| BlackRock, Inc. |
$99813069 |
4145061 |
8.38% |
股份
|
| TANG CAPITAL MANAGEMENT LLC |
$98725592 |
4099900 |
8.29% |
股份
|
| MONTANOVA CAPITAL, LLC |
$98554239 |
4092784 |
8.27% |
股份
|
| STATE STREET CORP |
$81803372 |
3397150 |
6.87% |
股份
|
| VANGUARD GROUP INC |
$73935857 |
2561880 |
6.20% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$55327990 |
2297674 |
4.64% |
股份
|
| GOLDMAN SACHS GROUP INC |
$38001394 |
1578131 |
3.19% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$36308884 |
1507844 |
3.05% |
股份
|
| Boxer Capital Management, LLC |
$33595356 |
1395156 |
2.82% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$33049660 |
1372286 |
2.77% |
股份
|
| FMR LLC |
$27396529 |
1137730 |
2.30% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$25637976 |
1064700 |
2.15% |
买入期权
|
| PERCEPTIVE ADVISORS LLC |
$24080000 |
1000000 |
2.02% |
买入期权
|
| CITADEL ADVISORS LLC |
$19611812 |
814444 |
1.65% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$19329786 |
802732 |
1.62% |
股份
|
| Soleus Capital Management, L.P. |
$18342627 |
761737 |
1.54% |
股份
|
| MORGAN STANLEY |
$16483121 |
684515 |
1.38% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$15316975 |
636087 |
1.29% |
股份
|
| UBS Group AG |
$14921437 |
619661 |
1.25% |
股份
|
| DG Capital Management, LLC |
$14727208 |
611595 |
1.24% |
股份
|
| Ikarian Capital, LLC |
$14549497 |
604215 |
1.22% |
股份
|
| DIADEMA PARTNERS LP |
$12868352 |
534400 |
1.08% |
卖出期权
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$12714240 |
528000 |
1.07% |
卖出期权
|
| NORTHERN TRUST CORP |
$12125051 |
503532 |
1.02% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$12040000 |
500000 |
1.01% |
卖出期权
|
| Balyasny Asset Management L.P. |
$11723011 |
486836 |
0.98% |
股份
|
| SB Capital Management Inc |
$11544028 |
400001 |
0.97% |
股份
|
| CITADEL ADVISORS LLC |
$11394656 |
473200 |
0.96% |
买入期权
|
| Caption Management, LLC |
$10802288 |
448600 |
0.91% |
买入期权
|
| J. Goldman & Co LP |
$10289890 |
427321 |
0.86% |
股份
|
| Jones Hill Capital LP |
$10131684 |
420751 |
0.85% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$8970739 |
372539 |
0.75% |
股份
|
| JPMORGAN CHASE & CO |
$8685239 |
362501 |
0.73% |
股份
|
| Ikarian Capital, LLC |
$8428000 |
350000 |
0.71% |
买入期权
|
| DIADEMA PARTNERS LP |
$7929544 |
329300 |
0.67% |
买入期权
|
| D. E. Shaw & Co., Inc. |
$7585200 |
315000 |
0.64% |
买入期权
|
| GROUP ONE TRADING LLC |
$6564425 |
272609 |
0.55% |
股份
|
| CITADEL ADVISORS LLC |
$6222272 |
258400 |
0.52% |
卖出期权
|
| BANK OF AMERICA CORP /DE/ |
$6049739 |
251235 |
0.51% |
股份
|
| RTW INVESTMENTS, LP |
$6020000 |
250000 |
0.51% |
股份
|
| Nuveen, LLC |
$5697617 |
236612 |
0.48% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$5632938 |
233926 |
0.47% |
股份
|
| Palo Alto Investors LP |
$5532693 |
229763 |
0.46% |
股份
|
| Trexquant Investment LP |
$4762855 |
197793 |
0.40% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$4740292 |
196856 |
0.40% |
股份
|
| Caption Management, LLC |
$4659480 |
193500 |
0.39% |
卖出期权
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$4646525 |
192962 |
0.39% |
股份
|
| Moody Aldrich Partners LLC |
$4280316 |
177754 |
0.36% |
股份
|
| Bank of New York Mellon Corp |
$3895348 |
161767 |
0.33% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$3875387 |
160938 |
0.33% |
股份
|
