| EcoR1 Capital, LLC |
$600,445,942 |
22,970,388 |
32.29% |
주식
|
| Rubric Capital Management LP |
$182,980,000 |
7,000,000 |
9.84% |
주식
|
| BlackRock, Inc. |
$111,121,925 |
4,251,030 |
5.98% |
주식
|
| PERCEPTIVE ADVISORS LLC |
$109,342,391 |
4,182,953 |
5.88% |
주식
|
| BVF INC/IL |
$95,388,572 |
3,649,142 |
5.13% |
주식
|
| VANGUARD GROUP INC |
$61,315,382 |
2,328,727 |
3.30% |
주식
|
| MORGAN STANLEY |
$58,325,141 |
2,231,260 |
3.14% |
주식
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$46,558,373 |
1,781,116 |
2.50% |
주식
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$40,752,208 |
1,558,998 |
2.19% |
주식
|
| Assenagon Asset Management S.A. |
$32,727,986 |
1,252,027 |
1.76% |
주식
|
| Nextech Invest Ltd. |
$29,118,548 |
1,113,946 |
1.57% |
주식
|
| STATE STREET CORP |
$28,445,966 |
1,088,216 |
1.53% |
주식
|
| DIMENSIONAL FUND ADVISORS LP |
$25,995,770 |
994,955 |
1.40% |
주식
|
| CITADEL ADVISORS LLC |
$23,895,516 |
914,136 |
1.29% |
주식
|
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
$23,259,000 |
889,802 |
1.25% |
주식
|
| FMR LLC |
$18,365,133 |
702,568 |
0.99% |
주식
|
| GEODE CAPITAL MANAGEMENT, LLC |
$18,099,012 |
692,410 |
0.97% |
주식
|
| Prosight Management, LP |
$17,629,705 |
674,434 |
0.95% |
주식
|
| Qube Research & Technologies Ltd |
$15,516,443 |
593,590 |
0.83% |
주식
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$13,332,236 |
510,032 |
0.72% |
주식
|
| Redmile Group, LLC |
$12,851,836 |
491,654 |
0.69% |
주식
|
| Capricorn Fund Managers Ltd |
$12,717,868 |
486,529 |
0.68% |
주식
|
| GOLDMAN SACHS GROUP INC |
$12,307,288 |
470,822 |
0.66% |
주식
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$10,939,512 |
418,497 |
0.59% |
주식
|
| DEUTSCHE BANK AG\ |
$10,382,547 |
397,190 |
0.56% |
주식
|
| Hillsdale Investment Management Inc. |
$10,009,581 |
382,922 |
0.54% |
주식
|
| FIRST TRUST ADVISORS LP |
$8,897,088 |
340,363 |
0.48% |
주식
|
| Granahan Investment Management, LLC |
$8,787,144 |
336,157 |
0.47% |
주식
|
| NORTHERN TRUST CORP |
$8,392,849 |
321,073 |
0.45% |
주식
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$7,997,401 |
319,385 |
0.43% |
주식
|
| Pictet Asset Management Holding SA |
$7,446,189 |
308,187 |
0.40% |
주식
|
| PICTON MAHONEY ASSET MANAGEMENT |
$7,092,908 |
271,343 |
0.38% |
주식
|
| SILVERCREST ASSET MANAGEMENT GROUP LLC |
$5,849,243 |
223,766 |
0.31% |
주식
|
| BANK OF AMERICA CORP /DE/ |
$5,726,515 |
219,071 |
0.31% |
주식
|
| WELLS FARGO & COMPANY/MN |
$5,677,573 |
217,199 |
0.31% |
주식
|
| SummitTX Capital, L.P. |
$5,510,364 |
210,802 |
0.30% |
주식
|
| Man Group plc |
$5,509,763 |
210,779 |
0.30% |
주식
|
| FEDERATED HERMES, INC. |
$4,914,190 |
187,995 |
0.26% |
주식
|
| RAYMOND JAMES FINANCIAL INC |
$4,350,114 |
166,416 |
0.23% |
주식
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$4,066,835 |
155,579 |
0.22% |
주식
