GREAT POINT PARTNERS LLC
Portfolio value QoQ: +21.6% 13F does not disclose cash
Top 10 holdings weight51.64%
Top 25 holdings weight87.13%
Positions above 1%29
Effective number of positions25.0
Based on 13F long-equity holdings only (cash, bonds, shorts not disclosed)
Turnover Q2 2026: 36.83% Est. buys $220,513,611 · sells $177,562,975
Median holding: 2.0 quarters Tracked Q1 2025–Q2 2026 · 46.2% still held
New positions13
Increased7
Decreased9
Closed13
Put-notional exposure: 8.8% puts 13F reports option positions at underlying notional value — may include hedges, not necessarily bearish bets
Portfolio value
$529.1M
Positions
42
As of
June 30, 2026 Data as of Q2 2026
Performance vs S&P 500
Tracked Q1 2025–Q2 2026
+253.1%
S&P 500 total return (same window)
+37.0%
Excess return
+216.1%
Annualized: +174.5% · S&P 500: +28.7%
Approximates a buy-and-hold portfolio built from quarterly SEC 13F snapshots. Excludes cash, short positions, options/derivatives, and non-13(f) securities — reflects the disclosed long-equity book only, not total fund AUM. SEC filing lag is up to 45 days; this is not a real-time-copyable timing.
Sector breakdown
Full portfolio 42 positions
| Type | Streak | 8Q trend | |||||
|---|---|---|---|---|---|---|---|
| ABVX | $53,304,000 | 10.07% | 400,000 | Call option | Up ×1 | ||
| VOR | $31,297,000 | 5.91% | 1,700,000 | $77,000 | Down ×1 | ||
| ABVX | $27,226,884 | 5.15% | 204,314 | ||||
| IBRX | $26,272,004 | 4.97% | 3,000,800 | Put option | $3,255,868 | ||
| VERA | $25,781,873 | 4.87% | 600,836 | $17,762,103 | Up ×1 | ||
| ZURA | $24,873,987 | 4.70% | 4,215,930 | $-210,797 | |||
| ALMS | $24,089,557 | 4.55% | 856,061 | $5,230,533 | |||
| SLGL | $20,341,273 | 3.84% | 274,363 | $-1,393,764 | |||
| RARE | $20,034,000 | 3.79% | 600,000 | Put option | Up ×1 | ||
| DFTX | $19,992,000 | 3.78% | 425,000 | Up ×1 | |||
| ANNX | $19,985,000 | 3.78% | 3,500,000 | $6,135,000 | Up ×1 | ||
| ORKA | $17,447,516 | 3.30% | 183,330 | $8,455,179 | |||
| MLTX | $16,662,679 | 3.15% | 855,813 | $7,342,679 | Up ×1 | ||
| SGMT | $15,691,382 | 2.97% | 2,029,933 | Up ×1 | |||
| CTNM | $15,103,074 | 2.85% | 921,481 | $4,652,488 | Up ×2 | ||
| IMMX | $13,172,489 | 2.49% | 1,277,642 | $9,983,989 | Up ×1 | ||
| CLYM | $13,040,000 | 2.46% | 1,000,000 | $3,901,209 | Down ×1 | ||
| AMLX | $12,572,000 | 2.38% | 700,000 | $-11,753,000 | Down ×1 | ||
| NKTR | $12,216,750 | 2.31% | 175,000 | $-10,552,043 | Down ×1 | ||
| NGNE | $11,076,061 | 2.09% | 352,180 | $996,061 | Down ×1 | ||
| LBRX | $10,295,408 | 1.95% | 317,221 | $2,897,408 | Up ×1 | ||
| IRD | $8,097,469 | 1.53% | 1,970,187 | $6,621,722 | Up ×1 | ||
| EPRX | $7,932,000 | 1.50% | 1,200,000 | $-756,000 | |||
| DRUG | $7,694,131 | 1.45% | 109,603 | $-8,359,269 | Down ×1 | ||
