| FMR LLC |
$97,294,233 |
2,830,378 |
19.94% |
주식
|
| TCG Crossover Management, LLC |
$41,418,128 |
1,204,891 |
8.49% |
주식
|
| Aberdeen Group plc |
$39,250,200 |
1,141,824 |
8.04% |
주식
|
| BlackRock, Inc. |
$29,651,600 |
862,592 |
6.08% |
주식
|
| First Light Asset Management, LLC |
$27,524,958 |
800,726 |
5.64% |
주식
|
| BAKER BROS. ADVISORS LP |
$20,892,713 |
607,788 |
4.28% |
주식
|
| 5AM Venture Management, LLC |
$20,853,938 |
606,660 |
4.27% |
주식
|
| BRAIDWELL LP |
$20,518,438 |
596,900 |
4.21% |
주식
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$16,802,672 |
488,805 |
3.44% |
주식
|
| Vestal Point Capital, LP |
$14,609,375 |
425,000 |
2.99% |
주식
|
| VANGUARD GROUP INC |
$12,513,872 |
599,898 |
2.56% |
주식
|
| KENNEDY CAPITAL MANAGEMENT LLC |
$9,700,694 |
282,202 |
1.99% |
주식
|
| GEODE CAPITAL MANAGEMENT, LLC |
$9,299,108 |
270,461 |
1.91% |
주식
|
| ORBIMED ADVISORS LLC |
$7,789,375 |
226,600 |
1.60% |
주식
|
| STATE STREET CORP |
$7,559,338 |
219,908 |
1.55% |
주식
|
| Ikarian Capital, LLC |
$7,075,647 |
205,837 |
1.45% |
주식
|
| D. E. Shaw & Co., Inc. |
$6,412,656 |
186,550 |
1.31% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$6,054,318 |
176,100 |
1.24% |
콜 옵션
|
| MARSHALL WACE, LLP |
$5,916,833 |
172,101 |
1.21% |
주식
|
| MILLENNIUM MANAGEMENT LLC |
$5,689,922 |
165,525 |
1.17% |
주식
|
| Squarepoint Ops LLC |
$4,985,338 |
145,028 |
1.02% |
주식
|
| AMERIPRISE FINANCIAL INC |
$4,896,673 |
142,448 |
1.00% |
주식
|
| WELLS FARGO & COMPANY/MN |
$4,036,588 |
117,428 |
0.83% |
주식
|
| NORTHERN TRUST CORP |
$3,915,450 |
113,904 |
0.80% |
주식
|
| Soleus Capital Management, L.P. |
$3,495,388 |
101,684 |
0.72% |
주식
|
| Woodline Partners LP |
$3,437,500 |
100,000 |
0.70% |
주식
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$3,245,481 |
94,414 |
0.67% |
주식
|
| CITADEL ADVISORS LLC |
$3,107,260 |
90,393 |
0.64% |
주식
|
| GOLDMAN SACHS GROUP INC |
$2,541,138 |
73,924 |
0.52% |
주식
|
| RAYMOND JAMES FINANCIAL INC |
$2,498,169 |
72,674 |
0.51% |
주식
|
| SECTORAL ASSET MANAGEMENT INC |
$2,440,934 |
71,009 |
0.50% |
주식
|
| VANGUARD FIDUCIARY TRUST CO |
$2,351,044 |
68,394 |
0.48% |
주식
|
| JANE STREET GROUP, LLC |
$2,262,596 |
65,821 |
0.46% |
주식
|
| MORGAN STANLEY |
$2,247,205 |
65,373 |
0.46% |
주식
|
| Connor, Clark & Lunn Investment Management Ltd. |
$2,232,313 |
64,940 |
0.46% |
주식
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$2,089,003 |
60,771 |
0.43% |
주식
|
| JPMORGAN CHASE & CO |
$1,831,995 |
55,364 |
0.38% |
주식
|
| KOTLER KEVIN |
$1,668,800 |
80,000 |
0.34% |
주식
|
| Tetragon Partners GP Ltd |
$1,598,988 |
46,516 |
0.33% |
주식
|
| PFM Health Sciences, LP |
$1,568,566 |
45,631 |
0.32% |
주식
|
| Jump Financial, LLC |
$1,491,875 |
43,400 |
0.31% |
주식
|
| Prosight Management, LP |
$1,365,753 |
39,731 |
0.28% |
주식
|
| Trexquant Investment LP |
$1,271,566 |
