IRON — Détenteurs institutionnels (13F)
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| FMR LLC | $357 981 753 | 4 894 473 | 11,37% | Actions |
| BlackRock, Inc. | $180 502 133 | 2 467 899 | 5,73% | Actions |
| RA CAPITAL MANAGEMENT, L.P. | $179 209 164 | 2 450 221 | 5,69% | Actions |
| VANGUARD GROUP INC | $140 371 470 | 1 767 680 | 4,46% | Actions |
| JPMORGAN CHASE & CO | $139 868 053 | 1 875 795 | 4,44% | Actions |
| WELLINGTON MANAGEMENT GROUP LLP | $127 362 413 | 1 741 351 | 4,05% | Actions |
| STATE STREET CORP | $120 595 865 | 1 648 836 | 3,83% | Actions |
| Vestal Point Capital, LP | $113 367 000 | 1 550 000 | 3,60% | Actions |
| Atlas Venture Life Science Advisors, LLC | $110 724 818 | 1 513 875 | 3,52% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $100 130 635 | 1 369 027 | 3,18% | Actions |
| Frazier Life Sciences Management, L.P. | $99 093 875 | 1 354 852 | 3,15% | Actions |
| TCG Crossover Management, LLC | $98 143 787 | 1 341 862 | 3,12% | Actions |
| BVF INC/IL | $84 375 182 | 1 153 612 | 2,68% | Actions |
| Woodline Partners LP | $70 088 672 | 958 281 | 2,23% | Actions |
| Siren, L.L.C. | $64 977 649 | 888 401 | 2,06% | Actions |
| Logos Global Management LP | $63 997 500 | 875 000 | 2,03% | Actions |
| Opaleye Management Inc. | $62 534 700 | 855 000 | 1,99% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $57 772 342 | 789 724 | 1,84% | Actions |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $48 052 980 | 657 000 | 1,53% | Actions |
| DIMENSIONAL FUND ADVISORS LP | $41 622 451 | 569 018 | 1,32% | Actions |
| Bellevue Group AG | $40 958 400 | 560 000 | 1,30% | Actions |
| Saturn V Capital Management LP | $38 378 752 | 524 730 | 1,22% | Actions |
| ARMISTICE CAPITAL, LLC | $33 644 400 | 460 000 | 1,07% | Actions |
| JENNISON ASSOCIATES LLC | $32 146 492 | 439 520 | 1,02% | Actions |
| Aberdeen Group plc | $32 048 046 | 438 174 | 1,02% | Actions |
| Palo Alto Investors LP | $30 473 488 | 416 646 | 0,97% | Actions |
| EVENTIDE ASSET MANAGEMENT, LLC | $28 938 480 | 395 651 | 0,92% | Actions |
| Pictet Asset Management Holding SA | $28 186 328 | 385 375 | 0,90% | Actions |
| Assenagon Asset Management S.A. | $28 097 316 | 384 158 | 0,89% | Actions |
| LOOMIS SAYLES & CO L P | $27 929 533 | 381 864 | 0,89% | Actions |
| Foresite Capital Management V, LLC | $27 359 407 | 374 069 | 0,87% | Actions |
| ORBIMED ADVISORS LLC | $26 150 110 | 357 535 | 0,83% | Actions |
| BAKER BROS. ADVISORS LP | $25 573 913 | 349 657 | 0,81% | Actions |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $20 620 872 | 281 937 | 0,66% | Actions |
| Octagon Capital Advisors LP | $19 747 800 | 270 000 | 0,63% | Actions |
| NORTHERN TRUST CORP | $19 381 368 | 264 990 | 0,62% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $18 824 919 | 257 382 | 0,60% | Actions |
| Checkpoint Capital L.P. | $17 562 743 | 240 125 | 0,56% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $16 470 982 | 225 198 | 0,52% | Actions |
| CITADEL ADVISORS LLC | $15 308 787 | 209 308 | 0,49% | Actions |
| Bank of New York Mellon Corp | $14 973 763 | 204 727 | 0,48% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $13 508 592 | 184 695 | 0,43% | Actions |
| Catalio Capital Management, LP | $11 657 346 | 159 384 | 0,37% | Actions |
