ZYME Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

03
Price $25.15
Market Cap (MRQ) $1.80B
P/E (TTM) -12.5
EPS (TTM) $-2.02
Revenue (TTM) $37M
ROE (TTM) -72.3%
52W Range $16–$31

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About Zymeworks Inc. - Common Stock Company overview from Wikipedia

05 · wikidata

Zymeworks Inc. is a publicly held biotechnology company based in Vancouver,

British Columbia, that develops protein therapeutics for the treatment of cancer as well as for autoimmune and inflammatory diseases. The products are based upon the company's molecular modeling software for optimizing protein structure. In 2014, Zymeworks raised $44 million across various funding rounds according to PitchBook, placing it among the top 10 HealthTech businesses in the world to raise the most capital that year. In May 2017, Zymeworks held an IPO on the Toronto Stock Exchange, raising $59 million. This was the largest Canadian biotech IPO in more than a decade. By alphabetical order, Zymeworks is the last company on the Toronto Stock Exchange.

In May 2019, Zymeworks announced that GSK has expanded its 2016 licensing and collaboration agreement for the research, development and commercialization of bispecific antibodies across multiple disease areas. The extended agreement has meant that GSK can have access to Zymeworks' heavy-light chain pairing technology, which enables the development of bispecific and multifunctional therapeutics.

In September 2019, Zymeworks announced that, following their clinical trials, it has been confirmed that their ZW25 monotherapy can provide durable disease control in patients with a variety of HER2-expressing solid tumors that have progressed following standard of care treatments.

In May 2022, Zymeworks rejected an unsolicited takeover proposal from a Dubai hedge fund, All Blue Falcons FZE, an arm of All Blue Capital.

Azymetric

This is an IgG1-based heterodimeric antibody scaffold that consists of two different heavy chains engineered to exclusively assemble into a single molecule, allowing bi-specific binding to two different antigens or drug targets. The Azymetric scaffold is engineered by making amino acid changes in the CH3 region of the constant Fc domain of the IgG1. This scaffold can also be engineered with tailored effector function and optimized serum half-life.

Awards and recognition

Deal of the Year, Lifesciences BC Awards, 2018

Life Sciences Company of the Year, Lifesciences BC Awards, 2016

Emerging company of the year – Health, BIOTECanada Gold Leaf Awards, 2015

12th Place, BC's Leading Innovators, 2011

Life Science Emerging Rocket, 2009, 2010, 2011

Early stage Company of the year – Industrial & Agriculture, BIOTECanada Gold Leaf Awards, 2009

== References ==

Source: Wikipedia, CC BY-SA 4.0 · View on Wikipedia ↗

Wikidata ↗

sectorHealthcare industryBiotechnology employees231 countryUS

10-Year Performance Revenue, net income, margins and EPS trends

06
Revenue$106M
2020-12-31 → 2025-12-31
EPS$-1.08
2020-12-31 → 2025-12-31
Free Cash Flow$-35M
2023-12-31 → 2025-12-31
Net margin-404.0%
2023-12-31 → 2025-12-31
Valuation & Ratios 07–12

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric 5Y trend ZYME 5Y avg Peer Median Verdict
P/E (TTM) -12.55Y avg ≈-8.8 ≈-8.8 · ·
P/S (TTM) 48.45Y avg ≈13.8 ≈13.8 10.3 Overvalued
P/B (MRQ) 22.35Y avg ≈4.0 ≈4.0 3.7 Overvalued
Price / FCF (TTM) -14.95Y avg ≈-24.0 ≈-24.0 · ·
Price / Cash Flow (TTM) -15.05Y avg ≈-25.0 ≈-25.0 · ·
Price / Tangible Book (MRQ) 22.65Y avg ≈3.4 ≈3.4 · ·

Peer median is calculated on a standardized basis per metric and may not always match the TTM/MRQ basis shown for this stock.

value · ≈ 5Y avg · industry median · verdict relative to median

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

14
Avg Surprise -16.9%
Next Report Nov 04, 2026
PeriodReportEPS ActualEPS EstSurprise
June 30, 2026 Aug 5, 2026 $-0.62 $-0.50 -25.1%
March 31, 2026 May 6, 2026 $-0.59 $-0.20 -201.3%
Dec. 31, 2025 $-0.55 $-0.42 -29.5%
Sept. 30, 2025 $-0.26 $-0.33 20.6%
June 30, 2025 $0.03 $-0.50 106.0%
March 31, 2025 $-0.30 $-0.42 28.0%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

