| EcoR1 Capital, LLC |
$531906345 |
7880094 |
24.81% |
股份
|
| BlackRock, Inc. |
$124473310 |
1844049 |
5.81% |
股份
|
| TANG CAPITAL MANAGEMENT LLC |
$89834333 |
1330879 |
4.19% |
股份
|
| STATE STREET CORP |
$86818095 |
1286194 |
4.05% |
股份
|
| VANGUARD GROUP INC |
$74854914 |
1544037 |
3.49% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$61170728 |
906233 |
2.85% |
股份
|
| Affinity Asset Advisors, LLC |
$55762358 |
826109 |
2.60% |
股份
|
| Sanofi |
$55479398 |
821917 |
2.59% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$54493830 |
807316 |
2.54% |
股份
|
| Woodline Partners LP |
$48398445 |
717014 |
2.26% |
股份
|
| 683 Capital Management, LLC |
$44550001 |
660000 |
2.08% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$43064353 |
637873 |
2.01% |
股份
|
| Palo Alto Investors LP |
$40735508 |
603489 |
1.90% |
股份
|
| GOLDMAN SACHS GROUP INC |
$39424725 |
584070 |
1.84% |
股份
|
| First Light Asset Management, LLC |
$39285270 |
582004 |
1.83% |
股份
|
| D. E. Shaw & Co., Inc. |
$36427456 |
539666 |
1.70% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$35630415 |
527858 |
1.66% |
股份
|
| Apis Capital Advisors, LLC |
$33547500 |
497000 |
1.56% |
股份
|
| Sofinnova Investments, Inc. |
$33313680 |
493536 |
1.55% |
股份
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$32983943 |
488651 |
1.54% |
股份
|
| Nuveen, LLC |
$28394821 |
420664 |
1.32% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$28202310 |
417812 |
1.32% |
股份
|
| CITADEL ADVISORS LLC |
$26620178 |
394373 |
1.24% |
股份
|
| FEDERATED HERMES, INC. |
$26437523 |
391667 |
1.23% |
股份
|
| Squarepoint Ops LLC |
$21900105 |
324446 |
1.02% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$17752163 |
262995 |
0.83% |
股份
|
| FIRST TRUST ADVISORS LP |
$17481757 |
258989 |
0.82% |
股份
|
| MORGAN STANLEY |
$17353682 |
257091 |
0.81% |
股份
|
| TWO SIGMA ADVISERS, LP |
$17292816 |
356700 |
0.81% |
股份
|
| Coppell Advisory Solutions LLC |
$16575695 |
3638 |
0.77% |
股份
|
| FMR LLC |
$16234486 |
240511 |
0.76% |
股份
|
| Qube Research & Technologies Ltd |
$15442448 |
228777 |
0.72% |
股份
|
| HSBC HOLDINGS PLC |
$14928261 |
216949 |
0.70% |
股份
|
| Empowered Funds, LLC |
$13905675 |
206010 |
0.65% |
股份
|
| NORTHERN TRUST CORP |
$13686773 |
202767 |
0.64% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$13655588 |
202305 |
0.64% |
股份
|
| Invesco Ltd. |
$13638781 |
202056 |
0.64% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$12517471 |
185444 |
0.58% |
股份
|
| Greenhaven Road Investment Management, L.P. |
$11546483 |
171059 |
0.54% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$11422823 |
169227 |
0.53% |
股份
|
| MACKENZIE FINANCIAL CORP |
$10191083 |
150979 |
0.48% |
股份
|
| UBS Group AG |
$9911161 |
146832 |
0.46% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$9903870 |
146724 |
0.46% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$9519256 |
141026 |
0.44% |
股份
|
| Ensign Peak Advisors, Inc |
$7228980 |
107096 |
0.34% |
股份
|
| FRANKLIN RESOURCES INC |
$7219058 |
106949 |
0.34% |
股份
|
| CITIGROUP INC |
$6690195 |
99114 |
0.31% |
股份
|
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
$6327000 |
93732 |
0.30% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$5800410 |
85932 |
0.27% |
股份
|
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main |
$5666085 |
83942 |
0.26% |
股份
|
| JPMORGAN CHASE & CO |
$5293169 |
80236 |
0.25% |
股份
|
| Granahan Investment Management, LLC |
$5127435 |
75962 |
0.24% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$4893750 |
72500 |
0.23% |
卖出期权
|
| Irenic Capital Management LP |
$4755173 |
70447 |
0.22% |
股份
|
| Eversept Partners, LP |
$4723852 |
69983 |