| IFRX | $6,824,288 | 1.29% | 3,046,557 | Up ×1 | |||
| RLMD | $5,827,374 | 1.10% | 842,106 | $-33,684 | |||
| Unknown issuer (CUSIP: G50765109) | $5,680,000 | 1.07% | 500,000 | Up ×1 | |||
| CGEM | $5,463,000 | 1.03% | 300,000 | $1,200,000 | |||
| ALT | $5,293,345 | 1.00% | 1,741,232 | Up ×1 | |||
| Unknown issuer (CUSIP: G0375M101) | $5,080,000 | 0.96% | 500,000 | Up ×1 | |||
| RZLT | $4,949,407 | 0.94% | 951,809 | $2,046,390 | |||
| SLN | $4,941,000 | 0.93% | 450,000 | $-436,977 | Down ×1 | ||
| PALI | $4,775,272 | 0.90% | 2,284,819 | $-1,184,803 | Down ×1 | ||
| EVMN | $4,319,250 | 0.82% | 325,000 | $-3,152,500 | |||
| Unknown issuer (CUSIP: 811292309) | $3,843,268 | 0.73% | 944,292 | Up ×1 | |||
| GALT | $3,712,000 | 0.70% | 800,000 | Call option | $1,480,000 | ||
| ELVN | $3,552,500 | 0.67% | 70,000 | Up ×1 | |||
| HUMA | $2,926,500 | 0.55% | 3,750,000 | $651,375 | |||
| RNTX | $2,678,000 | 0.51% | 2,575,000 | Up ×1 | |||
| DBVT | $2,573,258 | 0.49% | 156,906 | ||||
| AVXL | $1,350,167 | 0.26% | 521,300 | Call option | $-250,224 | ||
| PMN | $1,133,734 | 0.21% | 86,150 | $-3,583,071 | Down ×1 | ||
| No matches | |||||||
Biggest new bets
New positions opened this quarter, largest first.
| Security | Value | Shares | % of portfolio |
|---|---|---|---|
| ABVX | $53,304,000 | 400,000 | 10.07% |
| ABVX | $27,226,884 | 204,314 | 5.15% |
| RARE | $20,034,000 | 600,000 | 3.79% |
| DFTX | $19,992,000 | 425,000 | 3.78% |
| SGMT | $15,691,382 | 2,029,933 | 2.97% |
| IFRX | $6,824,288 | 3,046,557 | 1.29% |
| Unknown issuer (CUSIP: G50765109) | $5,680,000 | 500,000 | 1.07% |
| ALT | $5,293,345 | 1,741,232 | 1.00% |
| Unknown issuer (CUSIP: G0375M101) | $5,080,000 | 500,000 | 0.96% |
| Unknown issuer (CUSIP: 811292309) | $3,843,268 | 944,292 | 0.73% |
| ELVN | $3,552,500 | 70,000 | 0.67% |
| RNTX | $2,678,000 | 2,575,000 | 0.51% |
| DBVT | $2,573,258 | 156,906 | 0.49% |
Top movers (QoQ)
| Security | Action | Shares Δ | Value Δ |
|---|---|---|---|
| VERA | Bought more | +401K | +$17.8M |
| AMLX | Trimmed | -1.1M | -$11.8M |
| NKTR | Trimmed | -141K | -$10.6M |
| IMMX | Bought more | +928K | +$10.0M |
| ORKA | Price move only | +0 | +$8.5M |
| DRUG | Trimmed | -110K | -$8.4M |
| MLTX | Bought more | +356K | +$7.3M |
| ANNX | Bought more | +1.0M | +$6.1M |
| ALMS | Price move only | +0 | +$5.2M |
| CTNM | Bought more | +121K | +$4.7M |
1 position hidden — reported move looks larger than the position itself (data completeness check)
Exited positions
Includes corporate events (mergers, delistings) — not all exits are sells
Closed positions reflect 13F reporting changes; for index managers these are often mechanical (delisting, M&A, index rebalancing), not active decisions.