15
Income Statement 14
Metric Trend 20252024202320222021
Revenue $106M$76M$76M$412M$27M
R&D Expense ··$144M$209M$200M
SG&A Expense $62M$62M$70M$73M$43M
Operating Expenses $199M$213M$214M$282M$242M
Operating Income $-93M$-137M$-138M$131M$-216M
Other Non-op $51.0K$-218.0K$291.0K$-42.0K$118.0K
Pretax Income $-80M$-117M$-119M$135M$-212M
Income Tax $1M$6M$-568.0K$11M$-516.0K
Net Income $-81M$-123M$-119M$124M$-212M
EPS (Basic) $-1.08$-1.62$-1.72$1.91$-4.11
EPS (Diluted) $-1.08$-1.62$-1.72$1.90$-4.61
Shares (Basic) 75,404,89775,846,68168,863,01065,194,77551,553,869
Shares (Diluted) 75,413,39675,878,73868,863,01065,249,18452,131,596
EBITDA $-93M$-137M$-138M··
Balance Sheet 23
Metric Trend 20252024202320222021
Cash & Equivalents $41M$66M$158M$401M$202M
Short-term Investments ··$217M$91M$51M
Receivables $5M$56M$19M$33M$16M
Prepaid Expense $15M$19M$19M$19M$20M
Current Assets $249M$300M$413M$545M$288M
PP&E (Net) $16M$18M$20M$25M$23M
PP&E (Gross) $36M$35M$41M$38M$37M
Accum. Depreciation $21M$18M$21M$13M$14M
Goodwill $12M$12M$12M$12M$12M
Intangibles $1M$5M$8M$9M$4M
Total Assets $347M$463M$581M$649M$389M
Accounts Payable $36M$60M$46M$87M$63M
Current Liabilities $42M$88M$56M$96M$72M
Capital Leases $15M$16M$22M$25M$31M
Deferred Tax $6M$5M$3M$2M$2M
Other Non-current Liabilities $278.0K$923.0K$2M$3M$3M
Total Liabilities $78M$124M$116M$156M$140M
Common Stock $1.11B$1.02B$997M$886M$741M
Retained Earnings $-953M$-830M$-677M$-559M$-683M
AOCI $-6M$-7M$-7M$-7M$-7M
Stockholders' Equity $269M$339M$465M$493M$249M
Liabilities + Equity $347M$463M$581M$649M$389M
Shares Outstanding 74,638,41368,964,31970,115,99763,059,50146,633,935
Cash Flow 14
Metric Trend 20252024202320222021
Stock-based Comp $28M$18M$8M$4M$11M
Deferred Tax $945.0K$691.0K$-757.0K$2M$-953.0K
Amort. of Intangibles $4M$4M$3M$1M$3M
Restructuring ··$0··
Operating Cash Flow $-33M$-110M$-118M$144M$-192M
CapEx $2M$2M$2M$8M$12M
Investing Cash Flow $27M$39M$-207M$-54M$145M
Stock Issued $0$0$26M$108M$0
Stock Repurchased $42M$30M$0$0·
Net Stock Activity $-42M$-30M$26M··
Financing Cash Flow $-19M$-20M$82M$109M$8M
Net Change in Cash $-25M$-91M$-243M$199M$-40M
Taxes Paid $1M$3M$165.0K$10M·
Free Cash Flow $-35M$-112M$-121M··
Profitability 7
Metric Trend 20252024202320222021
Operating Margin -87.3%-179.7%-181.6%··
Net Margin -76.6%-160.8%-156.1%··
Pretax Margin -75.3%-152.8%-156.9%··
EBITDA Margin -87.3%-179.7%-181.6%··
ROA -20.0%-23.5%-19.3%··
ROE -26.9%-34.8%-26.7%··
ROIC -35.1%-42.6%-29.6%··
Liquidity & Solvency 2
Metric Trend 20252024202320222021
Current Ratio 5.93.47.4··
Quick Ratio 1.11.47.1··
Efficiency 2
Metric Trend 20252024202320222021
Asset Turnover 0.30.10.1··
Receivables Turnover 3.52.02.9··
Per Share 5
Metric Trend 20252024202320222021
Book Value / Share $3.60$4.91$6.63··
Revenue / Share $1.41$1.01$1.10··
Cash Flow / Share $-0.44$-1.45$-1.72··
Cash / Share $0.55$0.96$2.25··
EPS (TTM) $-1.08$-1.62$-1.72$1.90·
Growth Rates 3
Metric Trend 20252024202320222021
Revenue YoY 38.9%0.38%-81.6%1446.0%-31.5%
Revenue CAGR 3Y -36.4%41.9%25.0%··
Revenue CAGR 5Y 22.2%····
Valuation (TTM) 10
Metric Trend 20252024202320222021
Revenue TTM $106M$76M$76M$412M·
Net Income TTM $-81M$-123M$-119M$124M·
Market Cap $1.97B$1.01B$729M··
P/E -24.4-9.0-6.04.1·
P/S 18.513.29.6··
P/B 7.33.01.6··
P / Tangible Book 7.73.11.61.0·
P / Cash Flow -59.5-9.2-6.2··
P / FCF -56.9-9.0-6.0··
Earnings Yield -4.1%-11.1%-16.6%24.2%·