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$3,984,154 |
152,416 |
0.21% |
주식
|
| KENNEDY CAPITAL MANAGEMENT LLC |
$3,800,390 |
145,386 |
0.20% |
주식
|
| D. E. Shaw & Co., Inc. |
$3,785,255 |
144,807 |
0.20% |
주식
|
| DIADEMA PARTNERS LP |
$3,715,330 |
142,132 |
0.20% |
주식
|
| CITIGROUP INC |
$3,435,868 |
131,441 |
0.18% |
주식
|
| Bank of New York Mellon Corp |
$3,427,107 |
131,106 |
0.18% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$3,408,656 |
130,400 |
0.18% |
콜 옵션
|
| XTX Topco Ltd |
$3,290,425 |
125,877 |
0.18% |
주식
|
| Nuveen, LLC |
$3,120,829 |
119,389 |
0.17% |
주식
|
| PANAGORA ASSET MANAGEMENT INC |
$3,100,282 |
118,603 |
0.17% |
주식
|
| UBS Group AG |
$3,008,583 |
115,095 |
0.16% |
주식
|
| Invesco Ltd. |
$2,933,222 |
112,212 |
0.16% |
주식
|
| AQR CAPITAL MANAGEMENT LLC |
$2,908,911 |
111,282 |
0.16% |
주식
|
| WELLINGTON MANAGEMENT GROUP LLP |
$2,875,766 |
110,014 |
0.15% |
주식
|
| PLATINUM INVESTMENT MANAGEMENT LTD |
$2,749,510 |
105,184 |
0.15% |
주식
|
| AXA Investment Managers S.A. |
$2,705,745 |
158,416 |
0.15% |
주식
|
| Manatuck Hill Partners, LLC |
$2,614,000 |
100,000 |
0.14% |
주식
|
| JPMORGAN CHASE & CO |
$2,564,192 |
106,398 |
0.14% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2,451,932 |
93,800 |
0.13% |
풋 옵션
|
| KORNITZER CAPITAL MANAGEMENT INC /KS |
$2,321,232 |
88,800 |
0.12% |
주식
|
| MACKENZIE FINANCIAL CORP |
$2,293,654 |
87,745 |
0.12% |
주식
|
| PRINCIPAL FINANCIAL GROUP INC |
$2,221,639 |
84,990 |
0.12% |
주식
|
| Y-Intercept (Hong Kong) Ltd |
$2,181,514 |
83,455 |
0.12% |
주식
|
| LMR Partners LLP |
$2,156,550 |
82,500 |
0.12% |
주식
|
| AMERIPRISE FINANCIAL INC |
$2,150,380 |
82,264 |
0.12% |
주식
|
| VANGUARD FIDUCIARY TRUST CO |
$2,094,337 |
80,120 |
0.11% |
주식
|
| STIFEL FINANCIAL CORP |
$2,018,373 |
77,214 |
0.11% |
주식
|
| FRANKLIN RESOURCES INC |
$2,000,443 |
76,528 |
0.11% |
주식
|
| TEMA ETFS LLC |
$2,000,422 |
75,975 |
0.11% |
주식
|
| RHUMBLINE ADVISERS |
$1,962,211 |
75,066 |
0.11% |
주식
|
| Swiss National Bank |
$1,939,588 |
74,200 |
0.10% |
주식
|
| MARTINGALE ASSET MANAGEMENT L P |
$1,915,592 |
73,282 |
0.10% |
주식
|
| TWO SIGMA INVESTMENTS, LP |
$1,878,786 |
71,874 |
0.10% |
주식
|
| Dana Investment Advisors, Inc. |
$1,873,192 |
71,660 |
0.10% |
주식
|
| CREDIT AGRICOLE S A |
$1,855,940 |
71,000 |
0.10% |
주식
|
| Fisher Asset Management, LLC |
$1,850,057 |
70,775 |
0.10% |
주식
|
| SEGALL BRYANT & HAMILL, LLC |
$1,747,093 |
66,836 |
0.09% |
주식
|
| Verdad Advisers, LP |
$1,743,224 |
66,688 |
0.09% |
주식
|
| Susquehanna Portfolio Strategies, LLC |
$1,705,583 |
65,248 |
0.09% |
주식
|
| Campbell & CO Investment Adviser LLC |
$1,591,246 |
60,874 |
0.09% |
주식
|
| ROYAL BANK OF CANADA |
$1,471,000 |
56,278 |
0.08% |
주식
|
| ALLIANCEBERNSTEIN L.P. |
$1,399,636 |
55,896 |
0.08% |
주식
|
| CITADEL ADVISORS LLC |
$1,364,508 |
52,200 |