| Woodline Partners LP |
$3341654 |
138773 |
0.28% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$3010000 |
125000 |
0.25% |
买入期权
|
| D. E. Shaw & Co., Inc. |
$2979804 |
123746 |
0.25% |
股份
|
| PFM Health Sciences, LP |
$2943082 |
122221 |
0.25% |
股份
|
| LMR Partners LLP |
$2819768 |
117100 |
0.24% |
买入期权
|
| Pier Capital, LLC |
$2694745 |
111908 |
0.23% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$2550072 |
105900 |
0.21% |
买入期权
|
| Jefferies Financial Group Inc. |
$2546580 |
105755 |
0.21% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$2413924 |
100246 |
0.20% |
股份
|
| MARSHALL WACE, LLP |
$2364294 |
98185 |
0.20% |
股份
|
| JANE STREET GROUP, LLC |
$2330944 |
96800 |
0.20% |
买入期权
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$2321860 |
76377 |
0.19% |
股份
|
| Point72 Asset Management, L.P. |
$2280930 |
94723 |
0.19% |
股份
|
| Swiss National Bank |
$2237032 |
92900 |
0.19% |
股份
|
| ADAR1 Capital Management, LLC |
$2181479 |
90593 |
0.18% |
股份
|
| CITIGROUP INC |
$1929362 |
80123 |
0.16% |
股份
|
| Black Diamond Financial, LLC |
$1904174 |
79077 |
0.16% |
股份
|
| OPPENHEIMER & CO INC |
$1823193 |
75714 |
0.15% |
股份
|
| Rock Springs Capital Management LP |
$1792708 |
74448 |
0.15% |
股份
|
| Longaeva Partners L.P. |
$1783028 |
74046 |
0.15% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$1741920 |
57300 |
0.15% |
股份
|
| Caption Management, LLC |
$1733760 |
72000 |
0.15% |
股份
|
| RHUMBLINE ADVISERS |
$1634564 |
67881 |
0.14% |
股份
|
| BARCLAYS PLC |
$1623955 |
67440 |
0.14% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$1610663 |
66888 |
0.14% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1528478 |
63475 |
0.13% |
股份
|
| Rafferty Asset Management, LLC |
$1453782 |
60373 |
0.12% |
股份
|
| Foundations Investment Advisors, LLC |
$1445041 |
60010 |
0.12% |
股份
|
| DEUTSCHE BANK AG\ |
$1386502 |
57579 |
0.12% |
股份
|
| WELLS FARGO & COMPANY/MN |
$1280767 |
53188 |
0.11% |
股份
|
| Quinn Opportunity Partners LLC |
$1076328 |
44698 |
0.09% |
股份
|
| JANE STREET GROUP, LLC |
$1052296 |
43700 |
0.09% |
卖出期权
|
| FRANKLIN RESOURCES INC |
$1049117 |
43568 |
0.09% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$1042664 |
43300 |
0.09% |
卖出期权
|
| GLENMEDE TRUST CO NA |
$961634 |
39935 |
0.08% |
股份
|
| Legal & General Group Plc |
$927394 |
38513 |
0.08% |
股份
|
| HBK Sorce Advisory LLC |
$876689 |
223076 |
0.07% |
股份
|
| AlphaQuest LLC |
$867416 |
30056 |
0.07% |
股份
|
| J. Goldman & Co LP |
$866880 |
36000 |
0.07% |
买入期权
|
| WOLVERINE TRADING, LLC |
$786942 |
106200 |
0.07% |
卖出期权
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$776941 |
32265 |
0.07% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$763274 |
31779 |
0.06% |
股份
|
| CITIGROUP INC |
$758520 |
31500 |
0.06% |
买入期权
|
| MetLife Investment Management, LLC |
$755630 |
31380 |
0.06% |
股份
|
| ALGERT GLOBAL LLC |
$737089 |
30610 |
0.06% |
股份
|
| PROFUND ADVISORS LLC |
$734007 |
30482 |
0.06% |
股份
|
| HAP Trading, LLC |
$731500 |
191200 |
0.06% |
买入期权
|
| Invesco Ltd. |
$711612 |
29552 |
0.06% |
股份
|
| ENVESTNET ASSET MANAGEMENT INC |
$699717 |
29058 |
0.06% |
股份
|
| Persistent Asset Partners Ltd |
$697076 |
831 |
0.06% |
买入期权
|
| Vanguard Global Advisers, LLC |
$687532 |
28552 |
0.06% |
股份
|
| JANUS HENDERSON GROUP PLC |
$686588 |
22600 |
0.06% |
股份
|
