EcoR1 Capital, LLC

CIK 1587114 · View on SEC EDGAR ↗

Insider Activist

First SEC filing: July 30, 2025 · Latest: Jan. 20, 2026

On this page

Institution

View 13F portfolio

Insider at

Insider transactions

1 buys (P) 1 sells (S) Net: $-60,239,736 + 3 non-open-market transactions below Avg return of open purchases vs now: -0.9% last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

3 other filings hidden
Date Ticker Code Shares Price Value Owned after Δ own A/D vs now
May 7, 2026 ATRA P 507,407 $9.35 $4,744,255 1,552,000 Indirect +48.57% Acquired -0.9% (price as of 2026-08-21)
April 20, 2026 TRAX S 4,705,575 $13.81 $64,983,991 3,174,519 Indirect — Acquired 219.1% (price as of 2026-08-21)
July 30, 2025 1587114 S 27,433,338 $0.10 $2,743,334 100,371,882 Indirect -21.46% Disposed
July 29, 2025 1587114 S 2,687,460 $0.10 $268,746 127,805,220 Indirect -2.06% Disposed
July 28, 2025 1587114 S 33,931,740 $0.11 $3,732,491 130,492,680 Indirect -20.64% Disposed
May 15, 2025 1587114 P 3,300,000 $8.00 $26,400,000 10,688,978 Indirect +44.66% Acquired
May 14, 2025 1587114 P 1,658,978 $7.41 $12,293,027 7,388,978 Indirect +28.95% Acquired
May 6, 2025 PRTA S 1,984,053 $7.64 $15,158,165 5,304,596 Indirect -27.22% Disposed 20.3% (price as of 2026-08-21)
May 5, 2025 PRTA S 977,693 $8.11 $7,929,090 7,288,649 Indirect -11.83% Disposed 13.3% (price as of 2026-08-21)
May 2, 2025 PRTA S 3,317,938 $8.36 $27,737,962 8,266,342 Indirect -28.64% Disposed 9.9% (price as of 2026-08-21)
Jan. 17, 2025 ZYME P 19,748 $13.87 $273,905 15,720,161 Indirect +0.13% Acquired 95.0% (price as of 2026-08-21)
Jan. 16, 2025 ZYME P 121,681 $13.88 $1,688,932 15,700,413 Indirect +0.78% Acquired 94.8% (price as of 2026-08-21)
Jan. 15, 2025 ZYME P 39,029 $14.01 $546,796 15,578,732 Indirect +0.25% Acquired 93.0% (price as of 2026-08-21)
Jan. 14, 2025 ZYME P 54,500 $13.56 $739,020 15,539,703 Indirect +0.35% Acquired 99.4% (price as of 2026-08-21)
Jan. 13, 2025 ZYME P 74,125 $13.39 $992,534 15,485,203 Indirect +0.48% Acquired 102.0% (price as of 2026-08-21)
Jan. 10, 2025 ZYME P 204,098 $13.13 $2,679,807 15,411,078 Indirect +1.34% Acquired 106.0% (price as of 2026-08-21)
Jan. 8, 2025 ZYME P 21,021 $14.07 $295,765 15,206,980 Indirect +0.14% Acquired 92.2% (price as of 2026-08-21)
Jan. 2, 2025 ZYME P 157,880 $14.78 $2,333,466 15,185,959 Indirect +1.05% Acquired 83.0% (price as of 2026-08-21)
Dec. 31, 2024 ZYME P 146,501 $14.57 $2,134,520 15,028,079 Indirect +0.98% Acquired 85.6% (price as of 2026-08-21)
Dec. 30, 2024 ZYME P 58,988 $14.47 $853,556 14,881,578 Indirect +0.40% Acquired 86.9% (price as of 2026-08-21)
Dec. 27, 2024 ZYME P 101,659 $14.49 $1,473,039 14,822,590 Indirect +0.69% Acquired 86.6% (price as of 2026-08-21)
Dec. 26, 2024 ZYME P 16,692 $14.38 $240,031 14,720,931 Indirect +0.11% Acquired 88.1% (price as of 2026-08-21)
Dec. 24, 2024 ZYME P 11,958 $14.12 $168,847 14,704,239 Indirect +0.08% Acquired 91.5% (price as of 2026-08-21)
Dec. 23, 2024 ZYME P 251,502 $14.25 $3,583,904 14,692,281 Indirect +1.74% Acquired 89.8% (price as of 2026-08-21)
Dec. 20, 2024 ZYME P 704,488 $14.08 $9,919,191 14,440,779 Indirect +5.13% Acquired 92.1% (price as of 2026-08-21)
Dec. 19, 2024 ZYME P 298,818 $13.53 $4,043,008 13,736,291 Indirect +2.22% Acquired 99.9% (price as of 2026-08-21)
Nov. 7, 2024 TNGX S 1,143,124 $2.92 $3,337,922 10,630,736 Indirect -9.71% Disposed 723.1% (price as of 2026-08-21)
Nov. 7, 2024 TNGX S 62,318 $3.29 $205,026 11,773,860 Indirect -0.53% Disposed 630.5% (price as of 2026-08-21)
Nov. 6, 2024 TNGX S 1,494,558 $3.28 $4,902,150 11,836,178 Indirect -11.21% Disposed 632.8% (price as of 2026-08-21)
Aug. 14, 2024 ANAB P 273,972 $36.50 $9,999,978 7,794,996 Indirect +3.64% Acquired 136.2% (price as of 2026-08-21)
Dec. 26, 2023 ZYME P 5,086,521 $9.83 $50,000,501 5,086,521 Indirect — Acquired 175.1% (price as of 2026-08-21)
Dec. 26, 2023 ZYME P 5,086,521 $9.83 $50,000,501 5,086,521 Indirect — Acquired 175.1% (price as of 2026-08-21)
June 16, 2023 ZYME P 3,350,000 $8.12 $27,202,000 13,437,473 Indirect +33.21% Acquired 233.0% (price as of 2026-08-21)
March 28, 2023 ZYME P 200,000 $8.00 $1,600,000 10,087,473 Indirect +2.02% Acquired 238.0% (price as of 2026-08-21)
Dec. 1, 2021 1587114 S 185,941 $1.66 $308,662 0 — —
Dec. 1, 2021 1587114 P 185,941 $1.66 $308,662 0 — —
Sept. 1, 2020 1587114 S 332,780 $7.14 $2,376,681 4,701,081 — —
June 30, 2020 1587114 P 1,176,000 $17.00 $19,992,000 1,975,984 — —