0.07% |
콜 옵션
|
| Virtus Investment Advisers, LLC |
$1,328,566 |
50,825 |
0.07% |
주식
|
| ENVESTNET ASSET MANAGEMENT INC |
$1,272,365 |
48,675 |
0.07% |
주식
|
| Russell Investments Group, Ltd. |
$1,251,241 |
47,867 |
0.07% |
주식
|
| Quantinno Capital Management LP |
$1,245,362 |
47,642 |
0.07% |
주식
|
| Legal & General Group Plc |
$1,128,017 |
43,160 |
0.06% |
주식
|
| VICTORY CAPITAL MANAGEMENT INC |
$1,111,577 |
42,524 |
0.06% |
주식
|
| MARSHALL WACE, LLP |
$1,070,380 |
40,948 |
0.06% |
주식
|
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC |
$1,033,419 |
39,534 |
0.06% |
주식
|
| Aquilo Capital Management, LLC |
$1,006,181 |
84,482 |
0.05% |
주식
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$986,628 |
37,744 |
0.05% |
주식
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$965,141 |
36,922 |
0.05% |
주식
|
| TUDOR INVESTMENT CORP ET AL |
$953,352 |
36,471 |
0.05% |
주식
|
| HighTower Advisors, LLC |
$943,654 |
36,100 |
0.05% |
주식
|
| Persistent Asset Partners Ltd |
$939,341 |
35,935 |
0.05% |
주식
|
| HighVista Strategies LLC |
$889,100 |
34,013 |
0.05% |
주식
|
| COMMONWEALTH EQUITY SERVICES, LLC |
$837,838 |
32,052 |
0.05% |
주식
|
| TWO SIGMA ADVISERS, LP |
$827,157 |
31,415 |
0.04% |
주식
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$807,360 |
30,886 |
0.04% |
주식
|
| Creative Planning |
$777,168 |
29,731 |
0.04% |
주식
|
| SBI Okasan Asset Management Co.Ltd. |
$771,200 |
32,000 |
0.04% |
주식
|
| MetLife Investment Management, LLC |
$728,888 |
27,884 |
0.04% |
주식
|
| JOURNEY STRATEGIC WEALTH LLC |
$727,412 |
29,050 |
0.04% |
주식
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$723,294 |
27,670 |
0.04% |
주식
|
| STRS OHIO |
$692,710 |
26,500 |
0.04% |
주식
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$686,933 |
26,279 |
0.04% |
주식
|
| Brevan Howard Capital Management LP |
$678,490 |
25,956 |
0.04% |
주식
|
| Jump Financial, LLC |
$669,393 |
25,608 |
0.04% |
주식
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$657,735 |
25,162 |
0.04% |
주식
|
| RITHOLTZ WEALTH MANAGEMENT |
$633,712 |
24,243 |
0.03% |
주식
|
| BNP PARIBAS FINANCIAL MARKETS |
$607,206 |
23,229 |
0.03% |
주식
|
| Duncan Williams Asset Management, LLC |
$577,563 |
22,095 |
0.03% |
주식
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$564,049 |
21,578 |
0.03% |
주식
|
| BARCLAYS PLC |
$538,562 |
20,603 |
0.03% |
주식
|
| VIRGINIA RETIREMENT SYSTEMS ET Al |
$508,031 |
19,435 |
0.03% |
주식
|
| SIMPLEX TRADING, LLC |
$507,926 |
19,431 |
0.03% |
주식
|
| BetterWealth, LLC |
$486,779 |
18,622 |
0.03% |
주식
|
| BANK OF MONTREAL /CAN/ |
$481,394 |
18,416 |
0.03% |
주식
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$477,499 |
18,267 |
0.03% |
주식
|
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
$475,356 |
18,185 |
0.03% |
주식
|
| JANUS HENDERSON GROUP PLC |
$455,819 |
18,200 |
