MBX — Détenteurs institutionnels (13F)
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | $367 191 118 | 6 652 013 | 11,84% | Actions |
| FMR LLC | $293 823 234 | 5 322 885 | 9,47% | Actions |
| WELLINGTON MANAGEMENT GROUP LLP | $274 759 269 | 4 977 523 | 8,86% | Actions |
| NEA Management Company, LLC | $199 519 627 | 3 614 486 | 6,43% | Actions |
| ORBIMED ADVISORS LLC | $189 266 227 | 3 428 736 | 6,10% | Actions |
| BlackRock, Inc. | $183 466 695 | 3 323 672 | 5,91% | Actions |
| Paradigm Biocapital Advisors LP | $138 442 428 | 2 508 015 | 4,46% | Actions |
| NVP ASSOCIATES, LLC | $117 925 692 | 2 136 335 | 3,80% | Actions |
| Deep Track Capital, LP | $95 637 809 | 1 732 569 | 3,08% | Actions |
| Polar Capital Holdings Plc | $88 789 973 | 1 608 514 | 2,86% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $81 551 818 | 1 477 388 | 2,63% | Actions |
| Aaron Wealth Advisors LLC | $64 462 505 | 1 167 799 | 2,08% | Actions |
| Driehaus Capital Management LLC | $58 323 161 | 1 056 579 | 1,88% | Actions |
| VANGUARD GROUP INC | $57 333 759 | 1 817 811 | 1,85% | Actions |
| Kynam Capital Management, LP | $51 600 905 | 934 799 | 1,66% | Actions |
| Woodline Partners LP | $49 685 078 | 900 092 | 1,60% | Actions |
| EVENTIDE ASSET MANAGEMENT, LLC | $48 216 758 | 873 492 | 1,55% | Actions |
| STATE STREET CORP | $47 718 523 | 864 466 | 1,54% | Actions |
| Parkman Healthcare Partners LLC | $44 169 550 | 800 173 | 1,42% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $42 683 039 | 773 072 | 1,38% | Actions |
| BRAIDWELL LP | $39 240 576 | 710 880 | 1,26% | Actions |
| TCG Crossover Management, LLC | $35 880 000 | 650 000 | 1,16% | Actions |
| Cormorant Asset Management, LP | $30 360 000 | 550 000 | 0,98% | Actions |
| Soleus Capital Management, L.P. | $28 443 401 | 515 279 | 0,92% | Actions |
| GOLDMAN SACHS GROUP INC | $25 337 076 | 459 005 | 0,82% | Actions |
| MARSHALL WACE, LLP | $22 184 052 | 401 885 | 0,72% | Actions |
| EcoR1 Capital, LLC | $21 445 200 | 388 500 | 0,69% | Actions |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $19 138 778 | 346 717 | 0,62% | Actions |
| BANK OF AMERICA CORP /DE/ | $16 500 771 | 298 927 | 0,53% | Actions |
| Rock Springs Capital Management LP | $16 461 634 | 298 218 | 0,53% | Actions |
| Candriam S.C.A. | $15 986 698 | 289 893 | 0,52% | Actions |
| UBS Group AG | $15 055 635 | 272 747 | 0,49% | Actions |
| Opaleye Management Inc. | $14 352 000 | 260 000 | 0,46% | Actions |
| FRANKLIN RESOURCES INC | $13 947 108 | 252 665 | 0,45% | Actions |
| Schonfeld Strategic Advisors LLC | $13 726 583 | 248 670 | 0,44% | Actions |
| MORGAN STANLEY | $13 720 403 | 248 558 | 0,44% | Actions |
| NORTHERN TRUST CORP | $13 616 626 | 246 678 | 0,44% | Actions |
| DIMENSIONAL FUND ADVISORS LP | $12 900 240 | 233 700 | 0,42% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $12 866 844 | 233 095 | 0,41% | Actions |
| MILLENNIUM MANAGEMENT LLC | $12 483 535 | 226 151 | 0,40% | Actions |
| Tetragon Partners GP Ltd | $11 235 574 | 203 543 | 0,36% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $11 118 881 | 201 429 | 0,36% | Actions |
