| ORBIMED ADVISORS LLC |
$630516330 |
15518492 |
12.91% |
股份
|
| Paradigm Biocapital Advisors LP |
$415053937 |
10215455 |
8.50% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$340996620 |
8392730 |
6.98% |
股份
|
| BlackRock, Inc. |
$268415431 |
6606336 |
5.50% |
股份
|
| FMR LLC |
$223023556 |
5489135 |
4.57% |
股份
|
| NOVO HOLDINGS A/S |
$217370500 |
5350000 |
4.45% |
股份
|
| Driehaus Capital Management LLC |
$192123952 |
4728623 |
3.94% |
股份
|
| JANUS HENDERSON GROUP PLC |
$186289082 |
5915556 |
3.82% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$177714564 |
4373974 |
3.64% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$156859022 |
3860670 |
3.21% |
股份
|
| BAKER BROS. ADVISORS LP |
$150400843 |
3701719 |
3.08% |
股份
|
| Siren, L.L.C. |
$129391476 |
3184629 |
2.65% |
股份
|
| VANGUARD GROUP INC |
$120889349 |
4871624 |
2.48% |
股份
|
| Cormorant Asset Management, LP |
$101981300 |
2510000 |
2.09% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$88348054 |
2174051 |
1.81% |
股份
|
| Integral Health Asset Management, LLC |
$81260000 |
2000000 |
1.66% |
股份
|
| BRAIDWELL LP |
$81136688 |
1996965 |
1.66% |
股份
|
| MORGAN STANLEY |
$79171495 |
1948597 |
1.62% |
股份
|
| STATE STREET CORP |
$74268674 |
1827927 |
1.52% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$66749256 |
2119024 |
1.37% |
股份
|
| MPM BIOIMPACT LLC |
$65852291 |
1620780 |
1.35% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$63312105 |
1558260 |
1.30% |
股份
|
| Qube Research & Technologies Ltd |
$50889359 |
1252507 |
1.04% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$46309097 |
1139726 |
0.95% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$45793233 |
1127078 |
0.94% |
股份
|
| First Light Asset Management, LLC |
$44496798 |
1095171 |
0.91% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$36683608 |
902870 |
0.75% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$31953707 |
786456 |
0.65% |
股份
|
| NORTHERN TRUST CORP |
$27273701 |
671270 |
0.56% |
股份
|
| Aberdeen Group plc |
$26325233 |
647926 |
0.54% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$25212215 |
620532 |
0.52% |
股份
|
| Tyro Capital Management LLC |
$24904768 |
612965 |
0.51% |
股份
|
| GOLDMAN SACHS GROUP INC |
$24356425 |
599469 |
0.50% |
股份
|
| Parkman Healthcare Partners LLC |
$23444973 |
577036 |
0.48% |
股份
|
| Artisan Partners Limited Partnership |
$23359203 |
574925 |
0.48% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$22276820 |
548285 |
0.46% |
股份
|
| NORGES BANK |
$20726988 |
510140 |
0.42% |
股份
|
| Opaleye Management Inc. |
$20315000 |
500000 |
0.42% |
股份
|
| CITADEL ADVISORS LLC |
$19084196 |
469707 |
0.39% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$18771060 |
462000 |
0.38% |
股份
|
| Soleus Capital Management, L.P. |
$18319620 |
450889 |
0.38% |
股份
|
| Nuveen, LLC |
$16849506 |
414706 |
0.35% |
股份
|
| New Leaf Venture Partners, L.L.C. |
$16709211 |
1030161 |
0.34% |
股份
|
| Sofinnova Investments, Inc. |
$15476901 |
380923 |
0.32% |
股份
|
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
$13570989 |
334014 |
0.28% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$12902666 |
317565 |
0.26% |
股份
|
| Squadron Capital Management LLC |
$11782700 |
290000 |
0.24% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$11511820 |
283333 |
0.24% |
股份
|
| DIADEMA PARTNERS LP |
$11060055 |
272214 |
0.23% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$10593257 |
260725 |
0.22% |
股份
|
| KENNEDY CAPITAL MANAGEMENT LLC |
$10425983 |
256608 |
0.21% |
股份
|
| Schonfeld Strategic Advisors LLC |
$10368855 |
255202 |
0.21% |
股份
|
| DEUTSCHE BANK AG\ |
$9954147 |
244995 |
0.20% |
股份
|
| DAFNA Capital Management LLC |
$9215656 |
226819 |
0.19% |
股份
|
| Woodline Partners LP |
$9112903 |
224290 |
0.19% |
股份
|
| Bank of New York Mellon Corp |
$8627655 |
212347 |
0.18% |
股份
|
| JPMORGAN CHASE & CO |
$8477151 |
203151 |
0.17% |
股份
|
| PEREGRINE CAPITAL MANAGEMENT LLC |
$8067899 |
198570 |
0.17% |
股份
|
