| TCG Crossover Management, LLC |
$36,000,000 |
11,111,111 |
8.86% |
株式数
|
| BlackRock, Inc. |
$34,311,568 |
10,589,990 |
8.44% |
株式数
|
| RA CAPITAL MANAGEMENT, L.P. |
$28,800,360 |
8,889,000 |
7.09% |
株式数
|
| Commodore Capital LP |
$28,800,360 |
8,889,000 |
7.09% |
株式数
|
| ADAR1 Capital Management, LLC |
$28,800,360 |
8,889,000 |
7.09% |
株式数
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$19,897,929 |
6,141,336 |
4.90% |
株式数
|
| Paradigm Biocapital Advisors LP |
$18,100,665 |
5,586,625 |
4.45% |
株式数
|
| VANGUARD GROUP INC |
$16,826,539 |
8,208,068 |
4.14% |
株式数
|
| Opaleye Management Inc. |
$12,512,653 |
3,861,930 |
3.08% |
株式数
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$11,658,618 |
3,598,339 |
2.87% |
株式数
|
| Woodline Partners LP |
$11,519,810 |
3,555,497 |
2.84% |
株式数
|
| Vivo Capital, LLC |
$11,519,010 |
3,555,250 |
2.83% |
株式数
|
| GordonMD Global Investments LP |
$10,131,480 |
3,127,000 |
2.49% |
株式数
|
| GOLDMAN SACHS GROUP INC |
$8,469,476 |
2,614,036 |
2.08% |
株式数
|
| GEODE CAPITAL MANAGEMENT, LLC |
$8,325,643 |
2,569,072 |
2.05% |
株式数
|
| RENAISSANCE TECHNOLOGIES LLC |
$7,999,298 |
2,468,919 |
1.97% |
株式数
|
| Logos Global Management LP |
$7,199,280 |
2,222,000 |
1.77% |
株式数
|
| STATE STREET CORP |
$7,101,442 |
2,191,803 |
1.75% |
株式数
|
| MARSHALL WACE, LLP |
$6,600,808 |
2,037,287 |
1.62% |
株式数
|
| D. E. Shaw & Co., Inc. |
$6,159,246 |
1,901,002 |
1.52% |
株式数
|
| JPMORGAN CHASE & CO |
$5,959,980 |
1,862,494 |
1.47% |
株式数
|
| AQR CAPITAL MANAGEMENT LLC |
$5,094,065 |
1,572,242 |
1.25% |
株式数
|
| TWO SIGMA INVESTMENTS, LP |
$4,318,842 |
1,332,976 |
1.06% |
株式数
|
| Seven Fleet Capital Management LP |
$4,310,820 |
1,330,500 |
1.06% |
株式数
|
| RAYMOND JAMES FINANCIAL INC |
$4,273,389 |
1,318,947 |
1.05% |
株式数
|
| KENNEDY CAPITAL MANAGEMENT LLC |
$3,344,111 |
1,032,133 |
0.82% |
株式数
|
| MACKENZIE FINANCIAL CORP |
$2,844,856 |
878,042 |
0.70% |
株式数
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$2,812,424 |
868,032 |
0.69% |
株式数
|
| Nantahala Capital Management, LLC |
$2,762,748 |
852,700 |
0.68% |
株式数
|
| NORTHERN TRUST CORP |
$2,655,806 |
819,693 |
0.65% |
株式数
|
| TWO SIGMA ADVISERS, LP |
$2,509,405 |
1,224,100 |
0.62% |
株式数
|
| UBS Group AG |
$2,432,472 |
750,763 |
0.60% |
株式数
|
| VANGUARD FIDUCIARY TRUST CO |
$2,407,158 |
742,950 |
0.59% |
株式数
|
| Nuveen, LLC |
$1,688,730 |
521,213 |
0.42% |
株式数
|
| MILLENNIUM MANAGEMENT LLC |
$1,616,750 |
498,997 |
0.40% |
株式数
|
| Susquehanna Portfolio Strategies, LLC |
$1,545,801 |
477,099 |
0.38% |
株式数
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1,521,180 |
