| NEA Management Company, LLC |
$186153612 |
7692298 |
9.04% |
股份
|
| BlackRock, Inc. |
$165602706 |
6843087 |
8.05% |
股份
|
| TCG Crossover Management, LLC |
$111856054 |
4622151 |
5.43% |
股份
|
| Vestal Point Capital, LP |
$111320000 |
4600000 |
5.41% |
股份
|
| BVF INC/IL |
$107953441 |
4460886 |
5.25% |
股份
|
| BAKER BROS. ADVISORS LP |
$105166811 |
4345736 |
5.11% |
股份
|
| STATE STREET CORP |
$90300267 |
3731416 |
4.39% |
股份
|
| MONTANOVA CAPITAL, LLC |
$85898844 |
3549539 |
4.17% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$82592833 |
3412927 |
4.01% |
股份
|
| Versant Venture Management, LLC |
$76974876 |
3180780 |
3.74% |
股份
|
| BRAIDWELL LP |
$59327800 |
2451562 |
2.88% |
股份
|
| VANGUARD GROUP INC |
$50905120 |
3246500 |
2.47% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$45121645 |
1864113 |
2.19% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$39272873 |
1622846 |
1.91% |
股份
|
| MARSHALL WACE, LLP |
$38565119 |
1593600 |
1.87% |
股份
|
| Aisling Capital Management LP |
$37647069 |
1555664 |
1.83% |
股份
|
| Bellevue Group AG |
$28798000 |
1190000 |
1.40% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$28493337 |
1177488 |
1.38% |
股份
|
| MPM BIOIMPACT LLC |
$28098160 |
1161081 |
1.37% |
股份
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$26820739 |
1108295 |
1.30% |
股份
|
| Frazier Life Sciences Management, L.P. |
$24200000 |
1000000 |
1.18% |
股份
|
| GOLDMAN SACHS GROUP INC |
$24157723 |
998253 |
1.17% |
股份
|
| Woodline Partners LP |
$23301793 |
962884 |
1.13% |
股份
|
| FMR LLC |
$22612829 |
934414 |
1.10% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$19164754 |
791932 |
0.93% |
股份
|
| MORGAN STANLEY |
$19106990 |
789545 |
0.93% |
股份
|
| Nextech Invest Ltd. |
$18419903 |
761153 |
0.90% |
股份
|
| Opaleye Management Inc. |
$18029000 |
745000 |
0.88% |
股份
|
| NORTHERN TRUST CORP |
$15780505 |
652087 |
0.77% |
股份
|
| Nantahala Capital Management, LLC |
$15778231 |
651993 |
0.77% |
股份
|
| FIRST TRUST ADVISORS LP |
$15676663 |
647796 |
0.76% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$14914702 |
616310 |
0.72% |
股份
|
| BOONE CAPITAL MANAGEMENT LLC |
$14889945 |
615287 |
0.72% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$13372097 |
552566 |
0.65% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$12599682 |
520648 |
0.61% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$12233100 |
505500 |
0.59% |
股份
|
| JANUS HENDERSON GROUP PLC |
$11293772 |
685926 |
0.55% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$10890000 |
450000 |
0.53% |
股份
|
| KENNEDY CAPITAL MANAGEMENT LLC |
$9813802 |
405529 |
0.48% |
股份
|
| AMERIPRISE FINANCIAL INC |
$9276708 |
383335 |
0.45% |
股份
|
| Alphabet Inc. |
$9013871 |
372474 |
0.44% |
股份
|
| Fisher Asset Management, LLC |
$8797182 |
363520 |
0.43% |
股份
|
| Allspring Global Investments Holdings, LLC |
$8539139 |
352857 |
0.41% |
股份
|
| Empowered Funds, LLC |
$7968237 |
329266 |
0.39% |
股份
|
| Caption Management, LLC |
$7260000 |
300000 |
0.35% |
买入期权
|
| TD Asset Management Inc |
$6919651 |
285936 |
0.34% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$6160376 |
254561 |
0.30% |
股份
|
| Bank of New York Mellon Corp |
$5385007 |
222521 |
0.26% |
股份
|
| Longaeva Partners L.P. |
$5246366 |
216792 |
0.25% |
股份
|
| ADAR1 Capital Management, LLC |
$5245398 |
216752 |
0.25% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$5019734 |
207427 |
0.24% |
股份
|
| UBS Group AG |
$4860159 |
200833 |
0.24% |
股份
|
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
$4840000 |
200000 |
0.24% |
股份
|
| Balyasny Asset Management L.P. |
$4813259 |
198895 |
0.23% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$4643423 |
191877 |
0.23% |
股份
|
| FRANKLIN RESOURCES INC |
$4569759 |
188833 |
0.22% |
股份
|
| Casdin Capital, LLC |
$4501539 |
186014 |
0.22% |
股份
|
| D. E. Shaw & Co., Inc. |
$4163683 |
172053 |
0.20% |
股份
|
| DIADEMA PARTNERS LP |
$4116420 |
170100 |
0.20% |
买入期权
|
| VICTORY CAPITAL MANAGEMENT INC |
$4077990 |
168512 |
0.20% |
股份
|
| Nuveen, LLC |
$4035544 |
166758 |
0.20% |
股份
|
| CITADEL ADVISORS LLC |
$3958418 |
163571 |
0.19% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$3790518 |
156633 |
0.18% |
股份
|
| STEMPOINT CAPITAL LP |
$3715765 |
153544 |
0.18% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$3410337 |
140923 |
0.17% |
股份
|
| Exome Asset Management LLC |
$3318183 |
137115 |
0.16% |