| SEB Asset Management AB |
$7884765 |
194063 |
0.16% |
股份
|
| Granahan Investment Management, LLC |
$7873200 |
193778 |
0.16% |
股份
|
| NEUBERGER BERMAN GROUP LLC |
$7768253 |
191195 |
0.16% |
股份
|
| BARCLAYS PLC |
$7728029 |
190205 |
0.16% |
股份
|
| D. E. Shaw & Co., Inc. |
$7683743 |
189115 |
0.16% |
股份
|
| UBS Group AG |
$7108909 |
174967 |
0.15% |
股份
|
| Caption Management, LLC |
$6480485 |
159500 |
0.13% |
买入期权
|
| ADAR1 Capital Management, LLC |
$5818175 |
143199 |
0.12% |
股份
|
| KVP Capital Advisors, LP |
$5403790 |
133000 |
0.11% |
股份
|
| Invesco Ltd. |
$4913467 |
120932 |
0.10% |
股份
|
| Point72 Asset Management, L.P. |
$4764355 |
117262 |
0.10% |
股份
|
| Quantum Private Wealth, LLC |
$4606640 |
113380 |
0.09% |
股份
|
| ALPS ADVISORS INC |
$4420341 |
108795 |
0.09% |
股份
|
| Moody Aldrich Partners LLC |
$4264200 |
104952 |
0.09% |
股份
|
| KINGDON CAPITAL MANAGEMENT, L.L.C. |
$4063000 |
100000 |
0.08% |
卖出期权
|
| Artia Global Partners LP |
$4014244 |
98800 |
0.08% |
股份
|
| Swiss National Bank |
$3932984 |
96800 |
0.08% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$3846483 |
94671 |
0.08% |
股份
|
| HSBC HOLDINGS PLC |
$3723252 |
91638 |
0.08% |
股份
|
| HighVista Strategies LLC |
$3697168 |
90996 |
0.08% |
股份
|
| RHUMBLINE ADVISERS |
$3666114 |
90232 |
0.08% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$3613681 |
114720 |
0.07% |
股份
|
| Ally Bridge Group (NY) LLC |
$3384479 |
83300 |
0.07% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$3361482 |
82734 |
0.07% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$3258404 |
80197 |
0.07% |
股份
|
| WELLS FARGO & COMPANY/MN |
$3205636 |
78898 |
0.07% |
股份
|
| Russell Investments Group, Ltd. |
$3158321 |
77733 |
0.06% |
股份
|
| Centiva Capital, LP |
$3047250 |
75000 |
0.06% |
买入期权
|
| Jefferies Financial Group Inc. |
$2900535 |
71389 |
0.06% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$2897163 |
71306 |
0.06% |
股份
|
| Persistent Asset Partners Ltd |
$2821388 |
69441 |
0.06% |
股份
|
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
$2638000 |
64918 |
0.05% |
股份
|
| CITIGROUP INC |
$2420045 |
59563 |
0.05% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$2313228 |
56934 |
0.05% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$2312253 |
56910 |
0.05% |
股份
|
| CITADEL ADVISORS LLC |
$2263091 |
55700 |
0.05% |
买入期权
|
| HighMark Wealth Management LLC |
$2160662 |
53179 |
0.04% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$2013135 |
49548 |
0.04% |
股份
|
| SEI INVESTMENTS CO |
$1931667 |
47543 |
0.04% |
股份
|
| ALGERT GLOBAL LLC |
$1919361 |
47240 |
0.04% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1913673 |
47100 |
0.04% |
卖出期权
|
| XTX Topco Ltd |
$1862154 |
45832 |
0.04% |
股份
|
| Legal & General Group Plc |
$1815674 |
44688 |
0.04% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$1770940 |
43587 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$1698497 |
41804 |
0.03% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$1655957 |
40757 |
0.03% |
股份
|
| Ensign Peak Advisors, Inc |
$1640599 |
40379 |
0.03% |
股份
|
| Creative Planning |
$1592614 |
39198 |
0.03% |
股份
|
| Knights of Columbus Asset Advisors LLC |
$1569984 |
38641 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1568318 |
38600 |
0.03% |
买入期权
|
| FRANKLIN RESOURCES INC |
$1527891 |
37605 |
0.03% |
股份
|
| Aquatic Capital Management LLC |
$1499978 |
36918 |
0.03% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$1452279 |
35744 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$1434361 |
35303 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$1338312 |
32939 |
0.03% |
股份
|
| JANE STREET GROUP, LLC |
$1216218 |
29934 |
0.02% |
股份
|
| Verdad Advisers, LP |
$1106517 |
27234 |
0.02% |
股份
|
| Brevan Howard Capital Management LP |
$1079377 |
26566 |
0.02% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$1042525 |
25659 |
0.02% |
股份
|
| GLENMEDE TRUST CO NA |
$994784 |
24484 |
0.02% |
股份
|
| Campbell & CO Investment Adviser LLC |