0.22% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$4207680 |
62336 |
0.20% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$4168328 |
61753 |
0.19% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$3935250 |
58300 |
0.18% |
股份
|
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
$3884963 |
57555 |
0.18% |
股份
|
| Bank of New York Mellon Corp |
$3807069 |
56401 |
0.18% |
股份
|
| DEUTSCHE BANK AG\ |
$3164671 |
46884 |
0.15% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$3126804 |
46323 |
0.15% |
股份
|
| MARSHALL WACE, LLP |
$2957985 |
43822 |
0.14% |
股份
|
| Bleakley Financial Group, LLC |
$2886368 |
42761 |
0.13% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$2821231 |
41796 |
0.13% |
股份
|
| WELLS FARGO & COMPANY/MN |
$2815253 |
41707 |
0.13% |
股份
|
| Camber Capital Management LP |
$2775000 |
125000 |
0.13% |
股份
|
| HighMark Wealth Management LLC |
$2680830 |
39716 |
0.13% |
股份
|
| CAPITAL FUND MANAGEMENT S.A. |
$2642085 |
39142 |
0.12% |
股份
|
| Trexquant Investment LP |
$2389770 |
35404 |
0.11% |
股份
|
| Atom Investors LP |
$2289398 |
33917 |
0.11% |
股份
|
| Swiss National Bank |
$2139750 |
31700 |
0.10% |
股份
|
| Voleon Capital Management LP |
$2121188 |
31425 |
0.10% |
股份
|
| Moody Aldrich Partners LLC |
$2087505 |
30926 |
0.10% |
股份
|
| Aquatic Capital Management LLC |
$2079878 |
30813 |
0.10% |
股份
|
| SummitTX Capital, L.P. |
$1942583 |
28779 |
0.09% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$1820197 |
32820 |
0.08% |
股份
|
| RHUMBLINE ADVISERS |
$1778349 |
26346 |
0.08% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$1704119 |
30727 |
0.08% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1620000 |
24000 |
0.08% |
买入期权
|
| BURNEY CO/ |
$1522598 |
22557 |
0.07% |
股份
|
| Rafferty Asset Management, LLC |
$1475820 |
21864 |
0.07% |
股份
|
| XTX Topco Ltd |
$1445243 |
21411 |
0.07% |
股份
|
| HUSSMAN STRATEGIC ADVISORS, INC. |
$1417500 |
21000 |
0.07% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$1351283 |
20019 |
0.06% |
股份
|
| CREDIT AGRICOLE S A |
$1350000 |
20000 |
0.06% |
股份
|
| MARTINGALE ASSET MANAGEMENT L P |
$1346085 |
19942 |
0.06% |
股份
|
| Creative Planning |
$1267178 |
18773 |
0.06% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$1246590 |
18468 |
0.06% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1189958 |
17629 |
0.06% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$1183681 |
17536 |
0.06% |
股份
|
| VIRGINIA RETIREMENT SYSTEMS ET Al |
$1164375 |
17250 |
0.05% |
股份
|
| Diametric Capital, LP |
$1138590 |
16868 |
0.05% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$1113750 |
16500 |
0.05% |
股份
|
| Legal & General Group Plc |
$1108013 |
16415 |
0.05% |
股份
|
| Russell Investments Group, Ltd. |
$1100317 |
16301 |
0.05% |
股份
|
| TEMA ETFS LLC |
$1093709 |
22560 |
0.05% |
股份
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$1071225 |
15870 |
0.05% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$1012500 |
15000 |
0.05% |
买入期权
|
| Cresset Asset Management, LLC |
$972810 |
14412 |
0.05% |
股份
|
| Vanguard Global Advisers, LLC |
$939533 |
13919 |
0.04% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$904838 |
13405 |
0.04% |
股份
|
| Brevan Howard Capital Management LP |
$899708 |
13329 |
0.04% |
股份
|
| SEI INVESTMENTS CO |
$888368 |
13161 |
0.04% |
股份
|
| Orion Porfolio Solutions, LLC |
$801630 |
11876 |
0.04% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$783676 |
11610 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$781747 |
11639 |
0.04% |
股份
|
| Clear Harbor Asset Management, LLC |
$779625 |
11550 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$779490 |
11548 |
