ANAB AnaptysBio, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$59.63
Price · Aug 19, 2026
Fundamentals as of May 12, 2026

ANAB Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$59.63
Market Cap
P/E (TTM)
-105.4
EPS (TTM)
$-0.46
Revenue (TTM)
$235M
Div Yield
ROE
Debt/Equity
52W Range
$17 – $73

ANAB Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $235M
10-point trend, +1306.2%
2016-12-31 2025-12-31
EPS $-0.46
10-point trend, +71.6%
2016-12-31 2025-12-31
Free Cash Flow
7-point trend, -173.7%
2018-12-31 2024-12-31
Margins

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
ANAB
Peer Median
P/E (TTM)
5-point trend, -539.9%
-105.4
27.2

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
ANAB
Peer Median

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
ANAB
Peer Median

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
ANAB
Peer Median
Revenue YoY
5-point trend, +271.4%
157.0%
Revenue CAGR 3Y
5-point trend, +271.4%
183.6%
Revenue CAGR 5Y
5-point trend, +271.4%
25.6%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
ANAB
Peer Median
EPS (Diluted)
5-point trend, +78.2%
$-0.46

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
ANAB
Peer Median

ANAB Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 17 analysts
  • Strong Buy 6 35.3%
  • Buy 10 58.8%
  • Hold 1 5.9%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

11 analysts · 2026-08-20
Median target $81.00 +35.8%
Mean target $87.09 +46.1%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.42%
Period EPS Actual EPS Est Surprise
March 31, 2026 $-1.84 $-0.62 -1.2%
Dec. 31, 2025 $1.58 $0.96 0.62%
Sept. 30, 2025 $0.52 $-1.47 2.0%
June 30, 2025 $-1.34 $-1.57 0.23%
March 31, 2025 $-1.28 $-1.28 -0.00%
Dec. 31, 2024 $-0.72 $-1.65 0.93%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
ANAB -105.4 157.0%
ZBIO $1.98B -4.3 100.0% -3777.4% -156.8%
DMRA 38.3% -17981.1% -167.0%
SNDX $1.84B -6.4 627.8% -165.6% -257.1%
RXRX $2.16B -2.8 26.9% -863.4% -62.9%
NTLA $1.05B -2.4 16.9% -609.8% -59.5%
BCAX $953M -6.7 -33.0%
TRAX
FBRX $353M -5.8 106.6% -2555.2% -86.9%
ZYME $1.97B -24.4 38.9% -76.6% -26.9%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 16
Annual Income Statement data for ANAB
Metric Trend 2025202420232022202120202019201820172016
Revenue 10-point trend, +1306.2% $235M $91M $17M $10M $63M $75M $8M $5M $10M $17M
R&D Expense 7-point trend, +475.9% · · · $89M $98M $80M $99M $56M $29M $15M
SG&A Expense 10-point trend, +1082.7% $51M $42M $42M $37M $21M $19M $16M $16M $9M $4M
Operating Expenses 10-point trend, +847.3% $187M $206M $182M $125M $120M $99M $115M $72M $39M $20M
Operating Income 10-point trend, +1683.3% $48M $-115M $-164M $-115M $-57M $-24M $-107M $-67M $-29M $-3M
Interest Expense 6-point trend, -100.0% · · · · $0 $0 $1M $2M $2M $458.0K
Interest Income 2-point trend, +1178.0% · · · · · · · · $2M $127.0K
Other Non-op 10-point trend, +3793.9% $5M $14.0K $-2.0K $12.0K $37.0K $-11.0K $1.0K $-159.0K $229.0K $-147.0K
Pretax Income 10-point trend, -206.8% $-13M $-145M $-164M $-129M $-58M $-20M $-97M $-62M $-30M $-4M
Income Tax 10-point trend, +164000.00 $164.0K $3.0K $-4.0K $24.0K $0 $0 $-152.0K $-192.0K $0 $0
