| BVF INC/IL |
$24795531 |
6293282 |
12.81% |
股份
|
| BlackRock, Inc. |
$20187937 |
5123842 |
10.43% |
股份
|
| Defilade Capital Management, L.P. |
$13889832 |
3525338 |
7.18% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$13463859 |
3417223 |
6.96% |
股份
|
| GOLDMAN SACHS GROUP INC |
$9890613 |
2510308 |
5.11% |
股份
|
| Ensign Peak Advisors, Inc |
$8278823 |
2101224 |
4.28% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$7710867 |
1956601 |
3.98% |
股份
|
| Catalio Capital Management, LP |
$6678580 |
1695071 |
3.45% |
股份
|
| STATE STREET CORP |
$6390558 |
1621969 |
3.30% |
股份
|
| Zimmer Partners, LP |
$6290600 |
1596599 |
3.25% |
股份
|
| VANGUARD GROUP INC |
$6099926 |
4039686 |
3.15% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$4693277 |
1191187 |
2.42% |
股份
|
| AWM Investment Company, Inc. |
$4334000 |
1100000 |
2.24% |
股份
|
| UBS Group AG |
$4130085 |
1048245 |
2.13% |
股份
|
| KINGDON CAPITAL MANAGEMENT, L.L.C. |
$4094744 |
1039275 |
2.12% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$3860065 |
979712 |
1.99% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$3479402 |
883097 |
1.80% |
股份
|
| ADAR1 Capital Management, LLC |
$2552379 |
647812 |
1.32% |
股份
|
| 22NW, LP |
$2507274 |
636364 |
1.30% |
股份
|
| NORTHERN TRUST CORP |
$2428612 |
616399 |
1.25% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$2289251 |
581028 |
1.18% |
股份
|
| CM Management, LLC |
$2265500 |
575000 |
1.17% |
股份
|
| Blue Owl Capital Holdings LP |
$2232045 |
566509 |
1.15% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$2122256 |
538738 |
1.10% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$2101458 |
533365 |
1.09% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$2084114 |
528963 |
1.08% |
股份
|
| MORGAN STANLEY |
$1911262 |
485092 |
0.99% |
股份
|
| Triumph Capital Management |
$1195565 |
303443 |
0.62% |
股份
|
| Brevan Howard Capital Management LP |
$1174645 |
304707 |
0.61% |
股份
|
| CITADEL ADVISORS LLC |
$1100836 |
279400 |
0.57% |
卖出期权
|
| JANE STREET GROUP, LLC |
$1095320 |
278000 |
0.57% |
卖出期权
|
| BIT Capital GmbH |
$1048040 |
266000 |
0.54% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$993794 |
252232 |
0.51% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$978302 |
248300 |
0.51% |
卖出期权
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$974772 |
247404 |
0.50% |
股份
|
| CITADEL ADVISORS LLC |
$850934 |
215973 |
0.44% |
股份
|
| Nuveen, LLC |
$823842 |
209097 |
0.43% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$791546 |
200900 |
0.41% |
股份
|
| Bank of New York Mellon Corp |
$657690 |
166927 |
0.34% |
股份
|
| LPL Financial LLC |
$440078 |
111695 |
0.23% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$432774 |
109841 |
0.22% |
股份
|
| Maven Securities LTD |
$394000 |
100000 |
0.20% |
股份
|
| RHUMBLINE ADVISERS |
$349112 |
88609 |
0.18% |
股份
|
| SIMPLEX TRADING, LLC |
$349072 |
88597 |
0.18% |
股份
|
| Prodigy Asset Management LLC |
$341610 |
86703 |
0.18% |
股份
|
| Daytona Street Capital LLC |
$313301 |
81166 |
0.16% |
股份
|
| DEUTSCHE BANK AG\ |
$301973 |
76643 |
0.16% |
股份
|
| WELLS FARGO & COMPANY/MN |
$295280 |
74944 |
0.15% |
股份
|
| Rockefeller Capital Management L.P. |
$286304 |
72666 |
0.15% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$283361 |
71919 |
0.15% |
股份
|
| Shay Capital LLC |
$252160 |
64000 |
0.13% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$236006 |
59900 |
0.12% |
买入期权
|
| Invesco Ltd. |
$233630 |
59297 |
0.12% |
股份
|
| PW Nova Financial Services LLC |
$228682 |
58041 |
0.12% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$200983 |
51011 |
0.10% |
股份
|
| Mariner, LLC |
$197149 |
50041 |
