ALMS — Détenteurs institutionnels (13F)
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| AyurMaya Capital Management Company, LP | $426 031 355 | 15 139 707 | 13,18% | Actions |
| BlackRock, Inc. | $231 258 771 | 8 218 151 | 7,16% | Actions |
| FMR LLC | $190 484 444 | 6 769 170 | 5,89% | Actions |
| Deep Track Capital, LP | $178 648 422 | 6 348 558 | 5,53% | Actions |
| SAMSARA BIOCAPITAL, LLC | $178 554 463 | 6 345 219 | 5,53% | Actions |
| Foresite Capital Management V, LLC | $165 941 439 | 5 896 995 | 5,14% | Actions |
| venBio Partners LLC | $127 429 401 | 4 528 408 | 3,94% | Actions |
| Foresite Capital Management VI LLC | $119 529 434 | 4 247 670 | 3,70% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $118 629 882 | 4 215 703 | 3,67% | Actions |
| Nextech Invest Ltd. | $99 643 684 | 3 540 998 | 3,08% | Actions |
| Cormorant Asset Management, LP | $92 456 671 | 3 285 596 | 2,86% | Actions |
| Saturn V Capital Management LP | $82 040 566 | 2 915 443 | 2,54% | Actions |
| Octagon Capital Advisors LP | $79 655 898 | 2 830 700 | 2,47% | Actions |
| STATE STREET CORP | $61 549 665 | 2 187 266 | 1,90% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $61 033 791 | 2 168 517 | 1,89% | Actions |
| MPM BIOIMPACT LLC | $56 815 223 | 2 019 020 | 1,76% | Actions |
| BAKER BROS. ADVISORS LP | $56 631 750 | 2 012 500 | 1,75% | Actions |
| SR One Capital Management, LP | $55 151 473 | 1 959 896 | 1,71% | Actions |
| JANUS HENDERSON GROUP PLC | $46 790 086 | 2 124 408 | 1,45% | Actions |
| VANGUARD GROUP INC | $40 048 110 | 4 103 290 | 1,24% | Actions |
| Invesco Ltd. | $33 022 796 | 1 173 518 | 1,02% | Actions |
| NOVO HOLDINGS A/S | $30 954 000 | 1 100 000 | 0,96% | Actions |
| PRINCIPAL FINANCIAL GROUP INC | $30 055 208 | 1 068 060 | 0,93% | Actions |
| D. E. Shaw & Co., Inc. | $27 246 105 | 968 234 | 0,84% | Actions |
| UBS Group AG | $26 783 540 | 951 796 | 0,83% | Actions |
| JPMORGAN CHASE & CO | $26 407 356 | 969 617 | 0,82% | Actions |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $25 922 878 | 921 211 | 0,80% | Actions |
| Ikarian Capital, LLC | $24 497 220 | 870 548 | 0,76% | Actions |
| GREAT POINT PARTNERS LLC | $24 089 557 | 856 061 | 0,75% | Actions |
| GOLDMAN SACHS GROUP INC | $23 409 581 | 831 897 | 0,72% | Actions |
| NORTHERN TRUST CORP | $20 369 111 | 723 849 | 0,63% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $19 701 771 | 700 134 | 0,61% | Actions |
| Integral Health Asset Management, LLC | $19 698 000 | 700 000 | 0,61% | Actions |
| MILLENNIUM MANAGEMENT LLC | $18 576 396 | 660 142 | 0,57% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $17 221 961 | 612 010 | 0,53% | Actions |
| Opaleye Management Inc. | $15 477 000 | 550 000 | 0,48% | Actions |
| ORBIMED ADVISORS LLC | $15 425 307 | 548 163 | 0,48% | Actions |
| ROYCE & ASSOCIATES LP | $14 782 026 | 525 303 | 0,46% | Actions |
| Woodline Partners LP | $13 677 503 | 486 052 | 0,42% | Actions |
| Spruce Street Capital LP | $11 047 032 | 392 574 | 0,34% | Actions |
| Trium Capital LLP | $10 982 142 | 390 268 | 0,34% | Actions |