0.04% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$760388 |
11265 |
0.04% |
股份
|
| PROFUND ADVISORS LLC |
$745470 |
11044 |
0.03% |
股份
|
| CITADEL ADVISORS LLC |
$722250 |
10700 |
0.03% |
卖出期权
|
| Quantedge Capital Pte Ltd |
$702000 |
10400 |
0.03% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$699705 |
10366 |
0.03% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$654075 |
9690 |
0.03% |
股份
|
| DCF Advisers, LLC |
$615195 |
9114 |
0.03% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$599197 |
8877 |
0.03% |
股份
|
| CIBC WORLD MARKET INC. |
$587250 |
8700 |
0.03% |
股份
|
| CITADEL ADVISORS LLC |
$580500 |
8600 |
0.03% |
买入期权
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$544725 |
8070 |
0.03% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$537772 |
7967 |
0.03% |
股份
|
| Verition Fund Management LLC |
$506250 |
7500 |
0.02% |
股份
|
| Lombard Odier Asset Management (USA) Corp |
$499500 |
7400 |
0.02% |
股份
|
| GLENMEDE TRUST CO NA |
$473580 |
7016 |
0.02% |
股份
|
| Quantinno Capital Management LP |
$441922 |
6547 |
0.02% |
股份
|
| Duncan Williams Asset Management, LLC |
$440438 |
6525 |
0.02% |
股份
|
| Gotham Asset Management, LLC |
$424710 |
6292 |
0.02% |
股份
|
| Vinva Investment Management Ltd |
$420234 |
4383 |
0.02% |
股份
|
| JANUS HENDERSON GROUP PLC |
$413879 |
7464 |
0.02% |
股份
|
| Virtus Investment Advisers, LLC |
$393863 |
5835 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$393390 |
5828 |
0.02% |
股份
|
| Savant Capital, LLC |
$387156 |
5736 |
0.02% |
股份
|
| Ascent Group, LLC |
$377865 |
5598 |
0.02% |
股份
|
| FMB WEALTH MANAGEMENT |
$377460 |
5592 |
0.02% |
股份
|
| AlphaQuest LLC |
$376253 |
7761 |
0.02% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$373005 |
5526 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$364298 |
5397 |
0.02% |
股份
|
| ENVESTNET ASSET MANAGEMENT INC |
$359640 |
5328 |
0.02% |
股份
|
| Hillsdale Investment Management Inc. |
$347625 |
5150 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$345128 |
5113 |
0.02% |
股份
|
| Nebula Research & Development LLC |
$344833 |
15533 |
0.02% |
股份
|
| BARCLAYS PLC |
$344723 |
5107 |
0.02% |
股份
|
| Ancora Advisors LLC |
$337500 |
5000 |
0.02% |
股份
|
| Marex Group Ltd |
$334935 |
4962 |
0.02% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$329535 |
4882 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$312593 |
4631 |
0.01% |
股份
|
| Latash Investments, LLC |
$296528 |
4393 |
0.01% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$294503 |
4363 |
0.01% |
股份
|
| Allen Capital Group, LLC |
$272633 |
4039 |
0.01% |
股份
|
| Moran Wealth Management, LLC |
$268718 |
3981 |
0.01% |
股份
|
| Mitsubishi UFJ Trust & Banking Corp |
$261360 |
3872 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$252000 |
3740 |
0.01% |
股份
|
| ADAR1 Capital Management, LLC |
$249615 |
3698 |
0.01% |
股份
|
| Swiss Life Asset Management Ltd |
$244418 |
3621 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$241313 |
3575 |
0.01% |
股份
|
| nVerses Capital, LLC |
$240097 |
3557 |
0.01% |
股份
|
| ProShare Advisors LLC |
$239221 |
3544 |
0.01% |
股份
|
| Verdad Advisers, LP |
$236115 |
3498 |
0.01% |
股份
|
| MANGROVE PARTNERS IM, LLC |
$234563 |
3475 |
0.01% |
股份
|
| JANE STREET GROUP, LLC |
$209250 |
3100 |
0.01% |
买入期权
|
| E Fund Management Co., Ltd. |
$208103 |
3083 |
0.01% |
股份
|
| Kestra Advisory Services, LLC |
$206955 |
3066 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$202500 |
3000 |
0.01% |
股份
|
| Rangeley Capital, LLC |
$202500 |
3000 |
0.01% |
股份
|
| State of Wyoming |
$158422 |
2347 |
0.01% |
股份
|
| OSAIC HOLDINGS, INC. |
$146948 |
2177 |
0.01% |
股份
|
| GROUP ONE TRADING LLC |
$139995 |
