SEPN — Détenteurs institutionnels (13F)
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $234 291 284 | 6 995 858 | 14,22% | Actions |
| TRV GP V, LLC | $208 160 143 | 6 215 591 | 12,64% | Actions |
| Driehaus Capital Management LLC | $148 463 112 | 4 433 058 | 9,01% | Actions |
| TRV GP VI, LLC | $141 048 460 | 4 211 659 | 8,56% | Actions |
| SAMSARA BIOCAPITAL, LLC | $105 464 297 | 3 149 128 | 6,40% | Actions |
| GOLDMAN SACHS GROUP INC | $102 572 033 | 3 062 766 | 6,23% | Actions |
| BlackRock, Inc. | $64 705 629 | 1 932 088 | 3,93% | Actions |
| Siren, L.L.C. | $63 631 000 | 1 900 000 | 3,86% | Actions |
| Avoro Capital Advisors LLC | $44 792 875 | 1 337 500 | 2,72% | Actions |
| VANGUARD GROUP INC | $42 048 476 | 1 508 195 | 2,55% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $40 913 829 | 1 221 673 | 2,48% | Actions |
| PRIMECAP MANAGEMENT CO/CA/ | $39 095 624 | 1 167 382 | 2,37% | Actions |
| First Light Asset Management, LLC | $32 259 577 | 963 260 | 1,96% | Actions |
| ADAR1 Capital Management, LLC | $31 505 617 | 940 747 | 1,91% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $22 750 071 | 679 163 | 1,38% | Actions |
| STATE STREET CORP | $21 856 579 | 652 630 | 1,33% | Actions |
| JANUS HENDERSON GROUP PLC | $21 333 558 | 890 754 | 1,30% | Actions |
| LOOMIS SAYLES & CO L P | $20 922 944 | 624 752 | 1,27% | Actions |
| Casdin Capital, LLC | $18 528 945 | 553 268 | 1,12% | Actions |
| Catalio Capital Management, LP | $17 955 730 | 536 152 | 1,09% | Actions |
| Caption Management, LLC | $14 735 600 | 440 000 | 0,89% | Option d'achat |
| ALGERT GLOBAL LLC | $13 311 840 | 397 487 | 0,81% | Actions |
| Balyasny Asset Management L.P. | $11 736 303 | 350 442 | 0,71% | Actions |
| Longaeva Partners L.P. | $9 985 747 | 298 171 | 0,61% | Actions |
| Soleus Capital Management, L.P. | $9 209 750 | 275 000 | 0,56% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $8 774 380 | 262 000 | 0,53% | Option d'achat |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $7 708 862 | 230 184 | 0,47% | Actions |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $7 458 290 | 222 702 | 0,45% | Actions |
| TWO SIGMA INVESTMENTS, LP | $7 397 439 | 220 885 | 0,45% | Actions |
| NORTHERN TRUST CORP | $6 735 877 | 201 131 | 0,41% | Actions |
| TUDOR INVESTMENT CORP ET AL | $6 698 000 | 200 000 | 0,41% | Option d'achat |
| Caption Management, LLC | $6 698 000 | 200 000 | 0,41% | Option de vente |
| Kalehua Capital Management LLC | $6 515 279 | 194 544 | 0,40% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $6 264 003 | 187 041 | 0,38% | Actions |
| Woodline Partners LP | $6 213 567 | 185 535 | 0,38% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $5 547 819 | 165 656 | 0,34% | Actions |
| MORGAN STANLEY | $4 500 286 | 134 377 | 0,27% | Actions |
| TUDOR INVESTMENT CORP ET AL | $3 349 000 | 100 000 | 0,20% | Option de vente |
| UBS Group AG | $3 009 880 | 89 874 | 0,18% | Actions |
| JPMORGAN CHASE & CO | $2 964 211 | 85 301 | 0,18% | Actions |