| Caption Management, LLC | $11 040 000 | 200 000 | 0,36% | Option d'achat |
| Caption Management, LLC | $11 040 000 | 200 000 | 0,36% | Option de vente |
| Caligan Partners LP | $11 040 000 | 200 000 | 0,36% | Actions |
| D. E. Shaw & Co., Inc. | $10 088 738 | 182 767 | 0,33% | Actions |
| JPMORGAN CHASE & CO | $7 518 053 | 139 611 | 0,24% | Actions |
| KVP Capital Advisors, LP | $6 708 125 | 121 524 | 0,22% | Actions |
| TWO SIGMA INVESTMENTS, LP | $6 263 820 | 113 475 | 0,20% | Actions |
| Burkehill Global Management, LP | $5 520 000 | 100 000 | 0,18% | Actions |
| Nuveen, LLC | $5 450 062 | 98 733 | 0,18% | Actions |
| TD Asset Management Inc | $5 277 010 | 95 598 | 0,17% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $5 210 880 | 94 400 | 0,17% | Option d'achat |
| Elmind Capital, LP | $5 023 200 | 91 000 | 0,16% | Actions |
| Bank of New York Mellon Corp | $4 908 760 | 88 927 | 0,16% | Actions |
| PRUDENTIAL FINANCIAL INC | $4 860 084 | 88 045 | 0,16% | Actions |
| BARCLAYS PLC | $4 849 540 | 87 854 | 0,16% | Actions |
| Affinity Asset Advisors, LLC | $4 140 000 | 75 000 | 0,13% | Actions |
| PFM Health Sciences, LP | $3 917 599 | 70 971 | 0,13% | Actions |
| BOOTHBAY FUND MANAGEMENT, LLC | $3 883 486 | 70 353 | 0,13% | Actions |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $3 649 382 | 66 112 | 0,12% | Actions |
| MOORE CAPITAL MANAGEMENT, LP | $3 582 094 | 64 893 | 0,12% | Actions |
| Rhenman & Partners Asset Management AB | $3 422 400 | 62 000 | 0,11% | Actions |
| Invesco Ltd. | $2 797 425 | 50 678 | 0,09% | Actions |
| ALPS ADVISORS INC | $2 650 262 | 48 012 | 0,09% | Actions |
| PLATINUM INVESTMENT MANAGEMENT LTD | $2 406 554 | 43 597 | 0,08% | Actions |
| Swiss National Bank | $2 368 080 | 42 900 | 0,08% | Actions |
| Ensign Peak Advisors, Inc | $2 327 011 | 42 156 | 0,08% | Actions |
| ALGERT GLOBAL LLC | $2 322 264 | 42 070 | 0,07% | Actions |
| Creative Planning | $2 181 724 | 39 524 | 0,07% | Actions |
| JANE STREET GROUP, LLC | $2 075 520 | 37 600 | 0,07% | Option d'achat |
| RHUMBLINE ADVISERS | $2 053 213 | 37 196 | 0,07% | Actions |
| DEUTSCHE BANK AG\ | $1 749 454 | 31 693 | 0,06% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1 711 200 | 31 000 | 0,06% | Option de vente |
| WELLS FARGO & COMPANY/MN | $1 562 878 | 28 313 | 0,05% | Actions |
| EXCHANGE TRADED CONCEPTS, LLC | $1 513 639 | 27 421 | 0,05% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1 472 957 | 26 684 | 0,05% | Actions |
| VOYA INVESTMENT MANAGEMENT LLC | $1 442 486 | 26 132 | 0,05% | Actions |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $1 424 160 | 25 800 | 0,05% | Actions |
| CITIGROUP INC | $1 386 734 | 25 122 | 0,04% | Actions |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $1 290 355 | 23 376 | 0,04% | Actions |
| AMERICAN CENTURY COMPANIES INC | $1 251 936 | 22 680 | 0,04% | Actions |
| AQR CAPITAL MANAGEMENT LLC | $1 247 023 | 22 591 | 0,04% | Actions |
| CITADEL ADVISORS LLC | $1 236 480 | 22 400 | 0,04% | Option d'achat |
| Legal & General Group Plc | $1 191 382 | 21 583 | 0,04% | Actions |
| Cerity Partners LLC | $1 159 034 | 20 997 | 0,04% | Actions |
| Vanguard Global Advisers, LLC | $1 047 089 | 18 969 | 0,03% | Actions |