Most recent period on the left · null values shown as ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

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Metric 2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $106M $76M $76M $412M $27M
Operating Margin % -87.3% -179.7% -181.6% · ·
Net Income $-81M $-123M $-119M $124M $-212M
Diluted EPS $-1.08 $-1.62 $-1.72 $1.90 $-4.61

Institutional owners (13F) 212 filers · $1.9B total · As of Sept. 30, 2026

17

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Holders 212
Value held $1.9B
New positions 22
Exited positions 31
Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
22 (-20 vs prior Q) 31 (0 vs prior Q) 59 (-16 vs prior Q) 73 (+13 vs prior Q) -2.0M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
EcoR1 Capital, LLC $600,445,942 22,970,388 32.29% Shares
Rubric Capital Management LP $182,980,000 7,000,000 9.84% Shares
BlackRock, Inc. $111,121,925 4,251,030 5.98% Shares
PERCEPTIVE ADVISORS LLC $109,342,391 4,182,953 5.88% Shares
BVF INC/IL $95,388,572 3,649,142 5.13% Shares
VANGUARD GROUP INC $61,315,382 2,328,727 3.30% Shares
MORGAN STANLEY $58,325,141 2,231,260 3.14% Shares
BNP PARIBAS ASSET MANAGEMENT Holding S.A. $46,558,373 1,781,116 2.50% Shares
VANGUARD CAPITAL MANAGEMENT LLC $40,752,208 1,558,998 2.19% Shares
Assenagon Asset Management S.A. $32,727,986 1,252,027 1.76% Shares
Nextech Invest Ltd. $29,118,548 1,113,946 1.57% Shares
STATE STREET CORP $28,445,966 1,088,216 1.53% Shares
DIMENSIONAL FUND ADVISORS LP $25,995,770 994,955 1.40% Shares
CITADEL ADVISORS LLC $23,895,516 914,136 1.29% Shares
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. $23,259,000 889,802 1.25% Shares
FMR LLC $18,365,133 702,568 0.99% Shares
GEODE CAPITAL MANAGEMENT, LLC $18,099,012 692,410 0.97% Shares
Prosight Management, LP $17,629,705 674,434 0.95% Shares
Qube Research & Technologies Ltd $15,516,443 593,590 0.83% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $13,332,236 510,032 0.72% Shares
Redmile Group, LLC $12,851,836 491,654 0.69% Shares
Capricorn Fund Managers Ltd $12,717,868 486,529 0.68% Shares
GOLDMAN SACHS GROUP INC $12,307,288 470,822 0.66% Shares
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP $10,939,512 418,497 0.59% Shares
DEUTSCHE BANK AG\ $10,382,547 397,190 0.56% Shares
Hillsdale Investment Management Inc. $10,009,581 382,922 0.54% Shares
FIRST TRUST ADVISORS LP $8,897,088 340,363 0.48% Shares
Granahan Investment Management, LLC $8,787,144 336,157 0.47% Shares
NORTHERN TRUST CORP $8,392,849 321,073 0.45% Shares
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC $7,997,401 319,385 0.43% Shares
Pictet Asset Management Holding SA $7,446,189 308,187 0.40% Shares
PICTON MAHONEY ASSET MANAGEMENT $7,092,908 271,343 0.38% Shares
SILVERCREST ASSET MANAGEMENT GROUP LLC $5,849,243 223,766 0.31% Shares
BANK OF AMERICA CORP /DE/ $5,726,515 219,071 0.31% Shares
WELLS FARGO & COMPANY/MN $5,677,573 217,199 0.31% Shares
SummitTX Capital, L.P. $5,510,364 210,802 0.30% Shares
Man Group plc $5,509,763 210,779 0.30% Shares
FEDERATED HERMES, INC. $4,914,190 187,995 0.26% Shares
RAYMOND JAMES FINANCIAL INC $4,350,114 166,416 0.23% Shares
STATE OF WISCONSIN INVESTMENT BOARD $4,066,835 155,579 0.22% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $3,984,154 152,416 0.21% Shares
KENNEDY CAPITAL MANAGEMENT LLC $3,800,390 145,386 0.20% Shares
D. E. Shaw & Co., Inc. $3,785,255 144,807 0.20% Shares
DIADEMA PARTNERS LP $3,715,330 142,132 0.20% Shares
CITIGROUP INC $3,435,868 131,441 0.18% Shares
Bank of New York Mellon Corp $3,427,107 131,106 0.18% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $3,408,656 130,400 0.18% Call option
XTX Topco Ltd $3,290,425 125,877 0.18% Shares
Nuveen, LLC $3,120,829 119,389 0.17% Shares
PANAGORA ASSET MANAGEMENT INC $3,100,282 118,603 0.17% Shares