| CITIGROUP INC | $10 845 156 | 385 400 | 0,34% | Actions |
| TWO SIGMA INVESTMENTS, LP | $10 583 989 | 376 119 | 0,33% | Actions |
| MARSHALL WACE, LLP | $10 355 915 | 368 014 | 0,32% | Actions |
| Ikarian Capital, LLC | $10 026 282 | 356 300 | 0,31% | Option d'achat |
| MORGAN STANLEY | $9 037 528 | 321 163 | 0,28% | Actions |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $9 029 029 | 320 861 | 0,28% | Actions |
| Weiss Asset Management LP | $8 761 980 | 311 371 | 0,27% | Actions |
| Artia Global Partners LP | $7 838 284 | 278 546 | 0,24% | Actions |
| BARCLAYS PLC | $7 702 368 | 273 716 | 0,24% | Actions |
| Yu Fan | $7 110 190 | 252 672 | 0,22% | Actions |
| Nuveen, LLC | $6 862 558 | 243 872 | 0,21% | Actions |
| BOOTHBAY FUND MANAGEMENT, LLC | $6 825 019 | 242 538 | 0,21% | Actions |
| Omega Fund Management, LLC | $6 788 916 | 241 255 | 0,21% | Actions |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $6 427 865 | 236 841 | 0,20% | Actions |
| Bank of New York Mellon Corp | $6 377 030 | 226 618 | 0,20% | Actions |
| TOWERVIEW LLC | $6 255 353 | 222 294 | 0,19% | Actions |
| BANK OF AMERICA CORP /DE/ | $5 847 183 | 207 789 | 0,18% | Actions |
| Exome Asset Management LLC | $5 752 323 | 204 418 | 0,18% | Actions |
| DIADEMA PARTNERS LP | $5 628 000 | 200 000 | 0,17% | Option d'achat |
| HighVista Strategies LLC | $5 627 100 | 199 968 | 0,17% | Actions |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | $5 583 008 | 1 399 250 | 0,17% | Actions |
| WELLINGTON MANAGEMENT GROUP LLP | $5 059 628 | 179 802 | 0,16% | Actions |
| WELLS FARGO & COMPANY/MN | $4 922 024 | 174 912 | 0,15% | Actions |
| Susquehanna Portfolio Strategies, LLC | $4 862 001 | 172 779 | 0,15% | Actions |
| PRUDENTIAL FINANCIAL INC | $4 575 086 | 162 583 | 0,14% | Actions |
| Russell Investments Group, Ltd. | $4 330 918 | 153 906 | 0,13% | Actions |
| Ensign Peak Advisors, Inc | $4 135 736 | 146 970 | 0,13% | Actions |
| AQR CAPITAL MANAGEMENT LLC | $4 120 736 | 146 437 | 0,13% | Actions |
| VOYA INVESTMENT MANAGEMENT LLC | $3 895 082 | 138 418 | 0,12% | Actions |
| MOORE CAPITAL MANAGEMENT, LP | $3 849 636 | 136 803 | 0,12% | Actions |
| Swiss National Bank | $3 824 226 | 135 900 | 0,12% | Actions |
| STEMPOINT CAPITAL LP | $3 819 611 | 135 736 | 0,12% | Actions |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $3 795 000 | 134 850 | 0,12% | Actions |
| VICTORY CAPITAL MANAGEMENT INC | $3 723 794 | 132 331 | 0,12% | Actions |
| Quantinno Capital Management LP | $3 688 929 | 131 092 | 0,11% | Actions |
| Elmind Capital, LP | $3 658 200 | 130 000 | 0,11% | Actions |
| STIFEL FINANCIAL CORP | $3 097 510 | 110 075 | 0,10% | Actions |
| BOOTHBAY FUND MANAGEMENT, LLC | $2 943 444 | 104 600 | 0,09% | Option d'achat |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $2 820 050 | 100 215 | 0,09% | Actions |
| Caption Management, LLC | $2 814 000 | 100 000 | 0,09% | Option d'achat |
| Ghisallo Capital Management LLC | $2 814 000 | 100 000 | 0,09% | Actions |
| TD Asset Management Inc | $2 729 636 | 97 002 | 0,08% | Actions |
| RHUMBLINE ADVISERS | $2 723 010 | 96 767 | 0,08% | Actions |