469,500 |
0.37% |
コールオプション
|
| Eversept Partners, LP |
$1,486,541 |
458,809 |
0.37% |
株式数
|
| Casdin Capital, LLC |
$1,441,800 |
445,000 |
0.35% |
株式数
|
| PEAK6 LLC |
$1,346,029 |
415,441 |
0.33% |
株式数
|
| DIADEMA PARTNERS LP |
$1,296,000 |
400,000 |
0.32% |
コールオプション
|
| MORGAN STANLEY |
$1,108,616 |
342,165 |
0.27% |
株式数
|
| BIT Capital GmbH |
$1,056,240 |
326,000 |
0.26% |
株式数
|
| WELLINGTON MANAGEMENT GROUP LLP |
$1,002,440 |
309,395 |
0.25% |
株式数
|
| Cubist Systematic Strategies, LLC |
$994,094 |
286,482 |
0.24% |
株式数
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$878,642 |
271,186 |
0.22% |
株式数
|
| Bank of New York Mellon Corp |
$850,907 |
262,625 |
0.21% |
株式数
|
| BANK OF AMERICA CORP /DE/ |
$751,119 |
231,827 |
0.18% |
株式数
|
| LPL Financial LLC |
$748,813 |
231,115 |
0.18% |
株式数
|
| Erste Asset Management GmbH |
$736,000 |
230,000 |
0.18% |
株式数
|
| IEQ CAPITAL, LLC |
$705,623 |
217,785 |
0.17% |
株式数
|
| CITADEL ADVISORS LLC |
$689,345 |
212,761 |
0.17% |
株式数
|
| Invesco Ltd. |
$686,492 |
211,880 |
0.17% |
株式数
|
| Walleye Capital LLC |
$595,703 |
183,859 |
0.15% |
株式数
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$558,900 |
172,500 |
0.14% |
プットオプション
|
| CITADEL ADVISORS LLC |
$557,604 |
172,100 |
0.14% |
プットオプション
|
| DAFNA Capital Management LLC |
$552,323 |
170,470 |
0.14% |
株式数
|
| Mariner, LLC |
$548,500 |
169,291 |
0.13% |
株式数
|
| Green Alpha Advisors, LLC |
$505,589 |
156,046 |
0.12% |
株式数
|
| PEAK6 LLC |
$497,340 |
153,500 |
0.12% |
コールオプション
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$490,555 |
151,406 |
0.12% |
株式数
|
| Russell Investments Group, Ltd. |
$485,558 |
149,864 |
0.12% |
株式数
|
| BARCLAYS PLC |
$483,615 |
149,264 |
0.12% |
株式数
|
| ALLIANCEBERNSTEIN L.P. |
$464,187 |
187,930 |
0.11% |
株式数
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$445,030 |
137,355 |
0.11% |
株式数
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$408,240 |
126,000 |
0.10% |
株式数
|
| Point72 Asset Management, L.P. |
$405,758 |
125,234 |
0.10% |
株式数
|
| WELLS FARGO & COMPANY/MN |
$391,240 |
120,753 |
0.10% |
株式数
|
| RHUMBLINE ADVISERS |
$380,421 |
117,417 |
0.09% |
株式数
|
| JANE STREET GROUP, LLC |
$374,473 |
115,578 |
0.09% |
株式数
|
| FMR LLC |
$360,281 |
111,198 |
0.09% |
株式数
|
| DEUTSCHE BANK AG\ |
$321,942 |
99,365 |
0.08% |
株式数
|
| HSBC HOLDINGS PLC |
$314,481 |
97,062 |
0.08% |
株式数
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$300,818 |
92,845 |
0.07% |
株式数
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$300,226 |
92,094 |
0.07% |
株式数
|
| AMERICAN CENTURY COMPANIES INC |