| Caption Management, LLC | $10 971 000 | 150 000 | 0,35% | Option d'achat |
| Sofinnova Investments, Inc. | $10 695 920 | 146 239 | 0,34% | Actions |
| Bain Capital Life Sciences Investors, LLC | $10 329 855 | 141 234 | 0,33% | Actions |
| TWO SIGMA INVESTMENTS, LP | $10 001 895 | 136 750 | 0,32% | Actions |
| BANK OF AMERICA CORP /DE/ | $9 882 018 | 135 111 | 0,31% | Actions |
| Alyeska Investment Group, L.P. | $9 142 500 | 125 000 | 0,29% | Actions |
| Ensign Peak Advisors, Inc | $8 931 199 | 122 111 | 0,28% | Actions |
| UBS Group AG | $8 116 419 | 110 971 | 0,26% | Actions |
| Trexquant Investment LP | $7 877 105 | 107 699 | 0,25% | Actions |
| KENNEDY CAPITAL MANAGEMENT LLC | $7 809 085 | 106 769 | 0,25% | Actions |
| MILLENNIUM MANAGEMENT LLC | $7 770 979 | 106 248 | 0,25% | Actions |
| GOLDMAN SACHS GROUP INC | $7 122 593 | 97 383 | 0,23% | Actions |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $7 090 307 | 110 890 | 0,23% | Actions |
| MORGAN STANLEY | $6 699 315 | 91 595 | 0,21% | Actions |
| SILVERARC CAPITAL MANAGEMENT, LLC | $6 055 992 | 82 800 | 0,19% | Actions |
| RAYMOND JAMES FINANCIAL INC | $5 703 384 | 77 980 | 0,18% | Actions |
| Squarepoint Ops LLC | $5 549 278 | 75 872 | 0,18% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $5 383 104 | 73 600 | 0,17% | Option d'achat |
| DNB Asset Management AS | $5 348 509 | 73 127 | 0,17% | Actions |
| Casdin Capital, LLC | $4 754 100 | 65 000 | 0,15% | Actions |
| SPHERA FUNDS MANAGEMENT LTD. | $4 647 169 | 63 538 | 0,15% | Actions |
| Nuveen, LLC | $4 414 511 | 60 357 | 0,14% | Actions |
| PEAK6 LLC | $4 388 400 | 60 000 | 0,14% | Option d'achat |
| KVP Capital Advisors, LP | $4 260 405 | 58 250 | 0,14% | Actions |
| MOORE CAPITAL MANAGEMENT, LP | $4 227 199 | 57 796 | 0,13% | Actions |
| XTX Topco Ltd | $4 147 769 | 56 710 | 0,13% | Actions |
| NEXTBio Capital Management LP | $3 851 187 | 52 655 | 0,12% | Actions |
| ALGERT GLOBAL LLC | $3 792 309 | 51 850 | 0,12% | Actions |
| ExodusPoint Capital Management, LP | $3 775 706 | 51 623 | 0,12% | Actions |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $3 725 000 | 50 000 | 0,12% | Actions |
| Burkehill Global Management, LP | $3 657 000 | 50 000 | 0,12% | Actions |
| Brevan Howard Capital Management LP | $3 656 707 | 49 996 | 0,12% | Actions |
| Swiss National Bank | $3 642 372 | 49 800 | 0,12% | Actions |
| AMERIPRISE FINANCIAL INC | $3 355 224 | 45 874 | 0,11% | Actions |
| Atle Fund Management AB | $3 194 901 | 43 682 | 0,10% | Actions |
| Quadrature Capital Ltd | $3 102 526 | 42 419 | 0,10% | Actions |
| Invesco Ltd. | $3 076 049 | 42 057 | 0,10% | Actions |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $2 878 790 | 39 360 | 0,09% | Actions |
| ALPS ADVISORS INC | $2 820 644 | 38 565 | 0,09% | Actions |
| CITIGROUP INC | $2 802 506 | 38 317 | 0,09% | Actions |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $2 798 483 | 38 262 | 0,09% | Actions |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $2 679 411 | 36 634 | 0,09% | Actions |
| RHUMBLINE ADVISERS | $2 621 620 | 35 844 | 0,08% | Actions |
| LAZARD ASSET MANAGEMENT LLC | $2 562 387 | 35 034 | 0,08% | Actions |
| SEVEN GRAND MANAGERS, LLC | $2 559 900 | 35 000 | 0,08% | Actions |
| MARSHALL WACE, LLP | $2 515 577 | 34 394 | 0,08% | Actions |
