| Frazier Life Sciences Management, L.P. |
$49724879 |
7614836 |
9.06% |
股份
|
| TPG GP A, LLC |
$44910597 |
6877580 |
8.19% |
股份
|
| venBio Partners LLC |
$38623122 |
5914720 |
7.04% |
股份
|
| Logos Global Management LP |
$35425250 |
5425000 |
6.46% |
股份
|
| BlackRock, Inc. |
$34426271 |
5272017 |
6.28% |
股份
|
| FRANKLIN RESOURCES INC |
$32344527 |
4953220 |
5.90% |
股份
|
| Paradigm Biocapital Advisors LP |
$32335620 |
4951856 |
5.89% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$27039502 |
4140812 |
4.93% |
股份
|
| Propel Bio Management, LLC |
$26342138 |
4034018 |
4.80% |
股份
|
| MARSHALL WACE, LLP |
$24620145 |
3770313 |
4.49% |
股份
|
| STATE STREET CORP |
$19234285 |
2945526 |
3.51% |
股份
|
| Venrock Adviser, LLC |
$17964239 |
2751032 |
3.27% |
股份
|
| Vivo Capital, LLC |
$17964239 |
2751032 |
3.27% |
股份
|
| EVENTIDE ASSET MANAGEMENT, LLC |
$14496600 |
2220000 |
2.64% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$13471818 |
2062721 |
2.46% |
股份
|
| Alyeska Investment Group, L.P. |
$12574965 |
1925722 |
2.29% |
股份
|
| VANGUARD GROUP INC |
$12297331 |
2474312 |
2.24% |
股份
|
| Simplify Asset Management Inc. |
$9351646 |
1432105 |
1.70% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$9317755 |
1426915 |
1.70% |
股份
|
| Caption Management, LLC |
$7676015 |
1175500 |
1.40% |
买入期权
|
| LPL Financial LLC |
$5891725 |
902255 |
1.07% |
股份
|
| NORTHERN TRUST CORP |
$4856753 |
743760 |
0.89% |
股份
|
| Spruce Street Capital LP |
$4810240 |
736637 |
0.88% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$3877194 |
593751 |
0.71% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$3771075 |
577500 |
0.69% |
买入期权
|
| RAYMOND JAMES FINANCIAL INC |
$3567457 |
546318 |
0.65% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$3510502 |
537596 |
0.64% |
股份
|
| KVP Capital Advisors, LP |
$3019178 |
462355 |
0.55% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$2880951 |
441187 |
0.53% |
股份
|
| UBS Group AG |
$2043916 |
313004 |
0.37% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1515861 |
232138 |
0.28% |
股份
|
| Caption Management, LLC |
$1487096 |
227733 |
0.27% |
股份
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$1483472 |
227178 |
0.27% |
股份
|
| Bank of New York Mellon Corp |
$1424364 |
218126 |
0.26% |
股份
|
| JANE STREET GROUP, LLC |
$1331467 |
203900 |
0.24% |
买入期权
|
| CITADEL ADVISORS LLC |
$1326243 |
203100 |
0.24% |
买入期权
|
| Nuveen, LLC |
$1248210 |
191150 |
0.23% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$1208540 |
185075 |
0.22% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$1162660 |
178049 |
0.21% |
股份
|
| WELLS FARGO & COMPANY/MN |
$1114233 |
170633 |
0.20% |
股份
|
| TWO SIGMA ADVISERS, LP |
$1043203 |
209900 |
0.19% |
股份
|
| CITADEL ADVISORS LLC |
$804032 |
123129 |
0.15% |
股份
|
| CANTOR FITZGERALD, L. P. |
$794250 |
121631 |
0.14% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$791534 |
121215 |
0.14% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$677161 |
103700 |
0.12% |
卖出期权
|
| Shay Capital LLC |
$606049 |
92810 |
0.11% |
股份
|
| XTX Topco Ltd |
$587896 |
90030 |
0.11% |
股份
|
| RHUMBLINE ADVISERS |
$568253 |
87023 |
0.10% |
股份
|
| Blue Trust, Inc. |
$560849 |
85888 |
0.10% |
股份
|
| Diametric Capital, LP |
$530098 |
81179 |
0.10% |
股份
|
| DEUTSCHE BANK AG\ |
$505977 |
77485 |
0.09% |
股份
|
| CITIGROUP INC |
$483965 |
74114 |
0.09% |
股份
|
| MANCHESTER FINANCIAL INC |
$438666 |
67177 |
0.08% |
股份
|
| MEMBERS WEALTH LLC |
$435962 |
66763 |
0.08% |
股份
|
| MORGAN STANLEY |
$387713 |
59374 |
0.07% |
股份
|
| Virtus Investment Advisers, LLC |
$387066 |
59275 |
0.07% |
股份
|
| ADAR1 Capital Management, LLC |
$351314 |
53800 |
0.06% |
股份
|
| JANE STREET GROUP, LLC |
$329478 |
50456 |
0.06% |
股份
|
| MetLife Investment Management, LLC |
$300282 |
45985 |
0.05% |
股份
|
| OSAIC HOLDINGS, INC. |
$281540 |
43115 |
0.05% |
股份
|
| WINTON GROUP Ltd |