股份
|
| CITIGROUP INC |
$3133102 |
129467 |
0.15% |
股份
|
| ExodusPoint Capital Management, LP |
$2931128 |
121121 |
0.14% |
股份
|
| Trexquant Investment LP |
$2791785 |
115363 |
0.14% |
股份
|
| Caption Management, LLC |
$2718192 |
112322 |
0.13% |
股份
|
| Atom Investors LP |
$2686490 |
111012 |
0.13% |
股份
|
| Jain Global LLC |
$2677657 |
110647 |
0.13% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$2480500 |
102500 |
0.12% |
股份
|
| Invesco Ltd. |
$2347714 |
97013 |
0.11% |
股份
|
| Swiss National Bank |
$2330460 |
96300 |
0.11% |
股份
|
| RHUMBLINE ADVISERS |
$2289140 |
94593 |
0.11% |
股份
|
| Squarepoint Ops LLC |
$2007463 |
82953 |
0.10% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$1914752 |
79122 |
0.09% |
股份
|
| DIADEMA PARTNERS LP |
$1897062 |
78391 |
0.09% |
股份
|
| JPMORGAN CHASE & CO |
$1835998 |
76820 |
0.09% |
股份
|
| DEUTSCHE BANK AG\ |
$1816477 |
75061 |
0.09% |
股份
|
| WELLS FARGO & COMPANY/MN |
$1661330 |
68650 |
0.08% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$1614285 |
66706 |
0.08% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$1438059 |
87420 |
0.07% |
股份
|
| Rafferty Asset Management, LLC |
$1421871 |
58755 |
0.07% |
股份
|
| Tetragon Partners GP Ltd |
$1356458 |
56052 |
0.07% |
股份
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$1314738 |
54328 |
0.06% |
股份
|
| Quantinno Capital Management LP |
$1311616 |
54199 |
0.06% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1311543 |
54196 |
0.06% |
股份
|
| SEI INVESTMENTS CO |
$1210681 |
50028 |
0.06% |
股份
|
| PRINCIPAL FINANCIAL GROUP INC |
$1185824 |
49001 |
0.06% |
股份
|
| SEVEN GRAND MANAGERS, LLC |
$1089000 |
45000 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$1053402 |
43529 |
0.05% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1043020 |
43100 |
0.05% |
卖出期权
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$988290 |
40923 |
0.05% |
股份
|
| Legal & General Group Plc |
$977099 |
40376 |
0.05% |
股份
|
| XTX Topco Ltd |
$964975 |
39875 |
0.05% |
股份
|
| Russell Investments Group, Ltd. |
$938336 |
38774 |
0.05% |
股份
|
| Vanguard Global Advisers, LLC |
$934967 |
38635 |
0.05% |
股份
|
| Round Rock Advisors LLC |
$900942 |
37229 |
0.04% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$885720 |
36600 |
0.04% |
买入期权
|
| ACT CAPITAL MANAGEMENT, LLC |
$847000 |
35000 |
0.04% |
股份
|
| Jump Financial, LLC |
$844580 |
34900 |
0.04% |
股份
|
| BARCLAYS PLC |
$834102 |
34467 |
0.04% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$829600 |
34281 |
0.04% |
股份
|
| Persistent Asset Partners Ltd |
$824808 |
34083 |
0.04% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$816314 |
33732 |
0.04% |
股份
|
| Arax Advisory Partners |
$773311 |
31955 |
0.04% |
股份
|
| ADVISORY RESEARCH INC |
$759783 |
31396 |
0.04% |
股份
|
| Aquatic Capital Management LLC |
$739310 |
30550 |
0.04% |
股份
|
| Informed Momentum Co LLC |
$736067 |
30416 |
0.04% |
股份
|
| PROFUND ADVISORS LLC |
$728686 |
30111 |
0.04% |
股份
|
| Campbell & CO Investment Adviser LLC |
$686675 |
28375 |
0.03% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$663104 |
27401 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$628571 |
25974 |
0.03% |
股份
|
| Harvest Investment Services, LLC |
$613543 |
25353 |
0.03% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$608606 |
25149 |
0.03% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$597220 |
25921 |
0.03% |
股份
|
| PSP Research LLC |
$556600 |
23000 |
0.03% |
股份
|
| Creative Planning |
$549969 |
22726 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$528528 |
21840 |
0.03% |
股份
|
| Verition Fund Management LLC |
$496100 |
20500 |
0.02% |
股份
|
| CWM, LLC |
$488351 |
29687 |
0.02% |
股份
|
| DLD Asset Management, LP |
$484200 |
20000 |
0.02% |
买入期权
|
| Corient Private Wealth LP |
$462704 |
19120 |
0.02% |
股份
|
| IEQ CAPITAL, LLC |
$458808 |
18959 |
0.02% |
股份
|
| AlphaQuest LLC |
$444089 |
28322 |
0.02% |
股份
|
| Virtus Investment Advisers, LLC |
$434245 |
17944 |
0.02% |
股份
|
| Seven Fleet Capital Management LP |
$406560 |
16800 |
0.02% |
股份
|
| TEMA ETFS LLC |
$388347 |
24767 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$375657 |
15523 |
0.02% |
股份
|
| HighTower Advisors, LLC |
$370526 |
15311 |
0.02% |
股份
|
| J. Goldman & Co LP |
$365880 |
15119 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$364089 |
15045 |
0.02% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$360169 |