$300,011 |
92,596 |
0.07% |
株式数
|
| CWM, LLC |
$259,352 |
105,001 |
0.06% |
株式数
|
| STIFEL FINANCIAL CORP |
$242,293 |
74,782 |
0.06% |
株式数
|
| CITADEL ADVISORS LLC |
$229,392 |
70,800 |
0.06% |
コールオプション
|
| OSAIC HOLDINGS, INC. |
$227,198 |
70,124 |
0.06% |
株式数
|
| SEI INVESTMENTS CO |
$221,188 |
68,268 |
0.05% |
株式数
|
| Joel Isaacson & Co., LLC |
$220,787 |
68,144 |
0.05% |
株式数
|
| JANE STREET GROUP, LLC |
$218,376 |
67,400 |
0.05% |
プットオプション
|
| SIMPLEX TRADING, LLC |
$207,275 |
63,974 |
0.05% |
株式数
|
| CITIGROUP INC |
$200,763 |
61,964 |
0.05% |
株式数
|
| MetLife Investment Management, LLC |
$182,140 |
56,216 |
0.04% |
株式数
|
| Cerity Partners LLC |
$181,867 |
56,132 |
0.04% |
株式数
|
| MML INVESTORS SERVICES, LLC |
$168,765 |
52,088 |
0.04% |
株式数
|
| GROUP ONE TRADING LLC |
$163,131 |
50,349 |
0.04% |
株式数
|
| Creative Planning |
$147,653 |
45,572 |
0.04% |
株式数
|
| China Universal Asset Management Co., Ltd. |
$143,934 |
44,424 |
0.04% |
株式数
|
| WINTON GROUP Ltd |
$141,588 |
43,700 |
0.03% |
株式数
|
| Vanguard Global Advisers, LLC |
$138,876 |
42,863 |
0.03% |
株式数
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$137,376 |
42,400 |
0.03% |
株式数
|
| Graham Capital Management, L.P. |
$134,369 |
41,472 |
0.03% |
株式数
|
| Quinn Opportunity Partners LLC |
$129,600 |
40,000 |
0.03% |
株式数
|
| Vanguard Personalized Indexing Management, LLC |
$124,108 |
38,305 |
0.03% |
株式数
|
| MERCER GLOBAL ADVISORS INC /ADV |
$121,967 |
37,644 |
0.03% |
株式数
|
| Balyasny Asset Management L.P. |
$121,947 |
37,638 |
0.03% |
株式数
|
| AXQ CAPITAL, LP |
$118,104 |
36,452 |
0.03% |
株式数
|
| SCS Capital Management LLC |
$113,400 |
35,000 |
0.03% |
株式数
|
| Police & Firemen's Retirement System of New Jersey |
$109,749 |
33,873 |
0.03% |
株式数
|
| Thrive Wealth Management, LLC |
$108,540 |
33,500 |
0.03% |
株式数
|
| TWO SIGMA SECURITIES, LLC |
$107,367 |
33,138 |
0.03% |
株式数
|
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC |
$102,359 |
31,207 |
0.03% |
株式数
|
| CAPTRUST FINANCIAL ADVISORS |
$98,159 |
30,296 |
0.02% |
株式数
|
| HORIZON KINETICS ASSET MANAGEMENT LLC |
$89,683 |
27,680 |
0.02% |
株式数
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$88,339 |
27,265 |
0.02% |
株式数
|
| Focus Partners Wealth |
$88,336 |
27,264 |
0.02% |
株式数
|
| EntryPoint Capital, LLC |
$87,299 |
26,944 |
0.02% |
株式数
|
| Prime Capital Investment Advisors, LLC |
$85,766 |
26,471 |
0.02% |
株式数
|
| JANE STREET GROUP, LLC |
$85,536 |
26,400 |
0.02% |
コールオプション
|
| Vise Technologies, Inc. |
$83,573 |
25,794 |
0.02% |
株式数
|
| INTECH INVESTMENT MANAGEMENT LLC |