$277525 |
42500 |
0.05% |
股份
|
| Invesco Ltd. |
$276167 |
42292 |
0.05% |
股份
|
| GOLDMAN SACHS GROUP INC |
$267573 |
40976 |
0.05% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$260219 |
40050 |
0.05% |
股份
|
| Rafferty Asset Management, LLC |
$245012 |
37521 |
0.04% |
股份
|
| Next Capital Management LLC |
$228517 |
34995 |
0.04% |
股份
|
| AMERIFLEX GROUP, INC. |
$219395 |
33598 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$211624 |
32408 |
0.04% |
股份
|
| JPMORGAN CHASE & CO |
$201160 |
32289 |
0.04% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$198329 |
30372 |
0.04% |
股份
|
| Rockefeller Capital Management L.P. |
$195900 |
30000 |
0.04% |
股份
|
| Jones Hill Capital LP |
$174743 |
26760 |
0.03% |
股份
|
| BCV Asset Management Inc. |
$164591 |
26365 |
0.03% |
股份
|
| AXQ CAPITAL, LP |
$164380 |
25173 |
0.03% |
股份
|
| Robertson Stephens Wealth Management, LLC |
$163250 |
25000 |
0.03% |
股份
|
| Keating Financial Advisory Services, Inc. |
$162669 |
24911 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$149916 |
22958 |
0.03% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$143884 |
48940 |
0.03% |
股份
|
| Scientech Research LLC |
$143706 |
22007 |
0.03% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$134583 |
20610 |
0.02% |
股份
|
| SEI INVESTMENTS CO |
$133865 |
20500 |
0.02% |
股份
|
| BARCLAYS PLC |
$130561 |
19994 |
0.02% |
股份
|
| PROFUND ADVISORS LLC |
$129660 |
19856 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$125376 |
19200 |
0.02% |
股份
|
| nVerses Capital, LLC |
$118852 |
18201 |
0.02% |
股份
|
| FMR LLC |
$115628 |
17707 |
0.02% |
股份
|
| Cubist Systematic Strategies, LLC |
$111898 |
35523 |
0.02% |
股份
|
| MAGNOLIA CAPITAL ADVISORS LLC |
$98603 |
15100 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$96931 |
14844 |
0.02% |
股份
|
| SBI Securities Co., Ltd. |
$96912 |
14841 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$89696 |
13736 |
0.02% |
股份
|
| StoneX Group Inc. |
$86507 |
16342 |
0.02% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$85151 |
13040 |
0.02% |
股份
|
| Alpine Global Management, LLC |
$81625 |
12500 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$81000 |
12376 |
0.01% |
股份
|
| Windsor Capital Management, LLC |
$70635 |
10817 |
0.01% |
股份
|
| ProShare Advisors LLC |
$66554 |
10192 |
0.01% |
股份
|
| Legal & General Group Plc |
$49334 |
7555 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$46128 |
7064 |
0.01% |
股份
|
| Russell Investments Group, Ltd. |
$41622 |
6374 |
0.01% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$23641 |
7505 |
0.00% |
股份
|
| Allworth Financial LP |
$19590 |
3000 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$19551 |
2994 |
0.00% |
股份
|
| Persistent Asset Partners Ltd |
$18153 |
2780 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$15881 |
2432 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$14954 |
2290 |
0.00% |
股份
|
| Federation des caisses Desjardins du Quebec |
$13060 |
2000 |
0.00% |
股份
|
| COMERICA BANK |
$11839 |
2382 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$7000 |
1072 |
0.00% |
股份
|
| CWM, LLC |
$5004 |
1702 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$4826 |
739 |
0.00% |
股份
|
| SITTNER & NELSON, LLC |
$4395 |
673 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$1806 |
300 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$1783 |
273 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$1715 |
212 |
0.00% |
股份
|
| Point72 (DIFC) Ltd |
$595 |
189 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$423 |
64769 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$131 |
20 |
0.00% |
股份
|
| Arax Advisory Partners |
$65 |
10 |
0.00% |
股份
|
| Optiver Holding B.V. |
$13 |
2 |
0.00% |
股份
|
| Capital Analysts, LLC |
$5 |
700 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$4 |
627 |
0.00% |
股份
|
| Avion Wealth |
$3 |
500 |
0.00% |
股份
|