$968172 |
23829 |
0.02% |
股份
|
| ORACLE INVESTMENT MANAGEMENT INC |
$951482 |
38343 |
0.02% |
股份
|
| ENVESTNET ASSET MANAGEMENT INC |
$921692 |
22685 |
0.02% |
股份
|
| STRS OHIO |
$857293 |
21100 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$857130 |
21096 |
0.02% |
股份
|
| Quantinno Capital Management LP |
$824748 |
20299 |
0.02% |
股份
|
| LMR Partners LLP |
$812600 |
20000 |
0.02% |
股份
|
| Longaeva Partners L.P. |
$763438 |
18790 |
0.02% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$749869 |
18456 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$746495 |
18373 |
0.02% |
股份
|
| Odyssean, LLC |
$725936 |
17867 |
0.01% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$685428 |
16870 |
0.01% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$673564 |
16578 |
0.01% |
股份
|
| CAPTRUST FINANCIAL ADVISORS |
$661781 |
16288 |
0.01% |
股份
|
| AlphaCentric Advisors LLC |
$643579 |
15840 |
0.01% |
股份
|
| State of New Jersey Common Pension Fund D |
$634153 |
15608 |
0.01% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$621151 |
15288 |
0.01% |
股份
|
| SummitTX Capital, L.P. |
$598805 |
14738 |
0.01% |
股份
|
| Point72 Asset Management, L.P. |
$593198 |
14600 |
0.01% |
卖出期权
|
| JANE STREET GROUP, LLC |
$589135 |
14500 |
0.01% |
买入期权
|
| Vanguard Investments Australia, Ltd. |
$556062 |
13686 |
0.01% |
股份
|
| GUGGENHEIM CAPITAL LLC |
$554558 |
13649 |
0.01% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$541192 |
13320 |
0.01% |
股份
|
| State of Wyoming |
$524655 |
12913 |
0.01% |
股份
|
| ProShare Advisors LLC |
$523721 |
12890 |
0.01% |
股份
|
| Skopos Labs, Inc. |
$510962 |
16221 |
0.01% |
股份
|
| Corient Private Wealth LP |
$502393 |
12365 |
0.01% |
股份
|
| Advisory Services Network, LLC |
$496068 |
12209 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$459119 |
11300 |
0.01% |
股份
|
| J. Goldman & Co LP |
$413735 |
10183 |
0.01% |
股份
|
| Verition Fund Management LLC |
$406300 |
10000 |
0.01% |
股份
|
| FIRST TRUST ADVISORS LP |
$401302 |
9877 |
0.01% |
股份
|
| Connecticut Capital Management Group, LLC |
$399149 |
9824 |
0.01% |
股份
|
| Virtus Investment Advisers, LLC |
$381719 |
9395 |
0.01% |
股份
|
| Private Advisor Group, LLC |
$379525 |
9341 |
0.01% |
股份
|
| Bridgefront Capital, LLC |
$373146 |
9184 |
0.01% |
股份
|
| PROFUND ADVISORS LLC |
$372333 |
9164 |
0.01% |
股份
|
| Allianz Asset Management GmbH |
$369733 |
9100 |
0.01% |
股份
|
| Lion Point Capital, LP |
$369733 |
9100 |
0.01% |
股份
|
| OSAIC HOLDINGS, INC. |
$353237 |
8694 |
0.01% |
股份
|
| XPONANCE LLC |
$285507 |
7027 |
0.01% |
股份
|
| VARCOV Co. |
$284776 |
7009 |
0.01% |
股份
|
| Orion Porfolio Solutions, LLC |
$281566 |
6930 |
0.01% |
股份
|
| Engineers Gate Manager LP |
$271002 |
6670 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$263729 |
6491 |
0.01% |
股份
|
| Orion Portfolio Solutions, LLC |
$255926 |
11633 |
0.01% |
股份
|
| Pictet Asset Management Holding SA |
$255156 |
6280 |
0.01% |
股份
|
| Marex Group Ltd |
$254913 |
6274 |
0.01% |
股份
|
| MARSHALL WACE, LLP |
$247843 |
6100 |
0.01% |
股份
|
| Rafferty Asset Management, LLC |
$245202 |
6035 |
0.01% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$244349 |
6014 |
0.01% |
股份
|
| VIRGINIA RETIREMENT SYSTEMS ET Al |
$239717 |
5900 |
0.00% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$231266 |
5692 |
0.00% |
股份
|
| Squarepoint Ops LLC |
$229763 |
5655 |
0.00% |
股份
|
| TEACHER RETIREMENT SYSTEM OF TEXAS |
$226268 |
5569 |
0.00% |
股份
|
| AXQ CAPITAL, LP |
$224968 |
5537 |
0.00% |
股份
|
| PRINCIPAL FINANCIAL GROUP INC |
$222246 |
5470 |
0.00% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$222084 |
5466 |
0.00% |
股份
|
| CITADEL ADVISORS LLC |
$219402 |
5400 |
0.00% |
卖出期权
|
| PSP Research LLC |
$203150 |
5000 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$195512 |
4812 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$181901 |
4477 |
0.00% |
股份
|
| Glenmede Investment Management, LP |
$180642 |
11137 |
0.00% |
股份
|
| AlphaQuest LLC |
$177254 |