0.10% |
股份
|
| IEQ CAPITAL, LLC |
$189770 |
48165 |
0.10% |
股份
|
| WOLVERINE TRADING, LLC |
$179324 |
70600 |
0.09% |
卖出期权
|
| Russell Investments Group, Ltd. |
$161237 |
40923 |
0.08% |
股份
|
| MetLife Investment Management, LLC |
$161217 |
40918 |
0.08% |
股份
|
| Kera Capital Partners, Inc. |
$158420 |
40208 |
0.08% |
股份
|
| WOLVERINE TRADING, LLC |
$151318 |
59574 |
0.08% |
股份
|
| XTX Topco Ltd |
$150930 |
38307 |
0.08% |
股份
|
| CITIGROUP INC |
$142147 |
36078 |
0.07% |
股份
|
| NAVELLIER & ASSOCIATES INC |
$141545 |
35925 |
0.07% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$139764 |
35473 |
0.07% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$139527 |
35413 |
0.07% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$133268 |
34615 |
0.07% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$131986 |
33499 |
0.07% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$129803 |
32945 |
0.07% |
股份
|
| JPMORGAN CHASE & CO |
$125367 |
32311 |
0.06% |
股份
|
| MARCO INVESTMENT MANAGEMENT LLC |
$119555 |
30344 |
0.06% |
股份
|
| Retirement Planning Group, LLC |
$118204 |
30001 |
0.06% |
股份
|
| HOWARD FINANCIAL SERVICES, LTD. |
$118200 |
30000 |
0.06% |
股份
|
| Cetera Investment Advisers |
$113736 |
28867 |
0.06% |
股份
|
| KESTRA PRIVATE WEALTH SERVICES, LLC |
$108350 |
27500 |
0.06% |
股份
|
| SEI INVESTMENTS CO |
$106857 |
27121 |
0.06% |
股份
|
| Cerity Partners LLC |
$104793 |
26597 |
0.05% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$99792 |
32400 |
0.05% |
股份
|
| Vanguard Global Advisers, LLC |
$98248 |
24936 |
0.05% |
股份
|
| GROUP ONE TRADING LLC |
$97416 |
24725 |
0.05% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$92622 |
23508 |
0.05% |
股份
|
| Creative Planning |
$92428 |
23459 |
0.05% |
股份
|
| Scientech Research LLC |
$90005 |
22844 |
0.05% |
股份
|
| JANE STREET GROUP, LLC |
$88173 |
22379 |
0.05% |
股份
|
| Private Advisor Group, LLC |
$85735 |
21760 |
0.04% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$84517 |
21451 |
0.04% |
股份
|
| Jump Financial, LLC |
$83847 |
21281 |
0.04% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$76570 |
19434 |
0.04% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$75419 |
19952 |
0.04% |
股份
|
| Relyea Zuckerberg Hanson LLC |
$66980 |
17000 |
0.03% |
股份
|
| COMMONWEALTH EQUITY SERVICES, LLC |
$65230 |
16556 |
0.03% |
股份
|
| Baker Ellis Asset Management LLC |
$63040 |
16000 |
0.03% |
股份
|
| China Universal Asset Management Co., Ltd. |
$63040 |
16000 |
0.03% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$62670 |
15906 |
0.03% |
股份
|
| CITADEL ADVISORS LLC |
$60282 |
15300 |
0.03% |
买入期权
|
| BLAIR WILLIAM & CO/IL |
$58875 |
14943 |
0.03% |
股份
|
| JANE STREET GROUP, LLC |
$57524 |
14600 |
0.03% |
买入期权
|
| Independent Advisor Alliance |
$56342 |
14300 |
0.03% |
股份
|
| Revolve Wealth Partners, LLC |
$55723 |
14143 |
0.03% |
股份
|
| Waverly Advisors, LLC |
$54577 |
13852 |
0.03% |
股份
|
| CAPTRUST FINANCIAL ADVISORS |
$53848 |
13667 |
0.03% |
股份
|
| NEUBERGER BERMAN GROUP LLC |
$52190 |
13246 |
0.03% |
股份
|
| Tower Research Capital LLC (TRC) |
$51039 |
12954 |
0.03% |
股份
|
| SIGNATUREFD, LLC |
$50964 |
12935 |
0.03% |
股份
|
| WINTON GROUP Ltd |
$50826 |
12900 |
0.03% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$49888 |
12662 |
0.03% |
股份
|
| BARCLAYS PLC |
$46843 |
11889 |
0.02% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$45389 |
11520 |
0.02% |
股份
|
| Summit Financial, LLC |
$45310 |
11500 |
0.02% |
股份
|
| GK Wealth Management LLC |
$45259 |
11487 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$44100 |
11193 |
0.02% |
股份
|
| Merit Financial Group, LLC |
$43860 |
11132 |
0.02% |