| MetLife Investment Management, LLC | $1 007 400 | 18 250 | 0,03% | Actions |
| Russell Investments Group, Ltd. | $1 002 541 | 18 162 | 0,03% | Actions |
| Koa Wealth Management, LLC | $944 638 | 17 113 | 0,03% | Actions |
| ALLIANCEBERNSTEIN L.P. | $925 350 | 31 000 | 0,03% | Actions |
| STATE OF WISCONSIN INVESTMENT BOARD | $881 599 | 15 971 | 0,03% | Actions |
| VANGUARD ASSET MANAGEMENT, Ltd | $814 310 | 14 752 | 0,03% | Actions |
| OPTIMIZE FINANCIAL INC. | $798 082 | 14 458 | 0,03% | Actions |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $788 918 | 14 292 | 0,03% | Actions |
| DAFNA Capital Management LLC | $651 857 | 11 809 | 0,02% | Actions |
| HighVista Strategies LLC | $642 197 | 11 634 | 0,02% | Actions |
| NEW YORK STATE COMMON RETIREMENT FUND | $607 200 | 11 000 | 0,02% | Actions |
| FRED ALGER MANAGEMENT, LLC | $545 210 | 9 877 | 0,02% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $544 272 | 9 860 | 0,02% | Actions |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $539 690 | 9 777 | 0,02% | Actions |
| Virtus Investment Advisers, LLC | $508 668 | 9 215 | 0,02% | Actions |
| China Universal Asset Management Co., Ltd. | $506 460 | 9 175 | 0,02% | Actions |
| Police & Firemen's Retirement System of New Jersey | $505 301 | 9 154 | 0,02% | Actions |
| PROFUND ADVISORS LLC | $486 422 | 8 812 | 0,02% | Actions |
| Brevan Howard Capital Management LP | $474 830 | 8 602 | 0,02% | Actions |
| ACT CAPITAL MANAGEMENT, LLC | $441 600 | 8 000 | 0,01% | Actions |
| DNB Asset Management AS | $430 174 | 7 793 | 0,01% | Actions |
| AXQ CAPITAL, LP | $428 186 | 7 757 | 0,01% | Actions |
| State of New Jersey Common Pension Fund D | $381 598 | 6 913 | 0,01% | Actions |
| Quantinno Capital Management LP | $358 634 | 6 497 | 0,01% | Actions |
| Rafferty Asset Management, LLC | $353 832 | 6 410 | 0,01% | Actions |
| XTX Topco Ltd | $352 838 | 6 392 | 0,01% | Actions |
| Vanguard Investments Australia, Ltd. | $336 886 | 6 103 | 0,01% | Actions |
| Seven Fleet Capital Management LP | $331 200 | 6 000 | 0,01% | Actions |
| INTECH INVESTMENT MANAGEMENT LLC | $328 495 | 5 951 | 0,01% | Actions |
| ARIZONA STATE RETIREMENT SYSTEM | $325 625 | 5 899 | 0,01% | Actions |
| SEI INVESTMENTS CO | $323 914 | 5 868 | 0,01% | Actions |
| ProShare Advisors LLC | $310 335 | 5 622 | 0,01% | Actions |
| JANUS HENDERSON GROUP PLC | $308 176 | 10 300 | 0,01% | Actions |
| Blackstone Inc. | $305 422 | 5 533 | 0,01% | Actions |
| GROUP ONE TRADING LLC | $288 751 | 5 231 | 0,01% | Actions |
| CANADA PENSION PLAN INVESTMENT BOARD | $287 040 | 5 200 | 0,01% | Actions |
| KLP KAPITALFORVALTNING AS | $270 480 | 4 900 | 0,01% | Actions |
| Verdad Advisers, LP | $252 485 | 4 574 | 0,01% | Actions |
| Pictet Asset Management Holding SA | $226 210 | 4 098 | 0,01% | Actions |
| Goelzer Investment Management, Inc. | $220 800 | 4 000 | 0,01% | Actions |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $216 054 | 7 238 | 0,01% | Actions |
| Quantbot Technologies LP | $212 796 | 3 855 | 0,01% | Actions |
| Susquehanna Portfolio Strategies, LLC | $209 760 | 3 800 | 0,01% | Actions |