| Jump Financial, LLC | $2 380 634 | 32 549 | 0,08% | Actions |
| BANK OF MONTREAL /CAN/ | $2 363 007 | 32 308 | 0,08% | Actions |
| DEUTSCHE BANK AG\ | $2 241 229 | 30 643 | 0,07% | Actions |
| ALLIANCEBERNSTEIN L.P. | $2 216 800 | 34 670 | 0,07% | Actions |
| RTW INVESTMENTS, LP | $2 194 200 | 30 000 | 0,07% | Actions |
| Squadron Capital Management LLC | $2 194 200 | 30 000 | 0,07% | Option d'achat |
| VICTORY CAPITAL MANAGEMENT INC | $2 129 618 | 29 117 | 0,07% | Actions |
| WELLS FARGO & COMPANY/MN | $2 115 464 | 28 924 | 0,07% | Actions |
| TUDOR INVESTMENT CORP ET AL | $2 096 412 | 28 663 | 0,07% | Actions |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $2 031 171 | 27 771 | 0,06% | Actions |
| Y-Intercept (Hong Kong) Ltd | $1 966 588 | 26 888 | 0,06% | Actions |
| Rafferty Asset Management, LLC | $1 943 037 | 26 566 | 0,06% | Actions |
| Campbell & CO Investment Adviser LLC | $1 870 044 | 25 568 | 0,06% | Actions |
| PNC Financial Services Group, Inc. | $1 633 435 | 22 333 | 0,05% | Actions |
| TD Asset Management Inc | $1 579 824 | 21 600 | 0,05% | Actions |
| Engineers Gate Manager LP | $1 430 033 | 19 552 | 0,05% | Actions |
| BARCLAYS PLC | $1 368 450 | 18 710 | 0,04% | Actions |
| Legal & General Group Plc | $1 350 019 | 18 458 | 0,04% | Actions |
| DLD Asset Management, LP | $1 330 238 | 18 200 | 0,04% | Option de vente |
| CITADEL ADVISORS LLC | $1 258 008 | 17 200 | 0,04% | Option de vente |
| MetLife Investment Management, LLC | $1 213 246 | 16 588 | 0,04% | Actions |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $1 182 775 | 16 114 | 0,04% | Actions |
| VANGUARD ASSET MANAGEMENT, Ltd | $1 178 359 | 16 111 | 0,04% | Actions |
| JANE STREET GROUP, LLC | $1 171 045 | 16 011 | 0,04% | Actions |
| CITADEL ADVISORS LLC | $1 155 612 | 15 800 | 0,04% | Option d'achat |
| STATE OF WISCONSIN INVESTMENT BOARD | $1 128 477 | 15 429 | 0,04% | Actions |
| Man Group plc | $1 091 615 | 14 925 | 0,03% | Actions |
| HighVista Strategies LLC | $1 039 978 | 14 219 | 0,03% | Actions |
| PROFUND ADVISORS LLC | $988 048 | 13 509 | 0,03% | Actions |
| Ikarian Capital, LLC | $972 762 | 13 300 | 0,03% | Option d'achat |
| Ikarian Capital, LLC | $972 762 | 13 300 | 0,03% | Option de vente |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $948 699 | 12 971 | 0,03% | Actions |
| Qube Research & Technologies Ltd | $933 120 | 12 758 | 0,03% | Actions |
| SEI INVESTMENTS CO | $925 008 | 12 647 | 0,03% | Actions |
| MARTINGALE ASSET MANAGEMENT L P | $878 339 | 12 009 | 0,03% | Actions |
| Vanguard Global Advisers, LLC | $848 205 | 11 597 | 0,03% | Actions |
| JANUS HENDERSON GROUP PLC | $739 462 | 11 555 | 0,02% | Actions |
| NEW YORK STATE COMMON RETIREMENT FUND | $736 959 | 10 076 | 0,02% | Actions |
| AQR CAPITAL MANAGEMENT LLC | $721 745 | 9 868 | 0,02% | Actions |
| JANE STREET GROUP, LLC | $665 574 | 9 100 | 0,02% | Option d'achat |
| Entropy Technologies, LP | $614 961 | 8 408 | 0,02% | Actions |
| Police & Firemen's Retirement System of New Jersey | $610 353 | 8 345 | 0,02% | Actions |
| China Universal Asset Management Co., Ltd. | $602 600 | 8 239 | 0,02% | Actions |
| Lion Point Capital, LP | $592 434 | 8 100 | 0,02% | Actions |
| Russell Investments Group, Ltd. | $591 190 | 8 083 | 0,02% | Actions |
