| Nantahala Capital Management, LLC |
$38878026 |
5602021 |
10.71% |
股份
|
| BlackRock, Inc. |
$33595347 |
4840828 |
9.25% |
股份
|
| VANGUARD GROUP INC |
$22222997 |
3341804 |
6.12% |
股份
|
| BRAIDWELL LP |
$21897150 |
3155209 |
6.03% |
股份
|
| Frazier Life Sciences Management, L.P. |
$18256815 |
2630665 |
5.03% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$17067438 |
2459285 |
4.70% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$16398477 |
2362893 |
4.52% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$12408227 |
1787929 |
3.42% |
股份
|
| STATE STREET CORP |
$11779220 |
1697294 |
3.24% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$11165325 |
1608394 |
3.08% |
股份
|
| Stonepine Capital Management, LLC |
$11035724 |
1590162 |
3.04% |
股份
|
| Point72 Asset Management, L.P. |
$10469115 |
1508518 |
2.88% |
股份
|
| PINNACLE ASSOCIATES LTD |
$10321612 |
1487264 |
2.84% |
股份
|
| ARMISTICE CAPITAL, LLC |
$9965840 |
1436000 |
2.75% |
股份
|
| RICE HALL JAMES & ASSOCIATES, LLC |
$8951823 |
1289888 |
2.47% |
股份
|
| GOLDMAN SACHS GROUP INC |
$8462768 |
1219419 |
2.33% |
股份
|
| Assenagon Asset Management S.A. |
$6302769 |
908180 |
1.74% |
股份
|
| Soleus Capital Management, L.P. |
$5707650 |
822428 |
1.57% |
股份
|
| Soviero Asset Management, LP |
$5343800 |
770000 |
1.47% |
股份
|
| UBS Group AG |
$5223592 |
752679 |
1.44% |
股份
|
| AWH Capital, L.P. |
$4337500 |
625000 |
1.19% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$3787172 |
545702 |
1.04% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$3684050 |
530843 |
1.01% |
股份
|
| CITADEL ADVISORS LLC |
$3514097 |
506354 |
0.97% |
股份
|
| NORTHERN TRUST CORP |
$3449306 |
497018 |
0.95% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$3165910 |
456183 |
0.87% |
股份
|
| DEUTSCHE BANK AG\ |
$3157214 |
454930 |
0.87% |
股份
|
| Stonepine Capital Management, LLC |
$3150000 |
420000 |
0.87% |
买入期权
|
| STIFEL FINANCIAL CORP |
$2936833 |
423174 |
0.81% |
股份
|
| CM Management, LLC |
$2776000 |
400000 |
0.76% |
股份
|
| D. E. Shaw & Co., Inc. |
$2338093 |
336901 |
0.64% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$2099829 |
302569 |
0.58% |
股份
|
| Walleye Capital LLC |
$1761490 |
253817 |
0.49% |
股份
|
| MORGAN STANLEY |
$1648664 |
237559 |
0.45% |
股份
|
| Nuveen, LLC |
$1621281 |
233614 |
0.45% |
股份
|
| Caption Management, LLC |
$1501233 |
216316 |
0.41% |
股份
|
| Caption Management, LLC |
$1388000 |
200000 |
0.38% |
卖出期权
|
| DIADEMA PARTNERS LP |
$1388000 |
200000 |
0.38% |
买入期权
|
| National Philanthropic Trust |
$1388000 |
200000 |
0.38% |
股份
|
| Squarepoint Ops LLC |
$1372094 |
197708 |
0.38% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$1179342 |
169934 |
0.32% |
股份
|
| Bank of New York Mellon Corp |
$1130172 |
162849 |
0.31% |
股份
|
| KVP Capital Advisors, LP |
$1041000 |
150000 |
0.29% |
股份
|
| Trexquant Investment LP |
$1015496 |
146325 |
0.28% |
股份
|
| Potomac Capital Management, Inc. |
$982010 |
141500 |
0.27% |
股份
|
| NATIXIS |
$981573 |
141437 |
0.27% |
股份
|
| Quantinno Capital Management LP |
$888861 |
128078 |
0.24% |
股份
|
| JANE STREET GROUP, LLC |
$769542 |
110885 |
0.21% |
股份
|
| XTX Topco Ltd |
$739117 |
106501 |
0.20% |
股份
|
| ANGELES WEALTH MANAGEMENT, LLC |
$732482 |
105545 |
0.20% |
股份
|
| ADAR1 Capital Management, LLC |
$694000 |
100000 |
0.19% |
股份
|
| BARCLAYS PLC |
$681363 |
98179 |
0.19% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$677087 |
97563 |
0.19% |
股份
|
| CenterBook Partners LP |
$636683 |
91741 |
0.18% |
股份
|
| WELLS FARGO & COMPANY/MN |
$588151 |
84748 |
0.16% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$567470 |
81768 |
0.16% |
股份
|
| Allostery Investments LP |
$552600 |
60000 |
0.15% |
股份
|
| Seven Fleet Capital Management LP |
$541716 |