Net Income 10-point trend, -210.7% $-13M $-145M $-164M $-129M $-58M $-20M $-97M $-62M $-30M $-4M
EPS (Basic) 10-point trend, +71.6% $-0.46 $-5.12 $-6.08 $-4.57 $-2.11 $-0.73 $-3.60 $-2.50 $-1.52 $-1.62
EPS (Diluted) 10-point trend, +71.6% $-0.46 $-5.12 $-6.08 $-4.57 $-2.11 $-0.73 $-3.60 $-2.50 $-1.52 $-1.62
Shares (Basic) 7-point trend, +6.3% 28,758,000 28,382,000 26,924,000 28,165,000 27,431,000 27,302,000 27,059,000 · · ·
Shares (Diluted) 7-point trend, +6.3% 28,758,000 28,382,000 26,924,000 28,165,000 27,431,000 27,302,000 27,059,000 · · ·
EBITDA 7-point trend, -72.2% · $-114M $-164M $-114M $-56M $-23M $-107M $-66M · ·
Balance Sheet 23
Annual Balance Sheet data for ANAB
Metric Trend 2025202420232022202120202019201820172016
Cash & Equivalents 10-point trend, +364.9% $238M $123M $36M $71M $496M $250M $171M $114M $81M $51M
Receivables 10-point trend, +2663.3% $34M $41M $7M $1M $876.0K $0 $0 $0 $0 $1M
Prepaid Expense 10-point trend, +191.6% $5M $6M $9M $5M $5M $3M $4M $7M $3M $2M
Current Assets 10-point trend, +501.7% $350M $432M $407M $447M $554M $397M $378M $434M $253M $58M
PP&E (Net) 10-point trend, +190.9% $1M $2M $2M $2M $2M $2M $2M $1M $665.0K $471.0K
PP&E (Gross) 10-point trend, +99.3% $9M $8M $8M $8M $7M $7M $6M $6M $5M $4M
Accum. Depreciation 10-point trend, +88.0% $7M $7M $6M $6M $5M $5M $5M $4M $4M $4M
Other Non-current Assets 9-point trend, +456.5% $256.0K $256.0K $256.0K $256.0K $256.0K $258.0K $1M $148.0K $46.0K ·
Total Assets 10-point trend, +486.0% $364M $484M $452M $610M $643M $417M $435M $509M $329M $62M
Accounts Payable 10-point trend, +69.9% $4M $4M $5M $3M $2M $4M $16M $5M $2M $2M
Accrued Liabilities 10-point trend, +852.9% $33M $40M $31M $22M $13M $15M $11M $9M $5M $3M
Short-term Debt 5-point trend, +0.00 · · · · · $0 $1M $8M $7M $0
Current Liabilities 10-point trend, +576.7% $39M $45M $37M $26M $16M $20M $30M $22M $14M $6M
Capital Leases 7-point trend, +1739.8% $12M $14M $16M $18M $19M $0 $654.0K · · ·
Other Non-current Liabilities 3-point trend, -100.0% · · · · · $0 $654.0K $796.0K · ·
Total Debt 3-point trend, -100.0% · · · · · $0 $1M $8M · ·
Common Stock 10-point trend, +833.3% $28.0K $30.0K $27.0K $29.0K $28.0K $27.0K $27.0K $27.0K $24.0K $3.0K
Paid-in Capital 10-point trend, +4757.0% $810M $830M $703M $718M $679M $661M $649M $633M $393M $17M
Retained Earnings 10-point trend, -1306.6% $-773M $-759M $-614M $-450M $-322M $-264M $-244M $-147M $-85M $-55M
AOCI 10-point trend, -24000.00 $-24.0K $305.0K $-797.0K $-5M $-422.0K $-4.0K $338.0K $-223.0K $-426.0K $0
Stockholders' Equity 10-point trend, +197.3% $37M $71M $88M $262M $356M $397M $405M $486M $308M $-38M
Liabilities + Equity 10-point trend, +486.0% $364M $484M $452M $610M $643M $417M $435M $509M $329M $62M
Shares Outstanding 10-point trend, +956.9% 28,019,000 30,473,000 26,597,000 28,513,000 27,647,000 27,356,000 27,255,000 26,922,000 23,791,000 2,651,000
Cash Flow 13
Annual Cash Flow data for ANAB
Metric Trend 2025202420232022202120202019201820172016
D&A 10-point trend, +139.9% $559.0K $606.0K $652.0K $675.0K $619.0K $559.0K $514.0K $315.0K $183.0K $233.0K
Stock-based Comp 7-point trend, +3009.7% $36M $34M $33M $27M $15M · · · $4M $1M
