 14
- Closed
- 26
On this page
- Performance vs S&P How this manager's 13F portfolio performed against the S&P 500.
- Sector breakdown How the portfolio splits across market sectors.
- Portfolio Every stock this institution reports holding, from its latest 13F.
- Biggest new bets Brand-new positions opened in the latest quarter.
- Top moves The biggest position increases and decreases this quarter.
- Exited positions Positions the manager fully sold out of last quarter.
Performance vs S&P 500
Approximates a buy-and-hold portfolio built from quarterly SEC 13F snapshots. Excludes cash, short positions, options/derivatives, and non-13(f) securities — reflects the disclosed long-equity book only, not total fund AUM. SEC filing lag is up to 45 days; this is not a real-time-copyable timing.
Priceable coverage: 92.2% · Options excluded: 27.1%
Sector breakdown
Healthcare
100.0%
Full portfolio 20 positions
| Type | Streak | 8Q trend | |||||
|---|---|---|---|---|---|---|---|
| ABVX Abivax SA - American Depositary Shares | $1,280,228 | 16.31% | 167,350 | $-5,592,610 | Down ×1 | ||
| AKRO Akero Therapeutics, Inc. - Common Stock | $1,200,600 | 15.29% | 22,500 | $471,960 | Up ×1 | ||
| AMLX Amylyx Pharmaceuticals, Inc. - Common Stock | $769,963 | 9.81% | 120,119 | $-172,027 | Down ×1 | ||
| CNTA Centessa Pharmaceuticals plc - American Depositary Shares | $689,850 | 8.79% | 52,500 | $-4,810,845 | Down ×1 | ||
| EOLS Evolus, Inc. - Common Stock | $552,600 | 7.04% | 60,000 | $-4,412,831 | Down ×2 | ||
| RZLT Rezolute, Inc. - Common Stock (NV) | $532,051 | 6.78% | 119,294 | Up ×1 | |||
| MRUS Merus N.V. - Common Shares | $473,400 | 6.03% | 9,000 | $-4,773,413 | Down ×1 | ||
| KALV KalVista Pharmaceuticals, Inc. - Common Stock | $452,200 | 5.76% | 40,000 | $-4,836,605 | Down ×2 | ||
| FULC Fulcrum Therapeutics, Inc. - Common Stock | $277,629 | 3.54% | 40,353 | Up ×1 | |||
| APGE Apogee Therapeutics, Inc. - Common Stock | $260,580 | 3.32% | 6,000 | $-3,849,020 | Down ×1 | ||
| VRNA Verona Pharma plc - American Depositary Shares | $236,450 | 3.01% | 2,500 | $-557,175 | Down ×1 | ||
| TNGX Tango Therapeutics, Inc. - Common Stock | $204,800 | 2.61% | 40,000 | Up ×1 | |||
| BBIO BridgeBio Pharma, Inc. - Common Stock | $172,720 | 2.20% | 4,000 | $-2,592,880 | Down ×1 | ||
| CYTK Cytokinetics, Incorporated - Common Stock | $165,200 | 2.10% | 5,000 | $-2,648,100 | Down ×1 | ||
| TRML Tourmaline Bio, Inc. - Common Stock | $149,602 | 1.91% | 9,356 | Up ×1 | |||
| LEGN Legend Biotech Corporation - American Depositary Shares | $141,960 | 1.81% | 4,000 | $-19,208 | Down ×1 | ||
| NKTR Nektar Therapeutics - Common Stock | $103,360 | 1.32% | 4,000 | Up ×1 | |||
| PMN ProMIS Neurosciences Inc. - Common Shares | $76,303 | 0.97% | 155,720 | $-88,855 | Down ×1 | ||
| ACLX Arcellx, Inc. - Common Stock | $65,850 | 0.84% | 1,000 | $-2,820,550 | Down ×1 | ||
| AVTX Avalo Therapeutics, Inc. - Common Stock | $44,910 | 0.57% | 9,000 | $-813,289 | Down ×1 | ||
| No matches | |||||||
Biggest new bets
New positions opened this quarter, largest first.
