GPCR — Détenteurs institutionnels (13F)
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| FMR LLC | $419 179 123 | 7 810 306 | 11,69% | Actions |
| WELLINGTON MANAGEMENT GROUP LLP | $396 054 169 | 7 379 433 | 11,05% | Actions |
| Avoro Capital Advisors LLC | $351 836 637 | 6 555 555 | 9,81% | Actions |
| JANUS HENDERSON GROUP PLC | $258 260 143 | 5 354 981 | 7,20% | Actions |
| Deep Track Capital, LP | $254 399 664 | 4 740 072 | 7,10% | Actions |
| BVF INC/IL | $180 697 390 | 3 366 823 | 5,04% | Actions |
| MORGAN STANLEY | $150 632 372 | 2 806 640 | 4,20% | Actions |
| ORBIMED ADVISORS LLC | $118 578 498 | 2 209 400 | 3,31% | Actions |
| PRINCIPAL FINANCIAL GROUP INC | $94 070 254 | 1 752 753 | 2,62% | Actions |
| AMERICAN CENTURY COMPANIES INC | $90 282 956 | 1 682 179 | 2,52% | Actions |
| RTW INVESTMENTS, LP | $86 274 901 | 1 607 507 | 2,41% | Actions |
| Driehaus Capital Management LLC | $83 361 264 | 1 553 219 | 2,33% | Actions |
| BAKER BROS. ADVISORS LP | $76 883 831 | 1 432 529 | 2,14% | Actions |
| Casdin Capital, LLC | $63 062 250 | 1 175 000 | 1,76% | Actions |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $58 285 620 | 1 086 000 | 1,63% | Actions |
| CAPITOLIS LIQUID GLOBAL MARKETS LLC | $55 875 837 | 1 041 100 | 1,56% | Actions |
| Siren, L.L.C. | $46 852 139 | 872 967 | 1,31% | Actions |
| Pacific Heights Asset Management LLC | $42 936 000 | 800 000 | 1,20% | Actions |
| Rock Springs Capital Management LP | $34 365 813 | 640 317 | 0,96% | Actions |
| Aberdeen Group plc | $34 344 238 | 639 915 | 0,96% | Actions |
| FRANKLIN RESOURCES INC | $31 066 308 | 578 839 | 0,87% | Actions |
| BANK OF AMERICA CORP /DE/ | $30 238 858 | 563 422 | 0,84% | Actions |
| ALLIANCEBERNSTEIN L.P. | $29 484 326 | 611 708 | 0,82% | Actions |
| BlackRock, Inc. | $27 433 368 | 511 149 | 0,77% | Actions |
| Logos Global Management LP | $26 835 000 | 500 000 | 0,75% | Actions |
| Parkman Healthcare Partners LLC | $26 065 426 | 485 661 | 0,73% | Actions |
| Davern Capital Partners, LP | $23 939 987 | 446 059 | 0,67% | Actions |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $22 476 996 | 418 800 | 0,63% | Actions |
| UBS Group AG | $20 340 179 | 378 986 | 0,57% | Actions |
| DEUTSCHE BANK AG\ | $17 811 302 | 331 867 | 0,50% | Actions |
| NEXTBio Capital Management LP | $16 771 660 | 312 496 | 0,47% | Actions |
| Catalio Capital Management, LP | $14 842 438 | 276 550 | 0,41% | Actions |
| MARSHALL WACE, LLP | $14 361 663 | 267 592 | 0,40% | Actions |
| HSG Holding Ltd | $14 279 548 | 266 062 | 0,40% | Actions |
| SEB Asset Management AB | $13 151 433 | 245 043 | 0,37% | Actions |
| GOLDMAN SACHS GROUP INC | $13 030 539 | 242 790 | 0,36% | Actions |
| AMERIPRISE FINANCIAL INC | $12 371 685 | 230 514 | 0,35% | Actions |
| NATIONAL BANK OF CANADA /FI/ | $11 581 986 | 215 800 | 0,32% | Actions |
| TWO SIGMA INVESTMENTS, LP | $10 957 053 | 204 156 | 0,31% | Actions |