| FIRST TRUST ADVISORS LP | $2 646 454 | 94 046 | 0,08% | Actions |
| Harvest Investment Services, LLC | $2 610 407 | 92 765 | 0,08% | Actions |
| Caption Management, LLC | $2 532 600 | 90 000 | 0,08% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $2 490 390 | 88 500 | 0,08% | Option d'achat |
| DEUTSCHE BANK AG\ | $2 366 939 | 84 113 | 0,07% | Actions |
| ALLIANCEBERNSTEIN L.P. | $2 299 800 | 104 394 | 0,07% | Actions |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $2 217 939 | 78 818 | 0,07% | Actions |
| Ally Bridge Group (NY) LLC | $2 151 556 | 76 459 | 0,07% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $2 040 150 | 72 500 | 0,06% | Option de vente |
| Mariner, LLC | $2 018 263 | 71 726 | 0,06% | Actions |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $1 808 090 | 82 074 | 0,06% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1 652 296 | 58 717 | 0,05% | Actions |
| ALGERT GLOBAL LLC | $1 625 648 | 57 770 | 0,05% | Actions |
| CITADEL ADVISORS LLC | $1 581 468 | 56 200 | 0,05% | Option d'achat |
| Legal & General Group Plc | $1 545 730 | 54 930 | 0,05% | Actions |
| ACT CAPITAL MANAGEMENT, LLC | $1 452 024 | 51 600 | 0,04% | Actions |
| VANGUARD ASSET MANAGEMENT, Ltd | $1 424 306 | 50 615 | 0,04% | Actions |
| STATE OF WISCONSIN INVESTMENT BOARD | $1 418 622 | 50 413 | 0,04% | Actions |
| Vanguard Global Advisers, LLC | $1 400 134 | 49 756 | 0,04% | Actions |
| Squarepoint Ops LLC | $1 339 183 | 47 590 | 0,04% | Actions |
| MetLife Investment Management, LLC | $1 303 220 | 46 312 | 0,04% | Actions |
| CITADEL ADVISORS LLC | $1 224 090 | 43 500 | 0,04% | Option de vente |
| FRED ALGER MANAGEMENT, LLC | $1 211 624 | 43 057 | 0,04% | Actions |
| Creative Planning | $1 176 759 | 41 818 | 0,04% | Actions |
| JANE STREET GROUP, LLC | $1 136 856 | 40 400 | 0,04% | Option de vente |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $1 023 536 | 36 373 | 0,03% | Actions |
| Corient Private Wealth LP | $988 953 | 35 144 | 0,03% | Actions |
| Trexquant Investment LP | $960 615 | 34 137 | 0,03% | Actions |
| FRANKLIN RESOURCES INC | $918 321 | 32 634 | 0,03% | Actions |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $882 949 | 31 377 | 0,03% | Actions |
| NEW YORK STATE COMMON RETIREMENT FUND | $781 363 | 27 767 | 0,02% | Actions |
| J. Goldman & Co LP | $727 306 | 25 846 | 0,02% | Actions |
| Jain Global LLC | $710 704 | 25 256 | 0,02% | Actions |
| Y-Intercept (Hong Kong) Ltd | $710 141 | 25 236 | 0,02% | Actions |
| JANE STREET GROUP, LLC | $680 988 | 24 200 | 0,02% | Option d'achat |
| BNP PARIBAS FINANCIAL MARKETS | $677 555 | 24 078 | 0,02% | Actions |
| FOX RUN MANAGEMENT, L.L.C. | $675 163 | 23 993 | 0,02% | Actions |
| Inscription Capital, LLC | $664 076 | 23 599 | 0,02% | Actions |
| RENAISSANCE TECHNOLOGIES LLC | $656 647 | 23 335 | 0,02% | Actions |
| Police & Firemen's Retirement System of New Jersey | $655 521 | 23 295 | 0,02% | Actions |
| XTX Topco Ltd | $642 549 | 22 834 | 0,02% | Actions |
| State of New Jersey Common Pension Fund D | $616 238 | 21 899 | 0,02% | Actions |