| FEDERATED HERMES, INC. | $2 905 358 | 86 753 | 0,18% | Actions |
| CITADEL ADVISORS LLC | $2 739 482 | 81 800 | 0,17% | Option d'achat |
| LAZARD ASSET MANAGEMENT LLC | $2 525 983 | 75 425 | 0,15% | Actions |
| DIMENSIONAL FUND ADVISORS LP | $2 522 961 | 75 309 | 0,15% | Actions |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $2 499 995 | 74 649 | 0,15% | Actions |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $2 283 348 | 68 180 | 0,14% | Actions |
| HUSSMAN STRATEGIC ADVISORS, INC. | $2 109 870 | 63 000 | 0,13% | Actions |
| AMERICAN CENTURY COMPANIES INC | $2 041 986 | 60 973 | 0,12% | Actions |
| DIADEMA PARTNERS LP | $1 999 353 | 59 700 | 0,12% | Option de vente |
| JANE STREET GROUP, LLC | $1 915 628 | 57 200 | 0,12% | Option d'achat |
| Bank of New York Mellon Corp | $1 881 334 | 56 176 | 0,11% | Actions |
| XTX Topco Ltd | $1 824 837 | 54 489 | 0,11% | Actions |
| MILLENNIUM MANAGEMENT LLC | $1 693 321 | 50 562 | 0,10% | Actions |
| BARCLAYS PLC | $1 668 506 | 49 821 | 0,10% | Actions |
| Elmind Capital, LP | $1 655 880 | 49 444 | 0,10% | Actions |
| Nuveen, LLC | $1 615 189 | 48 229 | 0,10% | Actions |
| Sofinnova Investments, Inc. | $1 590 976 | 47 506 | 0,10% | Actions |
| D. E. Shaw & Co., Inc. | $1 556 716 | 46 483 | 0,09% | Actions |
| JANE STREET GROUP, LLC | $1 525 537 | 45 552 | 0,09% | Actions |
| Voleon Capital Management LP | $1 488 128 | 44 435 | 0,09% | Actions |
| RENAISSANCE TECHNOLOGIES LLC | $1 387 122 | 41 419 | 0,08% | Actions |
| Russell Investments Group, Ltd. | $1 346 606 | 40 209 | 0,08% | Actions |
| Caption Management, LLC | $1 272 821 | 38 006 | 0,08% | Actions |
| BANK OF AMERICA CORP /DE/ | $1 201 453 | 35 875 | 0,07% | Actions |
| Alyeska Investment Group, L.P. | $1 172 150 | 35 000 | 0,07% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1 135 311 | 33 900 | 0,07% | Option de vente |
| Brevan Howard Capital Management LP | $986 347 | 29 452 | 0,06% | Actions |
| HighVista Strategies LLC | $982 496 | 29 337 | 0,06% | Actions |
| TUDOR INVESTMENT CORP ET AL | $970 071 | 28 966 | 0,06% | Actions |
| RHUMBLINE ADVISERS | $925 521 | 27 636 | 0,06% | Actions |
| Trexquant Investment LP | $858 851 | 25 645 | 0,05% | Actions |
| Invesco Ltd. | $806 908 | 24 094 | 0,05% | Actions |
| Logos Global Management LP | $788 623 | 23 548 | 0,05% | Actions |
| FMR LLC | $778 308 | 23 240 | 0,05% | Actions |
| FOX RUN MANAGEMENT, L.L.C. | $738 053 | 22 038 | 0,04% | Actions |
| DEUTSCHE BANK AG\ | $732 527 | 21 873 | 0,04% | Actions |
| ALLIANCEBERNSTEIN L.P. | $718 497 | 29 900 | 0,04% | Actions |
| TWO SIGMA ADVISERS, LP | $716 516 | 25 700 | 0,04% | Actions |
| Squarepoint Ops LLC | $710 624 | 21 219 | 0,04% | Actions |
| STRS OHIO | $703 290 | 21 000 | 0,04% | Actions |
| FRED ALGER MANAGEMENT, LLC | $701 883 | 20 958 | 0,04% | Actions |
| Jump Financial, LLC | $676 498 | 20 200 | 0,04% | Actions |
| Swiss National Bank | $663 102 | 19 800 | 0,04% | Actions |