| Eversept Partners, LP | $10 535 528 | 196 302 | 0,29% | Actions |
| Schonfeld Strategic Advisors LLC | $10 234 062 | 190 685 | 0,29% | Actions |
| Woodline Partners LP | $8 254 875 | 153 808 | 0,23% | Actions |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $8 218 000 | 153 119 | 0,23% | Actions |
| ArrowMark Colorado Holdings LLC | $8 081 575 | 150 579 | 0,23% | Actions |
| Susquehanna Portfolio Strategies, LLC | $7 994 039 | 148 948 | 0,22% | Actions |
| CenterBook Partners LP | $7 944 770 | 148 030 | 0,22% | Actions |
| Rhenman & Partners Asset Management AB | $7 787 517 | 145 100 | 0,22% | Actions |
| GOLDMAN SACHS GROUP INC | $7 782 150 | 145 000 | 0,22% | Option d'achat |
| B Group, Inc. | $7 513 800 | 140 000 | 0,21% | Actions |
| HighVista Strategies LLC | $7 019 177 | 130 784 | 0,20% | Actions |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $6 745 728 | 125 689 | 0,19% | Actions |
| Squarepoint Ops LLC | $6 739 610 | 125 575 | 0,19% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $6 566 202 | 122 344 | 0,18% | Actions |
| D. E. Shaw & Co., Inc. | $6 188 151 | 115 300 | 0,17% | Actions |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $6 027 141 | 112 300 | 0,17% | Actions |
| Soleus Capital Management, L.P. | $5 742 690 | 107 000 | 0,16% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $5 302 596 | 98 800 | 0,15% | Option d'achat |
| Avidity Partners Management LP | $5 259 660 | 98 000 | 0,15% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $5 215 811 | 97 183 | 0,15% | Actions |
| Qube Research & Technologies Ltd | $5 012 939 | 93 403 | 0,14% | Actions |
| PEREGRINE CAPITAL MANAGEMENT LLC | $4 949 930 | 92 229 | 0,14% | Actions |
| PFM Health Sciences, LP | $4 913 489 | 91 550 | 0,14% | Actions |
| PLATINUM INVESTMENT MANAGEMENT LTD | $4 849 782 | 90 363 | 0,14% | Actions |
| MILLENNIUM MANAGEMENT LLC | $4 807 115 | 89 568 | 0,13% | Actions |
| ExodusPoint Capital Management, LP | $4 200 536 | 78 266 | 0,12% | Actions |
| Boxer Capital Management, LLC | $4 025 250 | 75 000 | 0,11% | Actions |
| Cormorant Asset Management, LP | $4 025 250 | 75 000 | 0,11% | Actions |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $4 025 250 | 75 000 | 0,11% | Actions |
| CITADEL ADVISORS LLC | $4 014 516 | 74 800 | 0,11% | Option d'achat |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $3 869 607 | 72 100 | 0,11% | Option de vente |
| ALPS ADVISORS INC | $3 855 277 | 71 833 | 0,11% | Actions |
| TD Asset Management Inc | $3 701 191 | 68 962 | 0,10% | Actions |
| Point72 Europe (London) LLP | $3 267 516 | 116 697 | 0,09% | Actions |
| Brevan Howard Capital Management LP | $3 258 144 | 60 336 | 0,09% | Actions |
| Burkehill Global Management, LP | $3 220 200 | 60 000 | 0,09% | Actions |
| RAYMOND JAMES FINANCIAL INC | $3 185 689 | 59 357 | 0,09% | Actions |