Show all 212 institutional owners →

Activists & 5%+ owners 2 positions

18

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
EcoR1 Capital, LLC, Oleg Nodelman, EcoR1 Capital Fund Qualified, L.P. ×8 filings Nov. 19, 2025 30.70% Amendment Board campaign SEC
All Blue Falcons FZE, Daniel Edward Llewellen Cookson ×2 filings Dec. 28, 2022 · Initial filing · SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Company insiders 28 insiders · 12 officers · 17 directors

19
Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Kenneth Galbraith Chair & CEO Jan. 12, 2026 A 226,842 0 4 $-3,337,929
Kristin Stafford EVP, Chief Financial Officer April 6, 2026 A · 0 0 $0
Christopher Astle SVP & Chief Financial Officer Jan. 5, 2024 A 6,503 0 0 $0
Neil A Klompas President & COO March 10, 2023 M 17,032 0 0 $0
Mark Hollywood EVP & Chief Operating Officer July 6, 2026 A 133,852 0 1 $-138,740
Paul R Schneider EVP, General Counsel May 13, 2026 A · 0 0 $0
Adam Schayowitz EVP, Head of Research & Development April 9, 2026 A · 0 0 $0
Scott Platshon EVP, Chief Business Officer April 9, 2026 A · 0 0 $0
Paul Andrew Moore Chief Scientific Officer Jan. 12, 2026 A 48,497 0 3 $-721,486
Jeffrey T L Smith EVP & Chief Medical Officer Jan. 12, 2026 M 26,708 0 2 $-475,562
Leone D Patterson EVP, Chief Bus & Fin Officer Jan. 6, 2026 A 459 0 0 $0
Neil Josephson Chief Medical Officer Nov. 10, 2022 M 14,449 0 0 $0
Gregory A. Ciongoli Director Jan. 12, 2026 A 488,500 0 0 $0
Alessandra Cesano Director Jan. 12, 2026 A · 0 0 $0
Carlos Campoy Director Jan. 12, 2026 A · 0 0 $0
Robert E Landry Director Jan. 12, 2026 A · 0 0 $0
Kelvin Neu Director Jan. 12, 2026 A · 0 0 $0
Susan Mahony Director Jan. 12, 2026 A · 0 0 $0
Brian N Cherry Director Jan. 12, 2026 A · 0 0 $0
EcoR1 Capital, LLC Director Jan. 17, 2025 P 15,720,161 0 0 $0
Nancy Davidson Director Dec. 10, 2024 A · 0 0 $0
Neil Gallagher Director Dec. 10, 2024 A · 0 0 $0
Derek John Michael Miller Director Dec. 10, 2024 A · 0 0 $0
Troy Cox Director Dec. 10, 2024 A · 0 0 $0
Kenneth J. Hillan Director Dec. 7, 2023 A · 0 0 $0
Hollings Renton Director Dec. 7, 2023 A · 0 0 $0
Natalie Sacks Director Dec. 21, 2022 A · 0 0 $0
Lota S. Zoth Director Dec. 21, 2022 A · 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