Other Non-cash 7-point trend, -292.9% · $-25M $9M $54M $11M $5M $27M $13M · ·
Operating Cash Flow 10-point trend, +318.1% $20M $-135M $-121M $-74M $-46M $-14M $-70M $-49M $-19M $-9M
CapEx 10-point trend, +74.0% $87.0K $358.0K $807.0K $358.0K $1M $569.0K $805.0K $1M $290.0K $50.0K
Investing Cash Flow 10-point trend, +456164.0% $228M $95M $145M $-395M $39M $94M $131M $-142M $-243M $-50.0K
Stock Issued 10-point trend, +14261000.00 $14M $6M $2M $12M $3M $496.0K $3M $227M $293M $0
Stock Repurchased 8-point trend, +6862500.0% $69M $456.0K $50M $0 $0 · · $0 $0 $1.0K
Net Stock Activity 7-point trend, -97.4% · $6M $-48M $12M $3M $0 $0 $227M · ·
Financing Cash Flow 10-point trend, -1637.0% $-133M $127M $-59M $44M $252M $-879.0K $-4M $223M $292M $9M
Net Change in Cash 8-point trend, +255.2% $115M $87M $-35M $-424M $245M $79M $57M $32M · ·
Free Cash Flow 7-point trend, -173.7% · $-136M $-122M $-74M $-47M $-15M $-70M $-50M · ·
Levered FCF 4-point trend, +7.7% · · · · $-47M $-15M $-71M $-51M · ·
Profitability 7
Annual Profitability data for ANAB
Metric Trend 2025202420232022202120202019201820172016
Operating Margin 7-point trend, +90.6% · -125.9% -958.3% -1119.4% -89.9% -31.8% -1342.9% -1334.4% · ·
Net Margin 7-point trend, +87.1% · -159.1% -953.7% -1251.3% -91.5% -26.6% -1216.7% -1233.1% · ·
Pretax Margin 7-point trend, +87.1% · -159.1% -953.7% -1251.1% -91.5% -26.6% -1218.6% -1237.0% · ·
EBITDA Margin 7-point trend, +90.6% · -125.3% -954.5% -1112.9% -88.9% -31.1% -1336.5% -1328.1% · ·
ROA 7-point trend, -110.9% · -31.0% -30.8% -20.5% -10.9% -4.7% -20.6% -14.7% · ·
ROE 7-point trend, -1395.7% · -187.1% -157.0% -47.7% -15.6% -5.3% -23.6% -12.5% · ·
ROIC 7-point trend, -1104.2% · -162.2% -186.6% -43.9% -15.9% -6.0% -26.4% -13.5% · ·
Liquidity & Solvency 4
Annual Liquidity & Solvency data for ANAB
Metric Trend 2025202420232022202120202019201820172016
Current Ratio 7-point trend, -52.2% · 9.5 10.9 17.2 34.4 20.0 12.8 19.9 · ·
Quick Ratio 7-point trend, -30.7% · 3.6 1.1 2.8 30.8 12.6 5.8 5.2 · ·
Debt / Equity 3-point trend, -100.0% · · · · · 0.0 0.0 0.0 · ·
Interest Coverage 2-point trend, -155.5% · · · · · · -103.2 -40.4 · ·
Efficiency 2
Annual Efficiency data for ANAB
Metric Trend 2025202420232022202120202019201820172016
Asset Turnover 7-point trend, +1538.7% · 0.2 0.0 0.0 0.1 0.2 0.0 0.0 · ·
Receivables Turnover 4-point trend, -97.3% · 3.8 4.1 9.0 144.2 · · · · ·
Per Share 5
Annual Per Share data for ANAB
Metric Trend 2025202420232022202120202019201820172016
Book Value / Share 7-point trend, -87.1% · $2.33 $3.31 $9.19 $12.89 $14.50 $14.86 $18.07 · ·
Revenue / Share 4-point trend, +39.6% · $3.22 $0.64 $0.37 $2.30 · · · · ·
Cash Flow / Share 4-point trend, -184.9% · $-4.77 $-4.49 $-2.61 $-1.67 · · · · ·
Cash / Share 7-point trend, -4.3% · $4.04 $1.35 $2.50 $17.93 $9.16 $6.27 $4.22 · ·
EPS (TTM) 10-point trend, +71.6% $-0.46 $-5.12 $-6.08 $-4.57 $-2.11 $-0.73 $-3.60 $-2.50 $-1.52 $-1.62
Growth Rates 3
Annual Growth Rates data for ANAB
Metric Trend 2025202420232022202120202019201820172016
Revenue YoY 5-point trend, +1095.6% 157.0% 432.0% 66.8% -83.7% -15.8% · · · · ·
Revenue CAGR 3Y 3-point trend, +572.7% 183.6% 13.1% -38.8% · · · · · · ·