| WELLS FARGO & COMPANY/MN | $659 218 | 19 684 | 0,04% | Actions |
| FRANKLIN RESOURCES INC | $623 148 | 18 607 | 0,04% | Actions |
| CITIGROUP INC | $596 390 | 17 808 | 0,04% | Actions |
| Aquatic Capital Management LLC | $583 630 | 17 427 | 0,04% | Actions |
| Engineers Gate Manager LP | $581 052 | 17 350 | 0,04% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $567 522 | 16 946 | 0,03% | Actions |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $555 833 | 16 597 | 0,03% | Actions |
| State of Wyoming | $548 533 | 16 379 | 0,03% | Actions |
| Vanguard Global Advisers, LLC | $544 112 | 16 247 | 0,03% | Actions |
| AQR CAPITAL MANAGEMENT LLC | $515 646 | 15 397 | 0,03% | Actions |
| VIRGINIA RETIREMENT SYSTEMS ET Al | $445 417 | 13 300 | 0,03% | Actions |
| Verdad Advisers, LP | $434 365 | 12 970 | 0,03% | Actions |
| MetLife Investment Management, LLC | $431 351 | 12 880 | 0,03% | Actions |
| OSAIC HOLDINGS, INC. | $421 772 | 12 594 | 0,03% | Actions |
| Man Group plc | $384 097 | 11 469 | 0,02% | Actions |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $363 902 | 10 866 | 0,02% | Actions |
| China Universal Asset Management Co., Ltd. | $360 821 | 10 774 | 0,02% | Actions |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $341 364 | 10 193 | 0,02% | Actions |
| Legal & General Group Plc | $336 976 | 10 062 | 0,02% | Actions |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $334 297 | 9 982 | 0,02% | Actions |
| Gotham Asset Management, LLC | $312 194 | 9 322 | 0,02% | Actions |
| Virtus Investment Advisers, LLC | $304 826 | 9 102 | 0,02% | Actions |
| CANADA PENSION PLAN INVESTMENT BOARD | $298 061 | 8 900 | 0,02% | Actions |
| NEW YORK STATE COMMON RETIREMENT FUND | $284 665 | 8 500 | 0,02% | Actions |
| FIRST TRUST ADVISORS LP | $259 179 | 7 739 | 0,02% | Actions |
| Creative Planning | $255 729 | 7 636 | 0,02% | Actions |
| VANGUARD ASSET MANAGEMENT, Ltd | $248 496 | 7 420 | 0,02% | Actions |
| Quantinno Capital Management LP | $245 482 | 7 330 | 0,01% | Actions |
| CIBC Bancorp USA Inc. | $241 865 | 7 222 | 0,01% | Actions |
| Rangeley Capital, LLC | $241 128 | 7 200 | 0,01% | Actions |
| OCCUDO QUANTITATIVE STRATEGIES LP | $240 827 | 7 191 | 0,01% | Actions |
| WINTON GROUP Ltd | $240 525 | 7 182 | 0,01% | Actions |
| Police & Firemen's Retirement System of New Jersey | $218 589 | 6 527 | 0,01% | Actions |
| CITADEL ADVISORS LLC | $212 662 | 6 350 | 0,01% | Actions |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $211 121 | 6 304 | 0,01% | Actions |
| CAPTRUST FINANCIAL ADVISORS | $208 006 | 6 211 | 0,01% | Actions |
| STATE OF WISCONSIN INVESTMENT BOARD | $204 122 | 6 095 | 0,01% | Actions |
| Chung Wu Investment Group, LLC | $160 752 | 4 800 | 0,01% | Actions |
| Congress Wealth Management LLC / DE / | $133 065 | 12 589 | 0,01% | Actions |
| Vanguard Investments Australia, Ltd. | $130 444 | 3 895 | 0,01% | Actions |
| Lindbrook Capital, LLC | $121 590 | 21 000 | 0,01% | Actions |