| JANE STREET GROUP, LLC | $3 026 988 | 56 400 | 0,08% | Option d'achat |
| CITADEL ADVISORS LLC | $2 908 914 | 54 200 | 0,08% | Option de vente |
| TUDOR INVESTMENT CORP ET AL | $2 879 718 | 53 656 | 0,08% | Actions |
| ANTIPODES PARTNERS Ltd | $2 751 232 | 51 262 | 0,08% | Actions |
| SCOGGIN MANAGEMENT LP | $2 683 500 | 50 000 | 0,07% | Option d'achat |
| Buckland Partners Management Co LLC | $2 683 500 | 50 000 | 0,07% | Actions |
| SEVEN GRAND MANAGERS, LLC | $2 683 500 | 50 000 | 0,07% | Actions |
| DAFNA Capital Management LLC | $2 495 655 | 46 500 | 0,07% | Actions |
| Mariner, LLC | $2 484 116 | 46 285 | 0,07% | Actions |
| OSAIC HOLDINGS, INC. | $2 403 594 | 44 786 | 0,07% | Actions |
| STATE STREET CORP | $2 395 238 | 44 629 | 0,07% | Actions |
| VOYA INVESTMENT MANAGEMENT LLC | $2 383 485 | 44 410 | 0,07% | Actions |
| BANQUE PICTET & CIE SA | $2 325 628 | 43 332 | 0,06% | Actions |
| Jump Financial, LLC | $2 289 455 | 42 658 | 0,06% | Actions |
| BANK OF MONTREAL /CAN/ | $2 284 733 | 42 570 | 0,06% | Actions |
| Cinctive Capital Management LP | $2 193 869 | 40 877 | 0,06% | Actions |
| Jefferies Financial Group Inc. | $2 180 344 | 40 625 | 0,06% | Actions |
| Jones Hill Capital LP | $2 177 231 | 40 567 | 0,06% | Actions |
| STEMPOINT CAPITAL LP | $2 049 013 | 38 178 | 0,06% | Actions |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $2 045 256 | 38 108 | 0,06% | Actions |
| CAPITAL FUND MANAGEMENT S.A. | $2 000 871 | 37 281 | 0,06% | Actions |
| PSquared Asset Management AG | $1 996 524 | 37 200 | 0,06% | Actions |
| FLAX POND CAPITAL, LLC | $1 932 120 | 36 000 | 0,05% | Actions |
| TrueMark Investments, LLC | $1 803 312 | 33 600 | 0,05% | Actions |
| NOMURA ASSET MANAGEMENT CO LTD | $1 759 839 | 32 790 | 0,05% | Actions |
| DCF Advisers, LLC | $1 722 807 | 32 100 | 0,05% | Actions |
| EXCHANGE TRADED CONCEPTS, LLC | $1 651 587 | 30 773 | 0,05% | Actions |
| SPHERA FUNDS MANAGEMENT LTD. | $1 534 962 | 28 600 | 0,04% | Actions |
| Verition Fund Management LLC | $1 530 615 | 28 519 | 0,04% | Actions |
| Y-Intercept (Hong Kong) Ltd | $1 479 843 | 27 573 | 0,04% | Actions |
| Seven Fleet Capital Management LP | $1 441 572 | 26 800 | 0,04% | Actions |
| MML INVESTORS SERVICES, LLC | $1 374 006 | 25 601 | 0,04% | Actions |
| Birchview Capital, LP | $1 288 080 | 24 000 | 0,04% | Actions |
| NOMURA HOLDINGS INC | $1 227 594 | 22 873 | 0,03% | Actions |
| BARCLAYS PLC | $1 085 798 | 20 231 | 0,03% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $954 306 | 17 781 | 0,03% | Actions |
| ADAR1 Capital Management, LLC | $939 225 | 17 500 | 0,03% | Actions |
| STIFEL FINANCIAL CORP | $806 771 | 15 032 | 0,02% | Actions |
| LPL Financial LLC | $769 252 | 14 333 | 0,02% | Actions |
| WEXFORD CAPITAL LP | $735 762 | 13 709 | 0,02% | Actions |
| SEI INVESTMENTS CO | $734 422 | 13 684 | 0,02% | Actions |
| BRANDYWINE MANAGERS, LLC | $716 870 | 13 357 | 0,02% | Actions |