Revenue CAGR 5Y 25.6% · · · · · · · · ·
Valuation (TTM) 14
Annual Valuation (TTM) data for ANAB
Metric Trend 2025202420232022202120202019201820172016
Revenue TTM 10-point trend, +1306.2% $235M $91M $17M $10M $63M $75M $8M $5M $10M $17M
Net Income TTM 10-point trend, -210.7% $-13M $-145M $-164M $-129M $-58M $-20M $-97M $-62M $-30M $-4M
Market Cap 7-point trend, -76.5% · $403M $570M $884M $961M $588M $443M $1.72B · ·
Enterprise Value 3-point trend, -79.0% · · · · · $338M $273M $1.61B · ·
P/E 9-point trend, -59.0% -105.4 -2.6 -3.5 -6.8 -16.5 -29.5 -4.5 -25.5 -66.3 ·
P/S 7-point trend, -98.7% · 4.4 33.2 85.9 15.2 7.8 55.4 343.5 · ·
P/B 7-point trend, +61.2% · 5.7 6.5 3.4 2.7 1.5 1.1 3.5 · ·
P / Tangible Book 6-point trend, +2362.4% 36.5 5.7 6.5 3.4 2.7 1.5 · · · ·
P / Cash Flow 7-point trend, +91.6% · -3.0 -4.7 -12.0 -20.9 -41.5 -6.4 -35.4 · ·
P / FCF 7-point trend, +91.4% · -3.0 -4.7 -11.9 -20.3 -39.9 -6.3 -34.6 · ·
EV / EBITDA 3-point trend, +40.3% · · · · · -14.5 -2.6 -24.3 · ·
EV / FCF 3-point trend, +29.5% · · · · · -22.9 -3.9 -32.5 · ·
EV / Revenue 3-point trend, -98.6% · · · · · 4.5 34.2 322.3 · ·
Earnings Yield 9-point trend, +37.1% -0.95% -38.7% -28.4% -14.8% -6.1% -3.4% -22.1% -3.9% -1.5% ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $235M$91M$17M$10M$63M
Operating Margin % -125.9%-958.3%-1119.4%-89.9%
Net Income $-13M$-145M$-164M$-129M$-58M
Diluted EPS $-0.46$-5.12$-6.08$-4.57$-2.11
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio 9.510.917.234.4
Quick Ratio 3.61.12.830.8
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-136M$-122M$-74M$-47M

Latest News Recent headlines mentioning this company

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Institutional owners (13F) 229 filers · $1.8B total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
55 (+2 vs prior Q) 34 (+15 vs prior Q) 67 (+14 vs prior Q) 62 (-9 vs prior Q) +2.6M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
EcoR1 Capital, LLC $531,906,345 7,880,094 30.01% Shares
TANG CAPITAL MANAGEMENT LLC $89,834,333 1,330,879 5.07% Shares
STATE STREET CORP $86,818,095 1,286,194 4.90% Shares
VANGUARD CAPITAL MANAGEMENT LLC $61,170,728 906,233 3.45% Shares
Affinity Asset Advisors, LLC $55,762,358 826,109 3.15% Shares
Sanofi $55,479,398 821,917 3.13% Shares
MILLENNIUM MANAGEMENT LLC $54,493,830 807,316 3.07% Shares
Woodline Partners LP $48,398,445 717,014 2.73% Shares
683 Capital Management, LLC $44,550,001 660,000 2.51% Shares
Palo Alto Investors LP $40,735,508 603,489 2.30% Shares
First Light Asset Management, LLC $39,285,270 582,004 2.22% Shares
GEODE CAPITAL MANAGEMENT, LLC $37,982,346 562,584 2.14% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $35,630,415 527,858 2.01% Shares
Apis Capital Advisors, LLC $33,547,500 497,000 1.89% Shares
Sofinnova Investments, Inc. $33,313,680 493,536 1.88% Shares
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP $32,983,943 488,651 1.86% Shares
GOLDMAN SACHS GROUP INC $28,015,335 415,042 1.58% Shares
CITADEL ADVISORS LLC $26,620,178 394,373 1.50% Shares
D. E. Shaw & Co., Inc. $24,649,718 365,181 1.39% Shares
Squarepoint Ops LLC $21,900,105 324,446 1.24% Shares