78057 |
0.15% |
股份
|
| Russell Investments Group, Ltd. |
$538877 |
77648 |
0.15% |
股份
|
| ExodusPoint Capital Management, LP |
$534359 |
76997 |
0.15% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$508230 |
73232 |
0.14% |
股份
|
| RHUMBLINE ADVISERS |
$474519 |
68376 |
0.13% |
股份
|
| Corient Private Wealth LP |
$437241 |
63003 |
0.12% |
股份
|
| Pathstone Holdings, LLC |
$426447 |
61448 |
0.12% |
股份
|
| Aquatic Capital Management LLC |
$422688 |
60906 |
0.12% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$406684 |
58600 |
0.11% |
卖出期权
|
| Caption Management, LLC |
$402520 |
58000 |
0.11% |
买入期权
|
| LPL Financial LLC |
$395212 |
56947 |
0.11% |
股份
|
| FULLER & THALER ASSET MANAGEMENT, INC. |
$382033 |
55048 |
0.11% |
股份
|
| PRELUDE CAPITAL MANAGEMENT, LLC |
$355793 |
51267 |
0.10% |
股份
|
| CITIGROUP INC |
$298406 |
42998 |
0.08% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$285398 |
69440 |
0.08% |
股份
|
| Creative Planning |
$285116 |
41083 |
0.08% |
股份
|
| Jump Financial, LLC |
$273680 |
39435 |
0.08% |
股份
|
| State of Wyoming |
$271021 |
39052 |
0.07% |
股份
|
| Global Retirement Partners, LLC |
$250534 |
36100 |
0.07% |
股份
|
| Invesco Ltd. |
$246322 |
35493 |
0.07% |
股份
|
| MetLife Investment Management, LLC |
$243455 |
35080 |
0.07% |
股份
|
| JPMORGAN CHASE & CO |
$237778 |
33349 |
0.07% |
股份
|
| HSBC HOLDINGS PLC |
$227285 |
32423 |
0.06% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$225918 |
32553 |
0.06% |
股份
|
| AMERIPRISE FINANCIAL INC |
$225862 |
32545 |
0.06% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$218936 |
31547 |
0.06% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$204036 |
29400 |
0.06% |
买入期权
|
| Concurrent Investment Advisors, LLC |
$193133 |
27829 |
0.05% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$189781 |
27346 |
0.05% |
股份
|
| Vanguard Global Advisers, LLC |
$186866 |
26926 |
0.05% |
股份
|
| SEI INVESTMENTS CO |
$183456 |
26438 |
0.05% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$173500 |
25000 |
0.05% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$141909 |
20448 |
0.04% |
股份
|
| Chicago Partners Investment Group LLC |
$133266 |
22248 |
0.04% |
股份
|
| TWO SIGMA ADVISERS, LP |
$129010 |
19400 |
0.04% |
股份
|
| Pure Financial Advisors, LLC |
$123532 |
17800 |
0.03% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$121679 |
17533 |
0.03% |
股份
|
| INCEPTIONR LLC |
$112518 |
16213 |
0.03% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$111186 |
16021 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$109881 |
15833 |
0.03% |
股份
|
| AlphaQuest LLC |
$109146 |
16413 |
0.03% |
股份
|
| OneDigital Investment Advisors LLC |
$103950 |
15000 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$98229 |
14154 |
0.03% |
股份
|
| PROFUND ADVISORS LLC |
$95841 |
13810 |
0.03% |
股份
|
| AXQ CAPITAL, LP |
$92871 |
13382 |
0.03% |
股份
|
| CITADEL ADVISORS LLC |
$88832 |
12800 |
0.02% |
卖出期权
|
| Tradition Wealth Management, LLC |
$88138 |
12700 |
0.02% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$85959 |
12386 |
0.02% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$85612 |
12336 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$82732 |
11921 |
0.02% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$82301 |
11859 |
0.02% |
股份
|
| Krilogy Financial LLC |
$80414 |
11587 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$80324 |
11574 |
0.02% |
股份
|
| WINTON GROUP Ltd |
$77034 |
11100 |
0.02% |
股份
|
| ENVESTNET ASSET MANAGEMENT INC |
$76402 |
11009 |
0.02% |
股份
|
| Accelerate Investment Advisors LLC |
$74050 |
10670 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$72738 |
10481 |
0.02% |
股份
|
| Sequoia Financial Advisors, LLC |
$70913 |
10218 |
0.02% |