| Gladstone Institutional Advisory LLC | $712 469 | 13 275 | 0,02% | Actions |
| Fulcrum Asset Management LLP | $684 996 | 13 252 | 0,02% | Actions |
| China Universal Asset Management Co., Ltd. | $665 991 | 12 409 | 0,02% | Actions |
| ENVESTNET ASSET MANAGEMENT INC | $621 241 | 11 575 | 0,02% | Actions |
| Verdad Advisers, LP | $608 349 | 11 335 | 0,02% | Actions |
| DNB Asset Management AS | $578 509 | 10 779 | 0,02% | Actions |
| FOX RUN MANAGEMENT, L.L.C. | $578 348 | 10 776 | 0,02% | Actions |
| WELLS FARGO & COMPANY/MN | $558 033 | 10 398 | 0,02% | Actions |
| HighTower Advisors, LLC | $538 253 | 10 029 | 0,02% | Actions |
| Quinn Opportunity Partners LLC | $536 700 | 10 000 | 0,01% | Actions |
| SmartHarvest Portfolios, LLC | $532 836 | 9 928 | 0,01% | Actions |
| CITIGROUP INC | $519 526 | 9 680 | 0,01% | Actions |
| Gilbert & Cook, Inc. | $491 993 | 9 167 | 0,01% | Actions |
| IMC-Chicago, LLC | $462 528 | 8 618 | 0,01% | Actions |
| Cubist Systematic Strategies, LLC | $456 736 | 16 312 | 0,01% | Actions |
| JANE STREET GROUP, LLC | $450 828 | 8 400 | 0,01% | Option de vente |
| SIMPLEX TRADING, LLC | $422 436 | 7 871 | 0,01% | Actions |
| Clearstead Advisors, LLC | $420 021 | 7 826 | 0,01% | Actions |
| Quadcap Wealth Management, LLC | $409 769 | 7 635 | 0,01% | Actions |
| Virtus Investment Advisers, LLC | $409 073 | 7 622 | 0,01% | Actions |
| Allianz Asset Management GmbH | $407 892 | 7 600 | 0,01% | Actions |
| MISSION WEALTH MANAGEMENT, LP | $406 980 | 7 583 | 0,01% | Actions |
| Vestmark Advisory Solutions, Inc. | $404 350 | 7 534 | 0,01% | Actions |
| Parallel Advisors, LLC | $394 582 | 7 352 | 0,01% | Actions |
| Cetera Investment Advisers | $356 261 | 6 638 | 0,01% | Actions |
| EntryPoint Capital, LLC | $329 319 | 6 136 | 0,01% | Actions |
| Good Life Advisors, LLC | $311 100 | 15 000 | 0,01% | Actions |
| Mirae Asset Global Investments Co., Ltd. | $274 093 | 5 107 | 0,01% | Actions |
| NORTHERN TRUST CORP | $272 644 | 5 080 | 0,01% | Actions |
| Concurrent Investment Advisors, LLC | $268 350 | 5 000 | 0,01% | Actions |
| Bellevue Group AG | $255 577 | 4 762 | 0,01% | Actions |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | $249 297 | 4 645 | 0,01% | Actions |
| Independent Advisor Alliance | $243 823 | 4 543 | 0,01% | Actions |
| SECTORAL ASSET MANAGEMENT INC | $232 123 | 4 325 | 0,01% | Actions |
| PEAK6 LLC | $222 999 | 4 155 | 0,01% | Actions |
| Walleye Trading LLC | $220 745 | 4 113 | 0,01% | Actions |
| Prospera Financial Services Inc | $220 042 | 4 100 | 0,01% | Actions |
| E. Ohman J:or Asset Management AB | $217 768 | 4 518 | 0,01% | Actions |
| GABELLI FUNDS LLC | $217 364 | 4 050 | 0,01% | Actions |
| TUDOR INVESTMENT CORP ET AL | $214 680 | 4 000 | 0,01% | Option d'achat |
| Invesco Ltd. | $212 050 | 3 951 | 0,01% | Actions |