| KLP KAPITALFORVALTNING AS | $83 725 | 2 500 | 0,01% | Actions |
| ROYAL BANK OF CANADA | $70 000 | 2 098 | 0,00% | Actions |
| Mirae Asset Global Investments Co., Ltd. | $67 516 | 2 016 | 0,00% | Actions |
| Ameritas Investment Partners, Inc. | $65 105 | 1 944 | 0,00% | Actions |
| Steward Partners Investment Advisory, LLC | $44 374 | 1 325 | 0,00% | Actions |
| GAMMA Investing LLC | $37 475 | 1 119 | 0,00% | Actions |
| Tower Research Capital LLC (TRC) | $35 466 | 1 059 | 0,00% | Actions |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $32 519 | 971 | 0,00% | Actions |
| SIGNATUREFD, LLC | $32 351 | 966 | 0,00% | Actions |
| GF FUND MANAGEMENT CO. LTD. | $31 816 | 950 | 0,00% | Actions |
| NISA INVESTMENT ADVISORS, LLC | $25 720 | 768 | 0,00% | Actions |
| CWM, LLC | $21 483 | 894 | 0,00% | Actions |
| Persistent Asset Partners Ltd | $18 207 | 152 | 0,00% | Option de vente |
| Quantbot Technologies LP | $17 247 | 515 | 0,00% | Actions |
| Amova Asset Management Americas, Inc. | $16 934 | 507 | 0,00% | Actions |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $12 123 | 362 | 0,00% | Actions |
| Pinnacle Wealth Planning Services, Inc. | $10 784 | 322 | 0,00% | Actions |
| Versant Capital Management, Inc | $10 213 | 261 | 0,00% | Actions |
| Arax Advisory Partners | $7 904 | 236 | 0,00% | Actions |
| US BANCORP \DE\ | $7 368 | 220 | 0,00% | Actions |
| Sterling Capital Management LLC | $6 698 | 200 | 0,00% | Actions |
| Larson Financial Group LLC | $6 564 | 196 | 0,00% | Actions |
| N.E.W. Advisory Services LLC | $6 028 | 180 | 0,00% | Actions |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $3 725 | 155 | 0,00% | Actions |
| MassMutual Private Wealth & Trust, FSB | $3 483 | 104 | 0,00% | Actions |
| Aster Capital Management (DIFC) Ltd | $3 416 | 102 | 0,00% | Actions |
| Caitong International Asset Management Co., Ltd | $2 579 | 77 | 0,00% | Actions |
| EverSource Wealth Advisors, LLC | $2 142 | 64 | 0,00% | Actions |
| SBI Securities Co., Ltd. | $1 842 | 55 | 0,00% | Actions |
| Cornerstone Financial Management LLC | $1 741 | 52 | 0,00% | Actions |
| PNC Financial Services Group, Inc. | $1 507 | 45 | 0,00% | Actions |
| HRT FINANCIAL LP | $1 407 | 42 022 | 0,00% | Actions |
| PRICE T ROWE ASSOCIATES INC /MD/ | $1 183 | 35 323 | 0,00% | Actions |
| ROTHSCHILD INVESTMENT LLC | $1 005 | 30 | 0,00% | Actions |
| ACADIAN ASSET MANAGEMENT LLC | $701 | 20 996 | 0,00% | Actions |
| Fortitude Family Office, LLC | $670 | 20 | 0,00% | Actions |
| Ameritas Advisory Services, LLC | $603 | 18 | 0,00% | Actions |
| NATIONAL BANK OF CANADA /FI/ | $234 | 7 | 0,00% | Actions |
| SJS Investment Consulting Inc. | $201 | 6 | 0,00% | Actions |
| Global Retirement Partners, LLC | $100 | 3 | 0,00% | Actions |
| Covestor Ltd | $72 | 2 123 | 0,00% | Actions |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | $65 | 1 946 | 0,00% | Actions |
| Allworth Financial LP | $34 | 1 | 0,00% | Actions |
| Silver Grove Financial Group, Inc. | $33 | 1 | 0,00% | Actions |