BANK OF AMERICA CORP /DE/ $19,603,148 290,417 1.11% Shares
TWO SIGMA INVESTMENTS, LP $17,752,163 262,995 1.00% Shares
FIRST TRUST ADVISORS LP $17,481,757 258,989 0.99% Shares
TWO SIGMA ADVISERS, LP $17,292,816 356,700 0.98% Shares
Coppell Advisory Solutions LLC $16,575,695 3,638 0.94% Shares
Qube Research & Technologies Ltd $15,442,448 228,777 0.87% Shares
HSBC HOLDINGS PLC $14,928,261 216,949 0.84% Shares
Empowered Funds, LLC $13,905,675 206,010 0.78% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $13,655,588 202,305 0.77% Shares
DIMENSIONAL FUND ADVISORS LP $12,337,313 182,775 0.70% Shares
Greenhaven Road Investment Management, L.P. $11,546,483 171,059 0.65% Shares
VICTORY CAPITAL MANAGEMENT INC $11,422,823 169,227 0.64% Shares
MACKENZIE FINANCIAL CORP $10,191,083 150,979 0.57% Shares
VANGUARD FIDUCIARY TRUST CO $9,903,870 146,724 0.56% Shares
Connor, Clark & Lunn Investment Management Ltd. $9,189,518 136,141 0.52% Shares
Ensign Peak Advisors, Inc $7,228,980 107,096 0.41% Shares
CITIGROUP INC $6,613,245 97,974 0.37% Shares
VANGUARD GROUP INC $6,452,300 133,092 0.36% Shares
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. $6,327,000 93,732 0.36% Shares
DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main $5,666,085 83,942 0.32% Shares
FMR LLC $5,224,838 77,405 0.29% Shares
Granahan Investment Management, LLC $5,127,435 75,962 0.29% Shares
PRUDENTIAL FINANCIAL INC $4,936,410 73,132 0.28% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $4,893,750 72,500 0.28% Put option
Irenic Capital Management LP $4,755,173 70,447 0.27% Shares
Eversept Partners, LP $4,723,852 69,983 0.27% Shares
JPMORGAN CHASE & CO $4,251,635 64,448 0.24% Shares
JACOBS LEVY EQUITY MANAGEMENT, INC $4,207,680 62,336 0.24% Shares
STATE OF WISCONSIN INVESTMENT BOARD $4,168,328 61,753 0.24% Shares
RENAISSANCE TECHNOLOGIES LLC $3,935,250 58,300 0.22% Shares
VOLORIDGE INVESTMENT MANAGEMENT, LLC $3,884,963 57,555 0.22% Shares
AQR CAPITAL MANAGEMENT LLC $3,091,230 45,796 0.17% Shares
MARSHALL WACE, LLP $2,957,985 43,822 0.17% Shares
Bleakley Financial Group, LLC $2,886,368 42,761 0.16% Shares
Camber Capital Management LP $2,775,000 125,000 0.16% Shares
WELLS FARGO & COMPANY/MN $2,742,323 40,627 0.15% Shares
HighMark Wealth Management LLC $2,680,830 39,716 0.15% Shares
CAPITAL FUND MANAGEMENT S.A. $2,642,085 39,142 0.15% Shares
Trexquant Investment LP $2,389,770 35,404 0.13% Shares
Atom Investors LP $2,289,398 33,917 0.13% Shares
Swiss National Bank $2,139,750 31,700 0.12% Shares
Voleon Capital Management LP $2,121,188 31,425 0.12% Shares
Moody Aldrich Partners LLC $2,087,505 30,926 0.12% Shares
Aquatic Capital Management LLC $2,079,878 30,813 0.12% Shares
SummitTX Capital, L.P. $1,942,583 28,779 0.11% Shares
ALLIANCEBERNSTEIN L.P. $1,820,197 32,820 0.10% Shares
RHUMBLINE ADVISERS $1,778,349 26,346 0.10% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $1,620,000 24,000 0.09% Call option
BURNEY CO/ $1,522,598 22,557 0.09% Shares
Rafferty Asset Management, LLC $1,475,820 21,864 0.08% Shares
XTX Topco Ltd $1,445,243 21,411 0.08% Shares
HUSSMAN STRATEGIC ADVISORS, INC. $1,417,500 21,000 0.08% Shares