36,991 |
0.26% |
주식
|
| Aldebaran Capital, LLC |
$1,264,897 |
36,797 |
0.26% |
주식
|
| ExodusPoint Capital Management, LP |
$1,211,341 |
35,239 |
0.25% |
주식
|
| WELLINGTON MANAGEMENT GROUP LLP |
$1,080,475 |
31,432 |
0.22% |
주식
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1,046,306 |
30,438 |
0.21% |
주식
|
| MONIMUS CAPITAL MANAGEMENT, LP |
$967,416 |
28,143 |
0.20% |
주식
|
| Bank of New York Mellon Corp |
$867,872 |
25,247 |
0.18% |
주식
|
| ALPS ADVISORS INC |
$658,178 |
19,147 |
0.13% |
주식
|
| Fisher Asset Management, LLC |
$657,318 |
19,122 |
0.13% |
주식
|
| AMERICAN CENTURY COMPANIES INC |
$653,159 |
19,001 |
0.13% |
주식
|
| Quadrature Capital Ltd |
$621,053 |
18,067 |
0.13% |
주식
|
| SEI INVESTMENTS CO |
$585,372 |
17,029 |
0.12% |
주식
|
| CITADEL ADVISORS LLC |
$584,375 |
17,000 |
0.12% |
콜 옵션
|
| Clearstead Advisors, LLC |
$571,657 |
16,630 |
0.12% |
주식
|
| UBS Group AG |
$517,516 |
15,055 |
0.11% |
주식
|
| ADAR1 Capital Management, LLC |
$498,472 |
14,501 |
0.10% |
주식
|
| RHUMBLINE ADVISERS |
$473,439 |
13,773 |
0.10% |
주식
|
| Nuveen, LLC |
$464,544 |
13,514 |
0.10% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$398,808 |
11,600 |
0.08% |
풋 옵션
|
| BANK OF AMERICA CORP /DE/ |
$379,604 |
11,043 |
0.08% |
주식
|
| AlphaQuest LLC |
$379,381 |
18,187 |
0.08% |
주식
|
| Virtus Investment Advisers, LLC |
$371,456 |
10,806 |
0.08% |
주식
|
| DIMENSIONAL FUND ADVISORS LP |
$358,978 |
10,443 |
0.07% |
주식
|
| DEUTSCHE BANK AG\ |
$345,141 |
10,039 |
0.07% |
주식
|
| Brevan Howard Capital Management LP |
$329,072 |
9,573 |
0.07% |
주식
|
| BARCLAYS PLC |
$313,775 |
9,128 |
0.06% |
주식
|
| Creative Planning |
$308,036 |
8,961 |
0.06% |
주식
|
| FOX RUN MANAGEMENT, L.L.C. |
$304,734 |
8,865 |
0.06% |
주식
|
| Vanguard Global Advisers, LLC |
$301,297 |
8,765 |
0.06% |
주식
|
| AlphaCentric Advisors LLC |
$238,838 |
6,948 |
0.05% |
주식
|
| MetLife Investment Management, LLC |
$231,138 |
6,724 |
0.05% |
주식
|
| ALLIANCEBERNSTEIN L.P. |
$230,589 |
7,460 |
0.05% |
주식
|
| AQR CAPITAL MANAGEMENT LLC |
$227,460 |
6,617 |
0.05% |
주식
|
| Invesco Ltd. |
$219,588 |
6,388 |
0.05% |
주식
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$208,313 |
6,060 |
0.04% |
주식
|
| Velan Capital Investment Management LP |
$206,250 |
6,000 |
0.04% |
주식
|
| Rangeley Capital, LLC |
$206,250 |
6,000 |
0.04% |
주식
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$206,113 |
5,996 |
0.04% |
주식
|
| Russell Investments Group, Ltd. |
$191,365 |
5,567 |
0.04% |
주식
|
| CITIGROUP INC |
$190,712 |
5,548 |
0.04% |
주식
|
| China Universal Asset Management Co., Ltd. |
$189,166 |
5,503 |
0.04% |
주식
|
| NISA INVESTMENT ADVISORS, LLC |
$185,625 |
5,400 |
0.04% |
주식
|
| Clarius Group, LLC |
$179,402 |
10,130 |
0.04% |
주식
|
| BNP PARIBAS FINANCIAL MARKETS |
$176,894 |
5,146 |
0.04% |
주식