$83,148 |
25,663 |
0.02% |
株式数
|
| DLK Investment Management, LLC |
$82,668 |
17,702 |
0.02% |
株式数
|
| Corient Private Wealth LP |
$79,854 |
24,646 |
0.02% |
株式数
|
| XTX Topco Ltd |
$77,656 |
23,968 |
0.02% |
株式数
|
| COMMONWEALTH EQUITY SERVICES, LLC |
$74,370 |
22,954 |
0.02% |
株式数
|
| Rockefeller Capital Management L.P. |
$72,787 |
22,465 |
0.02% |
株式数
|
| BNP PARIBAS FINANCIAL MARKETS |
$71,231 |
21,985 |
0.02% |
株式数
|
| State of Wyoming |
$69,790 |
21,540 |
0.02% |
株式数
|
| HighTower Advisors, LLC |
$69,718 |
21,518 |
0.02% |
株式数
|
| VOYA INVESTMENT MANAGEMENT LLC |
$66,537 |
20,536 |
0.02% |
株式数
|
| INDEPENDENT FINANCIAL GROUP, LLC |
$66,128 |
20,410 |
0.02% |
株式数
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$61,884 |
19,100 |
0.02% |
株式数
|
| PRUDENTIAL FINANCIAL INC |
$60,718 |
18,740 |
0.01% |
株式数
|
| ROYAL BANK OF CANADA |
$59,000 |
18,103 |
0.01% |
株式数
|
| ProShare Advisors LLC |
$58,765 |
18,137 |
0.01% |
株式数
|
| BRIGHTON JONES LLC |
$57,515 |
17,751 |
0.01% |
株式数
|
| VICTORY CAPITAL MANAGEMENT INC |
$57,160 |
17,642 |
0.01% |
株式数
|
| Cetera Investment Advisers |
$52,336 |
16,153 |
0.01% |
株式数
|
| StoneX Group Inc. |
$51,085 |
16,213 |
0.01% |
株式数
|
| STRATEGIC ADVISORY PARTNERS, LLC |
$48,691 |
15,028 |
0.01% |
株式数
|
| Abel Hall, LLC |
$47,638 |
14,703 |
0.01% |
株式数
|
| Persistent Asset Partners Ltd |
$47,303 |
1,023 |
0.01% |
コールオプション
|
| Callan Family Office, LLC |
$46,860 |
14,463 |
0.01% |
株式数
|
| Brevan Howard Capital Management LP |
$46,523 |
14,359 |
0.01% |
株式数
|
| Keystone Financial Group |
$45,522 |
14,050 |
0.01% |
株式数
|
| Aries Wealth Management |
$40,500 |
12,500 |
0.01% |
株式数
|
| Pallas Capital Advisors LLC |
$37,944 |
11,711 |
0.01% |
株式数
|
| Merit Financial Group, LLC |
$37,474 |
11,566 |
0.01% |
株式数
|
| Gibbs Wealth Management |
$35,769 |
10,308 |
0.01% |
株式数
|
| Tower Research Capital LLC (TRC) |
$35,731 |
11,028 |
0.01% |
株式数
|
| Point72 (DIFC) Ltd |
$34,276 |
9,878 |
0.01% |
株式数
|
| Valeo Financial Advisors, LLC |
$32,536 |
10,042 |
0.01% |
株式数
|
| Kera Capital Partners, Inc. |
$32,462 |
10,019 |
0.01% |
株式数
|
| Raiffeisen Bank International AG |
$32,400 |
10,000 |
0.01% |
コールオプション
|
| Legal & General Group Plc |
$31,454 |
9,708 |
0.01% |
株式数
|
| PNC Financial Services Group, Inc. |
$29,166 |
9,002 |
0.01% |
株式数
|
| Ameritas Investment Partners, Inc. |
$26,714 |
8,245 |
0.01% |
株式数
|
| CIBC Private Wealth Group LLC |
$25,331 |
7,300 |
0.01% |
株式数
|
| Arax Advisory Partners |
$23,863 |
7,365 |
0.01% |
株式数
|
| Mirae Asset Global Investments Co., Ltd. |
$22,236 |
6,863 |
0.01% |
株式数