| INTECH INVESTMENT MANAGEMENT LLC | $586 803 | 20 853 | 0,02% | Actions |
| China Universal Asset Management Co., Ltd. | $552 782 | 19 644 | 0,02% | Actions |
| ARIZONA STATE RETIREMENT SYSTEM | $525 880 | 18 688 | 0,02% | Actions |
| Vanguard Investments Australia, Ltd. | $457 894 | 16 272 | 0,01% | Actions |
| Persistent Asset Partners Ltd | $443 667 | 508 | 0,01% | Option d'achat |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | $433 243 | 15 396 | 0,01% | Actions |
| OCCUDO QUANTITATIVE STRATEGIES LP | $430 458 | 15 297 | 0,01% | Actions |
| VIRGINIA RETIREMENT SYSTEMS ET Al | $422 100 | 15 000 | 0,01% | Actions |
| Brevan Howard Capital Management LP | $416 782 | 14 811 | 0,01% | Actions |
| ProShare Advisors LLC | $405 020 | 14 393 | 0,01% | Actions |
| PROFUND ADVISORS LLC | $401 023 | 14 251 | 0,01% | Actions |
| OpenArc Corporate Advisory, LLC | $400 714 | 14 240 | 0,01% | Actions |
| KLP KAPITALFORVALTNING AS | $399 588 | 14 200 | 0,01% | Actions |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $382 817 | 13 604 | 0,01% | Actions |
| Virtus Investment Advisers, LLC | $381 269 | 13 549 | 0,01% | Actions |
| TWO SIGMA ADVISERS, LP | $371 602 | 38 074 | 0,01% | Actions |
| Point72 Asset Management, L.P. | $343 308 | 12 200 | 0,01% | Option d'achat |
| Point72 Asset Management, L.P. | $343 308 | 12 200 | 0,01% | Option de vente |
| Verdad Advisers, LP | $342 942 | 12 187 | 0,01% | Actions |
| MERCER GLOBAL ADVISORS INC /ADV | $322 119 | 11 447 | 0,01% | Actions |
| SmartHarvest Portfolios, LLC | $303 096 | 10 771 | 0,01% | Actions |
| Allianz Asset Management GmbH | $301 098 | 10 700 | 0,01% | Actions |
| Vanguard Personalized Indexing Management, LLC | $300 169 | 10 667 | 0,01% | Actions |
| Voleon Capital Management LP | $299 550 | 10 645 | 0,01% | Actions |
| Pictet Asset Management Holding SA | $295 217 | 10 491 | 0,01% | Actions |
| Rafferty Asset Management, LLC | $278 670 | 9 903 | 0,01% | Actions |
| CAPSTONE INVESTMENT ADVISORS, LLC | $236 967 | 8 421 | 0,01% | Actions |
| SEI INVESTMENTS CO | $234 621 | 8 337 | 0,01% | Actions |
| Vident Advisory, LLC | $233 449 | 8 296 | 0,01% | Actions |
| CWM, LLC | $228 870 | 10 389 | 0,01% | Actions |
| TEACHER RETIREMENT SYSTEM OF TEXAS | $222 081 | 7 892 | 0,01% | Actions |
| Arax Advisory Partners | $221 884 | 7 885 | 0,01% | Actions |
| XPONANCE LLC | $218 113 | 7 751 | 0,01% | Actions |
| HAP Trading, LLC | $213 125 | 402 500 | 0,01% | Option de vente |
| Abel Hall, LLC | $209 277 | 7 437 | 0,01% | Actions |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | $201 794 | 7 128 | 0,01% | Actions |
| Ameritas Investment Partners, Inc. | $201 708 | 7 168 | 0,01% | Actions |
| Fulcrum Asset Management LLP | $193 128 | 7 116 | 0,01% | Actions |
| State of Wyoming | $188 876 | 6 712 | 0,01% | Actions |
| Farther Finance Advisors, LLC | $174 890 | 6 215 | 0,01% | Actions |
| Mirae Asset Global Investments Co., Ltd. | $155 333 | 5 520 | 0,00% | Actions |
| Tower Research Capital LLC (TRC) | $153 279 | 5 447 | 0,00% | Actions |
| PRICE T ROWE ASSOCIATES INC /MD/ | $146 325 | 5 199 838 | 0,00% | Actions |