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$161,356 |
4,694 |
0.03% |
주식
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$158,125 |
4,600 |
0.03% |
주식
|
| Police & Firemen's Retirement System of New Jersey |
$90,681 |
2,638 |
0.02% |
주식
|
| Quantbot Technologies LP |
$62,528 |
1,819 |
0.01% |
주식
|
| CWM, LLC |
$56,534 |
1,829 |
0.01% |
주식
|
| Ameritas Investment Partners, Inc. |
$38,569 |
1,122 |
0.01% |
주식
|
| US BANCORP \DE\ |
$37,125 |
1,080 |
0.01% |
주식
|
| Legal & General Group Plc |
$34,375 |
1,000 |
0.01% |
주식
|
| Mirae Asset Global Investments Co., Ltd. |
$29,013 |
844 |
0.01% |
주식
|
| Chung Wu Investment Group, LLC |
$27,500 |
800 |
0.01% |
주식
|
| Arax Advisory Partners |
$24,922 |
725 |
0.01% |
주식
|
| Tower Research Capital LLC (TRC) |
$22,722 |
661 |
0.00% |
주식
|
| State of Wyoming |
$20,659 |
601 |
0.00% |
주식
|
| HighMark Wealth Management LLC |
$20,161 |
587 |
0.00% |
주식
|
| Point72 (DIFC) Ltd |
$17,301 |
1,103 |
0.00% |
주식
|
| SIMPLEX TRADING, LLC |
$15,090 |
439 |
0.00% |
주식
|
| GF FUND MANAGEMENT CO. LTD. |
$13,750 |
400 |
0.00% |
주식
|
| Rockefeller Capital Management L.P. |
$12,719 |
370 |
0.00% |
주식
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$11,808 |
382 |
0.00% |
주식
|
| ROYAL BANK OF CANADA |
$11,000 |
311 |
0.00% |
주식
|
| Bollard Group LLC |
$10,414 |
302,953 |
0.00% |
주식
|
| GAMMA Investing LLC |
$9,969 |
290 |
0.00% |
주식
|
| Federation des caisses Desjardins du Quebec |
$8,594 |
250 |
0.00% |
주식
|
| Sterling Capital Management LLC |
$6,050 |
176 |
0.00% |
주식
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$4,847 |
141 |
0.00% |
주식
|
| Axiom Investment Management LLC |
$4,297 |
125 |
0.00% |
주식
|
| Farther Finance Advisors, LLC |
$2,613 |
76 |
0.00% |
주식
|
| Allworth Financial LP |
$1,788 |
52 |
0.00% |
주식
|
| Marshall & Sterling Wealth Advisors Inc. |
$1,719 |
50 |
0.00% |
주식
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$1,651 |
48,001 |
0.00% |
주식
|
| HRT FINANCIAL LP |
$1,531 |
44,540 |
0.00% |
주식
|
| PNC Financial Services Group, Inc. |
$1,375 |
40 |
0.00% |
주식
|
| Caldwell Trust Co |
$688 |
20 |
0.00% |
주식
|
| HUNTINGTON NATIONAL BANK |
$447 |
13 |
0.00% |
주식
|
| EASTERN BANK |
$447 |
13 |
0.00% |
주식
|
| SBI Securities Co., Ltd. |
$378 |
11 |
0.00% |
주식
|
| GSA CAPITAL PARTNERS LLP |
$284 |
8,275 |
0.00% |
주식
|
| First Bancorp, Inc /ME/ |
$275 |
8 |
0.00% |
주식
|
| Sunbelt Securities, Inc. |
$247 |
8 |
0.00% |
주식
|
| EverSource Wealth Advisors, LLC |
$240 |
7 |
0.00% |
주식
|
| NATIONAL BANK OF CANADA /FI/ |
$205 |
6 |
0.00% |
주식
|
| Essential Partners LLC |
$172 |
5 |
0.00% |
주식
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$103 |
3 |
0.00% |
주식
|
| OSAIC HOLDINGS, INC. |
$69 |
2 |
0.00% |
주식
|
| ROTHSCHILD INVESTMENT LLC |
$69 |
2 |
0.00% |
주식
|
| IFP Advisors, Inc |
$69 |
2 |
0.00% |
주식
|