股份
|
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
$43242 |
10975 |
0.02% |
股份
|
| ProShare Advisors LLC |
$39738 |
10086 |
0.02% |
股份
|
| GRANDFIELD & DODD, LLC |
$39400 |
10000 |
0.02% |
股份
|
| Everhart Financial Group, Inc. |
$39400 |
10000 |
0.02% |
股份
|
| Ellis Investment Partners, LLC |
$39400 |
10000 |
0.02% |
股份
|
| Split Rock Private Trading & Wealth Management, LLC |
$39400 |
10000 |
0.02% |
股份
|
| Clarity Capital Partners LLC |
$31165 |
11500 |
0.02% |
股份
|
| CWM, LLC |
$30628 |
9944 |
0.02% |
股份
|
| OSAIC HOLDINGS, INC. |
$27697 |
7030 |
0.01% |
股份
|
| Legal & General Group Plc |
$27580 |
7000 |
0.01% |
股份
|
| Congress Wealth Management LLC / DE / |
$27100 |
10000 |
0.01% |
股份
|
| FARMERS & MERCHANTS INVESTMENTS INC |
$24905 |
6321 |
0.01% |
股份
|
| FMR LLC |
$24566 |
6235 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$24000 |
6073 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$23577 |
5984 |
0.01% |
股份
|
| Arax Advisory Partners |
$23577 |
5984 |
0.01% |
股份
|
| SOA Wealth Advisors, LLC. |
$17990 |
4566 |
0.01% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$16548 |
4200 |
0.01% |
股份
|
| FIFTH THIRD BANCORP |
$15311 |
3886 |
0.01% |
股份
|
| LANARK FINANCIAL, INC. |
$11820 |
3000 |
0.01% |
股份
|
| Federation des caisses Desjardins du Quebec |
$9850 |
2500 |
0.01% |
股份
|
| Costello Asset Management, INC |
$7880 |
2000 |
0.00% |
股份
|
| Allworth Financial LP |
$7699 |
1954 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$5910 |
1500 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$5685 |
1443 |
0.00% |
股份
|
| HARBOUR INVESTMENTS, INC. |
$5548 |
1408 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$5494 |
1398 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$5142 |
1305 |
0.00% |
股份
|
| Sankala Group LLC |
$5137 |
1425 |
0.00% |
股份
|
| Anchor Investment Management, LLC |
$5024 |
1275 |
0.00% |
股份
|
| GAMMA Investing LLC |
$4681 |
1188 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$4342 |
1102 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$4125 |
1047 |
0.00% |
股份
|
| Essential Partners LLC |
$4094 |
1039 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$2499 |
637 |
0.00% |
股份
|
| True Wealth Design, LLC |
$1947 |
494 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$1651 |
419 |
0.00% |
股份
|
| IMG Wealth Management, Inc. |
$1387 |
352 |
0.00% |
股份
|
| St. Johns Investment Management Company, LLC |
$1269 |
322 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$1064 |
270 |
0.00% |
股份
|
| Quaker Wealth Management, LLC |
$753 |
191 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$520 |
132 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$426 |
108 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$363 |
92 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$339 |
86 |
0.00% |
股份
|
| MCGUIRE CAPITAL ADVISORS INC |
$260 |
66 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$253 |
63984 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$248 |
63 |
0.00% |
股份
|
| Cambridge Investment Research Advisors, Inc. |
$236 |
59945 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$232 |
59 |
0.00% |
股份
|
| INGALLS & SNYDER LLC |
$204 |
51849 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$166 |
42028 |
0.00% |
股份
|
| Virtu Financial LLC |
$158 |
40043 |
0.00% |
股份
|
| PITTENGER & ANDERSON INC |
$138 |
35 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$80 |
26 |
0.00% |
股份
|
| JPL Wealth Management, LLC |
$44 |
11 |
0.00% |
股份
|
| IFP Advisors, Inc |
$32 |
8 |
0.00% |
股份
|
| Byrne Asset Management LLC |
$4 |
1 |
0.00% |
股份
|
| Navigoe, LLC |
$3 |
1005 |
0.00% |
股份
|