| TWINBEECH CAPITAL LP |
$682355 |
28337 |
0.06% |
股份
|
| LPL Financial LLC |
$659238 |
27377 |
0.06% |
股份
|
| WOLVERINE TRADING, LLC |
$655785 |
88500 |
0.06% |
买入期权
|
| COMMONWEALTH EQUITY SERVICES, LLC |
$644740 |
26775 |
0.05% |
股份
|
| Aquatic Capital Management LLC |
$632269 |
26257 |
0.05% |
股份
|
| PEAK6 LLC |
$602000 |
25000 |
0.05% |
买入期权
|
| SEVEN GRAND MANAGERS, LLC |
$602000 |
25000 |
0.05% |
股份
|
| Anson Funds Management LP |
$602000 |
25000 |
0.05% |
股份
|
| LMR Partners LLP |
$558656 |
23200 |
0.05% |
卖出期权
|
| Jump Financial, LLC |
$554707 |
23036 |
0.05% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$545797 |
22666 |
0.05% |
股份
|
| XTX Topco Ltd |
$529591 |
21993 |
0.04% |
股份
|
| WOLVERINE TRADING, LLC |
$525547 |
70924 |
0.04% |
股份
|
| OSAIC HOLDINGS, INC. |
$489640 |
20334 |
0.04% |
股份
|
| Squarepoint Ops LLC |
$475122 |
19731 |
0.04% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$455112 |
18900 |
0.04% |
股份
|
| Creative Planning |
$447564 |
18587 |
0.04% |
股份
|
| SEI INVESTMENTS CO |
$418631 |
17385 |
0.04% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$412105 |
17114 |
0.03% |
股份
|
| Persistent Asset Partners Ltd |
$404940 |
1356 |
0.03% |
卖出期权
|
| Police & Firemen's Retirement System of New Jersey |
$381957 |
15862 |
0.03% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$380849 |
15816 |
0.03% |
股份
|
| State of New Jersey Common Pension Fund D |
$360285 |
14962 |
0.03% |
股份
|
| Quantinno Capital Management LP |
$357371 |
14841 |
0.03% |
股份
|
| Birchview Capital, LP |
$345596 |
14352 |
0.03% |
股份
|
| Russell Investments Group, Ltd. |
$344103 |
14290 |
0.03% |
股份
|
| US BANCORP \DE\ |
$342778 |
14235 |
0.03% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$337626 |
14021 |
0.03% |
股份
|
| nVerses Capital, LLC |
$335940 |
13951 |
0.03% |
股份
|
| Vanguard Investments Australia, Ltd. |
$312294 |
12969 |
0.03% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$309187 |
12840 |
0.03% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$307453 |
12768 |
0.03% |
股份
|
| Virtus Investment Advisers, LLC |
$305383 |
12682 |
0.03% |
股份
|
| STIFEL FINANCIAL CORP |
$287902 |
11956 |
0.02% |
股份
|
| OneDigital Investment Advisors LLC |
$274127 |
11384 |
0.02% |
股份
|
| KLP KAPITALFORVALTNING AS |
$260064 |
10800 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$254742 |
10579 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$251203 |
10432 |
0.02% |
股份
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$243088 |
10095 |
0.02% |
股份
|
| DLD Asset Management, LP |
$240600 |
10000 |
0.02% |
卖出期权
|
| Orion Porfolio Solutions, LLC |
$234684 |
9746 |
0.02% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$227845 |
9462 |
0.02% |
股份
|
| MONETA GROUP INVESTMENT ADVISORS LLC |
$226328 |
9399 |
0.02% |
股份
|
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. |
$224955 |
9342 |
0.02% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$222475 |
9239 |
0.02% |
股份
|
| DeepCurrents Investment Group LLC |
$217804 |
9045 |
0.02% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$215468 |
8948 |
0.02% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$210941 |
8760 |
0.02% |
股份
|
| E Fund Management Co., Ltd. |
$204993 |
8513 |
0.02% |
股份
|
| HAP Trading, LLC |
$161370 |
115200 |
0.01% |
买入期权
|