TUDOR INVESTMENT CORP ET AL $1,351,283 20,019 0.08% Shares
CREDIT AGRICOLE S A $1,350,000 20,000 0.08% Shares
MARTINGALE ASSET MANAGEMENT L P $1,346,085 19,942 0.08% Shares
Bank of New York Mellon Corp $1,298,768 19,241 0.07% Shares
Y-Intercept (Hong Kong) Ltd $1,246,590 18,468 0.07% Shares
LOS ANGELES CAPITAL MANAGEMENT LLC $1,183,681 17,536 0.07% Shares
Diametric Capital, LP $1,138,590 16,868 0.06% Shares
CANADA PENSION PLAN INVESTMENT BOARD $1,113,750 16,500 0.06% Shares
TEMA ETFS LLC $1,093,709 22,560 0.06% Shares
MILLENNIUM MANAGEMENT LLC $1,012,500 15,000 0.06% Call option
BlackRock, Inc. $998,258 14,789 0.06% Shares
Cresset Asset Management, LLC $972,810 14,412 0.05% Shares
Vanguard Global Advisers, LLC $939,533 13,919 0.05% Shares
Zurcher Kantonalbank (Zurich Cantonalbank) $904,838 13,405 0.05% Shares
Brevan Howard Capital Management LP $899,708 13,329 0.05% Shares
MASSACHUSETTS FINANCIAL SERVICES CO /MA/ $897,345 13,294 0.05% Shares
SEI INVESTMENTS CO $888,368 13,161 0.05% Shares
WELLINGTON MANAGEMENT GROUP LLP $886,343 13,131 0.05% Shares
Orion Porfolio Solutions, LLC $801,630 11,876 0.05% Shares
Universal- Beteiligungs- und Servicegesellschaft mbH $783,676 11,610 0.04% Shares
Clear Harbor Asset Management, LLC $779,625 11,550 0.04% Shares
MetLife Investment Management, LLC $779,490 11,548 0.04% Shares
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $776,440 14,000 0.04% Shares
VOYA INVESTMENT MANAGEMENT LLC $760,388 11,265 0.04% Shares
Nuveen, LLC $753,773 11,167 0.04% Shares
PROFUND ADVISORS LLC $745,470 11,044 0.04% Shares
CITADEL ADVISORS LLC $722,250 10,700 0.04% Put option
Quantedge Capital Pte Ltd $702,000 10,400 0.04% Shares

Company insiders 23 insiders · 4 officers · 11 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Hamza Suria President, CEO Feb. 10, 2022 A 68,600 0 0 $0
Dominic Piscitelli Chief Financial Officer Feb. 8, 2019 A 0 0 0 $0
Marco Londei Chief Medical Officer Dec. 6, 2019 A 68,579 0 0 $0
Matthew Moyle Chief Scientific Officer Feb. 24, 2017 A 0 0 $0
John P. Schmid Director June 15, 2026 M 37,652 0 0 $0
John A Orwin Director June 15, 2026 M 16,695 0 0 $0
Hollings Renton Director June 15, 2026 M 10,995 0 0 $0
Dennis M Fenton Director Jan. 6, 2026 A 0 0 $0
Anthony J. Ware Director Jan. 3, 2024 A 3,600 0 0 $0
Rita Jain Director Jan. 3, 2024 A 0 0 $0
Magda Marquet Director Jan. 3, 2024 A 0 0 $0
Nicholas Lydon Director Feb. 8, 2019 A 271,106 0 0 $0
James A Schoeneck Director Feb. 2, 2018 A 0 0 $0
Carol Giltner Gallagher Director Feb. 2, 2018 A 64,296 0 0 $0
EcoR1 Capital, LLC 10% owner Aug. 14, 2024 P 7,794,996 0 0 $0
Novo Holdings A/S 10% owner Aug. 21, 2017 S 1,936,604 0 0 $0
ANAPTYSBIO, INC April 20, 2026 J 0 0 0 $0
Lizzul Paul F. March 12, 2026 A 10,118 0 0 $0
Daniel Faga March 12, 2026 A 898,027 0 0 $0
Eric J Loumeau Feb. 11, 2026 M 12,835 0 13 $-2,983,468
Dennis Mulroy Jan. 7, 2026 M 21,852 0 6 $-1,549,401
Laura Hamill Jan. 6, 2023 A 0 0 $0
James N. Topper Jan. 6, 2023 A 80,812 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 2 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
EcoR1 Capital, LLC, Oleg Nodelman, EcoR1 Capital Fund Qualified, L.P. ×5 filings Aug. 16, 2024 Initial filing Board campaign SEC