| SIMPLEX TRADING, LLC | $140 306 | 4 986 | 0,00% | Actions |
| ASSETMARK, INC | $118 441 | 4 209 | 0,00% | Actions |
| GF FUND MANAGEMENT CO. LTD. | $75 331 | 2 677 | 0,00% | Actions |
| STRS OHIO | $73 164 | 2 600 | 0,00% | Actions |
| EverSource Wealth Advisors, LLC | $72 630 | 2 581 | 0,00% | Actions |
| ROYAL BANK OF CANADA | $72 000 | 2 559 | 0,00% | Actions |
| Parallel Advisors, LLC | $57 940 | 2 059 | 0,00% | Actions |
| SIGNATUREFD, LLC | $36 188 | 1 286 | 0,00% | Actions |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $32 839 | 1 167 | 0,00% | Actions |
| GAMMA Investing LLC | $27 971 | 994 | 0,00% | Actions |
| JONES FINANCIAL COMPANIES LLLP | $27 852 | 1 055 | 0,00% | Actions |
| NISA INVESTMENT ADVISORS, LLC | $27 774 | 987 | 0,00% | Actions |
| Kemnay Advisory Services Inc. | $25 664 | 912 | 0,00% | Actions |
| Global Retirement Partners, LLC | $15 280 | 543 | 0,00% | Actions |
| Allworth Financial LP | $13 142 | 467 | 0,00% | Actions |
| Essential Partners LLC | $12 382 | 440 | 0,00% | Actions |
| ROTHSCHILD INVESTMENT LLC | $11 566 | 411 | 0,00% | Actions |
| PNC Financial Services Group, Inc. | $11 031 | 392 | 0,00% | Actions |
| Aster Capital Management (DIFC) Ltd | $9 258 | 329 | 0,00% | Actions |
| COMERICA BANK | $9 096 | 932 | 0,00% | Actions |
| OSAIC HOLDINGS, INC. | $8 188 | 291 | 0,00% | Actions |
| MassMutual Private Wealth & Trust, FSB | $7 851 | 279 | 0,00% | Actions |
| Sterling Capital Management LLC | $7 795 | 277 | 0,00% | Actions |
| US BANCORP \DE\ | $7 401 | 263 | 0,00% | Actions |
| True Wealth Design, LLC | $6 529 | 232 | 0,00% | Actions |
| BFSG, LLC | $5 403 | 192 | 0,00% | Actions |
| Larson Financial Group LLC | $4 334 | 154 | 0,00% | Actions |
| Versant Capital Management, Inc | $4 013 | 543 | 0,00% | Actions |
| Parkside Financial Bank & Trust | $3 994 | 142 | 0,00% | Actions |
| Transamerica Financial Advisors, LLC | $2 729 | 97 | 0,00% | Actions |
| Quarry LP | $2 701 | 96 | 0,00% | Actions |
| Optiver Holding B.V. | $2 645 | 94 | 0,00% | Actions |
| Decker Retirement Planning Inc. | $2 561 | 91 | 0,00% | Actions |
| Fortitude Family Office, LLC | $2 167 | 77 | 0,00% | Actions |
| IFP Advisors, Inc | $1 548 | 55 | 0,00% | Actions |
| SBI Securities Co., Ltd. | $957 | 34 | 0,00% | Actions |
| Silver Grove Financial Group, Inc. | $900 | 32 | 0,00% | Actions |
| CoreCap Advisors, LLC | $732 | 26 | 0,00% | Actions |
| NATIONAL BANK OF CANADA /FI/ | $703 | 25 | 0,00% | Actions |
| SG Americas Securities, LLC | $643 | 22 867 | 0,00% | Actions |
| HARBOUR INVESTMENTS, INC. | $634 | 23 | 0,00% | Actions |
| Stone House Investment Management, LLC | $619 | 22 | 0,00% | Actions |
| SALEM INVESTMENT COUNSELORS INC | $563 | 20 | 0,00% | Actions |
| HAP Trading, LLC | $272 | 340 000 | 0,00% | Option de vente |
| HAP Trading, LLC | $260 | 266 900 | 0,00% | Option d'achat |
| Sunbelt Securities, Inc. | $154 | 7 | 0,00% | Actions |
| ACADIAN ASSET MANAGEMENT LLC | $103 | 3 696 | 0,00% | Actions |
| KBC Group NV | $54 | 1 929 | 0,00% | Actions |
| Covestor Ltd | $1 | 28 | 0,00% | Actions |