| Security | Quarter | Shares before | Value before | Price since exit |
|---|---|---|---|---|
| APGE | June 30, 2026 | 374,000 | $31,479,580 | No longer tracked |
| IRON | March 31, 2026 | 250,000 | $19,852,500 | 0.9% |
| RAPT | March 31, 2026 | 581,187 | $19,684,804 | No longer tracked |
| SLNO | March 31, 2026 | 400,000 | $18,520,000 | No longer tracked |
| ASND | Dec. 31, 2025 | 75,000 | $14,910,750 | 6.9% |
| DNTH | March 31, 2026 | 350,000 | $14,423,500 | 5.1% |
| KALV | June 30, 2026 | 675,000 | $13,587,750 | No longer tracked |
| IMVT | June 30, 2026 | 545,625 | $13,553,325 | -12.7% |
| JBIO | June 30, 2026 | 964,462 | $13,550,691 | -36.5% |
| ABVX | Dec. 31, 2025 | 150,000 | $12,735,000 | -31.1% |
| ZBIO | June 30, 2026 | 524,066 | $10,245,490 | 11.5% |
| VRDN | June 30, 2025 | 750,000 | $10,110,000 | 38.8% |
| MRUS | June 30, 2025 | 237,156 | $9,981,896 | No longer tracked |
| FULC | March 31, 2026 | 800,000 | $9,048,000 | -51.9% |
| CYTK | Dec. 31, 2025 | 150,000 | $8,244,000 | 3.2% |
| UPB | March 31, 2026 | 300,000 | $8,145,000 | -44.0% |
| XENE | Dec. 31, 2025 | 200,000 | $8,030,000 | -15.2% |
| ASND | June 30, 2025 | 50,000 | $7,793,000 | 32.0% |
| DVAX | June 30, 2025 | 595,879 | $7,728,551 | No longer tracked |
| AKBA | Sept. 30, 2025 | 1,985,915 | $7,228,731 | -68.3% |
| CMPX | June 30, 2026 | 1,350,000 | $7,141,500 | -60.9% |
| SCYX | June 30, 2026 | 7,554,347 | $6,926,581 | 25.8% |
| RARE | March 31, 2026 | 300,000 | $6,900,000 | -27.4% |
| EOLS | Sept. 30, 2025 | 720,118 | $6,632,287 | 16.3% |
| ACLX | Sept. 30, 2025 | 100,000 | $6,585,000 | No longer tracked |
| CNTX | June 30, 2026 | 2,238,496 | $5,864,860 | -44.1% |
| UNCY | June 30, 2026 | 796,558 | $5,241,352 | -10.0% |
| TENX | June 30, 2026 | 327,307 | $5,233,639 | -86.4% |
| IONS | Dec. 31, 2025 | 80,000 | $5,233,600 | -45.0% |
| DNTH | June 30, 2025 | 275,000 | $4,988,500 | 373.5% |
| AKRO | Dec. 31, 2025 | 103,848 | $4,930,703 | No longer tracked |
| TSHA | Dec. 31, 2025 | 1,500,000 | $4,905,000 | -15.8% |
| SMMT | June 30, 2025 | 250,000 | $4,822,500 | -21.3% |
| PCVX | June 30, 2025 | 115,517 | $4,361,922 | 73.7% |
| AUTL | June 30, 2025 | 2,728,910 | $4,229,811 | -21.9% |
| DBVT | Dec. 31, 2025 | 378,594 | $3,785,940 | -45.0% |
| LEGN | Dec. 31, 2025 | 113,460 | $3,699,931 | -14.6% |
| KALV | Sept. 30, 2025 | 323,170 | $3,653,437 | No longer tracked |
| BEAM | June 30, 2025 | 175,562 | $3,428,726 | 44.0% |
| CNTA | Sept. 30, 2025 | 225,000 | $2,956,500 | No longer tracked |
| MREO | June 30, 2025 | 1,275,000 | $2,868,750 | -86.0% |
| SANA | March 31, 2026 | 700,000 | $2,849,000 | 0.3% |
| ABSI | Dec. 31, 2025 | 796,438 | $2,421,172 | 217.2% |
| HRMY | Dec. 31, 2025 | 85,000 | $2,342,600 | 5.9% |
| PHVS | June 30, 2026 | 82,800 | $2,339,100 | -9.8% |
| SRRK | Sept. 30, 2025 | 61,607 | $2,182,120 | 25.7% |
| VYGR | June 30, 2025 | 626,275 | $2,116,810 | -21.2% |
| AVTX | June 30, 2026 | 124,666 | $1,861,263 | -18.9% |
| ALKS | June 30, 2026 | 50,000 | $1,768,000 | -20.3% |
| PMN | Sept. 30, 2025 | 2,645,128 | $1,279,713 | 2086.0% |
| PLRX | Dec. 31, 2025 | 850,000 | $1,258,000 | -15.2% |
| CAPR | Dec. 31, 2025 | 87,700 | $632,317 | -69.0% |
| HLXB | Sept. 30, 2025 | 29,381 | $312,026 | No longer tracked |