| JPMORGAN CHASE & CO | $205 933 | 3 984 | 0,01% | Actions |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | $187 845 | 3 500 | 0,01% | Actions |
| State of Wyoming | $166 431 | 3 101 | 0,00% | Actions |
| PNC Financial Services Group, Inc. | $149 310 | 2 782 | 0,00% | Actions |
| ASSETMARK, INC | $146 304 | 2 726 | 0,00% | Actions |
| NATIXIS | $135 095 | 2 482 | 0,00% | Actions |
| Rockefeller Capital Management L.P. | $134 926 | 2 514 | 0,00% | Actions |
| Sterling Capital Management LLC | $109 755 | 2 045 | 0,00% | Actions |
| Farther Finance Advisors, LLC | $88 878 | 1 656 | 0,00% | Actions |
| GF FUND MANAGEMENT CO. LTD. | $88 609 | 1 651 | 0,00% | Actions |
| Federation des caisses Desjardins du Quebec | $80 490 | 1 500 | 0,00% | Actions |
| Steward Partners Investment Advisory, LLC | $75 138 | 1 400 | 0,00% | Actions |
| Tower Research Capital LLC (TRC) | $48 142 | 897 | 0,00% | Actions |
| IFP Advisors, Inc | $46 049 | 858 | 0,00% | Actions |
| PRICE T ROWE ASSOCIATES INC /MD/ | $45 380 | 845 532 | 0,00% | Actions |
| GAMMA Investing LLC | $44 868 | 836 | 0,00% | Actions |
| ROYAL BANK OF CANADA | $30 000 | 550 | 0,00% | Actions |
| WOLFF WIESE MAGANA LLC | $21 468 | 400 | 0,00% | Actions |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $20 663 | 385 | 0,00% | Actions |
| North Star Investment Management Corp. | $17 711 | 330 | 0,00% | Actions |
| Quarry LP | $13 149 | 245 | 0,00% | Actions |
| Godfrey Financial Associates, Inc. | $13 149 | 245 | 0,00% | Actions |
| JONES FINANCIAL COMPANIES LLLP | $8 699 | 175 | 0,00% | Actions |
| Dynamic Wealth Strategies, LLC | $8 051 | 150 | 0,00% | Actions |
| CWM, LLC | $6 025 | 125 | 0,00% | Actions |
| Key Financial Inc | $5 367 | 100 | 0,00% | Actions |
| SHP Wealth Management | $5 367 | 100 | 0,00% | Actions |
| SIGNATUREFD, LLC | $5 367 | 100 | 0,00% | Actions |
| HUNTINGTON NATIONAL BANK | $4 240 | 79 | 0,00% | Actions |
| Rakuten Securities, Inc. | $3 220 | 60 | 0,00% | Actions |
| Arax Advisory Partners | $1 825 | 34 | 0,00% | Actions |
| GSA CAPITAL PARTNERS LLP | $1 538 | 28 665 | 0,00% | Actions |
| Transamerica Financial Advisors, LLC | $1 180 | 22 | 0,00% | Actions |
| Ares Financial Consulting, LLC | $1 073 | 20 | 0,00% | Actions |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $928 | 17 297 | 0,00% | Actions |
| Smartleaf Asset Management LLC | $879 | 17 | 0,00% | Actions |
| Janney Capital Management LLC | $592 | 8 513 | 0,00% | Actions |
| Caitong International Asset Management Co., Ltd | $537 | 10 | 0,00% | Actions |
| Cullen/Frost Bankers, Inc. | $429 | 8 | 0,00% | Actions |
| Larson Financial Group LLC | $322 | 6 | 0,00% | Actions |
| Janney Montgomery Scott LLC | $288 | 5 364 | 0,00% | Actions |
| SG Americas Securities, LLC | $130 | 2 427 | 0,00% | Actions |
| Point72 Asia (Singapore) Pte. Ltd. | $28 | 1 | 0,00% | Actions |
| Capital Analysts, LLC | $1 | 18 | 0,00% | Actions |
| BESSEMER GROUP INC | $1 | 22 | 0,00% | Actions |