| CITADEL ADVISORS LLC | $209 760 | 3 800 | 0,01% | Option de vente |
| Tower Research Capital LLC (TRC) | $201 535 | 3 651 | 0,01% | Actions |
| Ameritas Investment Partners, Inc. | $155 498 | 2 817 | 0,01% | Actions |
| Mirae Asset Global Investments Co., Ltd. | $117 521 | 2 129 | 0,00% | Actions |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $115 147 | 2 086 | 0,00% | Actions |
| NISA INVESTMENT ADVISORS, LLC | $111 118 | 2 013 | 0,00% | Actions |
| STRS OHIO | $110 400 | 2 000 | 0,00% | Actions |
| ROYAL BANK OF CANADA | $81 000 | 1 464 | 0,00% | Actions |
| SIMPLEX TRADING, LLC | $73 250 | 1 327 | 0,00% | Actions |
| State of Wyoming | $58 236 | 1 055 | 0,00% | Actions |
| CWM, LLC | $52 894 | 1 772 | 0,00% | Actions |
| GF FUND MANAGEMENT CO. LTD. | $52 550 | 952 | 0,00% | Actions |
| PRICE T ROWE ASSOCIATES INC /MD/ | $44 978 | 814 807 | 0,00% | Actions |
| Kemnay Advisory Services Inc. | $17 719 | 321 | 0,00% | Actions |
| GAMMA Investing LLC | $16 781 | 304 | 0,00% | Actions |
| OSAIC HOLDINGS, INC. | $15 566 | 282 | 0,00% | Actions |
| Arax Advisory Partners | $15 401 | 279 | 0,00% | Actions |
| Rockefeller Capital Management L.P. | $12 365 | 224 | 0,00% | Actions |
| PNC Financial Services Group, Inc. | $11 426 | 207 | 0,00% | Actions |
| Versant Capital Management, Inc | $10 552 | 180 | 0,00% | Actions |
| FIL Ltd | $9 826 | 178 | 0,00% | Actions |
| Aster Capital Management (DIFC) Ltd | $9 494 | 172 | 0,00% | Actions |
| Physician Wealth Advisors, Inc. | $6 680 | 121 | 0,00% | Actions |
| Sterling Capital Management LLC | $6 017 | 109 | 0,00% | Actions |
| US BANCORP \DE\ | $5 962 | 108 | 0,00% | Actions |
| J.Safra Asset Management Corp | $4 692 | 85 | 0,00% | Actions |
| Parallel Advisors, LLC | $4 361 | 79 | 0,00% | Actions |
| SIGNATUREFD, LLC | $4 306 | 78 | 0,00% | Actions |
| JONES FINANCIAL COMPANIES LLLP | $4 185 | 80 | 0,00% | Actions |
| Keating Financial Advisory Services, Inc. | $2 981 | 54 | 0,00% | Actions |
| Larson Financial Group LLC | $2 705 | 49 | 0,00% | Actions |
| Allworth Financial LP | $2 650 | 48 | 0,00% | Actions |
| EverSource Wealth Advisors, LLC | $2 649 | 48 | 0,00% | Actions |
| ROTHSCHILD INVESTMENT LLC | $2 153 | 39 | 0,00% | Actions |
| Cornerstone Financial Management LLC | $1 877 | 34 | 0,00% | Actions |
| Bare Financial Services, Inc | $1 877 | 34 | 0,00% | Actions |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $1 401 | 25 377 | 0,00% | Actions |
| Fortitude Family Office, LLC | $1 049 | 19 | 0,00% | Actions |
| Global Retirement Partners, LLC | $1 049 | 19 | 0,00% | Actions |
| Quarry LP | $994 | 18 | 0,00% | Actions |
| Essential Partners LLC | $828 | 15 | 0,00% | Actions |
| Silver Grove Financial Group, Inc. | $718 | 13 | 0,00% | Actions |
| NATIONAL BANK OF CANADA /FI/ | $607 | 11 | 0,00% | Actions |
| Farther Finance Advisors, LLC | $497 | 9 | 0,00% | Actions |
| SG Americas Securities, LLC | $345 | 6 245 | 0,00% | Actions |
| SJS Investment Consulting Inc. | $111 | 2 | 0,00% | Actions |
| Hughes Financial Services, LLC | $55 | 1 | 0,00% | Actions |
| KBC Group NV | $45 | 810 | 0,00% | Actions |
| Covestor Ltd | $1 | 10 | 0,00% | Actions |