| State of New Jersey Common Pension Fund D | $586 583 | 8 020 | 0,02% | Actions |
| PSP Research LLC | $585 120 | 8 000 | 0,02% | Actions |
| Cubist Systematic Strategies, LLC | $575 848 | 8 714 | 0,02% | Actions |
| Quantinno Capital Management LP | $533 703 | 7 297 | 0,02% | Actions |
| JANE STREET GROUP, LLC | $526 608 | 7 200 | 0,02% | Option de vente |
| ARIZONA STATE RETIREMENT SYSTEM | $500 570 | 6 844 | 0,02% | Actions |
| EntryPoint Capital, LLC | $465 975 | 6 371 | 0,01% | Actions |
| SummitTX Capital, L.P. | $461 440 | 6 309 | 0,01% | Actions |
| Creative Planning | $457 418 | 6 254 | 0,01% | Actions |
| INTECH INVESTMENT MANAGEMENT LLC | $442 790 | 6 054 | 0,01% | Actions |
| AXQ CAPITAL, LP | $441 400 | 6 035 | 0,01% | Actions |
| D. E. Shaw & Co., Inc. | $440 815 | 6 027 | 0,01% | Actions |
| Vanguard Investments Australia, Ltd. | $435 841 | 5 959 | 0,01% | Actions |
| Susquehanna Portfolio Strategies, LLC | $424 797 | 5 808 | 0,01% | Actions |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $412 510 | 5 640 | 0,01% | Actions |
| VOYA INVESTMENT MANAGEMENT LLC | $397 150 | 5 430 | 0,01% | Actions |
| KLP KAPITALFORVALTNING AS | $380 328 | 5 200 | 0,01% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $365 700 | 5 000 | 0,01% | Option de vente |
| ProShare Advisors LLC | $362 701 | 4 959 | 0,01% | Actions |
| Virtus Investment Advisers, LLC | $351 950 | 4 812 | 0,01% | Actions |
| JONES FINANCIAL COMPANIES LLLP | $345 184 | 4 616 | 0,01% | Actions |
| PRUDENTIAL FINANCIAL INC | $338 638 | 4 630 | 0,01% | Actions |
| Eleva Capital SAS | $327 053 | 5 115 | 0,01% | Actions |
| Fiduciary Trust Co | $296 290 | 4 051 | 0,01% | Actions |
| AlphaCentric Advisors LLC | $294 754 | 4 030 | 0,01% | Actions |
| BOOTHBAY FUND MANAGEMENT, LLC | $292 560 | 4 000 | 0,01% | Option d'achat |
| BOOTHBAY FUND MANAGEMENT, LLC | $292 560 | 4 000 | 0,01% | Option de vente |
| E Fund Management Co., Ltd. | $273 982 | 3 746 | 0,01% | Actions |
| Bryce Point Capital, LLC | $258 505 | 3 912 | 0,01% | Actions |
| CAPSTONE INVESTMENT ADVISORS, LLC | $245 385 | 3 355 | 0,01% | Actions |
| Jain Global LLC | $228 928 | 3 130 | 0,01% | Actions |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $225 417 | 3 082 | 0,01% | Actions |
| DLD Asset Management, LP | $219 420 | 3 000 | 0,01% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $213 130 | 2 914 | 0,01% | Actions |
| TEACHER RETIREMENT SYSTEM OF TEXAS | $211 741 | 2 895 | 0,01% | Actions |
| STRS OHIO | $197 478 | 2 700 | 0,01% | Actions |
| Ameritas Investment Partners, Inc. | $187 824 | 2 568 | 0,01% | Actions |
| Quantbot Technologies LP | $152 863 | 2 090 | 0,00% | Actions |
| PRICE T ROWE ASSOCIATES INC /MD/ | $137 168 | 1 875 399 | 0,00% | Actions |
| Mirae Asset Global Investments Co., Ltd. | $124 923 | 1 708 | 0,00% | Actions |
| US BANCORP \DE\ | $89 889 | 1 229 | 0,00% | Actions |
| ROYAL BANK OF CANADA | $73 000 | 989 | 0,00% | Actions |
| Foresite Capital Management VI LLC | $70 946 | 970 | 0,00% | Actions |
| Tower Research Capital LLC (TRC) | $68 678 | 939 | 0,00% | Actions |
| CWM, LLC | $66 178 | 1 035 | 0,00% | Actions |
| GF FUND MANAGEMENT CO. LTD. | $59 170 | 809 | 0,00% | Actions |
| Allworth Financial LP | $46 298 | 633 | 0,00% | Actions |
| NISA INVESTMENT ADVISORS, LLC | $41 397 | 566 | 0,00% | Actions |