Top movers (QoQ)
| Security | Action | Shares Δ | Value Δ |
|---|---|---|---|
| VRNA | Trimmed | -10K | -$557K |
| AKRO | Bought more | +4K | +$472K |
| AMLX | Trimmed | -146K | -$172K |
| PMN | Trimmed | -78K | -$89K |
| LEGN | Trimmed | -750 | -$19K |
10 positions hidden (data completeness check)
Exited positions
Includes corporate events (mergers, delistings) — not all exits are sells
Closed positions reflect 13F reporting changes; for index managers these are often mechanical (delisting, M&A, index rebalancing), not active decisions.
| Security | Quarter | Shares before | Value before | Price since exit |
|---|---|---|---|---|
| XBI | March 31, 2025 | 175,000 | $15,760,500 | No longer tracked |
| QQQ | March 31, 2025 | 25,000 | $12,780,750 | |
| TLT | March 31, 2025 | 100,000 | $8,733,000 | |
| ALKS | June 30, 2025 | 115,000 | $3,797,300 | 68.0% |
| AVTE | June 30, 2025 | 1,421,568 | $3,568,136 | No longer tracked |
| ZURA | June 30, 2025 | 2,329,384 | $3,004,905 | 456.2% |
| APLS | March 31, 2025 | 80,000 | $2,552,800 | No longer tracked |
| SWTX | June 30, 2025 | 52,500 | $2,316,825 | No longer tracked |
| TGTX | March 31, 2025 | 75,000 | $2,257,500 | 39.9% |
| BEAM | June 30, 2025 | 92,754 | $1,811,486 | 71.5% |
| SLNO | June 30, 2025 | 20,000 | $1,429,000 | No longer tracked |
| PCVX | June 30, 2025 | 32,000 | $1,208,320 | 91.6% |
| NVAX | March 31, 2025 | 150,000 | $1,206,000 | 38.0% |
| IONS | June 30, 2025 | 35,000 | $1,055,950 | 51.6% |
| XENE | June 30, 2025 | 30,000 | $1,006,500 | 92.3% |
| MNMD | March 31, 2025 | 130,000 | $904,800 | No longer tracked |
| INSM | June 30, 2025 | 10,000 | $762,900 | 24.6% |
| TARS | June 30, 2025 | 13,600 | $698,632 | 78.4% |
| GOSS | June 30, 2025 | 613,028 | $674,331 | -87.5% |
| ANAB | March 31, 2025 | 50,000 | $662,000 | 209.1% |
| PLRX | June 30, 2025 | 441,686 | $596,276 | -3.4% |
| CNTX | June 30, 2025 | 950,166 | $581,502 | -18.0% |
| DNTH | March 31, 2025 | 25,000 | $545,000 | 516.3% |
| OLMA | March 31, 2025 | 90,000 | $524,700 | 197.3% |
| PHGE | June 30, 2025 | 940,629 | $522,708 | No longer tracked |
| CRNX | March 31, 2025 | 9,700 | $495,961 | 152.7% |
| RLYB | June 30, 2025 | 752,235 | $492,338 | 4858.6% |
| JSPR | March 31, 2025 | 22,000 | $470,360 | -83.4% |
| ELDN | June 30, 2025 | 100,000 | $339,000 | 31.7% |
| CLYM | June 30, 2025 | 244,988 | $298,885 | 1283.8% |
| ELEV | March 31, 2025 | 432,206 | $243,159 | No longer tracked |
| ORKA | June 30, 2025 | 20,000 | $205,200 | 854.0% |
| MDGL | June 30, 2025 | 600 | $198,738 | 71.5% |
| ETNB | June 30, 2025 | 25,000 | $181,750 | No longer tracked |
| VIR | June 30, 2025 | 22,202 | $143,869 | 86.7% |
| WVE | June 30, 2025 | 17,500 | $141,400 | -16.9% |
| ARQT | June 30, 2025 | 7,500 | $117,300 | 79.2% |
| VRDN | March 31, 2025 | 3,600 | $69,012 | 82.6% |
| EWTX | June 30, 2025 | 3,000 | $66,000 | 234.8% |
| LXEO | June 30, 2025 | 5,054 | $17,537 | 28.0% |