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$14,237 |
4,394 |
0.00% |
株式数
|
| Allworth Financial LP |
$13,542 |
4,180 |
0.00% |
株式数
|
| Point72 Europe (London) LLP |
$13,300 |
3,833 |
0.00% |
株式数
|
| Dunhill Financial, LLC |
$12,960 |
4,000 |
0.00% |
株式数
|
| Activest Wealth Management |
$12,960 |
4,000 |
0.00% |
株式数
|
| SBI Securities Co., Ltd. |
$10,744 |
3,316 |
0.00% |
株式数
|
| GF FUND MANAGEMENT CO. LTD. |
$9,827 |
3,033 |
0.00% |
株式数
|
| NATIONAL BANK OF CANADA /FI/ |
$8,236 |
2,542 |
0.00% |
株式数
|
| Owl Creek Wealth Partners LLC |
$7,728 |
2,385 |
0.00% |
株式数
|
| Atlantic Union Bankshares Corp |
$7,459 |
2,302 |
0.00% |
株式数
|
| Federation des caisses Desjardins du Quebec |
$7,452 |
2,300 |
0.00% |
株式数
|
| Essential Partners LLC |
$5,262 |
1,624 |
0.00% |
株式数
|
| JONES FINANCIAL COMPANIES LLLP |
$5,241 |
1,839 |
0.00% |
株式数
|
| Leonteq Securities AG |
$4,565 |
1,409 |
0.00% |
株式数
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$4,465 |
1,378 |
0.00% |
株式数
|
| EverSource Wealth Advisors, LLC |
$4,348 |
1,342 |
0.00% |
株式数
|
| SIGNATUREFD, LLC |
$4,212 |
1,300 |
0.00% |
株式数
|
| NewEdge Advisors, LLC |
$4,196 |
1,295 |
0.00% |
株式数
|
| GAMMA Investing LLC |
$4,154 |
1,282 |
0.00% |
株式数
|
| Twin Lakes Capital Management, LLC |
$4,050 |
1,250 |
0.00% |
株式数
|
| FEDERATED HERMES, INC. |
$3,726 |
1,150 |
0.00% |
株式数
|
| ACADIAN ASSET MANAGEMENT LLC |
$3,364 |
1,039,001 |
0.00% |
株式数
|
| Wilmington Savings Fund Society, FSB |
$3,240 |
1,000 |
0.00% |
株式数
|
| Stone House Investment Management, LLC |
$3,240 |
1,000 |
0.00% |
株式数
|
| Costello Asset Management, INC |
$3,240 |
1,000 |
0.00% |
株式数
|
| NISA INVESTMENT ADVISORS, LLC |
$3,020 |
932 |
0.00% |
株式数
|
| ROTHSCHILD INVESTMENT LLC |
$2,961 |
914 |
0.00% |
株式数
|
| Steward Partners Investment Advisory, LLC |
$2,686 |
829 |
0.00% |
株式数
|
| Tradewinds Capital Management, LLC |
$2,268 |
700 |
0.00% |
株式数
|
| Farther Finance Advisors, LLC |
$2,108 |
653 |
0.00% |
株式数
|
| Physician Wealth Advisors, Inc. |
$2,103 |
649 |
0.00% |
株式数
|
| Fortitude Family Office, LLC |
$1,944 |
600 |
0.00% |
株式数
|
| MassMutual Private Wealth & Trust, FSB |
$1,717 |
530 |
0.00% |
株式数
|
| Sterling Capital Management LLC |
$1,691 |
522 |
0.00% |
株式数
|
| AllSquare Wealth Management LLC |
$1,648 |
475 |
0.00% |
株式数
|
| IFP Advisors, Inc |
$1,639 |
506 |
0.00% |
株式数
|
| TRUST CO OF TOLEDO NA /OH/ |
$1,620 |
500 |
0.00% |
株式数
|
| GILL CAPITAL PARTNERS, LLC |
$1,377 |
425 |
0.00% |
株式数
|
| True Wealth Design, LLC |
$1,335 |
412 |
0.00% |
株式数
|
| Parkside Financial Bank & Trust |
$1,331 |