ETF ownership Held by 30 ETFs

20

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
BBP · ETFis Series Trust I 1.32% 59,315 NS July 31, 2026 N-PORT
OMFS · Invesco Exchange-Traded Self-Indexe… 0.15% 14,705 SH Oct. 1, 2026 Daily
IBB · iShares Trust 0.14% 537,742 SH Sept. 11, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.12% 5,008 SH Oct. 1, 2026 Daily
FYC · First Trust Exchange-Traded AlphaDE… 0.11% 65,877 NS July 31, 2026 N-PORT
VFMO · VANGUARD WELLINGTON FUND 0.10% 74,514 SH Aug. 19, 2026 Daily
IWO · iShares Trust 0.08% 439,290 SH Sept. 11, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.07% 50,443 SH Aug. 19, 2026 Daily
PRFZ · Invesco Exchange-Traded Fund Trust 0.07% 68,050 SH Oct. 1, 2026 Daily
IWM · iShares Trust 0.04% 1,202,863 SH Sept. 11, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.04% 270,692 SH Aug. 19, 2026 Daily
RSSL · Global X Funds 0.03% 22,528 NS July 31, 2026 N-PORT
DFAS · Dimensional ETF Trust 0.03% 189,632 NS July 31, 2026 N-PORT
FAD · First Trust Exchange-Traded AlphaDE… 0.02% 5,969 NS July 31, 2026 N-PORT
ISCG · iShares Trust 0.02% 5,910 SH Sept. 11, 2026 Daily
FHLC · FIDELITY COVINGTON TRUST 0.01% 18,267 NS July 31, 2026 N-PORT
WSML · iShares Trust 0.01% 3,039 SH Sept. 11, 2026 Daily
VHT · VANGUARD WORLD FUND 0.01% 110,298 SH Aug. 19, 2026 Daily
TILT · FlexShares Trust 0.01% 5,508 NS July 31, 2026 N-PORT
DFAC · Dimensional ETF Trust 0.00% 70,572 NS July 31, 2026 N-PORT
DCOR · Dimensional ETF Trust 0.00% 3,968 NS July 31, 2026 N-PORT
DFAU · Dimensional ETF Trust 0.00% 12,951 NS July 31, 2026 N-PORT
IWV · iShares Trust 0.00% 14,406 SH Sept. 10, 2026 Daily
DFUS · Dimensional ETF Trust 0.00% 8,364 NS July 31, 2026 N-PORT
DXUV · Dimensional ETF Trust 0.00% 130 NS July 31, 2026 N-PORT
VTI · VANGUARD INDEX FUNDS 0.00% 1,508,613 SH Aug. 19, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 4,085 SH Aug. 19, 2026 Daily
ISCB · iShares Trust · 1,999 SH Sept. 11, 2026 Daily
ISCV · iShares Trust · 5,753 SH Sept. 11, 2026 Daily
SMMV · iShares Trust · 16,029 SH Aug. 19, 2026 Daily

ZYME Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

21
rating · 18 analysts BUY
Median target $38.00 +51.1%
6 33.3% Strong Buy
11 61.1% Buy
1 5.6% Hold
0 0.0% Sell
0 0.0% Strong Sell

12-Month Price Target

13 analysts · 2026-09-27

Mean target $41.23 +63.9%

← Below all targets Current price $25.15
Low$32.00 Mean$41.23 High$60.00

Peer comparison (GICS sub-industry) Key metrics vs sector peers

22

FY basis, prices as of each company's last fiscal year-end close.

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
ZYME $1.97B -24.4 38.9% -76.6% -26.9% ·
AUPH $2.11B 7.7 20.4% 101.5% 62.7% ·
ABUS $926M -28.3 128.2% -237.9% -42.0% ·
ACOG $141M -5.5 · -202.2% -43.8% ·
ENGN · · · · · ·
XENE $3.59B -10.3 · -4612.1% -56.9% ·

My Metrics Your personal watchlist — selected rows from Full Fundamentals

26

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Source: SEC 10-Q filed Aug 6, 2026