7143 |
0.00% |
股份
|
| Nebula Research & Development LLC |
$173301 |
13219 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$153000 |
3762 |
0.00% |
股份
|
| US BANCORP \DE\ |
$137573 |
3386 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$114252 |
2812 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$92311 |
2272 |
0.00% |
股份
|
| GAMMA Investing LLC |
$85607 |
2107 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$61473 |
1513 |
0.00% |
股份
|
| Eleva Capital SAS |
$54990 |
17460 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$49487 |
1218 |
0.00% |
股份
|
| Centiva Capital, LP |
$49447 |
1217 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$49325 |
1214 |
0.00% |
股份
|
| FEDERATED HERMES, INC. |
$46237 |
1138 |
0.00% |
股份
|
| Kemnay Advisory Services Inc. |
$33682 |
829 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$33177 |
816518 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$31773 |
782 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$22743 |
558 |
0.00% |
股份
|
| Optiver Holding B.V. |
$14992 |
369 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$14749 |
363 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$13164 |
324 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$11945 |
294 |
0.00% |
股份
|
| CWM, LLC |
$11057 |
351 |
0.00% |
股份
|
| SMA Capital LLC |
$10239 |
252 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$10198 |
251 |
0.00% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$9345 |
230 |
0.00% |
股份
|
| CROWLEY WEALTH MANAGEMENT, INC. |
$9083 |
560 |
0.00% |
股份
|
| Aster Capital Management (DIFC) Ltd |
$8573 |
211 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$8451 |
208 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$8370 |
206 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$7833 |
193 |
0.00% |
股份
|
| Larson Financial Group LLC |
$7313 |
180 |
0.00% |
股份
|
| Allworth Financial LP |
$7151 |
176 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$7151 |
176 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$6629 |
162 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$6501 |
160 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$6270 |
285 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$6095 |
150 |
0.00% |
股份
|
| Hurley Capital, LLC |
$6054 |
149 |
0.00% |
股份
|
| BFSG, LLC |
$4063 |
100 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$4019 |
99 |
0.00% |
股份
|
| Quarry LP |
$2885 |
71 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$2884 |
71 |
0.00% |
股份
|
| DekaBank Deutsche Girozentrale |
$2522 |
80000 |
0.00% |
股份
|
| Arax Advisory Partners |
$2072 |
51 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$1807 |
44466 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$1423 |
35 |
0.00% |
股份
|
| Handelsbanken Fonder AB |
$980 |
31100 |
0.00% |
股份
|
| Ares Financial Consulting, LLC |
$934 |
23 |
0.00% |
股份
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$934 |
23 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$912 |
22 |
0.00% |
股份
|
| COMERICA BANK |
$890 |
35 |
0.00% |
股份
|
| Bare Financial Services, Inc |
$731 |
18 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$691 |
17 |
0.00% |
股份
|
| Bell Investment Advisors, Inc |
$610 |
15 |
0.00% |
股份
|
| IFP Advisors, Inc |
$163 |
4 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$122 |
3 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$122 |
3 |
0.00% |
股份
|
| Essential Partners LLC |
$122 |
3 |
0.00% |
股份
|
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO |
$116 |
2849 |
0.00% |
股份
|
| GHP Investment Advisors, Inc. |
$95 |
3 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$67 |
1669 |
0.00% |
股份
|
| KBC Group NV |
$63 |
1560 |
0.00% |
股份
|
| BI Asset Management Fondsmaeglerselskab A/S |
$58 |
1439 |
0.00% |
股份
|
| Winthrop Capital Management, LLC |
$43 |
1377 |
0.00% |
股份
|
| BESSEMER GROUP INC |
$17 |
426 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
21 |
0.00% |
股份
|