2074 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$121028 |
1793 |
0.01% |
股份
|
| Larson Financial Group LLC |
$109620 |
1624 |
0.01% |
股份
|
| US BANCORP \DE\ |
$107663 |
1595 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$87818 |
1301 |
0.00% |
股份
|
| SIMPLEX TRADING, LLC |
$85522 |
1267 |
0.00% |
股份
|
| Spire Wealth Management |
$81000 |
1200 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$65475 |
970 |
0.00% |
股份
|
| CWM, LLC |
$56292 |
1015 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$55415 |
840 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$41175 |
610 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$38880 |
576 |
0.00% |
股份
|
| Persistent Asset Partners Ltd |
$38813 |
575 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$30645 |
454 |
0.00% |
股份
|
| GAMMA Investing LLC |
$30173 |
447 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$26620 |
395 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$23963 |
355 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$22818 |
454 |
0.00% |
股份
|
| Pinnacle Wealth Planning Services, Inc. |
$22545 |
334 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$19508 |
289 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$16672 |
247 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$13838 |
205 |
0.00% |
股份
|
| Arax Advisory Partners |
$11846 |
176 |
0.00% |
股份
|
| Quantbot Technologies LP |
$11813 |
175 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$11138 |
165 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$10328 |
153 |
0.00% |
股份
|
| Allworth Financial LP |
$10125 |
150 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$7020 |
104 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$5738 |
85 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$4658 |
69 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$4504 |
66730 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$4389 |
65 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$3713 |
55 |
0.00% |
股份
|
| HOLLENCREST CAPITAL MANAGEMENT |
$3375 |
50 |
0.00% |
股份
|
| Optiver Holding B.V. |
$3038 |
45 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$2903 |
43 |
0.00% |
股份
|
| Decker Retirement Planning Inc. |
$2903 |
43 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$2498 |
37 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$2430 |
36 |
0.00% |
股份
|
| ASSETMARK, INC |
$2430 |
36 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$2186 |
32374 |
0.00% |
股份
|
| Quarry LP |
$1958 |
29 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$1688 |
25 |
0.00% |
股份
|
| Blue Trust, Inc. |
$1283 |
19 |
0.00% |
股份
|
| Essential Partners LLC |
$1148 |
17 |
0.00% |
股份
|
| Stone House Investment Management, LLC |
$810 |
12 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$787 |
11697 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$540 |
8 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$405 |
6 |
0.00% |
股份
|
| True Wealth Design, LLC |
$270 |
4 |
0.00% |
股份
|
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO |
$247 |
3652 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$223 |
12 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$222 |
4 |
0.00% |
股份
|
| CANADA LIFE ASSURANCE Co |
$114 |
1698 |
0.00% |
股份
|
| BESSEMER GROUP INC |
$96 |
1428 |
0.00% |
股份
|
| TFC Financial Management, Inc. |
$68 |
1 |
0.00% |
股份
|
| IFP Advisors, Inc |
$68 |
1 |
0.00% |
股份
|
| CIBC Private Wealth Group LLC |
$31 |
1 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$25 |
365 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
9 |
0.00% |
股份
|
| Avion Wealth |
$0 |
7 |
0.00% |
股份
|