| Steward Partners Investment Advisory, LLC | $38 618 | 528 | 0,00% | Actions |
| Bayforest Capital Ltd | $32 986 | 451 | 0,00% | Actions |
| AlphaQuest LLC | $29 064 | 366 | 0,00% | Actions |
| State of Wyoming | $25 306 | 346 | 0,00% | Actions |
| GAMMA Investing LLC | $21 357 | 292 | 0,00% | Actions |
| Kemnay Advisory Services Inc. | $19 675 | 269 | 0,00% | Actions |
| OSAIC HOLDINGS, INC. | $19 602 | 268 | 0,00% | Actions |
| TORONTO DOMINION BANK | $14 482 | 198 | 0,00% | Actions |
| J.Safra Asset Management Corp | $11 776 | 161 | 0,00% | Actions |
| Larson Financial Group LLC | $8 996 | 123 | 0,00% | Actions |
| Sterling Capital Management LLC | $7 241 | 99 | 0,00% | Actions |
| Smartleaf Asset Management LLC | $6 854 | 92 | 0,00% | Actions |
| HRT FINANCIAL LP | $6 642 | 90 822 | 0,00% | Actions |
| Arax Advisory Partners | $6 290 | 86 | 0,00% | Actions |
| CoreCap Advisors, LLC | $5 705 | 78 | 0,00% | Actions |
| iA Global Asset Management Inc. | $4 829 | 66 023 | 0,00% | Actions |
| Optiver Holding B.V. | $4 754 | 65 | 0,00% | Actions |
| Farther Finance Advisors, LLC | $3 439 | 47 | 0,00% | Actions |
| Versant Capital Management, Inc | $3 273 | 50 | 0,00% | Actions |
| Lindbrook Capital, LLC | $2 879 | 58 | 0,00% | Actions |
| FIRST HORIZON CORP | $2 633 | 36 | 0,00% | Actions |
| ROTHSCHILD INVESTMENT LLC | $2 340 | 32 | 0,00% | Actions |
| Silver Grove Financial Group, Inc. | $1 902 | 26 | 0,00% | Actions |
| FIFTH THIRD BANCORP | $1 844 | 25 | 0,00% | Actions |
| COMERICA BANK | $1 544 | 19 | 0,00% | Actions |
| Parkside Financial Bank & Trust | $1 462 | 20 | 0,00% | Actions |
| Quarry LP | $1 317 | 18 | 0,00% | Actions |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $1 287 | 17 599 | 0,00% | Actions |
| JPL Wealth Management, LLC | $1 244 | 17 | 0,00% | Actions |
| EverSource Wealth Advisors, LLC | $1 243 | 17 | 0,00% | Actions |
| GSA CAPITAL PARTNERS LLP | $1 194 | 16 324 | 0,00% | Actions |
| Geneos Wealth Management Inc. | $951 | 13 | 0,00% | Actions |
| HUNTINGTON NATIONAL BANK | $878 | 12 | 0,00% | Actions |
| ASSETMARK, INC | $878 | 12 | 0,00% | Actions |
| Cornerstone Financial Management LLC | $805 | 11 | 0,00% | Actions |
| Bare Financial Services, Inc | $658 | 9 | 0,00% | Actions |
| SG Americas Securities, LLC | $563 | 7 704 | 0,00% | Actions |
| Keating Financial Advisory Services, Inc. | $439 | 6 | 0,00% | Actions |
| Essential Partners LLC | $366 | 5 | 0,00% | Actions |
| Virtu Financial LLC | $343 | 4 694 | 0,00% | Actions |
| Global Retirement Partners, LLC | $293 | 4 | 0,00% | Actions |
| Clearstead Advisors, LLC | $148 | 2 | 0,00% | Actions |
| Hughes Financial Services, LLC | $146 | 2 | 0,00% | Actions |
| Downshift Financial, LLC | $146 | 2 | 0,00% | Actions |
| KBC Group NV | $74 | 1 011 | 0,00% | Actions |
| Fortitude Family Office, LLC | $73 | 1 | 0,00% | Actions |
| Wealth Enhancement Trust Services, Inc. | $73 | 1 | 0,00% | Actions |
| SBI Securities Co., Ltd. | $73 | 1 | 0,00% | Actions |
| IFP Advisors, Inc | $73 | 1 | 0,00% | Actions |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | $53 | 730 | 0,00% | Actions |
| Pacer Advisors, Inc. | $32 | 444 | 0,00% | Actions |
| Covestor Ltd | $1 | 7 | 0,00% | Actions |
| GW&K Investment Management, LLC | $1 | 16 | 0,00% | Actions |