Frazier Healthcare V, L.P., FHM V, L.P., FHM V, L.L.C., Frazier Healthcare VII, L.P., Frazier Healthcare VII-A, L.P., FHM VII, L.P., FHM VII, L.L.C., James N. Topper, Patrick J. Heron, Alan Frazier, Nader Naini, Nathan Every, Brian Morfitt ×5 filings Nov. 18, 2020 Initial filing SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 46 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
BBC · ETFis Series Trust I 1.08% 6,139 NS April 30, 2026 N-PORT
CANC · Tema ETF Trust 0.99% 31,270 NS May 31, 2026 N-PORT
FYC · First Trust Exchange-Traded AlphaDE… 0.87% 137,749 NS April 30, 2026 N-PORT
FYX · First Trust Exchange-Traded AlphaDE… 0.44% 81,861 NS April 30, 2026 N-PORT
AFSM · First Trust Exchange-Traded Fund VI… 0.39% 6,876 NS May 31, 2026 N-PORT
LABU · Direxion Shares ETF Trust 0.37% 29,328 NS April 30, 2026 N-PORT
ESSC · Strategy Shares 0.32% 1,246 NS April 30, 2026 N-PORT
FAD · First Trust Exchange-Traded AlphaDE… 0.18% 12,833 NS April 30, 2026 N-PORT
FSCC · Federated Hermes ETF Trust 0.17% 8,490 NS May 31, 2026 N-PORT
FSMD · FIDELITY COVINGTON TRUST 0.12% 43,589 NS April 30, 2026 N-PORT
TMFX · RBB Fund, Inc. 0.08% 457 NS May 31, 2026 N-PORT
BIB · ProShares Trust 0.08% 1,023 NS May 31, 2026 N-PORT
GSSC · Goldman Sachs ETF Trust 0.04% 7,749 NS May 31, 2026 N-PORT
ITWO · ProShares Trust 0.03% 859 NS May 31, 2026 N-PORT
SCHA · SCHWAB STRATEGIC TRUST 0.02% 94,549 NS May 31, 2026 N-PORT
UWM · ProShares Trust 0.02% 672 NS May 31, 2026 N-PORT
FHLC · FIDELITY COVINGTON TRUST 0.01% 6,418 NS April 30, 2026 N-PORT
URTY · ProShares Trust 0.01% 680 NS May 31, 2026 N-PORT
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.01% 856 NS May 31, 2026 N-PORT
ONEQ · Fidelity Commonwealth Trust 0.00% 8,753 NS May 31, 2026 N-PORT
HDG · ProShares Trust 0.00% 17 NS May 31, 2026 N-PORT
AVUQ · AMERICAN CENTURY ETF TRUST 0.00% 66 NS May 31, 2026 N-PORT
SCHB · SCHWAB STRATEGIC TRUST 0.00% 10,559 NS May 31, 2026 N-PORT
AVSU · AMERICAN CENTURY ETF TRUST 0.00% 18 NS May 31, 2026 N-PORT
DFAS · Dimensional ETF Trust 0.00% 483 NS April 30, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS July 15, 2026 Daily
VTI · VANGUARD INDEX FUNDS July 15, 2026 Daily
VFMO · VANGUARD WELLINGTON FUND July 30, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS July 15, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS July 15, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS July 15, 2026 Daily
ITOT · iShares Trust Aug. 5, 2026 Daily
IWV · iShares Trust Aug. 18, 2026 Daily
IWO · iShares Trust Aug. 18, 2026 Daily
IWM · iShares Trust Aug. 18, 2026 Daily
IBB · iShares Trust Aug. 18, 2026 Daily
PBE · Invesco Exchange-Traded Fund Trust July 13, 2026 Daily
PRFZ · Invesco Exchange-Traded Fund Trust July 13, 2026 Daily
OMFS · Invesco Exchange-Traded Self-Indexe… July 16, 2026 Daily
VHT · VANGUARD WORLD FUND July 20, 2026 Daily
ISCB · iShares Trust Aug. 5, 2026 Daily
ISCG · iShares Trust Aug. 5, 2026 Daily
ISCV · iShares Trust Aug. 5, 2026 Daily
SMMV · iShares Trust Aug. 18, 2026 Daily
WSML · iShares Trust Aug. 5, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … Aug. 5, 2026 Daily