410 |
0.00% |
株式数
|
| HOLLENCREST CAPITAL MANAGEMENT |
$1,296 |
400 |
0.00% |
株式数
|
| GSA CAPITAL PARTNERS LLP |
$1,190 |
367,147 |
0.00% |
株式数
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$1,186 |
480 |
0.00% |
株式数
|
| SJS Investment Consulting Inc. |
$1,167 |
360 |
0.00% |
株式数
|
| Rialto Wealth Management, LLC |
$1,053 |
325 |
0.00% |
株式数
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$1,008 |
311 |
0.00% |
株式数
|
| Larson Financial Group LLC |
$936 |
289 |
0.00% |
株式数
|
| Optiver Holding B.V. |
$839 |
259 |
0.00% |
株式数
|
| HM PAYSON & CO |
$681 |
210 |
0.00% |
株式数
|
| TD Waterhouse Canada Inc. |
$656 |
200 |
0.00% |
株式数
|
| Cambridge Investment Research Advisors, Inc. |
$524 |
161,878 |
0.00% |
株式数
|
| ISLAY CAPITAL MANAGEMENT, LLC |
$486 |
150 |
0.00% |
株式数
|
| Clearstead Advisors, LLC |
$399 |
123 |
0.00% |
株式数
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$387 |
119,429 |
0.00% |
株式数
|
| Quarry LP |
$363 |
112 |
0.00% |
株式数
|
| Plante Moran Financial Advisors, LLC |
$324 |
100 |
0.00% |
株式数
|
| Pinnacle Wealth Planning Services, Inc. |
$324 |
100 |
0.00% |
株式数
|
| Smartleaf Asset Management LLC |
$320 |
100 |
0.00% |
株式数
|
| Sunbelt Securities, Inc. |
$306 |
124 |
0.00% |
株式数
|
| HARBOUR INVESTMENTS, INC. |
$305 |
94 |
0.00% |
株式数
|
| SHP Wealth Management |
$292 |
90 |
0.00% |
株式数
|
| Versant Capital Management, Inc |
$257 |
100 |
0.00% |
株式数
|
| CANADA LIFE ASSURANCE Co |
$255 |
78,602 |
0.00% |
株式数
|
| Key Financial Inc |
$243 |
75 |
0.00% |
株式数
|
| Truvestments Capital LLC |
$198 |
61 |
0.00% |
株式数
|
| Parallel Advisors, LLC |
$194 |
60 |
0.00% |
株式数
|
| MCF Advisors LLC |
$175 |
54 |
0.00% |
株式数
|
| DT Investment Partners, LLC |
$175 |
54 |
0.00% |
株式数
|
| Gen-Wealth Partners Inc |
$172 |
53 |
0.00% |
株式数
|
| Center for Financial Planning, Inc. |
$162 |
50 |
0.00% |
株式数
|
| EVOLUTION WEALTH MANAGEMENT INC. |
$162 |
50 |
0.00% |
株式数
|
| North Star Investment Management Corp. |
$123 |
38 |
0.00% |
株式数
|
| COMERICA BANK |
$111 |
54 |
0.00% |
株式数
|
| Colonial Trust Advisors |
$97 |
30 |
0.00% |
株式数
|
| Hilton Head Capital Partners, LLC |
$87 |
27 |
0.00% |
株式数
|
| CoreCap Advisors, LLC |
$49 |
15 |
0.00% |
株式数
|
| Abich Financial Wealth Management LLC |
$42 |
12 |
0.00% |
株式数
|
| Financial Perspectives, Inc |
$19 |
6 |
0.00% |
株式数
|
| JPL Wealth Management, LLC |
$13 |
4 |
0.00% |
株式数
|
| Forum Finance Group S.A. |
$7 |
2,500 |
0.00% |
株式数
|
| Sandy Spring Bank |
$3 |
2 |
0.00% |
株式数
|
| Covestor Ltd |
$0 |
108 |
0.00% |
株式数
|
| HANTZ FINANCIAL SERVICES, INC. |
$0 |
100 |
0.00% |
株式数
|