14883 |
0.02% |
股份
|
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. |
$354796 |
14661 |
0.02% |
股份
|
| State of Wyoming |
$344003 |
14215 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$335969 |
13883 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$328346 |
13568 |
0.02% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$320577 |
13247 |
0.02% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$317140 |
19279 |
0.02% |
股份
|
| AlphaCentric Advisors LLC |
$306009 |
12645 |
0.01% |
股份
|
| MANGROVE PARTNERS IM, LLC |
$302911 |
12517 |
0.01% |
股份
|
| ProShare Advisors LLC |
$301581 |
12462 |
0.01% |
股份
|
| AXQ CAPITAL, LP |
$296934 |
12270 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$289795 |
11975 |
0.01% |
股份
|
| VIRGINIA RETIREMENT SYSTEMS ET Al |
$273460 |
11300 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$263780 |
10900 |
0.01% |
股份
|
| Persistent Asset Partners Ltd |
$258066 |
434 |
0.01% |
买入期权
|
| MERCER GLOBAL ADVISORS INC /ADV |
$257270 |
10631 |
0.01% |
股份
|
| WEALTH EFFECTS LLC |
$244396 |
10099 |
0.01% |
股份
|
| Mayflower Financial Advisors, LLC |
$242000 |
10000 |
0.01% |
股份
|
| BRIGHTON JONES LLC |
$235854 |
9746 |
0.01% |
股份
|
| JANE STREET GROUP, LLC |
$225060 |
9300 |
0.01% |
卖出期权
|
| Pallas Capital Advisors LLC |
$221140 |
9138 |
0.01% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$214442 |
8861171 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$214194 |
8851 |
0.01% |
股份
|
| CITADEL ADVISORS LLC |
$212960 |
8800 |
0.01% |
买入期权
|
| E Fund Management Co., Ltd. |
$200497 |
8285 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$162624 |
6720 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$148588 |
6140 |
0.01% |
股份
|
| Rockefeller Capital Management L.P. |
$128139 |
5295 |
0.01% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$118846 |
4911 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$91428 |
3778 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$76303 |
3153 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$76000 |
3164 |
0.00% |
股份
|
| STRS OHIO |
$70180 |
2900 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$64153 |
2651 |
0.00% |
股份
|
| GAMMA Investing LLC |
$51159 |
2114 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$39107 |
1616 |
0.00% |
股份
|
| Allworth Financial LP |
$29912 |
1236 |
0.00% |
股份
|
| IFP Advisors, Inc |
$28508 |
1178 |
0.00% |
股份
|
| Essential Partners LLC |
$19868 |
821 |
0.00% |
股份
|
| Kemnay Advisory Services Inc. |
$17303 |
715 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$15415 |
637 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$14423 |
596 |
0.00% |
股份
|
| Parkwood LLC |
$12221 |
505000 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$11059 |
457 |
0.00% |
股份
|
| COMERICA BANK |
$9345 |
596 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$7614 |
315 |
0.00% |
股份
|
| Duquesne Family Office LLC |
$7202 |
297600 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$6365 |
263 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$6292 |
260 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$5397 |
223 |
0.00% |
股份
|
| Optiver Holding B.V. |
$4840 |
200 |
0.00% |
股份
|
| Larson Financial Group LLC |
$4380 |
181 |
0.00% |
股份
|
| Point72 Europe (London) LLP |
$4379 |
591 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$2807 |
116 |
0.00% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$2589 |
107 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$2541 |
105 |
0.00% |
股份
|
| True Wealth Design, LLC |
$2033 |
84 |
0.00% |
股份
|
| Quarry LP |
$1621 |
67 |
0.00% |
股份
|
| Dogwood Wealth Management LLC |
$1307 |
54 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$968 |
40 |
0.00% |
股份
|
| Valued Wealth Advisors LLC |
$944 |
39 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$884 |
37 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$704 |
29083 |
0.00% |
股份
|
| US BANCORP \DE\ |
$702 |
29 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$630 |
26 |
0.00% |
股份
|
| Ameritas Advisory Services, LLC |
$557 |
23 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$266 |
11 |
0.00% |
股份
|
| Vestcor Inc |
$102 |
4234 |
0.00% |
股份
|
| Covestor Ltd |
$79 |
3268 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$24 |
981 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$16 |
1 |
0.00% |
股份
|