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II)

Options, RSUs and convertible securities reported on Form 4 Table II.

Date Ticker Security Underlying Exercise price Expiration Shares A/D
Dec. 19, 2024 1587114 Pre-Funded Warrants Common Stock $0.00 — 8,036,688 Acquired
Dec. 26, 2023 ZYME Pre-Funded Warrants Common Stock $0.00 — 5,086,521 Acquired
Dec. 26, 2023 ZYME Pre-Funded Warrants Common Stock $0.00 — 5,086,521 Acquired

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Initial ownership (Form 3) 10 holdings

Securities held when first becoming an insider, per SEC Form 3.

Date Ticker Security Shares Ownership
May 11, 2026 ATRA Common Stock — Indirect
April 22, 2026 TRAX Common Stock 7,880,094 Indirect
Oct. 16, 2023 TNGX Common Stock 13,330,736 Indirect
June 5, 2023 TCRX Voting Common Stock 5,000,000 Indirect
Jan. 6, 2023 LENZ Common Stock 8,538,446 Indirect
Nov. 1, 2022 ZYME Common Stock 7,568,573 Indirect
April 25, 2022 VYGR Common Stock 4,276,507 Indirect
Sept. 22, 2021 CRVS Common Stock 5,081,077 Indirect
Jan. 14, 2021 ANAB Common Stock 3,813,324 Indirect
Aug. 27, 2019 PRTA Ordinary Shares 9,426,640 Indirect