0.02% |
주식
|
| JANE STREET GROUP, LLC |
$455,803 |
17,437 |
0.02% |
주식
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$454,078 |
17,371 |
0.02% |
주식
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$452,483 |
17,310 |
0.02% |
주식
|
| Squarepoint Ops LLC |
$423,468 |
16,200 |
0.02% |
주식
|
| HSBC HOLDINGS PLC |
$421,205 |
15,588 |
0.02% |
주식
|
| Vinva Investment Management Ltd |
$419,717 |
11,983 |
0.02% |
주식
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$400,988 |
15,340 |
0.02% |
주식
|
| AGF MANAGEMENT LTD |
$392,100 |
15,000 |
0.02% |
주식
|
| Police & Firemen's Retirement System of New Jersey |
$358,170 |
13,702 |
0.02% |
주식
|
| INTECH INVESTMENT MANAGEMENT LLC |
$311,981 |
11,935 |
0.02% |
주식
|
| State of New Jersey Common Pension Fund D |
$311,667 |
11,923 |
0.02% |
주식
|
| China Universal Asset Management Co., Ltd. |
$303,799 |
11,622 |
0.02% |
주식
|
| JAMES INVESTMENT RESEARCH, INC. |
$285,580 |
10,925 |
0.02% |
주식
|
| Ewing Morris & Co. Investment Partners Ltd. |
$283,619 |
10,850 |
0.02% |
주식
|
| ARIZONA STATE RETIREMENT SYSTEM |
$265,975 |
10,175 |
0.01% |
주식
|
| Jain Global LLC |
$261,661 |
10,010 |
0.01% |
주식
|
| PSP Research LLC |
$261,400 |
10,000 |
0.01% |
주식
|
| Mitsubishi UFJ Trust & Banking Corp |
$250,134 |
9,569 |
0.01% |
주식
|
| VOYA INVESTMENT MANAGEMENT LLC |
$243,991 |
9,334 |
0.01% |
주식
|
| Vanguard Investments Australia, Ltd. |
$230,110 |
8,803 |
0.01% |
주식
|
| Allspring Global Investments Holdings, LLC |
$225,359 |
8,762 |
0.01% |
주식
|
| ProShare Advisors LLC |
$223,681 |
8,557 |
0.01% |
주식
|
| AlphaQuest LLC |
$218,881 |
8,313 |
0.01% |
주식
|
| INCEPTIONR LLC |
$217,302 |
8,313 |
0.01% |
주식
|
| Magnetar Financial LLC |
$216,753 |
8,292 |
0.01% |
주식
|
| KLP KAPITALFORVALTNING AS |
$209,120 |
8,000 |
0.01% |
주식
|
| PRUDENTIAL FINANCIAL INC |
$207,552 |
7,940 |
0.01% |
주식
|
| CWM, LLC |
$174,153 |
6,955 |
0.01% |
주식
|
| Vanguard Global Advisers, LLC |
$142,698 |
5,459 |
0.01% |
주식
|
| Northwest & Ethical Investments L.P. |
$111,583 |
4,630 |
0.01% |
주식
|
| Ameritas Investment Partners, Inc. |
$108,847 |
4,164 |
0.01% |
주식
|
| Mirae Asset Global Investments Co., Ltd. |
$85,373 |
3,266 |
0.00% |
주식
|
| Arax Advisory Partners |
$78,368 |
2,998 |
0.00% |
주식
|
| State of Wyoming |
$72,983 |
2,792 |
0.00% |
주식
|
| Tower Research Capital LLC (TRC) |
$62,030 |
2,373 |
0.00% |
주식
|
| GF FUND MANAGEMENT CO. LTD. |
$41,432 |
1,585 |
0.00% |
주식
|
| TD Waterhouse Canada Inc. |
$37,014 |
1,439 |
0.00% |
주식
|
| Caitong International Asset Management Co., Ltd |
$34,217 |
1,309 |
0.00% |
주식
|
| Eurizon Capital SGR S.p.A. |
$31,865 |
1,321 |
0.00% |
주식
|
| GAMMA Investing LLC |
$29,120 |
1,114 |
0.00% |
주식
|
| Optiver Holding B.V. |
$27,159 |
1,039 |
0.00% |
주식
|
| Steward Partners Investment Advisory, LLC |
$25,382 |
971 |