| ROYAL BANK OF CANADA |
$132000 |
5494 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$117534 |
4881 |
0.01% |
股份
|
| Sheets Smith Investment Management |
$107155 |
14862 |
0.01% |
股份
|
| Ensign Peak Advisors, Inc |
$74648 |
3100 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$68700 |
2853 |
0.01% |
股份
|
| SBI Securities Co., Ltd. |
$67785 |
2815 |
0.01% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$59227 |
8215 |
0.00% |
股份
|
| HAP Trading, LLC |
$49350 |
45500 |
0.00% |
卖出期权
|
| Activest Wealth Management |
$48160 |
2000 |
0.00% |
股份
|
| China Universal Asset Management Co., Ltd. |
$38528 |
1600 |
0.00% |
股份
|
| State of Wyoming |
$30148 |
1252 |
0.00% |
股份
|
| Allworth Financial LP |
$26368 |
1095 |
0.00% |
股份
|
| Federation des caisses Desjardins du Quebec |
$20612 |
856 |
0.00% |
股份
|
| GoalVest Advisory LLC |
$19887 |
2100 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$17265 |
717 |
0.00% |
股份
|
| SUMMIT SECURITIES GROUP LLC |
$16423 |
682 |
0.00% |
股份
|
| Quantbot Technologies LP |
$14472 |
601 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$14039 |
583 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$10017 |
416 |
0.00% |
股份
|
| Arax Advisory Partners |
$9849 |
409 |
0.00% |
股份
|
| CWM, LLC |
$9667 |
318 |
0.00% |
股份
|
| IFP Advisors, Inc |
$7826 |
325 |
0.00% |
股份
|
| GAMMA Investing LLC |
$7778 |
323 |
0.00% |
股份
|
| Geneos Wealth Management Inc. |
$7224 |
300 |
0.00% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$6694 |
278 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$6502 |
270 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$5948 |
247 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$4551 |
189 |
0.00% |
股份
|
| Point72 (DIFC) Ltd |
$3723 |
516 |
0.00% |
股份
|
| Optiver Holding B.V. |
$3564 |
148 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$2882 |
109 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$2529 |
105 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$2432 |
101 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$1078 |
44748 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$1035 |
43 |
0.00% |
股份
|
| Larson Financial Group LLC |
$987 |
41 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$867 |
36 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$506 |
21 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$493 |
52 |
0.00% |
股份
|
| Stone House Investment Management, LLC |
$433 |
18 |
0.00% |
股份
|
| New Millennium Group LLC |
$317 |
11 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$289 |
12 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$265 |
11 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$255 |
10604 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$241 |
10 |
0.00% |
股份
|
| WOLFF WIESE MAGANA LLC |
$145 |
6 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$144 |
6 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$120 |
5 |
0.00% |
股份
|
| KBC Group NV |
$35 |
1461 |
0.00% |
股份
|
| Johnson Financial Group, Inc. |
$25 |
1 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$24 |
1008 |
0.00% |
股份
|
| Dauntless Investment Group, LLC |
$24 |
1 |
0.00% |
股份
|
| Harel Insurance Investments & Financial Services Ltd. |
$17 |
689 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
19 |
0.00% |
股份
|