股份
|
| Federation des caisses Desjardins du Quebec |
$63015 |
9080 |
0.02% |
股份
|
| FMR LLC |
$59028 |
8505 |
0.02% |
股份
|
| Quantbot Technologies LP |
$56304 |
8113 |
0.02% |
股份
|
| Legal & General Group Plc |
$40072 |
5774 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$37580 |
5415 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$26733 |
3852 |
0.01% |
股份
|
| OSAIC HOLDINGS, INC. |
$21429 |
3088 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$20438 |
2945 |
0.01% |
股份
|
| PNC Financial Services Group, Inc. |
$19946 |
2874 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$14000 |
2206 |
0.00% |
股份
|
| GAMMA Investing LLC |
$13776 |
1985 |
0.00% |
股份
|
| Persistent Asset Partners Ltd |
$10240 |
512 |
0.00% |
买入期权
|
| GF FUND MANAGEMENT CO. LTD. |
$9341 |
1346 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$8828 |
1272 |
0.00% |
股份
|
| Plante Moran Financial Advisors, LLC |
$8467 |
1220 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$7372 |
1034 |
0.00% |
股份
|
| IAG Wealth Partners, LLC |
$6433 |
927 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$5878 |
847 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$5455 |
786 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$4782 |
689 |
0.00% |
股份
|
| CIBC Private Wealth Group LLC |
$4605 |
750 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$4077 |
587 |
0.00% |
股份
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$3921 |
565 |
0.00% |
股份
|
| CWM, LLC |
$3880 |
944 |
0.00% |
股份
|
| Arax Advisory Partners |
$3661 |
528 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$2960 |
370 |
0.00% |
股份
|
| Binnacle Investments Inc |
$2917 |
475 |
0.00% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$2193 |
316 |
0.00% |
股份
|
| HUNTINGTON NATIONAL BANK |
$2089 |
301 |
0.00% |
股份
|
| Allworth Financial LP |
$2082 |
300 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$2020 |
291 |
0.00% |
股份
|
| Stephens Consulting, LLC |
$1929 |
290 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$1860 |
268 |
0.00% |
股份
|
| True Wealth Design, LLC |
$1791 |
258 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$1763 |
254 |
0.00% |
股份
|
| Essential Partners LLC |
$1603 |
231 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$1450 |
209 |
0.00% |
股份
|
| US BANCORP \DE\ |
$1187 |
171 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$1139 |
164 |
0.00% |
股份
|
| Krensavage Asset Management, LLC |
$1096 |
157985 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$1005 |
145 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$957 |
137761 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$951 |
137 |
0.00% |
股份
|
| Bare Financial Services, Inc |
$805 |
116 |
0.00% |
股份
|
| Walleye Capital LLC |
$694 |
100 |
0.00% |
卖出期权
|
| NFSG Corp |
$694 |
100 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$684 |
96 |
0.00% |
股份
|
| Larson Financial Group LLC |
$541 |
78 |
0.00% |
股份
|
| Financial Management Professionals, Inc. |
$507 |
73 |
0.00% |
股份
|
| GHP Investment Advisors, Inc. |
$329 |
80 |
0.00% |
股份
|
| Optiver Holding B.V. |
$257 |
37 |
0.00% |
股份
|
| IFP Advisors, Inc |
$187 |
27 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$132 |
11 |
0.00% |
股份
|
| CoreCap Advisors, LLC |
$132 |
19 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$119 |
17 |
0.00% |
股份
|
| JPL Wealth Management, LLC |
$98 |
14 |
0.00% |
股份
|
| Transamerica Financial Advisors, LLC |
$76 |
11 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$71 |
10164 |
0.00% |
股份
|
| State of Alaska, Department of Revenue |
$30 |
4330 |
0.00% |
股份
|
| Wealth Enhancement Trust Services, Inc. |
$7 |
1 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
69 |
0.00% |
股份
|