0.00% |
주식
|
| LANARK FINANCIAL, INC. |
$25,146 |
962 |
0.00% |
주식
|
| PNC Financial Services Group, Inc. |
$23,474 |
898 |
0.00% |
주식
|
| OSAIC HOLDINGS, INC. |
$23,055 |
882 |
0.00% |
주식
|
| JONES FINANCIAL COMPANIES LLLP |
$20,214 |
837 |
0.00% |
주식
|
| Freestone Grove Partners LP |
$16,939 |
648 |
0.00% |
주식
|
| NATIONAL BANK OF CANADA /FI/ |
$15,182 |
581 |
0.00% |
주식
|
| Federation des caisses Desjardins du Quebec |
$14,894 |
570 |
0.00% |
주식
|
| NISA INVESTMENT ADVISORS, LLC |
$12,573 |
481 |
0.00% |
주식
|
| UMB Bank, n.a. |
$12,129 |
464 |
0.00% |
주식
|
| HUNTINGTON NATIONAL BANK |
$12,024 |
460 |
0.00% |
주식
|
| Parallel Advisors, LLC |
$8,600 |
329 |
0.00% |
주식
|
| US BANCORP \DE\ |
$8,234 |
315 |
0.00% |
주식
|
| SBI Securities Co., Ltd. |
$8,156 |
312 |
0.00% |
주식
|
| COMERICA BANK |
$5,556 |
211 |
0.00% |
주식
|
| Quarry LP |
$5,489 |
210 |
0.00% |
주식
|
| EverSource Wealth Advisors, LLC |
$4,888 |
187 |
0.00% |
주식
|
| Lindbrook Capital, LLC |
$4,419 |
371 |
0.00% |
주식
|
| Sterling Capital Management LLC |
$4,313 |
165 |
0.00% |
주식
|
| Fortitude Family Office, LLC |
$3,032 |
116 |
0.00% |
주식
|
| Allworth Financial LP |
$2,824 |
108 |
0.00% |
주식
|
| IFP Advisors, Inc |
$2,509 |
96 |
0.00% |
주식
|
| Versant Capital Management, Inc |
$2,490 |
94 |
0.00% |
주식
|
| ROTHSCHILD INVESTMENT LLC |
$2,091 |
80 |
0.00% |
주식
|
| HighMark Wealth Management LLC |
$2,091 |
80 |
0.00% |
주식
|
| SJS Investment Consulting Inc. |
$2,013 |
77 |
0.00% |
주식
|
| Kilter Group LLC |
$1,726 |
66 |
0.00% |
주식
|
| Bare Financial Services, Inc |
$1,673 |
64 |
0.00% |
주식
|
| Rockefeller Capital Management L.P. |
$1,595 |
61 |
0.00% |
주식
|
| True Wealth Design, LLC |
$1,517 |
58 |
0.00% |
주식
|
| Physician Wealth Advisors, Inc. |
$1,334 |
51 |
0.00% |
주식
|
| North Growth Management Ltd. |
$1,201 |
46,000 |
0.00% |
주식
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$1,007 |
38,486 |
0.00% |
주식
|
| Farther Finance Advisors, LLC |
$784 |
30 |
0.00% |
주식
|
| Sunbelt Securities, Inc. |
$676 |
27 |
0.00% |
주식
|
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC |
$643 |
25 |
0.00% |
주식
|
| Jackson Creek Investment Advisors LLC |
$409 |
18,648 |
0.00% |
주식
|
| Essential Partners LLC |
$314 |
12 |
0.00% |
주식
|
| Janney Montgomery Scott LLC |
$310 |
11,865 |
0.00% |
주식
|
| Smartleaf Asset Management LLC |
$289 |
12 |
0.00% |
주식
|
| SG Americas Securities, LLC |
$165 |
6,321 |
0.00% |
주식
|
| Clearstead Advisors, LLC |
$157 |
6 |
0.00% |
주식
|
| Larson Financial Group LLC |
$157 |
6 |
0.00% |
주식
|
| Silver Grove Financial Group, Inc. |
$105 |
4 |
0.00% |
주식
|
| DekaBank Deutsche Girozentrale |
$94 |
3,843 |
0.00% |
주식
|
| Hughes Financial Services, LLC |
$78 |
3 |
0.00% |
주식
|
| SHELL ASSET MANAGEMENT CO |
$72 |
4,212 |
0.00% |
주식
|
| Covestor Ltd |
$1 |
40 |
0.00% |
주식
|